nitrates has been researched along with Cardiomegaly in 18 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension." | 7.75 | Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009) |
| "The fact that both E and L delayed cardiac hypertrophy/hyperplasia and aortic growth and raised aortic endothelium NOS activity indicates a protective effect on cardiovascular damage due to aging, exerted through inhibition of angiotensin II." | 7.71 | Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging. ( Basso, N; González Bosc, LV; Kurnjek, ML; Müller, A; Terragno, NA, 2001) |
| " Perindoprilat (1 microM), an ACE inhibitor, also restrained the progression of cardiac hypertrophy and augmented NO release." | 7.69 | Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes. ( Fukuzawa, A; Ikeda, T; Ishigai, Y; Mori, T; Shibano, T, 1997) |
| "Two types of vasodilators are used for treatment of acute myocardial infarction: Nitrates on the one hand with predominant venodilation and agents like Phentolamie and Nitroprusside on the other hand with venodilation as well as arteriolar vasodilation." | 4.76 | [Hemodynamic guidelines in the treatment of acute myocardial infarction by means of vasodilators]. ( Zilcher, H, 1979) |
| " The electrophilic lipid 10-nitro-oleic acid (NO2-OA) inhibited hydrolase activity and also lowered BP in an angiotensin II-induced hypertension model in wild-type (WT) but not KI mice." | 3.80 | Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. ( Charles, RL; Eaton, P; Freeman, BA; Hammock, BD; Kamynina, A; Morisseau, C; Prysyazhna, O; Rudyk, O; Yang, J, 2014) |
| "Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension." | 3.75 | Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009) |
| " Body weight (BW), left ventricular (LV) weight (LVW), LVW/BW ratio, LV collagen volume fraction (LVCVF), cyclic GMP, and nitrite/nitrate were measured." | 3.73 | Ventricular hypertrophy and arterial hemodynamics following deprivation of nitric oxide in rats. ( Chang, HR; Chen, HI; Hsu, YH; Hu, CT; Liu, CJ, 2005) |
| "The fact that both E and L delayed cardiac hypertrophy/hyperplasia and aortic growth and raised aortic endothelium NOS activity indicates a protective effect on cardiovascular damage due to aging, exerted through inhibition of angiotensin II." | 3.71 | Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging. ( Basso, N; González Bosc, LV; Kurnjek, ML; Müller, A; Terragno, NA, 2001) |
| " Perindoprilat (1 microM), an ACE inhibitor, also restrained the progression of cardiac hypertrophy and augmented NO release." | 3.69 | Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes. ( Fukuzawa, A; Ikeda, T; Ishigai, Y; Mori, T; Shibano, T, 1997) |
| "Although the etiology of congestive heart failure is complex, a disturbance of myocardial function due to ischemic heart disease or various forms of cardiomyopathy is by far the leading causative factor." | 2.37 | Congestive heart failure--pathophysiology and medical treatment. ( Remme, WJ, 1986) |
| "Reduced bioavailability of endogenous nitric oxide (NO) is a central pathophysiological event in hypertension and other cardiovascular diseases." | 1.37 | Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. ( Carlström, M; Hezel, M; Larsson, E; Lundberg, JO; Persson, AE; Scheffer, PG; Teerlink, T; Weitzberg, E, 2011) |
| "Captopril treatment reversed the increments in pressure back to normal values by the fourth week." | 1.33 | Effects of captopril on cardiac and renal damage, and metabolic alterations in the nitric oxide-deficient hypertensive rat. ( Al-Shabanah, O; Khattab, MM; Mostafa, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Gee, LC | 1 |
| Massimo, G | 1 |
| Lau, C | 1 |
| Primus, C | 1 |
| Fernandes, D | 1 |
| Chen, J | 1 |
| Rathod, KS | 1 |
| Hamers, AJP | 1 |
| Filomena, F | 1 |
| Nuredini, G | 1 |
| Ibrahim, AS | 1 |
| Khambata, RS | 1 |
| Gupta, AK | 1 |
| Moon, JC | 1 |
| Kapil, V | 1 |
| Ahluwalia, A | 1 |
| Erkens, R | 1 |
| Suvorava, T | 1 |
| Sutton, TR | 1 |
| Fernandez, BO | 1 |
| Mikus-Lelinska, M | 1 |
| Barbarino, F | 1 |
| Flögel, U | 1 |
| Kelm, M | 1 |
| Feelisch, M | 1 |
| Cortese-Krott, MM | 1 |
| Charles, RL | 1 |
| Rudyk, O | 1 |
| Prysyazhna, O | 1 |
| Kamynina, A | 1 |
| Yang, J | 1 |
| Morisseau, C | 1 |
| Hammock, BD | 1 |
| Freeman, BA | 1 |
| Eaton, P | 1 |
| Vera, T | 1 |
| Granger, JP | 1 |
| Stec, DE | 1 |
| Carlström, M | 1 |
| Persson, AE | 1 |
| Larsson, E | 1 |
| Hezel, M | 1 |
| Scheffer, PG | 1 |
| Teerlink, T | 1 |
| Weitzberg, E | 1 |
| Lundberg, JO | 1 |
| Kase, H | 1 |
| Hashikabe, Y | 1 |
| Uchida, K | 1 |
| Nakanishi, N | 1 |
| Hattori, Y | 1 |
| Hu, CT | 1 |
| Chang, HR | 1 |
| Hsu, YH | 1 |
| Liu, CJ | 1 |
| Chen, HI | 1 |
| Khattab, MM | 1 |
| Mostafa, A | 1 |
| Al-Shabanah, O | 1 |
| Li, HJ | 1 |
| Yin, H | 2 |
| Yao, YY | 2 |
| Shen, B | 2 |
| Bader, M | 1 |
| Chao, L | 3 |
| Chao, J | 3 |
| Gorlin, R | 1 |
| Ishigai, Y | 1 |
| Mori, T | 1 |
| Ikeda, T | 1 |
| Fukuzawa, A | 1 |
| Shibano, T | 1 |
| Wolf, WC | 1 |
| Yoshida, H | 1 |
| Agata, J | 1 |
| González Bosc, LV | 1 |
| Kurnjek, ML | 1 |
| Müller, A | 1 |
| Terragno, NA | 1 |
| Basso, N | 1 |
| Plotnick, GD | 1 |
| Greene, HL | 1 |
| Carliner, NH | 1 |
| Becker, LC | 1 |
| Fisher, ML | 1 |
| Lloyd, EA | 1 |
| Zilcher, H | 1 |
| Remme, WJ | 1 |
4 reviews available for nitrates and Cardiomegaly
| Article | Year |
|---|---|
Prevention of remodeling of the heart after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiomegaly; Clinical Trials | 1995 |
The use of vasodilator agents in the treatment of heart failure.
Topics: Cardiac Output; Cardiomegaly; Catheterization; Chronic Disease; Coronary Vessels; Dose-Response Rela | 1979 |
[Hemodynamic guidelines in the treatment of acute myocardial infarction by means of vasodilators].
Topics: Arrhythmias, Cardiac; Cardiac Output; Cardiomegaly; Death, Sudden; Diuretics; Heart Block; Heart Ven | 1979 |
Congestive heart failure--pathophysiology and medical treatment.
Topics: Autonomic Nervous System; Blood Pressure; Calcium; Cardiomegaly; Cardiotonic Agents; Digitalis; Diur | 1986 |
14 other studies available for nitrates and Cardiomegaly
| Article | Year |
|---|---|
Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide.
Topics: Animals; Cardiomegaly; Case-Control Studies; Clinical Studies as Topic; Disease Models, Animal; Fibr | 2022 |
Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection.
Topics: Animals; Aorta; Cardiomegaly; Glutathione; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Repe | 2018 |
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cellulase; Diet, Mediterranean; Disease Model | 2014 |
Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice.
Topics: Angiotensin II; Animals; Bilirubin; Blood Pressure; Cardiomegaly; Disease Models, Animal; Glucuronos | 2009 |
Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension.
Topics: Animals; Arginine; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Renal; Kidney | 2011 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Dis | 2005 |
Ventricular hypertrophy and arterial hemodynamics following deprivation of nitric oxide in rats.
Topics: Algorithms; Animals; Arteries; Body Weight; Cardiomegaly; Cell Count; Collagen; Cyclic GMP; Electroc | 2005 |
Effects of captopril on cardiac and renal damage, and metabolic alterations in the nitric oxide-deficient hypertensive rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Blood Pressure; Body | 2005 |
Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation.
Topics: Adenoviridae; Animals; Blotting, Western; Cardiomegaly; Electrophoretic Mobility Shift Assay; Enzyme | 2007 |
Tissue kallikrein and kinin infusion rescues failing myocardium after myocardial infarction.
Topics: Animals; Capillaries; Cardiac Output, Low; Cardiomegaly; Cells, Cultured; Collagen; Coronary Vessels | 2007 |
Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Bradykinin; Bradykinin Receptor | 1997 |
Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure.
Topics: Adenoviridae; Animals; Blood Pressure; Blood Urea Nitrogen; Cardiomegaly; Cyclic GMP; Fibrosis; Gene | 2000 |
Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; A | 2001 |
Clinical indicators of left main coronary artery disease in unstable angina.
Topics: Angina Pectoris; Angiography; Anticoagulants; Calcinosis; Cardiac Catheterization; Cardiomegaly; Col | 1979 |