nitrates has been researched along with Brain Ischemia in 54 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anti-ischemic effect of angiotensin-converting enzyme inhibitor--chinapril was examined by exercise tolerance test [ETT] in randomised, cross-over double blind comparison in 20 pts with coronary artery disease treated with beta-blockers and nitrates." | 9.10 | [Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Randomized, cross-over, double-blind comparison]. ( Dqbrowski, R; Kośmicki, M; Kowalik, I; Malczewska, B; Pasierski, T, 2003) |
| "The study examined effects of inorganic magnesium agents: magnesium nitrate Mg(NO3)2, magnesium sulfate MgSO4, and magnesium chloride MgCl2 on the development of neurological disorders and mortality in rats resulting from cerebral ischemia provoked by a single-stage bilateral occlusion of the common carotid arteries." | 7.80 | Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats. ( Krushinskii, AL; Kuzenkov, VS, 2014) |
| "Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin." | 5.91 | Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023) |
| "Anti-ischemic effect of angiotensin-converting enzyme inhibitor--chinapril was examined by exercise tolerance test [ETT] in randomised, cross-over double blind comparison in 20 pts with coronary artery disease treated with beta-blockers and nitrates." | 5.10 | [Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Randomized, cross-over, double-blind comparison]. ( Dqbrowski, R; Kośmicki, M; Kowalik, I; Malczewska, B; Pasierski, T, 2003) |
| "Candesartan has been reported to have a protective effect on cerebral ischemia in vivo and in human ischemic stroke." | 3.81 | Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro. ( Deli, MA; Hayashi, K; Hiu, T; Matsuo, T; Morofuji, Y; Nagata, I; Nakagawa, S; Niwa, M; So, G; Suyama, K; Tanaka, K, 2015) |
| "The study examined effects of inorganic magnesium agents: magnesium nitrate Mg(NO3)2, magnesium sulfate MgSO4, and magnesium chloride MgCl2 on the development of neurological disorders and mortality in rats resulting from cerebral ischemia provoked by a single-stage bilateral occlusion of the common carotid arteries." | 3.80 | Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats. ( Krushinskii, AL; Kuzenkov, VS, 2014) |
| " Methylene blue exerted neuroprotective effects against the brain damage associated with the ischemia/reperfusion injury and ameliorated the blood-brain barrier disruption by decreasing nitric oxide metabolites." | 3.76 | Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. ( Martijn, C; Miclescu, A; Sharma, HS; Wiklund, L, 2010) |
| "Daily intake of green tea catechins efficiently protects the penumbra from irreversible damage due to cerebral ischemia, and consequent neurologic deficits." | 3.72 | Protective effects of green tea catechins on cerebral ischemic damage. ( Ikeda, M; Suzuki, M; Tabuchi, M; Tomita, T; Umegaki, K, 2004) |
| "Treatment with cynaropicrin in dosage-based manner increased the level of antioxidant enzymes, IL-10, Nrf-2, and Bcl-2 in the animals which indicates the antioxidative effect of cynaropicrin." | 1.91 | Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB. ( Jin, T; Leng, B, 2023) |
| " Studies have found increasing nitric oxide (NO) bioavailability improves neurological function following stroke, but whether dietary nitrate supplementation could reduce BPV remains unknown." | 1.48 | Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( Allan, PD; Clarkson, AN; Fan, JL; Gowing, EK; Tzeng, YC, 2018) |
| " In this clinical study, we investigated whether PD-mediated impairment of nitric oxide (NO) bioavailability and signaling, in patients with persistently low systolic blood pressure (SBP), can explain the occurrence of cerebral ischemia." | 1.43 | Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia. ( Bárány, P; Békássy, Z; Cananau, C; Carlström, M; Checa, A; Hansson, S; Krmar, RT; Lundberg, JO; Sartz, L; Svensson, A; Weitzberg, E; Westphal, S; Wheelock, CE; Wide, K, 2016) |
| "The neuronal damage following cerebral ischemia is a serious risk to stroke patients." | 1.37 | Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. ( Ji, A; Liang, H; Liu, P; Song, S; Wang, Y, 2011) |
| "Focal cerebral ischemia was induced in two sets of animals by permanent middle cerebral artery occlusion." | 1.35 | The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. ( Aral, E; Arslan, OC; Durmaz, R; Kanbak, G; Kartkaya, K; Ozden, H; Uzuner, K, 2008) |
| "We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage." | 1.34 | Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. ( Hu, M; Jiang, J; Li, F; Sun, YJ; Wang, W; Zhu, DY, 2007) |
| "Forebrain ischemia was induced for 30 min by occlusion of the bilateral common carotid arteries without hemorrhagic hypotension." | 1.31 | Severe cerebral blood flow reduction inhibits nitric oxide synthesis. ( Fujisawa, H; Shima, H; Suzuki, M; Uetsuka, S; Yasuda, H, 2002) |
| "However, in cerebral ischemia, excessive PARS activation may lead to energy depletion and exacerbation of neuronal damage." | 1.31 | Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain. ( Ben-Ari, Y; Benjelloun, N; Charriaut-Marlangue, C; Ducrocq, S; Plotkine, M, 2000) |
| "Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion." | 1.31 | Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000) |
| "Compared to sham-operated controls, cerebral ischemia-reperfusion resulted in a significant increase in total and inducible NOS activity and a significant increase in the production of NO and superoxide in the cerebral hemispheres." | 1.30 | Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat. ( Forman, LJ; Liu, P; Nagele, RG; Wong, PY; Yin, K, 1998) |
| "10 comatose patients (Glasgow Coma Score +/- 6)successfully resuscitated from a cardiac arrest occurring outside the hospital." | 1.29 | Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest? ( Buunk, G; Frölich, M; Meinders, AE; van der Hoeven, JG, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.85) | 18.7374 |
| 1990's | 14 (25.93) | 18.2507 |
| 2000's | 19 (35.19) | 29.6817 |
| 2010's | 17 (31.48) | 24.3611 |
| 2020's | 3 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, T | 1 |
| Leng, B | 1 |
| Gao, J | 1 |
| Cheng, Z | 1 |
| Jiang, S | 1 |
| Wills, M | 1 |
| Wehbe, A | 1 |
| Rajah, GB | 1 |
| Geng, X | 1 |
| Ding, Y | 1 |
| Medeiros, R | 1 |
| Sousa, B | 1 |
| Rossi, S | 1 |
| Afonso, C | 1 |
| Bonino, L | 1 |
| Pitt, A | 1 |
| López, E | 1 |
| Spickett, C | 1 |
| Borthagaray, G | 1 |
| Kuzenkov, VS | 3 |
| Allan, PD | 1 |
| Tzeng, YC | 1 |
| Gowing, EK | 1 |
| Clarkson, AN | 1 |
| Fan, JL | 1 |
| Wang, S | 1 |
| Li, Y | 1 |
| Wei, J | 1 |
| Li, P | 1 |
| Yang, Q | 1 |
| Krushinskii, AL | 2 |
| Reutov, VP | 1 |
| Gumanova, NG | 1 |
| Teplova, NV | 1 |
| Ryabchenko, AU | 1 |
| Denisov, EN | 1 |
| So, G | 1 |
| Nakagawa, S | 1 |
| Morofuji, Y | 1 |
| Hiu, T | 1 |
| Hayashi, K | 1 |
| Tanaka, K | 1 |
| Suyama, K | 1 |
| Deli, MA | 1 |
| Nagata, I | 1 |
| Matsuo, T | 1 |
| Niwa, M | 1 |
| Carlström, M | 1 |
| Cananau, C | 1 |
| Checa, A | 1 |
| Wide, K | 1 |
| Sartz, L | 1 |
| Svensson, A | 1 |
| Wheelock, CE | 1 |
| Westphal, S | 1 |
| Békássy, Z | 1 |
| Bárány, P | 1 |
| Lundberg, JO | 1 |
| Hansson, S | 1 |
| Weitzberg, E | 1 |
| Krmar, RT | 1 |
| Dohare, P | 1 |
| Garg, P | 1 |
| Jain, V | 1 |
| Nath, C | 1 |
| Ray, M | 1 |
| Ito, Y | 1 |
| Ohkubo, T | 1 |
| Asano, Y | 1 |
| Hattori, K | 1 |
| Shimazu, T | 1 |
| Yamazato, M | 1 |
| Nagoya, H | 1 |
| Kato, Y | 1 |
| Araki, N | 1 |
| Zhuang, P | 1 |
| Ji, H | 2 |
| Zhang, YH | 1 |
| Min, ZL | 1 |
| Ni, QG | 1 |
| You, R | 1 |
| Yuan, Z | 1 |
| Liu, W | 1 |
| Liu, B | 1 |
| Schnell, A | 1 |
| Liu, KJ | 1 |
| Miclescu, A | 1 |
| Sharma, HS | 1 |
| Martijn, C | 1 |
| Wiklund, L | 1 |
| Liang, H | 1 |
| Liu, P | 2 |
| Wang, Y | 1 |
| Song, S | 1 |
| Ji, A | 1 |
| Chomova, M | 1 |
| Tatarkova, Z | 1 |
| Dobrota, D | 1 |
| Racay, P | 1 |
| Ma, YH | 1 |
| Su, N | 1 |
| Chao, XD | 1 |
| Zhang, YQ | 1 |
| Zhang, L | 1 |
| Han, F | 1 |
| Luo, P | 1 |
| Fei, Z | 1 |
| Qu, Y | 1 |
| Di, JH | 1 |
| Li, C | 1 |
| Yu, HM | 1 |
| Zheng, JN | 1 |
| Zhang, GY | 1 |
| Wang, X | 2 |
| Zhao, Q | 1 |
| Li, T | 1 |
| Lai, Y | 1 |
| Peng, S | 1 |
| Xu, J | 1 |
| Zhang, Y | 1 |
| Reynolds, JN | 1 |
| Bennett, BM | 1 |
| Boegman, RJ | 1 |
| Jhamandas, K | 1 |
| Ratz, JD | 1 |
| Zavorin, SI | 1 |
| Scutaru, D | 1 |
| Dumitrascu, A | 1 |
| Thatcher, GR | 1 |
| Ding-Zhou, L | 1 |
| Marchand-Verrecchia, C | 1 |
| Croci, N | 1 |
| Plotkine, M | 2 |
| Margaill, I | 1 |
| Uetsuka, S | 1 |
| Fujisawa, H | 1 |
| Yasuda, H | 1 |
| Shima, H | 1 |
| Suzuki, M | 2 |
| Temiz, C | 1 |
| Tun, K | 1 |
| Ugur, HC | 1 |
| Dempsey, RJ | 1 |
| Egemen, N | 1 |
| Hassan, A | 1 |
| Gormley, K | 1 |
| O'Sullivan, M | 1 |
| Knight, J | 1 |
| Sham, P | 1 |
| Vallance, P | 1 |
| Bamford, J | 1 |
| Markus, H | 1 |
| Tabuchi, M | 1 |
| Ikeda, M | 1 |
| Umegaki, K | 1 |
| Tomita, T | 1 |
| Xia, CF | 2 |
| Yin, H | 1 |
| Borlongan, CV | 2 |
| Chao, J | 2 |
| Chao, L | 2 |
| Smith, RS | 1 |
| Shen, B | 1 |
| Yang, ZR | 1 |
| Dqbrowski, R | 1 |
| Malczewska, B | 1 |
| Kośmicki, M | 1 |
| Kowalik, I | 1 |
| Pasierski, T | 1 |
| Jiang, J | 1 |
| Wang, W | 1 |
| Sun, YJ | 1 |
| Hu, M | 1 |
| Li, F | 1 |
| Zhu, DY | 1 |
| Durmaz, R | 1 |
| Ozden, H | 1 |
| Kanbak, G | 1 |
| Aral, E | 1 |
| Arslan, OC | 1 |
| Kartkaya, K | 1 |
| Uzuner, K | 1 |
| Godin, DV | 1 |
| Mitchell, MJ | 1 |
| Saunders, BA | 1 |
| Beckman, JS | 1 |
| Chen, J | 1 |
| Crow, JP | 1 |
| Ye, YZ | 1 |
| Kumura, E | 2 |
| Kosaka, H | 2 |
| Shiga, T | 2 |
| Yoshimine, T | 2 |
| Hayakawa, T | 2 |
| Takaoka, M | 1 |
| Buunk, G | 1 |
| van der Hoeven, JG | 1 |
| Frölich, M | 1 |
| Meinders, AE | 1 |
| Keller, JN | 1 |
| Kindy, MS | 1 |
| Holtsberg, FW | 1 |
| St Clair, DK | 1 |
| Yen, HC | 1 |
| Germeyer, A | 1 |
| Steiner, SM | 1 |
| Bruce-Keller, AJ | 1 |
| Hutchins, JB | 1 |
| Mattson, MP | 1 |
| Forman, LJ | 1 |
| Nagele, RG | 1 |
| Yin, K | 1 |
| Wong, PY | 1 |
| Moro, MA | 1 |
| Leza, JC | 1 |
| Lorenzo, P | 1 |
| Lizasoain, I | 1 |
| Endres, M | 1 |
| Scott, G | 1 |
| Namura, S | 1 |
| Salzman, AL | 1 |
| Huang, PL | 1 |
| Moskowitz, MA | 1 |
| Szabó, C | 1 |
| Ramos-Zúñiga, R | 1 |
| Velázquez-Santana, H | 1 |
| Mercado-Pimentel, R | 1 |
| Cerda-Camacho, F | 1 |
| Kinouchi, H | 1 |
| Kamii, H | 1 |
| Mikawa, S | 1 |
| Epstein, CJ | 1 |
| Yoshimoto, T | 1 |
| Chan, PH | 1 |
| Bolaños, JP | 1 |
| Almeida, A | 1 |
| Dawson, VL | 1 |
| Lei, B | 1 |
| Adachi, N | 1 |
| Nagaro, T | 1 |
| Arai, T | 1 |
| LeBlanc, MH | 1 |
| Feng, Y | 1 |
| Fratkin, JD | 1 |
| Takizawa, S | 1 |
| Hirabayashi, H | 1 |
| Fukuyama, N | 1 |
| Nakazawa, H | 1 |
| Shinohara, Y | 1 |
| Ducrocq, S | 1 |
| Benjelloun, N | 1 |
| Ben-Ari, Y | 1 |
| Charriaut-Marlangue, C | 1 |
| Martin, LJ | 1 |
| Brambrink, AM | 1 |
| Price, AC | 1 |
| Kaiser, A | 1 |
| Agnew, DM | 1 |
| Ichord, RN | 1 |
| Traystman, RJ | 1 |
| Calapai, G | 1 |
| Marciano, MC | 1 |
| Corica, F | 1 |
| Allegra, A | 1 |
| Parisi, A | 1 |
| Frisina, N | 1 |
| Caputi, AP | 2 |
| Buemi, M | 1 |
| Fassbender, K | 1 |
| Fatar, M | 1 |
| Ragoschke, A | 1 |
| Picard, M | 1 |
| Bertsch, T | 1 |
| Kuehl, S | 1 |
| Hennerici, M | 1 |
| Cuzzocrea, S | 1 |
| Costantino, G | 1 |
| Gitto, E | 1 |
| Mazzon, E | 1 |
| Fulia, F | 1 |
| Serraino, I | 1 |
| Cordaro, S | 1 |
| Barberi, I | 1 |
| De Sarro, A | 1 |
| Sakowitz, OW | 1 |
| Wolfrum, S | 1 |
| Sarrafzadeh, AS | 1 |
| Stover, JF | 1 |
| Dreier, JP | 1 |
| Dendorfer, A | 1 |
| Benndorf, G | 1 |
| Lanksch, WR | 1 |
| Unterberg, AW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Metabolism Research of KLK Treating Acute Cerebral Ischemic Stroke: Focus on Drug Frequency-Efficacy Relationship[NCT02806128] | 100 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nitrates and Brain Ischemia
| Article | Year |
|---|---|
Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Cattle; Glutamic Acid; Humans; Macrophages; | 1994 |
Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Humans; Mice; Mice | 1998 |
Roles of nitric oxide in brain hypoxia-ischemia.
Topics: Animals; Brain; Brain Ischemia; Excitatory Amino Acids; Humans; Hypoxia, Brain; Nitrates; Nitric Oxi | 1999 |
Potent neuroprotectants linked to bifunctional inhibition.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Free Radical Scavengers; Mice; Models, Biological | 1999 |
2 trials available for nitrates and Brain Ischemia
| Article | Year |
|---|---|
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial.
Topics: Brain Ischemia; Humans; Ischemic Stroke; Neuroprotection; Nitrates; Nitric Oxide; Nitroglycerin; Pil | 2022 |
[Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Randomized, cross-over, double-blind comparison].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ascorbic Acid; Brain Ischemia | 2003 |
48 other studies available for nitrates and Brain Ischemia
| Article | Year |
|---|---|
Cynaropicrin Averts the Oxidative Stress and Neuroinflammation in Ischemic/Reperfusion Injury Through the Modulation of NF-kB.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Brain Ischemia; Caspase 3; Infarction, Middle Cer | 2023 |
Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Topics: Brain Ischemia; Chromatography, Liquid; Fibrinogen; Hemostatics; Humans; Ischemic Stroke; Nitrates; | 2021 |
Protective Role of Nitrate/Nitrite Reductase System during Transient Global Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Ischemic Attack, Transient; Male; Nitrate Reductase; Nitrates; Nitric Oxide | 2018 |
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion.
Topics: Animals; Blood Pressure; Brain Ischemia; Dietary Supplements; Heart Rate; Infarction, Middle Cerebra | 2018 |
Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration.
Topics: Administration, Inhalation; Animals; Brain Ischemia; Humans; Ischemic Preconditioning; Male; Nitrate | 2018 |
Effect of cation type and concentration of nitrates on neurological disorders during experimental cerebral ischemia.
Topics: Animals; Brain Ischemia; Cations; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ma | 2013 |
Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Carotid Artery, Common; Ligation; Magnesium Chloride; Magnesium Compounds; | 2014 |
Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: a multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Diet; Female; Humans; Hypertension; Male; Middle Age | 2015 |
Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain Ischemia; Cell Survival; Ele | 2015 |
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.
Topics: Arginine; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclic GMP; Female; Ho | 2016 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pr | 2010 |
ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischaemic-reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Cinnamates; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; | 2010 |
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Hyperoxia; Ischemic Attack, Transient; Male; Middle Ce | 2010 |
Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cardiopulmonary Resuscitation; Cere | 2010 |
Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats.
Topics: Alkaloids; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Leonurus; Male; M | 2011 |
Ischemia-induced inhibition of mitochondrial complex I in rat brain: effect of permeabilization method and electron acceptor.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Electron Transport; Electron Transport Complex I; Electro | 2012 |
Thioredoxin-1 attenuates post-ischemic neuronal apoptosis via reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Brain Ischemia; Enzyme Activation; Male; Mice; Mice, Inbred C57BL; Nitrates; Oxi | 2012 |
nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Down-Regulation; Gene Knockdown Techniq | 2012 |
Studies on the enantiomers of ZJM-289: synthesis and biological evaluation of antiplatelet, antithrombotic and neuroprotective activities.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Chemistry Techniques, Synthetic; Cinnamates; Endot | 2012 |
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cyclic GMP; Dose-Response Relationship, Drug; Guanyl | 2002 |
L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Enzyme | 2002 |
Severe cerebral blood flow reduction inhibits nitric oxide synthesis.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Enzyme Inhibitors; In | 2002 |
L-arginine in focal cerebral ischemia.
Topics: Animals; Arginine; Brain Edema; Brain Ischemia; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitr | 2003 |
Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease.
Topics: Aged; Alleles; Brain; Brain Infarction; Brain Ischemia; Female; Gene Frequency; Genotype; Haplotypes | 2004 |
Protective effects of green tea catechins on cerebral ischemic damage.
Topics: Animals; Brain Ischemia; Catechin; Chromatography, High Pressure Liquid; Dose-Response Relationship, | 2004 |
Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis.
Topics: Adrenomedullin; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; B | 2006 |
Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cerebral Infarction; Female; Glycogen Synthase Kinase 3; | 2006 |
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillaries; Curcuma; Curcumi | 2007 |
The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Cathepsin B; Cathepsin L; Cathepsins; Cell Death; Cerebral Cortex; Cysteine | 2008 |
Studies on the interaction of barbiturates with reactive oxygen radicals: implications regarding barbiturate protection against cerebral ischaemia.
Topics: Barbiturates; Brain; Brain Ischemia; Chemical Phenomena; Chemistry; Erythrocytes; Free Radicals; Hum | 1982 |
Elevation of plasma nitric oxide end products during focal cerebral ischemia and reperfusion in the rat.
Topics: Animals; Arginine; Blood Pressure; Brain Ischemia; Drug Combinations; Male; NG-Nitroarginine Methyl | 1994 |
Hypothermia suppresses nitric oxide elevation during reperfusion after focal cerebral ischemia in rats.
Topics: Animals; Body Temperature; Brain Ischemia; Hemoglobins; Hypothermia, Induced; Jugular Veins; Male; N | 1996 |
Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest?
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circu | 1996 |
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Line; Cysteine Endopeptidases; Humans; Intracellular Membra | 1998 |
Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat.
Topics: Animals; Brain Ischemia; Enzyme Induction; Immunohistochemistry; Leukocyte Count; Male; Nitrates; Ni | 1998 |
Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cerebellar Cortex; Dithiothreitol; Egtazic Acid; Gl | 1998 |
Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion.
Topics: Animals; Brain Ischemia; Enzyme Activation; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Ni | 1998 |
Neuroprotection in selective focal ischemia in rats by nitrates, an alternative redox manipulation on nitric oxide: experimental model.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Female; Hippocampus; Male; Neuroprotective Agents; | 1998 |
Measurement of total nitric oxide metabolite (NO(x)(-)) levels in vivo.
Topics: Animals; Brain Ischemia; Corpus Striatum; Gerbillinae; Male; Microdialysis; Nitrates; Nitric Oxide; | 1999 |
N-tosyl-L-phenylalanyl-chloromethylketone reduces hypoxic-ischemic brain injury in rat pups.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; DNA; DNA Fragmentation; Dose-Response Relationship | 2000 |
[Peroxynitrite production in cerebral ischemia].
Topics: Animals; Brain; Brain Ischemia; Nitrates; Oxidants; Rabbits; Rats | 1999 |
Poly(ADP-ribose) synthase inhibition reduces ischemic injury and inflammation in neonatal rat brain.
Topics: Animals; Animals, Newborn; Benzamides; Brain Ischemia; Cell Death; Cerebral Infarction; Encephalitis | 2000 |
Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Death; Corpus Striatum; Cytochrome c Group; DNA Dama | 2000 |
Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.
Topics: Aldehydes; Animals; Brain; Brain Edema; Brain Ischemia; Erythropoietin; Gerbillinae; Humans; Injecti | 2000 |
Subacute but not acute generation of nitric oxide in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Enzyme Inhibitors; Guanidines; Microdialysis; Nerve Degene | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng | 2000 |
Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Extracellular Space; Fe | 2001 |