nitrates has been researched along with Brain Edema in 17 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cognitive impairment and cerebral edema were observed in MHE rats and rats injected with 10 μg DA." | 5.40 | Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration. ( Chen, B; Ding, S; Hu, J; Liu, L; Wang, X; Yang, J; Ye, Y; Zhuge, Q, 2014) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 5.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "Ischaemia was induced by 90-minutes middle cerebral artery occlusion (MCAO) followed by 24 hours of reperfusion." | 1.46 | Fullerenol nanoparticles decrease ischaemia-induced brain injury and oedema through inhibition of oxidative damage and aquaporin-1 expression in ischaemic stroke. ( Darabi, S; Mohammadi, MT, 2017) |
| "Brain edema was determined by means of the wet-dry weight method and assessed with light microscopy on H&E-stained preparations of tissues obtained 6 and 24 hours after glyceryl trinitrate treatment." | 1.42 | Effects of nitric oxide on blood-brain barrier permeability in common carp (Cyprinus carpio L.). ( Gjurcevic, E; Ivkic, G; Klaric, MŠ; Kovacić, S; Rumora, L, 2015) |
| "Cognitive impairment and cerebral edema were observed in MHE rats and rats injected with 10 μg DA." | 1.40 | Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration. ( Chen, B; Ding, S; Hu, J; Liu, L; Wang, X; Yang, J; Ye, Y; Zhuge, Q, 2014) |
| "Uric acid is a natural antioxidant that protects the brain in a model of transient focal ischemia in rats." | 1.34 | Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke. ( Amaro, S; Chamorro, A; Planas, AM; Romanos, E, 2007) |
| "We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage." | 1.34 | Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. ( Hu, M; Jiang, J; Li, F; Sun, YJ; Wang, W; Zhu, DY, 2007) |
| "LPS induced cytotoxic brain swelling and maintained anatomical integrity of the blood-brain barrier." | 1.34 | Endotoxemia produces coma and brain swelling in bile duct ligated rats. ( Brooks, HF; Davies, C; Davies, NA; Harry, D; Hodges, SJ; Jalan, R; Mani, AR; Moore, KP; Shawcross, DL; Stadlbauer, V; Williams, R; Wright, G; Zou, Z; Zwingmann, C, 2007) |
| "Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion." | 1.31 | Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 12 (70.59) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Darabi, S | 1 |
| Mohammadi, MT | 1 |
| Jiang, YS | 1 |
| Wang, FR | 1 |
| Ding, S | 1 |
| Yang, J | 1 |
| Liu, L | 1 |
| Ye, Y | 1 |
| Wang, X | 1 |
| Hu, J | 1 |
| Chen, B | 1 |
| Zhuge, Q | 1 |
| Kovacić, S | 1 |
| Rumora, L | 1 |
| Gjurcevic, E | 1 |
| Klaric, MŠ | 1 |
| Ivkic, G | 1 |
| Dohare, P | 1 |
| Garg, P | 1 |
| Jain, V | 1 |
| Nath, C | 1 |
| Ray, M | 1 |
| Temiz, C | 1 |
| Tun, K | 1 |
| Ugur, HC | 1 |
| Dempsey, RJ | 1 |
| Egemen, N | 1 |
| Schliess, F | 2 |
| Foster, N | 1 |
| Görg, B | 1 |
| Reinehr, R | 1 |
| Häussinger, D | 2 |
| Romanos, E | 1 |
| Planas, AM | 1 |
| Amaro, S | 1 |
| Chamorro, A | 1 |
| Yatsushige, H | 1 |
| Calvert, JW | 1 |
| Cahill, J | 1 |
| Zhang, JH | 1 |
| Jiang, J | 1 |
| Wang, W | 1 |
| Sun, YJ | 1 |
| Hu, M | 1 |
| Li, F | 1 |
| Zhu, DY | 1 |
| Wright, G | 1 |
| Davies, NA | 1 |
| Shawcross, DL | 1 |
| Hodges, SJ | 1 |
| Zwingmann, C | 1 |
| Brooks, HF | 1 |
| Mani, AR | 1 |
| Harry, D | 1 |
| Stadlbauer, V | 1 |
| Zou, Z | 2 |
| Williams, R | 1 |
| Davies, C | 1 |
| Moore, KP | 1 |
| Jalan, R | 1 |
| Master, S | 1 |
| Gottstein, J | 1 |
| Blei, AT | 1 |
| Calapai, G | 2 |
| Marciano, MC | 2 |
| Corica, F | 1 |
| Allegra, A | 1 |
| Parisi, A | 2 |
| Frisina, N | 1 |
| Caputi, AP | 4 |
| Buemi, M | 1 |
| Cuzzocrea, S | 2 |
| McDonald, MC | 1 |
| Mazzon, E | 2 |
| Siriwardena, D | 1 |
| Costantino, G | 2 |
| Fulia, F | 2 |
| Cucinotta, G | 1 |
| Gitto, E | 2 |
| Cordaro, S | 2 |
| Barberi, I | 2 |
| De Sarro, A | 2 |
| Thiemermann, C | 1 |
| Serraino, I | 1 |
| Crupi, A | 1 |
| Firenzuoli, F | 1 |
| Squadrito, F | 1 |
| Inferrera, G | 1 |
| Rizzo, A | 1 |
| Crisafulli, C | 1 |
| Fiore, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset[NCT00860366] | Phase 2/Phase 3 | 421 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Shuxuening Injection for the Prevention of Cerebral Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage -- A Randomized, Double-blind, Placebo-parallel Controlled Clinical Trial[NCT06138353] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2023-11-13 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nitrates and Brain Edema
| Article | Year |
|---|---|
Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy.
Topics: Animals; Astrocytes; Brain Edema; Cell Size; Hepatic Encephalopathy; Humans; Nerve Tissue Proteins; | 2005 |
16 other studies available for nitrates and Brain Edema
| Article | Year |
|---|---|
Fullerenol nanoparticles decrease ischaemia-induced brain injury and oedema through inhibition of oxidative damage and aquaporin-1 expression in ischaemic stroke.
Topics: Animals; Aquaporin 1; Brain Edema; Brain Infarction; Brain Injuries; Cerebrovascular Circulation; Di | 2017 |
Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Edema; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; | 2013 |
Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cognition; Dopamine; Enzyme Inh | 2014 |
Effects of nitric oxide on blood-brain barrier permeability in common carp (Cyprinus carpio L.).
Topics: Animals; Blood-Brain Barrier; Brain Edema; Carps; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; P | 2015 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
L-arginine in focal cerebral ischemia.
Topics: Animals; Arginine; Brain Edema; Brain Ischemia; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitr | 2003 |
Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Calcium Signaling; Calmodulin; Cell Size; Cells, | 2004 |
Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Humans; Infarction, Middle Cerebral Artery; Male; Neuro | 2007 |
Limited role of inducible nitric oxide synthase in blood-brain barrier function after experimental subarachnoid hemorrhage.
Topics: Animals; Benzenesulfonates; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Male; Nitrates | 2006 |
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillaries; Curcuma; Curcumi | 2007 |
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; C | 2007 |
Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis.
Topics: Ammonia; Animals; Brain; Brain Edema; Cerebrovascular Circulation; Cranial Sinuses; Hemodynamics; In | 1999 |
Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.
Topics: Aldehydes; Animals; Brain; Brain Edema; Brain Ischemia; Erythropoietin; Gerbillinae; Humans; Injecti | 2000 |
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Cerebral Arteries; Cyclic N-Oxides; Free R | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng | 2000 |
Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis.
Topics: Administration, Oral; Animals; Brain; Brain Edema; Cell Death; Dose-Response Relationship, Drug; Ger | 2000 |