nitrates and Blood Poisoning studies

Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Research Excerpts

Excerpt	Relevance	Reference
" Memantine, an N-methyl-D-aspartic acid receptor (NMDAR) antagonist, is able to alleviate acute lung injury (ALI)."	8.12	Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice. ( Hu, H; Jiang, H; Sun, Y; Wang, Y; Yi, P; Zhang, G; Zhang, K; Zhang, Z, 2022)
"Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis."	7.85	Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis. ( Catalão, CH; de Freitas, LA; Felippotti, TT; Oliveira-Pelegrin, GR; Petenusci, S; Rocha, MJ; Silva, LS, 2017)
"Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)."	7.74	The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008)
"To investigate the effects of glutamine (GLN)-enriched diets before and GLN-containing total parenteral nutrition (TPN) after sepsis or both on the secretion of cytokines and their mRNA expression levels in splenocytes of rats with septic peritonitis."	7.73	Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. ( Chen, WJ; Chiu, WC; Lai, YN; Lin, MT; Shang, HF; Yeh, SL, 2005)
"To determine the changes in plasma nitrite/nitrate (NOx) and endothelin-1 (ET-1) concentrations during neonatal sepsis."	7.72	Plasma nitrite/nitrate and endothelin-1 concentrations in neonatal sepsis. ( Carbonell-Estrany, X; Figueras-Aloy, J; Gómez, L; Jiménez, W; Jordán, Y; Rodríguez-Miguélez, JM; Salvia, MD, 2003)
" Here we investigated whether in vivo N-acetylcysteine treatment inhibits cellular injury in macrophages collected from rats subjected to zymosan-induced shock."	7.70	Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat. ( Caputi, AP; Costantino, G; Cuzzocrea, S, 1999)
"Sepsis was induced by cecal ligation-puncture (CLP) surgery."	5.72	Corticosterone and Adrenocorticotrophic Hormone Secretion Is Recovered after Immune Challenge or Acute Restraint Stress in Sepsis Survivor Animals. ( Alves Rocha, MJ; Catalão, CHR; da Costa, LHA; Dos Santos-Junior, NN, 2022)
"Sepsis is caused by a dysregulated host response to infection, often associated with acute central nervous system (CNS) dysfunction, which results in long-term cognitive impairment."	5.48	Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. ( Barichello, T; da Rosa, N; Danielski, LG; de Oliveira Junior, AN; de Souza Goldim, MP; Florentino, D; Fortunato, JJ; Giustina, AD; Gomes, ML; Laurentino, AO; Mathias, K; Moreira, AP; Petronilho, F; Schuck, PF; Steckert, AV; Trombetta, T; Zarbato, GF, 2018)
"Inflammation is difficult to control when it spreads throughout the body and often progresses into multiple organ dysfunction, eventually leading to death."	5.37	Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. ( Hagiwara, S; Hasegawa, A; Koga, H; Kudo, K; Kusaka, J; Noguchi, T, 2011)
"Endotoxemia was associated with renal dysfunctions as indicated by decreases in renal blood flow, urinary potassium excretion, and renal nitrate clearance."	5.33	N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia. ( Chiao, CW; Lee, SS; Su, MJ; Wu, CC, 2006)
"Sepsis was produced by the CLP procedure."	5.33	N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis. ( Atis, S; Bagdatoglu, O; Comelekoglu, U; Gunes, S; Nayci, A; Ozge, A, 2006)
"Development of severe sepsis is thought to result from the overproduction of cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and nitric oxide."	5.31	Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. ( Ando, H; Kobayashi, K; Nagai, Y; Ota, T; Takamura, T, 2000)
" To evaluate the effects of NO radical on the liver in patients with postoperative sepsis, we analysed both the stable end-product of nitric oxide radical (NOx) as well as the arterial KBR (AKBR), which reflects liver tissue NAD+/NADH."	5.09	Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. ( Inoue, T; Kamiyama, Y; Kitade, H; Kwon, AH; Satoi, S; Takahashi, H; Takahashi, K; Wei, T, 2000)
" Memantine, an N-methyl-D-aspartic acid receptor (NMDAR) antagonist, is able to alleviate acute lung injury (ALI)."	4.12	Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice. ( Hu, H; Jiang, H; Sun, Y; Wang, Y; Yi, P; Zhang, G; Zhang, K; Zhang, Z, 2022)
"Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis."	3.85	Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis. ( Catalão, CH; de Freitas, LA; Felippotti, TT; Oliveira-Pelegrin, GR; Petenusci, S; Rocha, MJ; Silva, LS, 2017)
"Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)."	3.74	The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008)
"To investigate the effects of glutamine (GLN)-enriched diets before and GLN-containing total parenteral nutrition (TPN) after sepsis or both on the secretion of cytokines and their mRNA expression levels in splenocytes of rats with septic peritonitis."	3.73	Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. ( Chen, WJ; Chiu, WC; Lai, YN; Lin, MT; Shang, HF; Yeh, SL, 2005)
"Children with sepsis had a twofold reduction in antipyrine clearance."	3.72	Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. ( Burckart, GJ; Carcillo, JA; Doughty, L; Frye, RF; Kaplan, SS; Kofos, D; Sasser, H, 2003)
"To determine the changes in plasma nitrite/nitrate (NOx) and endothelin-1 (ET-1) concentrations during neonatal sepsis."	3.72	Plasma nitrite/nitrate and endothelin-1 concentrations in neonatal sepsis. ( Carbonell-Estrany, X; Figueras-Aloy, J; Gómez, L; Jiménez, W; Jordán, Y; Rodríguez-Miguélez, JM; Salvia, MD, 2003)
" Here we investigated whether in vivo N-acetylcysteine treatment inhibits cellular injury in macrophages collected from rats subjected to zymosan-induced shock."	3.70	Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat. ( Caputi, AP; Costantino, G; Cuzzocrea, S, 1999)
"To analyze the mechanism of vasodilation and circulatory shock occurring in patients who are treated with isolated limb perfusion with melphalan and recombinant tumor necrosis factor (TNF)-alpha for locally advanced malignant tumors."	3.69	Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock: a study in patients treated for cancer with isolated limb perfusion. ( Donse, IF; Girbes, AR; Hoekstra, HJ; Maring, JK; Moshage, H; Schraffordt Koops, H; van Ginkel, RJ; Zwaveling, JH, 1996)
"Increased plasma nitrite/nitrates and increased organ failure scores occurred in the children with sepsis who had an exaggerated proinflammatory state, despite a pronounced anti-inflammatory response."	3.69	Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. ( Carcillo, JA; Doughty, LA; Kaplan, SS, 1996)
"Treatment with gentamicin stabilized cardiac index (BL, 5."	2.71	Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. ( Enkhbaatar, P; Heggers, JP; Herndon, DN; Jodoin, JM; Maybauer, DM; Maybauer, MO; Morita, N; Traber, DL; Traber, LD; Westphal, M, 2005)
"Sepsis was induced by cecal ligation-puncture (CLP) surgery."	1.72	Corticosterone and Adrenocorticotrophic Hormone Secretion Is Recovered after Immune Challenge or Acute Restraint Stress in Sepsis Survivor Animals. ( Alves Rocha, MJ; Catalão, CHR; da Costa, LHA; Dos Santos-Junior, NN, 2022)
"Sepsis is caused by a dysregulated host response to infection, often associated with acute central nervous system (CNS) dysfunction, which results in long-term cognitive impairment."	1.48	Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. ( Barichello, T; da Rosa, N; Danielski, LG; de Oliveira Junior, AN; de Souza Goldim, MP; Florentino, D; Fortunato, JJ; Giustina, AD; Gomes, ML; Laurentino, AO; Mathias, K; Moreira, AP; Petronilho, F; Schuck, PF; Steckert, AV; Trombetta, T; Zarbato, GF, 2018)
" Dosing of mice with ND8008 (127."	1.43	A novel nitro-dexamethasone inhibits agr system activity and improves therapeutic effects in MRSA sepsis models without antibiotics. ( Cai, C; Gong, L; Gu, H; Guo, L; Li, H; Shi, Y; Song, Z; Sun, H; Tong, Y; Wei, C; Yang, L; Yang, Y; Zeng, H; Zou, Q, 2016)
"Acute kidney injury is a frequent and serious complication of sepsis."	1.38	Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury. ( Gokden, N; Holthoff, JH; Mayeux, PR; Pathak, E; Seely, KA; Spencer, HJ; Wang, Z, 2012)
" Nevertheless, vasopressin (AVP) release decreased in a dose-response manner in the early phase of sepsis."	1.37	Leukotriene synthesis inhibitor decreases vasopressin release in the early phase of sepsis. ( Faccioli, LH; Martins, TF; Rocha, MJ; Sorgi, CA, 2011)
"Sepsis is a major health threat that remains refractory to treatment."	1.37	ETS-GS, a new anti-oxidative drug, protects against lipopolysaccharide-induced acute lung and liver injury. ( Goto, K; Hagiwara, S; Iwasaka, H; Koga, H; Kusaka, J; Noguchi, T; Uchida, T; Yokoi, I, 2011)
"Inflammation is difficult to control when it spreads throughout the body and often progresses into multiple organ dysfunction, eventually leading to death."	1.37	Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. ( Hagiwara, S; Hasegawa, A; Koga, H; Kudo, K; Kusaka, J; Noguchi, T, 2011)
"Results Patients who developed septic shock (n = 35) had higher plasma NOx, total and free cortisol, and lower CBG concentrations than the nonseptic shock group (n = 27)."	1.36	Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. ( Chapman, MJ; Edwards, J; Ho, JT; Lam, S; Lewis, JG; Ludbrook, G; O'Connor, S; Torpy, DJ, 2010)
"Smoke inhalation injury is often complicated with pneumonia, which frequently leads to subsequent development of sepsis."	1.35	Role of neuronal nitric oxide synthase in ovine sepsis model. ( Enkhbaatar, P; Hamahata, A; Herndon, D; Jaroch, S; Jonkam, C; Lange, M; Nakano, Y; Traber, D; Traber, L; Wang, J, 2009)
"Severe sepsis is the leading cause of death for patients in intensive care units."	1.34	Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. ( Antonova, G; Cannon, J; Catravas, JD; Chatterjee, A; Dimitropoulou, C; Drakopanayiotakis, F; Snead, C; Venema, RC, 2007)
"Sepsis was produced by the CLP procedure."	1.33	N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis. ( Atis, S; Bagdatoglu, O; Comelekoglu, U; Gunes, S; Nayci, A; Ozge, A, 2006)
"Endotoxemia was associated with renal dysfunctions as indicated by decreases in renal blood flow, urinary potassium excretion, and renal nitrate clearance."	1.33	N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia. ( Chiao, CW; Lee, SS; Su, MJ; Wu, CC, 2006)
"The mechanism of gut injury in endotoxic shock seems unrelated to hypoxia and release of nitric oxide."	1.32	Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. ( De Backer, D; Dimopoulos, G; Lobo, SM; Nagy, N; Preiser, JC; Sun, Q; Terzi, RG; Tu, Z; Vercruy, V; Vincent, JL; Vray, B, 2003)
"Sepsis was induced by cecal ligation and puncture (CLP) method."	1.32	Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis. ( Bhaduri, S; Maitra, SR; Ramamurthy, N; Sorsa, T; Tervahartiala, T; Valane, PD, 2003)
"Recent findings in human septic shock suggest that glucocorticosteroids can limit and even reverse hemodynamic disturbances and dependence on catecholamines."	1.32	Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. ( Bollaert, PE; Levy, B; Longrois, D; Mallié, JP; Mansart, A; Seguin, C, 2003)
"Although sepsis is the major cause of mortality and morbidity in the critically ill, precise mechanism(s) causing multiorgan dysfunction remain unclear."	1.32	Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. ( Brealey, D; Jacques, TS; Karyampudi, S; Novelli, M; Singer, M; Smolenski, RT; Stidwill, R; Taylor, V, 2004)
"Polymicrobial sepsis is characterized by an early, hyperdynamic phase (i."	1.31	Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis. ( Chaudry, IH; Ornan, DA; Shieh, P; Wang, P; Zhou, M, 2000)
"Development of severe sepsis is thought to result from the overproduction of cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and nitric oxide."	1.31	Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. ( Ando, H; Kobayashi, K; Nagai, Y; Ota, T; Takamura, T, 2000)
"Acute lung injury is an important feature of sepsis and increased iNOS expression and NO production contribute to the pathogenesis of this syndrome."	1.31	Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. ( Joseph, M; McCormack, DG; Mehta, S; Razavi, HM; Scott, JA; Wang, LF; Weicker, S, 2001)
"Bone resorption was assessed by measurement of urinary pyridinoline and deoxypyridinoline as a ratio to urinary creatinine."	1.31	Increased bone resorption in the critically ill: association with sepsis and increased nitric oxide production. ( Cuthbertson, B; Harvie, J; Ralston, SH; Robins, S; Smith, LM; Webster, N, 2002)

Research

Studies (102)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

All-cause 28-day Mortality Rate.

Antibiotic-free Days

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (6.86)	18.7374
1990's	20 (19.61)	18.2507
2000's	51 (50.00)	29.6817
2010's	21 (20.59)	24.3611
2020's	3 (2.94)	2.80

Authors	Studies
Dos Santos-Junior, NN	1
da Costa, LHA	2
Catalão, CHR	2
Alves Rocha, MJ	1
Hu, H	1
Jiang, H	1
Zhang, K	1
Zhang, Z	1
Wang, Y	1
Yi, P	1
Zhang, G	1
Sun, Y	1
Danielski, LG	3
Giustina, AD	2
Bonfante, S	1
de Souza Goldim, MP	2
Joaquim, L	1
Metzker, KL	1
Biehl, EB	1
Vieira, T	1
de Medeiros, FD	1
da Rosa, N	2
Generoso, J	1
Simoes, L	1
Farias, HR	1
da Silva Lemos, I	1
Giridharan, V	1
Rezin, GT	1
Fortunato, JJ	3
Bitencourt, RM	1
Streck, EL	1
Dal-Pizzol, F	2
Barichello, T	3
Petronilho, F	3
Zarbato, GF	1
Mathias, K	1
Florentino, D	2
de Oliveira Junior, AN	1
Laurentino, AO	1
Trombetta, T	1
Gomes, ML	1
Steckert, AV	1
Moreira, AP	1
Schuck, PF	1
Sordi, R	1
Menezes-de-Lima, O	1
Della-Justina, AM	1
Rezende, E	1
Assreuy, J	1
Oliveira-Pelegrin, GR	2
Basso, PJ	1
Soares, AS	1
Martinez, MR	1
Riester, KD	1
Rocha, MJ	3
Vieira, A	1
Michels, M	1
Lauriano, AA	1
Quevedo, J	1
Shen, HH	1
Lam, KK	1
Cheng, PY	1
Kung, CW	1
Chen, SY	1
Lin, PC	1
Chung, MT	1
Lee, YM	1
Yang, Y	1
Li, H	2
Sun, H	1
Gong, L	1
Guo, L	1
Shi, Y	1
Cai, C	1
Gu, H	1
Song, Z	1
Yang, L	1
Tong, Y	1
Wei, C	1
Zou, Q	1
Zeng, H	1
Santos-Júnior, NN	1
Souza, AO	1
Alberici, LC	1
Rocha, MJA	1
Kado, T	1
Kashimoto, T	1
Yamazaki, K	1
Ueno, S	1
Silva, LS	1
Catalão, CH	1
Felippotti, TT	1
Petenusci, S	1
de Freitas, LA	1
Alvarez de Sotomayor, M	1
Vega, S	1
Mingorance, C	1
Marhuenda, E	1
Herrera, MD	1
Enkhbaatar, P	4
Lange, M	2
Nakano, Y	2
Hamahata, A	2
Jonkam, C	2
Wang, J	1
Jaroch, S	1
Traber, L	1
Herndon, D	1
Traber, D	1
Kudo, K	1
Hagiwara, S	2
Hasegawa, A	1
Kusaka, J	2
Koga, H	2
Noguchi, T	2
Ho, JT	1
Chapman, MJ	1
O'Connor, S	1
Lam, S	1
Edwards, J	1
Ludbrook, G	1
Lewis, JG	1
Torpy, DJ	1
Connelly, R	1
Traber, DL	6
Esechie, A	1
von Borzyskowski, S	1
Traber, LD	5
Schmalstieg, FC	2
Herndon, DN	4
Iwasaka, H	1
Uchida, T	1
Goto, K	1
Yokoi, I	1
Soriano, FG	1
Lorigados, CB	1
Pacher, P	1
Szabó, C	1
Choumar, A	1
Tarhuni, A	1
Lettéron, P	1
Reyl-Desmars, F	1
Dauhoo, N	1
Damasse, J	1
Vadrot, N	1
Nahon, P	1
Moreau, R	1
Pessayre, D	1
Mansouri, A	1
Martins, TF	1
Sorgi, CA	1
Faccioli, LH	1
Osterbur, K	1
Whitehead, Z	1
Sharp, CR	1
DeClue, AE	1
Pathak, E	2
MacMillan-Crow, LA	1
Mayeux, PR	2
Qian, Z	1
Li, J	1
Han, X	1
Liu, M	1
Wang, Z	1
Holthoff, JH	1
Seely, KA	1
Spencer, HJ	1
Gokden, N	1
van de Sandt, AM	1
Windler, R	1
Gödecke, A	1
Ohlig, J	1
Zander, S	1
Reinartz, M	1
Graf, J	1
van Faassen, EE	1
Rassaf, T	1
Schrader, J	1
Kelm, M	1
Merx, MW	1
Khadour, FH	1
Panas, D	1
Ferdinandy, P	1
Schulze, C	1
Csont, T	1
Lalu, MM	1
Wildhirt, SM	1
Schulz, R	1
Murakami, K	2
McGuire, R	2
Cox, RA	2
Jodoin, JM	2
Bjertnaes, LJ	1
Katahira, J	1
Hawkins, HK	2
Mansart, A	1
Bollaert, PE	1
Seguin, C	1
Levy, B	1
Longrois, D	1
Mallié, JP	1
Carcillo, JA	5
Doughty, L	3
Kofos, D	1
Frye, RF	1
Kaplan, SS	3
Sasser, H	2
Burckart, GJ	1
Soop, A	1
Sollevi, A	1
Weitzberg, E	1
Lundberg, JO	1
Palm, J	1
Albert, J	1
Figueras-Aloy, J	1
Gómez, L	1
Rodríguez-Miguélez, JM	1
Jordán, Y	1
Salvia, MD	1
Jiménez, W	1
Carbonell-Estrany, X	1
Lobo, SM	1
De Backer, D	1
Sun, Q	1
Tu, Z	2
Dimopoulos, G	1
Preiser, JC	2
Nagy, N	1
Vray, B	2
Vercruy, V	1
Terzi, RG	1
Vincent, JL	2
Maitra, SR	1
Bhaduri, S	1
Valane, PD	1
Tervahartiala, T	1
Sorsa, T	1
Ramamurthy, N	1
Brealey, D	1
Karyampudi, S	1
Jacques, TS	1
Novelli, M	1
Stidwill, R	1
Taylor, V	1
Smolenski, RT	1
Singer, M	1
Eaton, S	1
Fukumoto, K	1
Stefanutti, G	1
Spitz, L	1
Zammit, VA	1
Pierro, A	1
Demirbilek, S	2
Ersoy, MO	1
Karaman, A	1
Akin, M	1
Bayraktar, M	1
Bayraktar, N	1
Tsao, CM	1
Ho, ST	1
Chen, A	1
Wang, JJ	1
Li, CY	1
Tsai, SK	1
Wu, CC	2
Wu, F	1
Wilson, JX	1
Tyml, K	2
Connelly, L	1
Madhani, M	1
Hobbs, AJ	1
Hayashi, Y	1
Abe, M	1
Murai, A	1
Shimizu, N	1
Okamoto, I	1
Katsuragi, T	1
Tanaka, K	1
Yeh, SL	1
Lai, YN	1
Shang, HF	1
Lin, MT	1
Chiu, WC	1
Chen, WJ	1
Dong, HP	1
Chen, HW	1
Hsu, C	1
Chiu, HY	1
Lin, LC	1
Yang, RC	1
Maybauer, MO	2
Maybauer, DM	2
Westphal, M	2
Morita, N	2
Heggers, JP	1
Degano, B	1
Génestal, M	1
Serrano, E	1
Rami, J	1
Arnal, JF	1
Carvalho, M	1
Benjamim, C	1
Santos, F	1
Ferreira, S	1
Cunha, F	1
Supinski, GS	1
Callahan, LA	1
Atis, S	1
Nayci, A	1
Ozge, A	1
Comelekoglu, U	1
Gunes, S	1
Bagdatoglu, O	1
Chiao, CW	1
Lee, SS	1
Su, MJ	1
Torres-Dueñas, D	1
Benjamim, CF	2
Ferreira, SH	3
Cunha, FQ	4
Köstler, WJ	1
Rabitsch, W	1
Locker, GJ	1
Staudinger, T	1
El-Menyawi, I	1
Frass, M	1
Burgmann, H	1
Fraser, JF	1
Huda, R	1
Mizutani, A	1
Sigurdardottir, T	1
Andersson, P	1
Davoudi, M	1
Malmsten, M	1
Schmidtchen, A	1
Bodelsson, M	1
Machado, DP	1
Nunes, FB	1
Simões Pires, MG	1
D'Avila, LC	1
Leite, CE	1
Ruschel, RE	1
da Cunha, AA	1
Saciura, VC	1
Poloni, JA	1
Lunardelli, A	1
de Oliveira, JR	1
Alves Filho, JC	1
Dias, FS	1
Poli de Figueiredo, CE	1
Astolfi, RS	1
Khouri, DG	1
Brandizzi, LI	1
Avila-Campos, MJ	1
Andrade, HF	1
Wheeler, DS	1
Lahni, PM	1
Hake, PW	1
Denenberg, AG	1
Wong, HR	1
Snead, C	2
Catravas, JD	2
Zingarelli, B	1
Chatterjee, A	1
Dimitropoulou, C	1
Drakopanayiotakis, F	1
Antonova, G	1
Cannon, J	1
Venema, RC	1
Xie, XQ	1
Shinozawa, Y	1
Sasaki, J	1
Takuma, K	1
Akaishi, S	1
Yamanouchi, S	1
Endo, T	1
Nomura, R	1
Kobayashi, M	1
Kudo, D	1
Hojo, N	1
Geiseler, PJ	1
Harris, B	1
Andersen, BR	1
Barthlen, W	1
Stadler, J	1
Lehn, NL	1
Miethke, T	1
Bartels, H	1
Siewert, JR	1
Moshage, H	2
Kok, B	1
Huizenga, JR	1
Jansen, PL	1
Reper, P	1
Vlasselaer, D	1
Zhang, H	1
Metz, G	1
Vanderkelen, A	1
Doughty, LA	1
Endo, S	1
Inada, K	1
Takakuwa, T	1
Kasai, T	1
Yamada, Y	1
Wakabayashi, G	1
Niimi, M	1
Suzuki, T	1
Taniguchi, S	1
Zwaveling, JH	1
Maring, JK	1
van Ginkel, RJ	1
Hoekstra, HJ	1
Schraffordt Koops, H	1
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Ye, YZ	1
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Beckman, JS	1
Bone, HG	1
Schenarts, PJ	1
Booke, M	1
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Griffith, OW	1
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Imkampe, A	1
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Papavassilis, C	1
McDonough, KH	1
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Panis, Y	1
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Aubier, M	2
Boczkowski, J	2
Wang, LF	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]	Phase 3	293 participants (Actual)	Interventional	2007-04-30	Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	15
Enteral Whey Protein, IV Saline	8

Intervention	Days (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	1
Enteral Whey Protein, IV Saline	2

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	5
Enteral Whey Protein, IV Saline	12

Intervention	Mean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation	4.99
Whey Protein	4.83

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

Article	Year
Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis. Biochemical Society transactions, 2003, Volume: 31, Issue:Pt 6 Topics: Animals; Carnitine O-Palmitoyltransferase; Inflammation; Myocardium; Nitrates; Oxidation-Reduction;	2003
Nitric oxide production in neonatal and pediatric sepsis. Critical care medicine, 1999, Volume: 27, Issue:6 Topics: Adult; Animals; Child; Humans; Infant, Newborn; Meningococcal Infections; Nitrates; Nitric Oxide; Ni	1999
Nitric oxide and intestinal inflammation. The American journal of medicine, 2000, Aug-01, Volume: 109, Issue:2 Topics: Antioxidants; Enteritis; Free Radical Scavengers; Homeostasis; Humans; Inflammatory Bowel Diseases;	2000
[Right ventricle function]. Arquivos brasileiros de cardiologia, 1986, Volume: 47, Issue:6 Topics: Coronary Disease; Heart Ventricles; Humans; Hypertension, Pulmonary; Myocardial Contraction; Nitrate	1986

Article	Year
Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3 Topics: Animals; Arteries; Blood Pressure; Female; Gentamicins; Hemodynamics; Lung; Nitrates; Nitric Oxide;	2005
Serum levels of end products of nitric oxide synthesis correlate positively with tumor necrosis factor alpha and negatively with body temperature in patients with postoperative abdominal sepsis. Shock (Augusta, Ga.), 1994, Volume: 2, Issue:6 Topics: Abdomen; Body Temperature; Female; Humans; Interleukin-6; Male; Middle Aged; Nitrates; Nitric Oxide;	1994
Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:3 Topics: Aged; Female; Humans; Ketone Bodies; Liver Diseases; Male; Mitochondria, Liver; Multiple Organ Failu	2000

Article	Year
Corticosterone and Adrenocorticotrophic Hormone Secretion Is Recovered after Immune Challenge or Acute Restraint Stress in Sepsis Survivor Animals. Neuroimmunomodulation, 2022, Volume: 29, Issue:4 Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Hypothalamo-Hypophyseal System; Lipopolysaccha	2022
Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156 Topics: Acute Lung Injury; Animals; Inflammasomes; Lipopolysaccharides; Lung; Memantine; Mice; Mice, Inbred	2022
NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology, 2020, Volume: 57, Issue:12 Topics: Acute Disease; Animals; Astrocytes; Brain; Catalase; Cytokines; Electron Transport; Glial Fibrillary	2020
Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. Neurotoxicity research, 2018, Volume: 34, Issue:3 Topics: Animals; Catalase; Cognition Disorders; Cytokines; Dimethyl Fumarate; Disease Models, Animal; Explor	2018
Pneumonia-induced sepsis in mice: temporal study of inflammatory and cardiovascular parameters. International journal of experimental pathology, 2013, Volume: 94, Issue:2 Topics: Animals; Bacterial Load; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Kl	2013
Cleaved caspase-3 expression in hypothalamic magnocellular neurons may affect vasopressin secretion during experimental polymicrobial sepsis. Journal of neuroimmunology, 2013, May-15, Volume: 258, Issue:1-2 Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cytokines; Disease Models, Animal; Enzyme-Linked I	2013
Increased on oxidative brain injury in the diabetic rats following sepsis. Synapse (New York, N.Y.), 2014, Volume: 68, Issue:9 Topics: Animals; Brain; Catalase; Diabetes Mellitus, Experimental; Male; Nitrates; Nitrites; Peroxidase; Pro	2014
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats. Shock (Augusta, Ga.), 2015, Volume: 43, Issue:4 Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation;	2015
A novel nitro-dexamethasone inhibits agr system activity and improves therapeutic effects in MRSA sepsis models without antibiotics. Scientific reports, 2016, Feb-03, Volume: 6 Topics: Animals; Anti-Inflammatory Agents; Bacterial Proteins; Cell Survival; Cells, Cultured; Cytokines; De	2016
Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration. Molecular neurobiology, 2017, Volume: 54, Issue:9 Topics: Animals; Apoptosis; Brain; Caspase 3; Cecum; Citrate (si)-Synthase; Cytokines; Glial Fibrillary Acid	2017
Importance of fumarate and nitrate reduction regulatory protein for intestinal proliferation of Vibrio vulnificus. FEMS microbiology letters, 2017, Volume: 364, Issue:1 Topics: Anaerobiosis; Animals; Bacterial Proteins; Cell Division; Escherichia coli; Fumarates; Gene Deletion	2017
Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis. Pharmaceutical biology, 2017, Volume: 55, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Blood Glucose; Blood Volume; Cecum; Curcumin; Cytokin	2017
Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats. Pharmacology, 2008, Volume: 82, Issue:2 Topics: Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase	2008
Role of neuronal nitric oxide synthase in ovine sepsis model. Shock (Augusta, Ga.), 2009, Volume: 32, Issue:3 Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Interleukin-6; Lung; Lung Injury; Nitrates; N	2009
Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. The Journal of surgical research, 2011, Volume: 171, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Cell Line; Disease Models, An	2011
Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. Clinical endocrinology, 2010, Volume: 73, Issue:3 Topics: Analysis of Variance; Dobutamine; Epinephrine; Female; Humans; Hydrocortisone; Intensive Care Units;	2010
Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model. Critical care (London, England), 2010, Volume: 14, Issue:4 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lung; Nitrates; Nitric Oxide Synt	2010
ETS-GS, a new anti-oxidative drug, protects against lipopolysaccharide-induced acute lung and liver injury. The Journal of surgical research, 2011, Volume: 171, Issue:2 Topics: Acute Lung Injury; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Disease	2011
Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis. Shock (Augusta, Ga.), 2011, Volume: 35, Issue:6 Topics: Animals; Endotoxemia; Lipopolysaccharides; Malondialdehyde; Metalloporphyrins; Mice; Nitrates; Nitri	2011
Lipopolysaccharide-induced mitochondrial DNA depletion. Antioxidants & redox signaling, 2011, Dec-01, Volume: 15, Issue:11 Topics: Aconitate Hydratase; Adenosine Triphosphate; Alanine Transaminase; Animals; ATP Synthetase Complexes	2011
Leukotriene synthesis inhibitor decreases vasopressin release in the early phase of sepsis. Journal of neuroimmunology, 2011, Sep-15, Volume: 238, Issue:1-2 Topics: Animals; Cecum; Cell Movement; Disease Models, Animal; Enzyme Inhibitors; Hematocrit; Indoles; Leuko	2011
Plasma nitrate/nitrite concentrations in dogs with naturally developing sepsis and non-infectious forms of the systemic inflammatory response syndrome. The Veterinary record, 2011, Nov-19, Volume: 169, Issue:21 Topics: Animals; Dog Diseases; Dogs; Female; Male; Nitrates; Nitrites; Predictive Value of Tests; Prospectiv	2011
Role of mitochondrial oxidants in an in vitro model of sepsis-induced renal injury. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:1 Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cecum; Cell Survival; Cells, Cultured; Epithel	2012
Effects of early administration of a novel anticholinergic drug on acute respiratory distress syndrome induced by sepsis. Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:11 Topics: Animals; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Injections, Intraperitoneal; Interle	2011
Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury. The American journal of pathology, 2012, Volume: 180, Issue:2 Topics: Acute Kidney Injury; Animals; Blood Pressure; Capillaries; Capillary Permeability; Cell Hypoxia; Cel	2012
Endothelial NOS (NOS3) impairs myocardial function in developing sepsis. Basic research in cardiology, 2013, Volume: 108, Issue:2 Topics: Animals; Arterial Pressure; Cardiac Output; Cardiomyopathies; Coronary Circulation; Disease Models,	2013
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:3 Topics: Animals; Endotoxemia; Heart Diseases; Hydrogen Peroxide; Lipopolysaccharides; Male; Myocardial Contr	2002
Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep. Shock (Augusta, Ga.), 2002, Volume: 18, Issue:3 Topics: Animals; Blood Coagulation; Hemodynamics; Heparin; Lung; Nebulizers and Vaporizers; Nitrates; Nitrit	2002
Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Catecholamines; Cyclic AMP; Dexamethasone; Dose-Response Relatio	2003
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive care medicine, 2003, Volume: 29, Issue:6 Topics: Adolescent; Age Factors; Analysis of Variance; Antipyrine; Case-Control Studies; Child; Child, Presc	2003
Exhaled NO and plasma cGMP increase after endotoxin infusion in healthy volunteers. The European respiratory journal, 2003, Volume: 21, Issue:4 Topics: Adult; Analysis of Variance; Cyclic GMP; Endotoxins; Humans; Lipopolysaccharides; Luminescent Measur	2003
Plasma nitrite/nitrate and endothelin-1 concentrations in neonatal sepsis. Acta paediatrica (Oslo, Norway : 1992), 2003, Volume: 92, Issue:5 Topics: Birth Weight; Endothelin-1; Female; Gestational Age; Humans; Infant, Newborn; Male; Nitrates; Nitrit	2003
Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:5 Topics: Animals; Blood Pressure; Carbon Dioxide; Ileum; Intestinal Mucosa; Ischemia; Lactic Acid; Lipopolysa	2003
Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis. Shock (Augusta, Ga.), 2003, Volume: 20, Issue:3 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Extracellular Matrix;	2003
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 286, Issue:3 Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Blood Pressure; Blood Urea Nit	2004
Effects of polyenylphosphatidylcholine on cytokines, nitrite/nitrate levels, antioxidant activity and lipid peroxidation in rats with sepsis. Intensive care medicine, 2004, Volume: 30, Issue:10 Topics: Animals; Antioxidants; Cytokines; Fat Emulsions, Intravenous; Female; Lipid Peroxidation; Models, An	2004
Low-dose dexamethasone ameliorates circulatory failure and renal dysfunction in conscious rats with endotoxemia. Shock (Augusta, Ga.), 2004, Volume: 21, Issue:5 Topics: Animals; Arteries; Blood Pressure; Blotting, Western; Calcium; Dexamethasone; Endotoxemia; Escherich	2004
Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression. Free radical biology & medicine, 2004, Oct-15, Volume: 37, Issue:8 Topics: Angiotensin II; Animals; Arterioles; Ascorbic Acid; Blood Pressure; Cecum; Drug Administration Sched	2004
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11 Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Chromones; Cy	2005
Comparison of effects of nitric oxide synthase (NOS) inhibitors on plasma nitrite/nitrate levels and tissue NOS activity in septic organs. Microbiology and immunology, 2005, Volume: 49, Issue:2 Topics: Animals; Brain; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Lung; Male; Nitrates; Nitr	2005
Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. World journal of gastroenterology, 2005, Mar-28, Volume: 11, Issue:12 Topics: Animal Feed; Animals; Cytokines; Glutamine; Lymphocytes; Male; Nitrates; Nitrites; Peritonitis; Rats	2005
Previous heat shock treatment attenuates lipopolysaccharide-induced hyporesponsiveness of platelets in rats. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3 Topics: Animals; Blood Platelets; Catalase; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Hot T	2005
Effect of treatment on maxillary sinus and nasal nitric oxide concentrations in patients with nosocomial maxillary sinusitis. Chest, 2005, Volume: 128, Issue:3 Topics: Adult; Aged; Cross Infection; Device Removal; Drainage; Humans; Intubation, Gastrointestinal; Maxill	2005
Effect of mast cells depletion on the failure of neutrophil migration during sepsis. European journal of pharmacology, 2005, Nov-21, Volume: 525, Issue:1-3 Topics: Animals; Cell Movement; Colony Count, Microbial; Interleukin-1; Interleukin-10; Male; Mast Cells; Mi	2005
Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis. Free radical biology & medicine, 2006, Jan-01, Volume: 40, Issue:1 Topics: Adenosine Triphosphate; Animals; Blood Pressure; Diaphragm; Endotoxins; Enzyme Inhibitors; Free Radi	2006
N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis. Shock (Augusta, Ga.), 2006, Volume: 25, Issue:1 Topics: Acetylcysteine; Animals; Catalase; Electromyography; Malondialdehyde; Nitrates; Nitrites; Oxidation-	2006
N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia. European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3 Topics: Acute Kidney Injury; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists;	2006
Failure of neutrophil migration to infectious focus and cardiovascular changes on sepsis in rats: Effects of the inhibition of nitric oxide production, removal of infectious focus, and antimicrobial treatment. Shock (Augusta, Ga.), 2006, Volume: 25, Issue:3 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Blood Pressure; Cardiovascular System; Cecum;	2006
Influence of inhaled nitric oxide on plasma nitrate concentrations in patients with adult respiratory distress syndrome and sepsis: results of a pilot study. Journal of clinical anesthesia, 2006, Volume: 18, Issue:3 Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Fe	2006
Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis. Critical care medicine, 2006, Volume: 34, Issue:9 Topics: Airway Obstruction; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Female; Fibri	2006
In silico identification and biological evaluation of antimicrobial peptides based on human cathelicidin LL-37. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:9 Topics: Amino Acid Sequence; Animals; Antimicrobial Cationic Peptides; Blood Proteins; Cathelicidins; Chemot	2006
Effects of beta-lactam antibiotics and L-arginine in the treatment of experimental sepsis in rats. International journal of antimicrobial agents, 2006, Volume: 28, Issue:5 Topics: Animals; Arginine; Ascitic Fluid; Aztreonam; beta-Lactams; Ceftriaxone; Drug Therapy, Combination; I	2006
Antagonic effect of the inhibition of inducible nitric oxide on the mortality of mice acutely infected with Escherichia coli and Bacteroides fragilis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:3 Topics: Acute Disease; Animals; Bacteroides fragilis; Bacteroides Infections; Disease Models, Animal; Escher	2007
The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis. Shock (Augusta, Ga.), 2007, Volume: 28, Issue:3 Topics: Animals; Blood Pressure; Catechin; Disease Models, Animal; Gene Expression; Lung; Male; Mice; Mice,	2007
Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. American journal of respiratory and critical care medicine, 2007, Oct-01, Volume: 176, Issue:7 Topics: Animals; Benzoquinones; Chemokines; Cytokines; HSP90 Heat-Shock Proteins; Inflammation; Inflammation	2007
The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. The Journal of surgical research, 2008, May-15, Volume: 146, Issue:2 Topics: Animals; Arginine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines;	2008
Nosocomial outbreak of nitrate-negative Serratia marcescens infections. Journal of clinical microbiology, 1982, Volume: 15, Issue:4 Topics: Aged; Cross Infection; Disease Outbreaks; Enterobacteriaceae Infections; Humans; Male; Middle Aged;	1982
Nitrite and nitrate determinations in plasma: a critical evaluation. Clinical chemistry, 1995, Volume: 41, Issue:6 Pt 1 Topics: Drug Stability; Free Radicals; Hepatitis; Humans; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduct	1995
Nitric oxide production is increased in patients after burn injury. The Journal of trauma, 1996, Volume: 40, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Body Surface Area; Burns; Case-Control Studies; Child; E	1996
Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Critical care medicine, 1996, Volume: 24, Issue:7 Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Interleukin-10; Interl	1996
Nitrite/nitrate (NOx) and sFas antigen levels in patients with multiple organ failure. Research communications in molecular pathology and pharmacology, 1996, Volume: 92, Issue:2 Topics: fas Receptor; Humans; Multiple Organ Failure; Nitrates; Nitrites; Sepsis	1996
Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock: a study in patients treated for cancer with isolated limb perfusion. Critical care medicine, 1996, Volume: 24, Issue:11 Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Perfusion	1996
Plasma nitric oxide in posttrauma critical illness: a function of "sepsis" and the physiologic state severity classification quantifying the probability of death. Shock (Augusta, Ga.), 1997, Volume: 7, Issue:1 Topics: Adult; Creatinine; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Respiratory Distress S	1997
Relation between pro- and anti-inflammatory cytokines and the production of nitric oxide (NO) in severe sepsis. Cytokine, 1997, Volume: 9, Issue:2 Topics: Antigens, CD; Female; Humans; Inflammation; Interleukin-10; Interleukin-6; Interleukin-8; Interleuki	1997
The role of nitric oxide in experimental murine sepsis due to pyrogenic exotoxin A-producing Streptococcus pyogenes. Infection and immunity, 1997, Volume: 65, Issue:5 Topics: Animals; Cells, Cultured; Exotoxins; Immunohistochemistry; Interferon-gamma; Kidney; Kupffer Cells;	1997
Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Critical care medicine, 1997, Volume: 25, Issue:5 Topics: Adolescent; Autopsy; Child; Child, Preschool; Densitometry; Female; Humans; Infant; Infant, Newborn;	1997
Oxalated pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep. Critical care medicine, 1997, Volume: 25, Issue:6 Topics: Animals; Blood Circulation; Blood Pressure; Blood Substitutes; Endothelin-1; Female; Hemoglobins; Ni	1997
Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome. Critical care medicine, 1997, Volume: 25, Issue:6 Topics: Child, Preschool; Cohort Studies; Humans; Infant; Infant, Newborn; Nitrates; Nitrites; Predictive Va	1997
Nitric oxide and severe sepsis. Archives of disease in childhood, 1997, Volume: 77, Issue:5 Topics: Child; Diet; Humans; Multiple Organ Failure; Nitrates; Nitric Oxide; Sepsis	1997
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure. Chest, 1998, Volume: 113, Issue:6 Topics: Adolescent; Blood Cells; Cells, Cultured; Child; Child, Preschool; Humans; Infant; Infant, Newborn;	1998
Growth requirements and nitrogen metabolism of Malassezia furfur. Archives of dermatological research, 1998, Volume: 290, Issue:5 Topics: Allantoin; Amino Acids; Ammonium Chloride; Ammonium Sulfate; Cell Division; Creatine; Creatinine; Cu	1998
Myocardial dysfunction in the septic rat heart: role of nitric oxide. Shock (Augusta, Ga.), 1998, Volume: 10, Issue:5 Topics: Animals; Coronary Circulation; Dexamethasone; Escherichia coli Infections; In Vitro Techniques; Isot	1998
Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat. Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2 Topics: Acetylcysteine; Animals; Cell Membrane Permeability; Disease Models, Animal; DNA Damage; Dose-Respon	1999
Detection of an approximately 100 kD protein with strong immunoreactivity to antibodies specific for inducible nitric oxide synthase (iNOS) but without NOS activity in neutrophils of patients suffering from sepsis: results of a preliminary study. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48, Issue:12 Topics: Animals; Blotting, Western; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry;	1999
Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis. Shock (Augusta, Ga.), 2000, Volume: 13, Issue:4 Topics: Animals; Cecum; Gene Expression Regulation, Enzymologic; Hemodynamics; Intestine, Small; Kidney; Liv	2000
Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:5 Topics: Acetylcholine; Animals; Arterioles; Enzyme Inhibitors; Lactic Acid; Male; Muscle, Skeletal; Necrosis	2000
Effect of hemodialysis on plasma nitric oxide levels. Artificial organs, 2000, Volume: 24, Issue:5 Topics: Colorimetry; Cyclic GMP; Female; Follow-Up Studies; Humans; Inflammation Mediators; Kidney Failure,	2000
Role of nitric oxide in the failure of neutrophil migration in sepsis. The Journal of infectious diseases, 2000, Volume: 182, Issue:1 Topics: Animals; Ascitic Fluid; Bacteremia; Cell Movement; Colony Count, Microbial; Cytokines; Disease Model	2000
Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3 Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lipopolysaccharides; Mice; N	2000
Nitric oxide synthase and tissue injury. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Alprostadil; Animals; Arginine; Burns; Enzyme Inhibitors; Humans; Ischemia; Luminescent Measurements	2000
Muscular contractile failure in septic patients: role of the inducible nitric oxide synthase pathway. American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:6 Topics: Adult; Aged; Base Sequence; Biopsy; Female; Humans; Immunohistochemistry; Male; Middle Aged; Molecul	2000
Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. Biochemical and biophysical research communications, 2001, May-11, Volume: 283, Issue:3 Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chimera; Endotoxemia; In Vitro Techniques;	2001
Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6 Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Electron Spin R	2001
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs. Shock (Augusta, Ga.), 2001, Volume: 16, Issue:4 Topics: Animals; Blood Gas Analysis; Blotting, Western; Disease Models, Animal; Hemodynamics; Lipopolysaccha	2001
The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure. Thrombosis and haemostasis, 2002, Volume: 87, Issue:2 Topics: Adolescent; Child; Child, Preschool; Cytokines; Endothelium, Vascular; Female; Fibrinolysis; Humans;	2002
Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases. American journal of respiratory cell and molecular biology, 2002, Volume: 26, Issue:4 Topics: Animals; Extremities; Male; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitrate	2002
Increased bone resorption in the critically ill: association with sepsis and increased nitric oxide production. Critical care medicine, 2002, Volume: 30, Issue:4 Topics: Adult; Aged; Amino Acids; Bone Resorption; Creatinine; Critical Illness; Female; Humans; Intensive C	2002
Failure of neutrophil chemotactic function in septic patients. Critical care medicine, 2002, Volume: 30, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotaxis, Leukocyte; Female; Humans; Leukotriene B4; M	2002
Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity. The Biochemical journal, 2002, Sep-01, Volume: 366, Issue:Pt 2 Topics: Amino Acid Sequence; Animals; Cell Line; Humans; Mice; Models, Molecular; Molecular Sequence Data; M	2002
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nitrates and Blood Poisoning