nitrates has been researched along with Allergic Encephalomyelitis in 16 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uric acid (UA), a product of purine metabolism, is a known scavenger of peroxynitrite (ONOO(-)), which has been implicated in the pathogenesis of multiple sclerosis and experimental allergic encephalomyelitis (EAE)." | 7.70 | The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 5.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| "Uric acid (UA), a product of purine metabolism, is a known scavenger of peroxynitrite (ONOO(-)), which has been implicated in the pathogenesis of multiple sclerosis and experimental allergic encephalomyelitis (EAE)." | 3.70 | The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| " Importantly, the impact of subtherapeutic doses of CsA in combination with NOX-100 on disease progression in EAE was greater than that attained with either agent alone and led to near total protection." | 1.32 | A novel nitric oxide scavenger in combination with cyclosporine A ameliorates experimental autoimmune encephalomyelitis progression in mice. ( Chen, LS; Howard, RB; Jolivalt, CG; Lai, CS; Mizisin, AP, 2003) |
| "Uric acid (UA) is a natural scavenger of ONOO(-) that is present at high levels in the sera of humans and other higher order primates relative to most lower mammals." | 1.31 | Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid. ( Hooper, DC; Kean, RB; Mikheeva, T; Scott, GS; Spitsin, SV, 2000) |
| "Uric acid treatment also was found to diminish clinical signs of a disease resembling EAE in interferon-gamma receptor knockout mice." | 1.30 | Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. ( Champion, JM; Chaudhry, I; Dickson, GM; Hooper, DC; Kean, RB; Koprowski, H; Spitsin, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drzayich Antol, D | 1 |
| Waldman Casebeer, A | 1 |
| Khoury, R | 1 |
| Michael, T | 1 |
| Renda, A | 1 |
| Hopson, S | 1 |
| Parikh, A | 1 |
| Stein, A | 1 |
| Costantino, M | 1 |
| Stemkowski, S | 1 |
| Bunce, M | 1 |
| Nevo, N | 1 |
| Abu-Abeid, S | 1 |
| Hazzan, D | 1 |
| Lahat, G | 1 |
| Nachmani, I | 1 |
| Eldar, SM | 1 |
| Zhang, L | 1 |
| Xia, X | 1 |
| Zhong, Y | 1 |
| Xie, D | 1 |
| Liu, S | 1 |
| Wang, X | 1 |
| Tu, J | 1 |
| Faconti, L | 1 |
| Mills, CE | 1 |
| Govoni, V | 1 |
| Gu, H | 1 |
| Morant, S | 1 |
| Jiang, B | 1 |
| Cruickshank, JK | 1 |
| Webb, AJ | 1 |
| Lin, J | 1 |
| Wu, YJ | 1 |
| Liang, X | 1 |
| Ji, M | 1 |
| Ying, HM | 1 |
| Wang, XY | 1 |
| Sun, X | 1 |
| Shao, CH | 1 |
| Zhan, LX | 1 |
| Zhang, Y | 1 |
| Czamara, K | 1 |
| Karnas, E | 1 |
| Majka, Z | 1 |
| Wojcik, T | 1 |
| Zuba-Surma, EK | 1 |
| Baranska, M | 1 |
| Kaczor, A | 1 |
| Liu, X | 1 |
| Zhou, F | 1 |
| Yang, Y | 1 |
| Wang, W | 1 |
| Niu, L | 1 |
| Zuo, D | 1 |
| Li, X | 1 |
| Hua, H | 1 |
| Zhang, B | 1 |
| Kou, Y | 1 |
| Guo, J | 1 |
| Kong, F | 1 |
| Pan, W | 1 |
| Gao, D | 1 |
| Meves, JM | 1 |
| Sun, H | 1 |
| Xue, M | 1 |
| Zhang, Q | 1 |
| Wang, Y | 1 |
| Tang, R | 1 |
| Iso, T | 1 |
| Haruyama, H | 1 |
| Sunaga, H | 1 |
| Matsui, H | 1 |
| Matsui, M | 1 |
| Tanaka, R | 1 |
| Umbarawan, Y | 1 |
| Syamsunarno, MRAA | 1 |
| Putri, M | 1 |
| Yamaguchi, A | 1 |
| Hanaoka, H | 1 |
| Negishi, K | 1 |
| Yokoyama, T | 1 |
| Kurabayashi, M | 1 |
| Palomo-Briones, R | 1 |
| Esquivel-González, S | 1 |
| Aizpuru, A | 1 |
| Gómez-Hernández, N | 1 |
| Casas-Flores, S | 1 |
| Barba de la Rosa, AP | 1 |
| Arriaga, S | 1 |
| Peterson, ME | 1 |
| Carothers, MA | 1 |
| Gamble, DA | 1 |
| Rishniw, M | 1 |
| Moransard, M | 1 |
| Sawitzky, M | 1 |
| Fontana, A | 1 |
| Suter, T | 1 |
| Jolivalt, CG | 1 |
| Howard, RB | 1 |
| Chen, LS | 1 |
| Mizisin, AP | 1 |
| Lai, CS | 1 |
| Cross, AH | 3 |
| Misko, TP | 3 |
| Lin, RF | 1 |
| Hickey, WF | 1 |
| Trotter, JL | 1 |
| Tilton, RG | 1 |
| Hooper, DC | 5 |
| Bagasra, O | 1 |
| Marini, JC | 1 |
| Zborek, A | 2 |
| Ohnishi, ST | 1 |
| Kean, R | 1 |
| Champion, JM | 2 |
| Sarker, AB | 1 |
| Bobroski, L | 1 |
| Farber, JL | 1 |
| Akaike, T | 1 |
| Maeda, H | 1 |
| Koprowski, H | 3 |
| van der Veen, RC | 2 |
| Hinton, DR | 1 |
| Incardonna, F | 1 |
| Hofman, FM | 1 |
| Manning, PT | 1 |
| Stern, MK | 2 |
| Spitsin, S | 1 |
| Kean, RB | 4 |
| Dickson, GM | 1 |
| Chaudhry, I | 1 |
| Cowden, WB | 1 |
| Cullen, FA | 1 |
| Staykova, MA | 1 |
| Willenborg, DO | 1 |
| Roberts, LJ | 1 |
| Mayer, M | 1 |
| Scott, GS | 3 |
| Mikheeva, T | 3 |
| Spitsin, SV | 3 |
| San, M | 1 |
| Keeling, RM | 1 |
| Salvemini, D | 1 |
| Puerta, C | 1 |
| Martínez, I | 1 |
| Baranda, P | 1 |
| Blasco, MR | 1 |
| Castejón, R | 1 |
| Vargas, JA | 1 |
| García-Merino, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Multiple Sclerosis Using Over the Counter Inosine[NCT00067327] | Phase 2 | 30 participants | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nitrates and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Essential fatty acids and related molecular and cellular mechanisms in multiple sclerosis: new looks at old concepts.
Topics: Animals; Apoptosis; Autoimmune Diseases; Demyelinating Diseases; Dietary Fats; Double-Blind Method; | 1999 |
1 trial available for nitrates and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Topics: Adult; Aged; Animals; Astrocytes; Bariatric Surgery; Beta vulgaris; Bioreactors; Biotechnology; Bloo | 2018 |
14 other studies available for nitrates and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Topics: Animals; Antigens, CD; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Central Nervous Syste | 2010 |
A novel nitric oxide scavenger in combination with cyclosporine A ameliorates experimental autoimmune encephalomyelitis progression in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclosporine; Cytokines; Disease Progression; Drug | 2003 |
Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.
Topics: Amino Acid Oxidoreductases; Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Guanidines | 1994 |
Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
Topics: Animals; Brain; Bridged-Ring Compounds; Cyclic N-Oxides; Encephalomyelitis, Autoimmune, Experimental | 1997 |
Extensive peroxynitrite activity during progressive stages of central nervous system inflammation.
Topics: Animals; Antibody Specificity; Brain; Disease Progression; Encephalomyelitis, Autoimmune, Experiment | 1997 |
Evidence for the production of peroxynitrite in inflammatory CNS demyelination.
Topics: Acute Disease; Animals; Chronic Disease; Encephalomyelitis, Autoimmune, Experimental; Female; Immuno | 1997 |
Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis.
Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Mice, Knockout; Multiple | 1998 |
Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE.
Topics: Animals; Cell Division; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibit | 1998 |
Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids.
Topics: Animals; Central Nervous System; Dinoprost; Encephalomyelitis, Autoimmune, Experimental; F2-Isoprost | 1999 |
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Expe | 2000 |
A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis.
Topics: Animals; Catalysis; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Female; Fer | 2000 |
Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2000 |
Aminoguanidine reduces apoptosis of circulating V Beta 8.2 T lymphocytes in Lewis rats with actively induced experimental autoimmune encephalomyelitis. Association with persistent inflammation of the central nervous system and lack of recovery.
Topics: Animals; Apoptosis; Cell Division; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; G | 2000 |
The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cell Movement; Central Nervous System; Encepha | 2000 |