nitrates has been researched along with Aging in 142 studies
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report herein a novel mechanism, unraveled by proteomics and validated by in vitro and in vivo studies, of the aberrant aging-associated upregulation of ovarian transferrin and ferritin in rat ovaries." | 8.12 | Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demon ( Lam, JKW; Lee, KF; Lin, K; Ng, ML; Ng, TB; Sze, SCW; Yung, KKL; Zhang, L; Zhang, S; Zhang, Z, 2022) |
| "Aging is associated with erectile dysfunction (ED), in which nitric oxide synthase (NOS) activity and NO bioavailability are reduced due to deficiencies of NOS cofactor (tetrahydrobiopterin, BH(4)) and substrate (L-arginine)." | 7.80 | L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats. ( Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D, 2014) |
| "The nitration of protein tyrosine residues represents an important post-translational modification during development, oxidative stress, and biological aging." | 7.73 | Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry. ( Hong, SJ; Kanski, J; Schöneich, C, 2005) |
| "The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2)." | 7.73 | Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Pawluk, H; Szadujkis-Szadurski, L, 2006) |
| "The fact that both E and L delayed cardiac hypertrophy/hyperplasia and aortic growth and raised aortic endothelium NOS activity indicates a protective effect on cardiovascular damage due to aging, exerted through inhibition of angiotensin II." | 7.71 | Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging. ( Basso, N; González Bosc, LV; Kurnjek, ML; Müller, A; Terragno, NA, 2001) |
| "To assess whether serum creatinine and age are associated with headache induced by nitrates, 2742 hospitalized patients taking nitrates were studied during their hospital stay." | 7.69 | Association of serum creatinine and age with headache caused by nitrates. Gruppo Italiano di Farmacovigilanza nell'Anziano. ( Bernabei, R; Carosella, L; Cecchi, E; Cocchi, A; Fumagalli, S; Gambassi, G; Manto, A; Marchionni, N; Pahor, M; Pedone, C, 1995) |
| "The present study was performed to test the hypothesis that excretion of nitric oxide metabolites, nitrate and nitrite, are decreased with progressive aging in rats and that a decrease in nitric oxide precursor, L-arginine, also decreases with aging." | 7.69 | Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging. ( Bacon, EE; Blanchard, EJ; Kellum, JA; Kruckeberg, WC; Reckelhoff, JF; Wesley, AJ, 1994) |
| "To undertake a pilot RCT examining the efficacy of isometric handgrip exercise (IHGE) and beetroot juice (a rich source of inorganic nitrate) consumption in modifying clinic and 24-h ambulatory BP (24-h ABP), peripheral arterial function and plasma asymmetric dimethylarginine (ADMA) in older overweight and obese adults." | 5.20 | Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT. ( Ashor, A; Brandt, K; Lara, J; Mathers, JC; Ogbonmwan, I; Oggioni, C; Qadir, O; Siervo, M; Zheng, D, 2015) |
| "We report herein a novel mechanism, unraveled by proteomics and validated by in vitro and in vivo studies, of the aberrant aging-associated upregulation of ovarian transferrin and ferritin in rat ovaries." | 4.12 | Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demon ( Lam, JKW; Lee, KF; Lin, K; Ng, ML; Ng, TB; Sze, SCW; Yung, KKL; Zhang, L; Zhang, S; Zhang, Z, 2022) |
| "Aging is associated with erectile dysfunction (ED), in which nitric oxide synthase (NOS) activity and NO bioavailability are reduced due to deficiencies of NOS cofactor (tetrahydrobiopterin, BH(4)) and substrate (L-arginine)." | 3.80 | L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats. ( Bayatli, N; Gur, S; Kaya, E; Un, O; Yilmaz, D, 2014) |
| " Previously, we reported an increase in protein tyrosine nitration (a marker of oxidative/nitrosative damage) and a decrease in the antioxidant enzyme extracellular superoxide dismutase (EC-SOD) in the lungs of young mice during endotoxemia-induced SIRS." | 3.77 | The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation. ( Evers, BM; Saito, H; Starr, ME; Ueda, J; Yamamoto, S, 2011) |
| "The nitration of protein tyrosine residues represents an important post-translational modification during development, oxidative stress, and biological aging." | 3.73 | Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry. ( Hong, SJ; Kanski, J; Schöneich, C, 2005) |
| "The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2)." | 3.73 | Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Pawluk, H; Szadujkis-Szadurski, L, 2006) |
| "The fact that both E and L delayed cardiac hypertrophy/hyperplasia and aortic growth and raised aortic endothelium NOS activity indicates a protective effect on cardiovascular damage due to aging, exerted through inhibition of angiotensin II." | 3.71 | Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging. ( Basso, N; González Bosc, LV; Kurnjek, ML; Müller, A; Terragno, NA, 2001) |
| " This report emphasizes the importance of angiotensin II in vascular function alterations induced by aging in SHR." | 3.70 | Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats. ( Cachofeiro, V; Lahera, V; Maeso, R; Navarro-Cid, J; Rodrigo, E; Ruilope, LM, 1999) |
| "To assess whether serum creatinine and age are associated with headache induced by nitrates, 2742 hospitalized patients taking nitrates were studied during their hospital stay." | 3.69 | Association of serum creatinine and age with headache caused by nitrates. Gruppo Italiano di Farmacovigilanza nell'Anziano. ( Bernabei, R; Carosella, L; Cecchi, E; Cocchi, A; Fumagalli, S; Gambassi, G; Manto, A; Marchionni, N; Pahor, M; Pedone, C, 1995) |
| "The present study was performed to test the hypothesis that excretion of nitric oxide metabolites, nitrate and nitrite, are decreased with progressive aging in rats and that a decrease in nitric oxide precursor, L-arginine, also decreases with aging." | 3.69 | Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging. ( Bacon, EE; Blanchard, EJ; Kellum, JA; Kruckeberg, WC; Reckelhoff, JF; Wesley, AJ, 1994) |
| "Effects of aging and dietary protein on the L-arginine-nitric oxide (Arg-NO) pathway and the progress of chronic nephropathy were examined." | 3.69 | L-arginine-nitric oxide pathway and chronic nephropathy in aged rats. ( Futami, Y; Maki, T; Sonaka, I, 1994) |
| "Aging is associated with loss of nephron function and reductions in serum L-arginine and excretion of nitric oxide (NO) metabolites." | 3.69 | Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. ( Hildebrandt, DA; Kellum, JA; Racusen, LC; Reckelhoff, JF, 1997) |
| " Lower plasma nitrite and FeNO concentrations were found in older subjects, confirming the impact of ageing on NO bioavailability across different systems." | 3.11 | Pharmacokinetic Profile of Incremental Oral Doses of Dietary Nitrate in Young and Older Adults: A Crossover Randomized Clinical Trial. ( Capper, TE; Clifford, T; Iqbal, W; Siervo, M; Stevenson, EJ; Taylor, G; West, D, 2022) |
| "Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide." | 2.84 | Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study. ( Allen, JD; Briskey, D; Fassett, R; Hickey, D; Kerr, G; Leveritt, M; Neubauer, O; Ortiz de Zevallos Munoz, J; Parker, TJ; Peake, JM; Pecheniuk, NM; Raubenheimer, K, 2017) |
| " These effects are mediated, at least in part, by an age-related decrease in the bioavailability of nitric oxide (NO), a ubiquitous gasotransmitter and regulator of myriad physiological processes." | 2.82 | Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes. ( Clifford, T; Craighead, DH; Rossman, MJ; Seals, DR; Shannon, OM, 2022) |
| " Recent evidence suggests that NO bioavailability can be augmented by dietary nitrate through the nitrate-nitrite pathway." | 2.80 | Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults. ( Casey, DP; Ganger, CT; Schneider, AC; Treichler, DP; Ueda, K, 2015) |
| " In eight young sedentary (23 ± 1 years; Y), eight older lifelong sedentary (66 ± 2 years; OS) and eight older lifelong physically active subjects (62 ± 2 years; OA), we studied the effect of ROS on systemic and skeletal muscle NO bioavailability and leg blood flow by infusion of the antioxidant N-acetylcysteine (NAC)." | 2.77 | Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. ( Blackwell, JR; Damsgaard, R; Hellsten, Y; Jones, AM; Mortensen, SP; Nyberg, M, 2012) |
| " Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade." | 2.58 | Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research. ( Ashor, AW; Scialò, F; Shannon, OM; Siervo, M; Stephan, BCM, 2018) |
| " Inorganic nitrite is a promising precursor molecule for augmenting circulating and tissue NO bioavailability because it requires only a one-step reduction to NO." | 2.50 | Inorganic nitrite supplementation for healthy arterial aging. ( Devan, AE; Fleenor, BS; Seals, DR; Sindler, AL, 2014) |
| " Nitric oxide (NO) affects cardiovascular functions, and NO bioavailability is critically reduced with ageing." | 1.43 | Impact of dietary nitrate on age-related diastolic dysfunction. ( Deenen, R; Flögel, U; French, BA; Gödecke, A; Hendgen-Cotta, UB; Kelm, M; Köhrer, K; Lüdike, P; Pohl, J; Rammos, C; Rassaf, T; Totzeck, M, 2016) |
| "Aging and obesity are associated with raised oxidative stress and a reduction of nitric oxide (NO) bioavailability, with subsequent decline in insulin sensitivity and endothelial function." | 1.43 | Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress. ( Ashor, AW; Brandt, K; Chowdhury, S; Ishaq, A; Mathers, JC; Oggioni, C; Qadir, O; Saretzki, G; Siervo, M, 2016) |
| " Deterioration of vascular homoeostasis with increase in oxidative stress, chronic low-grade inflammation, and impaired nitric oxide bioavailability results in endothelial dysfunction, increased vascular stiffness, and compromised arterial-ventricular interactions." | 1.42 | Dietary nitrate is a modifier of vascular gene expression in old male mice. ( Deenen, R; Hendgen-Cotta, UB; Kelm, M; Köhrer, K; Rammos, C; Rassaf, T; Totzeck, M, 2015) |
| "Melatonin has been suggested as an effective free radical scavenger that might have a role during the process of aging." | 1.39 | Improvement of oxidative stress and immunity by melatonin: an age dependent study in golden hamster. ( Dash, D; Haldar, C; Mukherjee, A; Nayak, MK; Vishwas, DK, 2013) |
| "05) more toxic than KCl-K, indicating a toxicity interaction between K+ and NO3-." | 1.34 | Acute toxicity of sodium nitrate, potassium nitrate, and potassium chloride and their effects on the hemolymph composition and gill structure of early juvenile blue swimmer crabs(Portunus pelagicus Linnaeus, 1758) (Decapoda, Brachyura, Portunidae). ( Romano, N; Zeng, C, 2007) |
| "Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy." | 1.29 | Effects of cytidine diphosphate choline on rats with memory deficits. ( Getova, D; Kehayov, RA; Lazarova, MB; Mosharrof, AH; Petkov, VD; Petkov, VV; Vaglenova, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (6.34) | 18.7374 |
| 1990's | 35 (24.65) | 18.2507 |
| 2000's | 50 (35.21) | 29.6817 |
| 2010's | 38 (26.76) | 24.3611 |
| 2020's | 10 (7.04) | 2.80 |
| Authors | Studies |
|---|---|
| Capper, TE | 1 |
| Siervo, M | 7 |
| Clifford, T | 3 |
| Taylor, G | 2 |
| Iqbal, W | 2 |
| West, D | 2 |
| Stevenson, EJ | 1 |
| Capper, T | 1 |
| Stevenson, E | 1 |
| Shannon, OM | 3 |
| Seals, DR | 3 |
| Craighead, DH | 1 |
| Rossman, MJ | 1 |
| Gregory, S | 1 |
| Sze, SCW | 1 |
| Zhang, L | 4 |
| Zhang, S | 3 |
| Lin, K | 1 |
| Ng, TB | 1 |
| Ng, ML | 1 |
| Lee, KF | 1 |
| Lam, JKW | 1 |
| Zhang, Z | 3 |
| Yung, KKL | 1 |
| Piknova, B | 1 |
| Park, JW | 1 |
| Thomas, SM | 1 |
| Tunau-Spencer, KJ | 1 |
| Schechter, AN | 1 |
| Rasmussen, PM | 1 |
| Aamand, R | 1 |
| Weitzberg, E | 1 |
| Christiansen, M | 1 |
| Østergaard, L | 1 |
| Lund, TE | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 7 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 4 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 3 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 2 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 4 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 2 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 5 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
| Ibanez, B | 1 |
| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Xu, H | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
| Salem, HF | 1 |
| Nafady, MM | 1 |
| Kharshoum, RM | 1 |
| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
| Domiciano, D | 1 |
| Nery, FC | 1 |
| de Carvalho, PA | 1 |
| Prudente, DO | 1 |
| de Souza, LB | 1 |
| Chalfun-Júnior, A | 1 |
| Paiva, R | 1 |
| Marchiori, PER | 1 |
| Lu, M | 2 |
| An, Z | 1 |
| Jiang, J | 2 |
| Li, J | 7 |
| Du, S | 1 |
| Zhou, H | 1 |
| Cui, J | 1 |
| Wu, W | 1 |
| Liu, Y | 7 |
| Song, J | 1 |
| Lian, Q | 1 |
| Uddin Ahmad, Z | 1 |
| Gang, DD | 1 |
| Konggidinata, MI | 1 |
| Gallo, AA | 1 |
| Zappi, ME | 1 |
| Yang, TWW | 1 |
| Johari, Y | 1 |
| Burton, PR | 1 |
| Earnest, A | 1 |
| Shaw, K | 1 |
| Hare, JL | 1 |
| Brown, WA | 1 |
| Kim, GA | 1 |
| Han, S | 1 |
| Choi, GH | 1 |
| Choi, J | 1 |
| Lim, YS | 1 |
| Gallo, A | 1 |
| Cancelli, C | 1 |
| Ceron, E | 1 |
| Covino, M | 1 |
| Capoluongo, E | 1 |
| Pocino, K | 1 |
| Ianiro, G | 1 |
| Cammarota, G | 1 |
| Gasbarrini, A | 1 |
| Montalto, M | 1 |
| Somasundar, Y | 1 |
| Lu, IC | 1 |
| Mills, MR | 1 |
| Qian, LY | 1 |
| Olivares, X | 1 |
| Ryabov, AD | 1 |
| Collins, TJ | 1 |
| Zhao, L | 1 |
| Doddipatla, S | 1 |
| Thomas, AM | 1 |
| Nikolayev, AA | 1 |
| Galimova, GR | 1 |
| Azyazov, VN | 1 |
| Mebel, AM | 1 |
| Kaiser, RI | 1 |
| Guo, S | 1 |
| Yang, P | 1 |
| Yu, X | 2 |
| Wu, Y | 2 |
| Zhang, H | 2 |
| Yu, B | 2 |
| Han, B | 1 |
| George, MW | 1 |
| Moor, MB | 1 |
| Bonny, O | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Testing the Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function in Older Adults Living With Overweight or Obesity: A 28-Day Pilot Randomised Trial[NCT06151015] | 20 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke[NCT05720013] | 25 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | |||
| Effects of Dietary Nitrate on Vascular Function, Blood Pressure, the Oral Microbiome, and Biomarkers of Systemic Inflammation in Hypertensive Older Adults: a Randomized, Placebo-controlled Crossover Study[NCT04584372] | 20 participants (Actual) | Interventional | 2021-01-01 | Completed | |||
| Impact of the Daily Use of Hydroxyapatite-toothpaste on the Occurrence of Enamel Caries in the Primary Dentition (ECIPDEN17)[NCT03553966] | 200 participants (Actual) | Interventional | 2018-03-01 | Completed | |||
| Strength Testing After Nitrate Delivery (STAND) in ICU Patients[NCT02293616] | 25 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| "A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. KYMES"[NCT01168700] | Phase 4 | 46 participants (Anticipated) | Interventional | 2009-11-30 | Recruiting | ||
| Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome[NCT02633488] | 19 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794] | 36 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740] | 32 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
brachial artery ultrasonography % flow-mediated dilatation (FMD) for assessing endothelial function before and after an insulin clamp to assess insulin's effect on the vasculature (NCT02633488)
Timeframe: before and after 12 weeks on placebo or metformin
| Intervention | percentage of artery dilation (Mean) |
|---|---|
| Pre and Post Placebo 12 Weeks | 6.1 |
| Pre and Post Metformin 12 Weeks | 6.2 |
13 reviews available for nitrates and Aging
| Article | Year |
|---|---|
Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes.
Topics: Aged; Aging; Athletes; Citrulline; Dietary Supplements; Exercise; Humans; Nitrates; Nitric Oxide | 2022 |
Dietary nitrate, aging and brain health: the latest evidence.
Topics: Aged; Aging; Beta vulgaris; Brain; Dietary Supplements; Humans; Nitrates; Nitric Oxide | 2022 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Performance and Health Benefits of Dietary Nitrate Supplementation in Older Adults: A Systematic Review.
Topics: Aged; Aging; Beta vulgaris; Blood Pressure; Cardiovascular Diseases; Cerebrovascular Circulation; Co | 2017 |
Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research.
Topics: Aging; Biological Availability; Blood Pressure; Cardiovascular Diseases; Diet; Dietary Supplements; | 2018 |
Inorganic nitrite supplementation for healthy arterial aging.
Topics: Aging; Animals; Arteries; Cardiotonic Agents; Cardiovascular Diseases; Dietary Supplements; Endothel | 2014 |
Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: An individual participant meta-analysis.
Topics: Aged; Aging; Beta vulgaris; Beverages; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dietar | 2015 |
Aging, lipid modifications and phospholipases--new concepts.
Topics: Aging; Animals; Free Radicals; Humans; Lipid Metabolism; Lipid Peroxidation; Nitrates; Nitrites; Oxi | 2003 |
Why don't we use nitrates to treat older hypertensive patients?
Topics: Age Factors; Aging; Antihypertensive Agents; Humans; Hypertension; Nitrates | 2005 |
The nutritional relationship linking sulfur to nitrogen in living organisms.
Topics: Aging; Animals; Body Composition; Diet; Homeostasis; Homocysteine; Humans; Methionine; Methylation; | 2006 |
Carotid artery stiffness with applications to cardiovascular pharmacology.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blood Volume; Calcium Chan | 1996 |
Aging and the role of reactive nitrogen species.
Topics: Aging; Animals; Diet; Humans; Molecular Structure; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidat | 2002 |
New therapeutic modalities for the treatment of elderly patients with ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Calcium Channel Blockers; Coronary Disease; Humans; Kineti | 1987 |
12 trials available for nitrates and Aging
| Article | Year |
|---|---|
Pharmacokinetic Profile of Incremental Oral Doses of Dietary Nitrate in Young and Older Adults: A Crossover Randomized Clinical Trial.
Topics: Aged; Aging; Beta vulgaris; Blood Pressure; Cross-Over Studies; Humans; Nitrates; Nitrites; Vegetabl | 2022 |
Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial.
Topics: Adult; Aged; Aging; Beta vulgaris; Blood Pressure; Cross-Over Studies; Dietary Supplements; Humans; | 2023 |
APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.
Topics: Adult; Aged; Aging; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Breath Holding; Cerebro | 2019 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Simultaneous Pharmacokinetic Analysis of Nitrate and its Reduced Metabolite, Nitrite, Following Ingestion of Inorganic Nitrate in a Mixed Patient Population.
Topics: Administration, Oral; Aged; Aging; Biological Availability; Body Weight; Cross-Over Studies; Dietary | 2020 |
Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study.
Topics: Aged; Aging; Beta vulgaris; Biomarkers; Blood Platelets; Blood Pressure; Cardiovascular Diseases; CD | 2017 |
Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.
Topics: Adult; Age Factors; Aged; Aging; Beta vulgaris; Dietary Supplements; Exercise; Female; Humans; Hypox | 2015 |
Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: A pilot RCT.
Topics: Adult; Aged; Aging; Arginine; Beta vulgaris; Blood Pressure; Blood Pressure Monitoring, Ambulatory; | 2015 |
Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans.
Topics: Acetylcholine; Acetylcysteine; Adult; Aged; Aging; Antioxidants; Femoral Artery; Humans; Leg; Male; | 2012 |
Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults.
Topics: Age Factors; Aged; Aging; Beta vulgaris; Beverages; Blood Pressure; Brain; Cognition; Cross-Over Stu | 2013 |
Elevated urinary excretion of nitric oxide metabolites in young infants with Zellweger syndrome.
Topics: Aging; Creatinine; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Male; Nitrates; Nit | 2003 |
Estrogen therapy increases plasma concentrations of nitric oxide metabolites in postmenopausal women but increases flow-mediated vasodilation only in younger women.
Topics: Aged; Aging; Brachial Artery; Cross-Over Studies; Double-Blind Method; Estrogens, Conjugated (USP); | 2004 |
118 other studies available for nitrates and Aging
| Article | Year |
|---|---|
Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demon
Topics: Aging; Animals; Apoferritins; Estradiol; Female; Ferritins; Ferroptosis; Iron; Iron Regulatory Prote | 2022 |
Nitrate and Nitrite Metabolism in Aging Rats: A Comparative Study.
Topics: Aging; Animals; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats | 2023 |
Potential health effects of dietary nitrate supplementation in aging and chronic degenerative disease.
Topics: Aged; Aging; Beta vulgaris; Blood Pressure; Dietary Supplements; Humans; Nitrates | 2020 |
Assessing changes in nitrogen contamination in groundwater using water aging: Waikato River, New Zealand.
Topics: Aging; Environmental Monitoring; Groundwater; Humans; New Zealand; Nitrates; Nitrogen; Rivers; Silic | 2020 |
Dietary nitrate supplementation does not influence thermoregulatory or cardiovascular strain in older individuals during severe ambient heat stress.
Topics: Aged; Aged, 80 and over; Aging; Arterial Pressure; Beta vulgaris; Body Temperature Regulation; Cardi | 2020 |
Metabolomics of laminae and midvein during leaf senescence and source-sink metabolite management in Brassica napus L. leaves.
Topics: Aging; Brassica napus; Metabolome; Metabolomics; Nitrates; Plant Leaves | 2018 |
Inorganic nitrate alleviates the senescence-related decline in liver function.
Topics: Aging; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cellular Senescence; Dietary Supp | 2018 |
In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing.
Topics: Aging; Animals; Arginine; Calcium Carbonate; Cattle; Dentin; Dentin Permeability; Dentin Sensitivity | 2018 |
Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging.
Topics: Aging; Animals; Dopamine; Dopaminergic Neurons; Estradiol; Estrogens; Female; Hyperprolactinemia; Hy | 2019 |
Dietary nitrate intake is associated with muscle function in older women.
Topics: Aged; Aging; Australia; Cross-Sectional Studies; Dietary Supplements; Feeding Behavior; Female; Hand | 2019 |
Influence of aging on ethanol-induced oxidative stress in digestive tract of rats.
Topics: Aging; Animals; Ethanol; Gastric Mucosa; Liver; Male; Malondialdehyde; Nitrates; Nitrites; Oxidative | 2013 |
Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk.
Topics: Aging; Animals; Blood Vessels; Cardiovascular Diseases; Dietary Supplements; Endothelium, Vascular; | 2014 |
Nitrite treatment rescues cardiac dysfunction in aged mice treated with conjugated linoleic acid.
Topics: Aging; Animals; Blotting, Western; Cattle; Endothelial Cells; Humans; Linoleic Acids, Conjugated; Mi | 2014 |
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Topics: Aging; Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Erectile Dysfunction; Male; | 2014 |
Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice.
Topics: Aging; Animals; Cytokines; Dietary Supplements; Drug Evaluation, Preclinical; Inflammation; Male; Mi | 2015 |
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Topics: Aging; Animals; Arginase; Cell Hypoxia; Enzyme Activation; Hypertension; Lung; Male; Nitrates; Nitri | 2015 |
Dietary nitrate is a modifier of vascular gene expression in old male mice.
Topics: Aging; Animals; Calcium; Cells, Cultured; Dietary Supplements; Endothelium, Vascular; Gene Expressio | 2015 |
Effect of fetal hypothyroidism on tolerance to ischemia-reperfusion injury in aged male rats: Role of nitric oxide.
Topics: Aging; Animals; bcl-2-Associated X Protein; Congenital Hypothyroidism; Creatine Kinase; L-Lactate De | 2016 |
Impact of dietary nitrate on age-related diastolic dysfunction.
Topics: Aging; Animals; Calcium; Coronary Vessels; Diastole; Dietary Supplements; Echocardiography; Endothel | 2016 |
Magnetic resonance imaging biomarkers of exercise-induced improvement of oxidative stress and inflammation in the brain of old high-fat-fed ApoE
Topics: Aging; Animals; Aorta; Apolipoproteins E; Biomarkers; Brain; Catalase; Cholesterol; Diet, High-Fat; | 2016 |
Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress.
Topics: Adolescent; Adult; Aged; Aging; Biomarkers; Blood Glucose; Female; Humans; Inflammation; Insulin; Ma | 2016 |
Age related differences in stress-induced neurobehavioral responses in rats: modulation by antioxidants and nitrergic agents.
Topics: Aging; alpha-Tocopherol; Animals; Antioxidants; Arginine; Behavior, Animal; Catalase; Enzyme Inhibit | 2008 |
Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production.
Topics: Aging; Amino Acid Sequence; Animals; Brain; Coenzyme A-Transferases; Cytochromes c; Energy Metabolis | 2009 |
Hypercholesterolemia impairs exercise capacity in mice.
Topics: Aging; Animals; Aorta; Apolipoproteins E; Cholesterol, Dietary; Citrate (si)-Synthase; Disease Model | 2009 |
Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration.
Topics: Aging; Animals; Female; Immunohistochemistry; Manganese; Mice; Mice, Inbred C57BL; Nerve Tissue Prot | 2009 |
Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging.
Topics: Adenosine Triphosphate; Age Factors; Aging; Analysis of Variance; Animals; Binding Sites; Blotting, | 2010 |
Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people.
Topics: Aged; Aging; Blood Pressure; Exercise; Humans; Middle Aged; Nitrates; Nitric Oxide Synthase Type III | 2010 |
The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation.
Topics: Aging; Animals; Blotting, Western; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Endotoxem | 2011 |
Hypovolemic state: age-related influence of water restriction on cardiac nitric oxide synthase in rats.
Topics: Adaptation, Physiological; Aging; Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; H | 2011 |
S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase.
Topics: Aging; Animals; Aorta; Arginase; Cell Line; Endothelium, Vascular; Enzyme Assays; Humans; Immunoprec | 2011 |
Oxidative stress in the kidney of reproductive male rats during aging.
Topics: Aging; Animals; Ascorbic Acid; Catalase; Estradiol; Glutathione; Glutathione Peroxidase; Glutathione | 2011 |
[Nitric oxide and human aging].
Topics: Adolescent; Aging; Blood Pressure; Female; Heart Rate; Humans; Male; Nitrates; Nitric Oxide; Nitrite | 2011 |
Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle.
Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Mass Spectrometry; Mice; Mice, Inbred C57 | 2011 |
[Arginase-nitric oxide synthase system changes due to adaptation to swimming in adult and aged rat hearts].
Topics: Adaptation, Physiological; Aging; Animals; Arginase; Blood Pressure; Diastole; Heart; Hydrogen Perox | 2012 |
Potential hepato-protective effect of α-tocopherol or simvastatin in aged rats.
Topics: Age Factors; Aging; alpha-Tocopherol; Animals; Antioxidants; Catalase; Lipids; Liver; Liver Diseases | 2012 |
Improvement of oxidative stress and immunity by melatonin: an age dependent study in golden hamster.
Topics: Age Factors; Aging; Animals; Bone Marrow; Catalase; Cell Cycle; Cell Proliferation; Cells, Cultured; | 2013 |
[Protective effect of Ginkgo biloba extract on acute lung injury induced by lipopolysaccharide in D-galactose aging rats].
Topics: Aging; Animals; Disease Models, Animal; Endothelin-1; Galactose; Ginkgo biloba; Lipopolysaccharides; | 2002 |
Association of renal injury with nitric oxide deficiency in aged SHR: prevention by hypertension control with AT1 blockade.
Topics: Aging; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arterioles; Hypertension, | 2002 |
The results of the interference of nitrates and vitamin E in the metabolism in the connective tissue of rat's liver.
Topics: Administration, Oral; Aging; Animals; Antioxidants; Carcinogens; Connective Tissue; Drug Interaction | 2002 |
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging.
Topics: Aging; Animals; Animals, Newborn; Astrocytoma; Heme; Hippocampus; Humans; Male; Mitochondria; Neurob | 2002 |
Age-related changes of the nitric oxide system in the rat brain.
Topics: Aging; Animals; Blotting, Western; Brain; Cerebral Decortication; Male; Nitrates; Nitric Oxide; Nitr | 2002 |
[The effort test & the nitroglycerin test in the aged].
Topics: Aged; Aging; Electrocardiography; Humans; Nitrates; Nitroglycerin | 1959 |
[Changes induced in the electrocardiogram of the aged by the administration of nitroglycerin].
Topics: Aged; Aging; Electrocardiography; Humans; Nitrates; Nitroglycerin; Pharmaceutical Preparations | 1959 |
17beta-Oestradiol enhances aortic endothelium function and smooth muscle contraction in male spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta, Thoracic; Culture Techniques; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; | 2004 |
Increased breath nitrous oxide after ingesting nitrate in patients with atrophic gastritis and partial gastrectomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Breath Tests; Female; Gastrectomy; Gastritis, Atr | 2004 |
New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.
Topics: Adult; Aging; Animals; Antibody Specificity; Arthritis, Rheumatoid; Biomarkers; Collagen Type II; En | 2005 |
[Effect of selenium on reactions of elderly rats affected by low doses of radiochemical exposures].
Topics: Aging; Animals; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug I | 2004 |
The effect of age and calorie restriction on HIF-1-responsive genes in aged liver.
Topics: Aging; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Caloric Restriction; DNA-Binding Pro | 2005 |
Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry.
Topics: Aging; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Mole | 2005 |
Assessment of the nitric oxide system in the heart, aorta and kidney of aged Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Ve | 2005 |
Plasma nitrate values in patients with obsessive-compulsive disorder.
Topics: Adolescent; Adult; Aging; Female; Humans; Male; Nitrates; Nitric Oxide; Obsessive-Compulsive Disorde | 2005 |
Protein nitration in biological aging: proteomic and tandem mass spectrometric characterization of nitrated sites.
Topics: Aging; Amino Acid Sequence; Animals; Antibody Specificity; Chromatography, Affinity; Chromatography, | 2005 |
Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Ceruloplasmin; Humans; Hypertension; | 2006 |
Pro-inflammatory effects of early non-enzymatic glycated proteins in human mesothelial cells vary with cell donor's age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cells, Cultured; Cyclooxygenase 2; Cytokines; Epithelium; Gen | 2006 |
Proteomic analysis of age dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry.
Topics: Aging; Alkylation; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Electrophores | 2007 |
Serum nitric oxide metabolite (NO(x)) levels in hypertensive patients at rest: a comparison of age, gender, blood pressure and complications using normotensive controls.
Topics: Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Aging; Biomarkers; Blood Pressure; Ca | 2007 |
Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondria.
Topics: Acyl Coenzyme A; Aged; Aging; Animals; Coenzyme A-Transferases; Humans; Male; Mitochondria; Myocardi | 2007 |
Acute toxicity of sodium nitrate, potassium nitrate, and potassium chloride and their effects on the hemolymph composition and gill structure of early juvenile blue swimmer crabs(Portunus pelagicus Linnaeus, 1758) (Decapoda, Brachyura, Portunidae).
Topics: Aging; Animals; Brachyura; Calcium; Gills; Hemolymph; Indicator Dilution Techniques; Nitrates; Potas | 2007 |
Bruch's membrane aging decreases phagocytosis of outer segments by retinal pigment epithelium.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Bruch Membrane; Cattle; Cells, Cultured; | 2007 |
[Effect of age and gender on genotoxic and biochemical indexes in animal blood after low doses of radiation-mercury exposures].
Topics: Aging; Animals; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female | 2007 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise.
Topics: Adult; Age Factors; Aging; Biomarkers; Body Mass Index; Brachial Artery; Cholesterol, LDL; Endotheli | 2008 |
[Effects of ligfol after radiation-mercury exposure in rats of various age].
Topics: Aging; Animals; Antioxidants; DNA Damage; Female; Gamma Rays; Leukocyte Count; Leukocytes; Lignin; L | 2007 |
Ageing in the whole plant.
Topics: Aging; Amino Acids; Carbon Dioxide; Electrophoresis; Nitrates; Oxidoreductases; Photosynthesis; Plan | 1967 |
[Levels of lead, cadmium and mercury in the hair of inhabitants of the Nantes and Grenoble areas].
Topics: Adolescent; Adult; Aged; Aging; Animals; Cadmium; Child; Child, Preschool; Dental Amalgam; Diet; Fem | 1983 |
Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Arginine; Diabetes Mellitus, Type 1; Guanidines; Male; N | 1995 |
Association of serum creatinine and age with headache caused by nitrates. Gruppo Italiano di Farmacovigilanza nell'Anziano.
Topics: Aged; Aged, 80 and over; Aging; Comorbidity; Creatinine; Drug Interactions; Female; Headache; Humans | 1995 |
[Effect of nitrates on the dynamics of methemoglobin formation in rats of various ages].
Topics: Aging; Animals; Animals, Newborn; Body Mass Index; Cytochrome-B(5) Reductase; Dose-Response Relation | 1994 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA D | 1995 |
Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging.
Topics: Aging; Animals; Arginine; Fasting; Glomerular Filtration Rate; Male; Nitrates; Nitric Oxide; Nitrite | 1994 |
L-arginine-nitric oxide pathway and chronic nephropathy in aged rats.
Topics: Aging; Amino Acids; Animals; Arginine; Blood Urea Nitrogen; Chronic Disease; Creatinine; Dietary Pro | 1994 |
Effects of cytidine diphosphate choline on rats with memory deficits.
Topics: Aging; Animals; Avoidance Learning; Clonidine; Cytidine Diphosphate Choline; Electroshock; Fetal Alc | 1993 |
[The effect of nitrates on rats during pregnancy on the development of the digestive system in ontogeny].
Topics: Aging; Animals; Digestive System; Female; Hydrocortisone; Intestine, Small; Kidney; Liver; Nitrates; | 1993 |
Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process?
Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Male; Muscle, Skeletal; Nitrates; Rats; Rats, | 1996 |
Nitric oxide and endothelin 1 during postnatal life.
Topics: Aging; Endothelin-1; Fetal Blood; Humans; Infant, Newborn; Nitrates; Nitric Oxide; Nitrites; Referen | 1996 |
Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats.
Topics: Absorptiometry, Photon; Aging; Animals; Blood Pressure; Body Weight; Bone and Bones; Bone Density; E | 1996 |
Urinary nitrite/nitrate excretion in infancy: comparison between term and preterm infants.
Topics: Aging; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Nitrates; Nitric Oxide; Nitrites | 1997 |
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Arterial Occlusive Diseases; Cyclic GMP; Disease Pr | 1997 |
Age-related changes of urinary nitrite/nitrate excretion in normal children.
Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Male; Nitrates; Nitric Oxide; Ni | 1997 |
Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function.
Topics: Aging; Animals; Arginine; Body Weight; Cell Movement; Diet; Hemodynamics; Kidney; Kidney Glomerulus; | 1997 |
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.
Topics: Aged; Aged, 80 and over; Aging; Base Composition; DNA; DNA Damage; Gas Chromatography-Mass Spectrome | 1997 |
Age-dependent augmentation of cardiac endothelial NOS in a genetic rat model of heart failure.
Topics: Aging; Animals; Endothelium, Vascular; Heart; Heart Failure; Heart Ventricles; Male; Nitrates; Nitri | 1997 |
No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. Short communication.
Topics: Adult; Aged; Aging; Cyclic GMP; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites | 1997 |
Alterations of nitric oxide synthase expression with aging and hypertension in rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Endothelium, Vascular; Enzyme Induc | 1998 |
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats.
Topics: Aging; Animals; Antioxidants; Biomarkers; Copper; Female; Free Radicals; Gas Chromatography-Mass Spe | 1998 |
Klotho protein protects against endothelial dysfunction.
Topics: Acetylcholine; Aging; Animals; Arteriosclerosis; Cardiovascular System; Disease Models, Animal; Endo | 1998 |
Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production.
Topics: Aging; Animals; Cyclic GMP; Gene Expression Regulation, Developmental; Gene Expression Regulation, E | 1998 |
Hypotension induced by exercise is associated with enhanced release of adenyl purines from aged rat artery.
Topics: Adenine Nucleotides; Adenosine; Aging; Animals; Arteries; Blood Pressure; Cholesterol; Fatty Acids; | 1999 |
Cerebrospinal fluid nitric oxide metabolites in painful diseases.
Topics: Adult; Aged; Aged, 80 and over; Aging; Appendicitis; Female; Fractures, Bone; Humans; Lumbosacral Re | 1999 |
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
Topics: Aging; Amino Acid Sequence; Animals; Biological Transport; Calcium; Calcium-Transporting ATPases; Cy | 1999 |
Analysis of urinary nitric oxide metabolites in healthy subjects.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Chromatography, High Press | 1999 |
Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Aging; Angiotensin II; Animals; Antihypertensive Agents | 1999 |
Link between catecholamine and nitric oxide metabolism.
Topics: Aging; Animals; Catecholamines; Monoamine Oxidase; Nitrates; Nitric Oxide; Nitrites; Rats; Selegilin | 1999 |
Neuroprotection by (-)-deprenyl and related compounds.
Topics: Aging; Amphetamines; Animals; Antioxidants; Apoptosis; Cattle; DNA Damage; DNA, Neoplasm; Indans; Mo | 1999 |
Influence of age on nitric oxide modulatory action on Na(+), K(+)-ATPase activity through cyclic GMP pathway in proximal rat trachea.
Topics: Aging; Animals; Ca(2+) Mg(2+)-ATPase; Cyclic GMP; Enzyme Inhibitors; Indicators and Reagents; Male; | 2000 |
Deficits in nitric oxide production after tetanic stimulation are related to the reduction of long-term potentiation in Schaffer-CA1 synapses in aged Fischer 344 rats.
Topics: Action Potentials; Aging; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; Long-Term P | 2000 |
Age-Related differences on aluminium mobilization by chelating agents in aluminium-loaded uraemic rats.
Topics: Administration, Oral; Aging; Aluminum; Aluminum Compounds; Animals; Anthelmintics; Chelating Agents; | 2000 |
Age-associated changes in nitric oxide metabolites nitrite and nitrate.
Topics: Adolescent; Adult; Aging; Arteriosclerosis; Child; Cholesterol; Creatinine; Endothelium, Vascular; H | 2000 |
Inverse regulation of endothelin-1 and nitric oxide metabolites in tissue with aging: implications for the age-dependent increase of cardiorenal disease.
Topics: Aging; Animals; Endothelin-1; Female; Heart Diseases; Kidney Diseases; Male; Mice; Mice, Inbred C57B | 2000 |
Age-related alterations of nitric oxide production in the brains of seizure-susceptible EL mice.
Topics: Aging; Animals; Body Weight; Brain; Cell Count; Cerebral Cortex; Corpus Striatum; Hippocampus; Mice; | 2000 |
Enhanced peroxynitrite formation is associated with vascular aging.
Topics: Acetylcholine; Aging; Animals; Aorta; Body Weight; Calcimycin; Cellular Senescence; Endothelium, Vas | 2000 |
Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis.
Topics: Aging; Animals; Apoptosis; Blotting, Northern; Blotting, Western; Collagen; Cysteine Endopeptidases; | 2001 |
Effects of aging and alterations in dietary sodium intake on total nitric oxide production.
Topics: Adult; Age Factors; Aged; Aging; Blood Pressure; Cyclic GMP; Female; Humans; Hypertension; Male; Mid | 2001 |
Effect of chronic angiotensin II inhibition on the nitric oxide synthase in the normal rat during aging.
Topics: Aging; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; A | 2001 |
High constitutional nitrate status in young cattle.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Animals, Suckling; Cat | 2001 |
Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Brain Chemistry; Central Nervous System Stimulants; | 2001 |
Is the somatotropic axis related to sympathetic nerve activity in healthy ageing men?
Topics: Adult; Aged; Aging; Blood Pressure; Blood Vessels; Body Mass Index; Diastole; Humans; Insulin-Like G | 2001 |
The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage.
Topics: Aging; Collagen Type I; Humans; Nitrates; Nitrogen; Tyrosine | 2001 |
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis.
Topics: Aging; Angioplasty, Balloon, Coronary; Animals; Aspirin; Coronary Restenosis; Coronary Vessels; Dise | 2002 |
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Aging; Animals; Arginine; Arterioles; Blotti | 2002 |
Tolerance of developing salmonid eggs and fry to nitrate exposure.
Topics: Aging; Animals; Animals, Newborn; Fresh Water; Nitrates; Salmon; Salmonidae; Trout | 1979 |
Measurements of serum levels of nitrate ions in men and women: implications of endothelium-derived relaxing factor in blood pressure regulation and atherosclerosis.
Topics: Adult; Aging; Arteriosclerosis; Blood Glucose; Blood Pressure; Cholesterol; Female; Humans; Male; Ni | 1992 |
Association between salivary flow rate and the use of systemic medication among 76-, 81-, and 86-year-old inhabitants in Helsinki, Finland.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Anti-Arrhythmia Agents; Antidepressive Agents; Antihype | 1992 |
Influence of dietary nitrate on nitrite level of human saliva.
Topics: Adolescent; Adult; Aging; Child; Diet; Female; Humans; Male; Middle Aged; Nitrates; Nitrites; Paroti | 1992 |
Distribution of elastic fibres in the developing rabbit craniomandibular joint.
Topics: Aging; Animals; Cartilage, Articular; Chelating Agents; Connective Tissue; Elastic Tissue; Ferric Co | 1991 |
Baroreflex sensitivity and heredity in essential hypertension.
Topics: Administration, Inhalation; Adult; Aging; Forecasting; Humans; Hypertension; Male; Middle Aged; Nitr | 1992 |
[Effect of nitrates transferred from the mother on fetal hemoglobin and methemoglobin dynamics of lambs].
Topics: Aging; Animals; Animals, Newborn; Female; Fetal Hemoglobin; Lactation; Maternal-Fetal Exchange; Meth | 1987 |
Nitrates do not affect prostacyclin formation by rat arteries: this is unrelated to increased vascular prostacyclin formation with age.
Topics: 6-Ketoprostaglandin F1 alpha; Aging; Animals; Arteries; Epoprostenol; In Vitro Techniques; Isosorbid | 1987 |
Disappearance of tyrosine residues in collagen with age. Suggestion of a possible reaction mechanism.
Topics: Achilles Tendon; Aging; Amino Acids; Aniline Compounds; Animals; Anisoles; Biphenyl Compounds; Cattl | 1974 |