nitinol has been researched along with Weight-Gain* in 2 studies
2 other study(ies) available for nitinol and Weight-Gain
Article | Year |
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A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results.
To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model.. The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks.. FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig.. FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging. Topics: Alloys; Animals; Eating; Endoscopy; Feasibility Studies; Fluoroscopy; Foreign-Body Migration; Obesity; Prosthesis Design; Prosthesis Failure; Prosthesis Implantation; Random Allocation; Satiation; Stents; Stomach; Swine; Treatment Outcome; Weight Gain | 2019 |
Restoration of mechanically lengthened jejunum into intestinal continuity in rats.
Prior studies demonstrated the feasibility of lengthening intestinal segments with mechanical force, but no previous studies have restored the lengthened segment back into intestinal continuity.. A 1-cm segment of isolated rat jejunum was lengthened using a Nitinol spring. After lengthening, this segment was restored into intestinal continuity via a transection of the intact small intestine. Rats were euthanized 2 weeks later to retrieve the restored intestinal segment for histologic and enzymatic analyses.. The isolated jejunal segments were initially lengthened to 3.3 ± 0.9 cm. After the lengthened segments were restored into intestinal continuity for 2 weeks, the final length of the restored segment was 1.9 ± 0.7 cm. All rats continued to gain weight, and the intestine proximal to the restored jejunal segment remained normal 2 weeks later. The restored jejunal segment had an increase in crypt depth and no difference in villus height compared with normal jejunum. Sucrase activity in the restored segment was not different from that in normal jejunum.. Mechanically lengthened jejunum can be restored into intestinal continuity and appears to have normal function. This further demonstrates the feasibility of mechanical enterogenesis as a potential therapy for short bowel syndrome. Topics: Alloys; Anastomosis, Surgical; Animals; Capsules; Cellulose; Coated Materials, Biocompatible; Disease Models, Animal; Equipment Design; Female; Implants, Experimental; Intestinal Mucosa; Jejunum; Microvilli; Organ Size; Polyethylene; Rats; Rats, Sprague-Dawley; Short Bowel Syndrome; Stress, Mechanical; Sucrase; Tissue Expansion; Tissue Expansion Devices; Weight Gain | 2011 |