nisoxetine has been researched along with Seizures in 2 studies
nisoxetine: potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure
nisoxetine : A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nisoxetine and desipramine (inhibitors of norepinephrine reuptake) each exerted a suppressant effect on spinal cord seizures by decreasing the duration of tonic extension." | 3.66 | Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats. ( Jobe, PC; Ray, TB, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jobe, PC | 1 |
| Ray, TB | 1 |
| Bymaster, FB | 1 |
| Perry, KW | 1 |
| Fuller, RW | 1 |
| Wong, DT | 1 |
2 other studies available for nisoxetine and Seizures
| Article | Year |
|---|---|
Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.
Topics: Animals; Benzofurans; Citalopram; Desipramine; Electric Stimulation; Female; Fluoxetine; Norepinephr | 1980 |
Nisoxetine prevents the 6-hydroxydopamine induced decrease in post-decapitation convulsions.
Topics: Animals; Brain Stem; Cerebral Cortex; Decerebrate State; Desipramine; Dose-Response Relationship, Dr | 1977 |