nisoxetine has been researched along with Neuroblastoma in 4 studies
nisoxetine: potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure
nisoxetine : A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Excerpt | Relevance | Reference |
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"In in vitro studies, the voltage-clamp method was employed to examine whether nisoxetine blocked Na(+) currents in mouse neuroblastoma N2A cells." | 3.79 | Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. ( Chen, YW; Chu, CC; Kuo, CS; Leung, YM; Wang, JJ, 2013) |
"Treatment with genistein (10 nM-10 microM) for 20 min stimulated [(3)H]noradrenaline (NA) uptake by SK-N-SH cells." | 1.36 | Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity. ( Itoh, H; Saito, N; Sakai, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N, 2010) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (50.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Leung, YM | 1 |
Chu, CC | 1 |
Kuo, CS | 1 |
Chen, YW | 1 |
Wang, JJ | 1 |
Toyohira, Y | 1 |
Ueno, S | 1 |
Tsutsui, M | 1 |
Itoh, H | 1 |
Sakai, N | 1 |
Saito, N | 1 |
Takahashi, K | 1 |
Yanagihara, N | 1 |
Zavosh, A | 1 |
Schaefer, J | 1 |
Ferrel, A | 1 |
Figlewicz, DP | 1 |
Hadrich, D | 1 |
Berthold, F | 1 |
Steckhan, E | 1 |
Bönisch, H | 1 |
4 other studies available for nisoxetine and Neuroblastoma
Article | Year |
---|---|
Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; | 2013 |
Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Estradiol; Fluoxetine | 2010 |
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
Topics: Adrenergic Uptake Inhibitors; Carrier Proteins; Desipramine; Fluoxetine; Humans; Neuroblastoma; Nore | 1999 |
Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents.
Topics: Carrier Proteins; Cocaine; Dihydropyridines; Fluorescent Dyes; Fluoxetine; Guanidines; Humans; Isoxa | 1999 |