Page last updated: 2024-11-01

nisoxetine and Neuroblastoma

nisoxetine has been researched along with Neuroblastoma in 4 studies

nisoxetine: potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure
nisoxetine : A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"In in vitro studies, the voltage-clamp method was employed to examine whether nisoxetine blocked Na(+) currents in mouse neuroblastoma N2A cells."3.79Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. ( Chen, YW; Chu, CC; Kuo, CS; Leung, YM; Wang, JJ, 2013)
"Treatment with genistein (10 nM-10 microM) for 20 min stimulated [(3)H]noradrenaline (NA) uptake by SK-N-SH cells."1.36Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity. ( Itoh, H; Saito, N; Sakai, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N, 2010)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leung, YM1
Chu, CC1
Kuo, CS1
Chen, YW1
Wang, JJ1
Toyohira, Y1
Ueno, S1
Tsutsui, M1
Itoh, H1
Sakai, N1
Saito, N1
Takahashi, K1
Yanagihara, N1
Zavosh, A1
Schaefer, J1
Ferrel, A1
Figlewicz, DP1
Hadrich, D1
Berthold, F1
Steckhan, E1
Bönisch, H1

Other Studies

4 other studies available for nisoxetine and Neuroblastoma

ArticleYear
Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:2

    Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug;

2013
Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:4

    Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Estradiol; Fluoxetine

2010
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
    Brain research bulletin, 1999, Jul-01, Volume: 49, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Carrier Proteins; Desipramine; Fluoxetine; Humans; Neuroblastoma; Nore

1999
Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Carrier Proteins; Cocaine; Dihydropyridines; Fluorescent Dyes; Fluoxetine; Guanidines; Humans; Isoxa

1999