nisoxetine has been researched along with Depressive Disorder in 3 studies
nisoxetine: potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure
nisoxetine : A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overall, the dose-response and time-of-recovery relationships for altered NET expression matched those for production of antidepressant-like effects on behavior." | 1.35 | Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. ( Baros, AM; Bondi, CO; Lapiz, MD; Morilak, DA; O'Donnell, JM; Zhang, HT; Zhao, Z, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Z | 1 |
| Baros, AM | 1 |
| Zhang, HT | 1 |
| Lapiz, MD | 1 |
| Bondi, CO | 1 |
| Morilak, DA | 1 |
| O'Donnell, JM | 1 |
| Kelwala, S | 1 |
| Stanley, M | 1 |
| Gershon, S | 1 |
| Klimek, V | 1 |
| Stockmeier, C | 1 |
| Overholser, J | 1 |
| Meltzer, HY | 1 |
| Kalka, S | 1 |
| Dilley, G | 1 |
| Ordway, GA | 1 |
1 review available for nisoxetine and Depressive Disorder
| Article | Year |
|---|---|
History of antidepressants: successes and failures.
Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Dep | 1983 |
1 trial available for nisoxetine and Depressive Disorder
| Article | Year |
|---|---|
History of antidepressants: successes and failures.
Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Dep | 1983 |
2 other studies available for nisoxetine and Depressive Disorder
| Article | Year |
|---|---|
Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competit | 2008 |
Reduced levels of norepinephrine transporters in the locus coeruleus in major depression.
Topics: Adult; Aged; Carrier Proteins; Depressive Disorder; Female; Fluoxetine; Humans; Locus Coeruleus; Mal | 1997 |