nisoxetine has been researched along with Alzheimer Disease in 3 studies
nisoxetine: potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure
nisoxetine : A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McMillan, PJ | 1 |
| White, SS | 2 |
| Franklin, A | 1 |
| Greenup, JL | 2 |
| Leverenz, JB | 2 |
| Raskind, MA | 2 |
| Szot, P | 2 |
| Peskind, ER | 1 |
| Tejani-Butt, SM | 1 |
| Yang, J | 1 |
| Zaffar, H | 1 |
3 other studies available for nisoxetine and Alzheimer Disease
| Article | Year |
|---|---|
Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Cell Count; Dopamine beta-Hydroxylase; Fe | 2011 |
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dendrites; Female; | 2006 |
Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Carrier Proteins; Female; Fluoxetine; H | 1993 |