nisoxetine has been researched along with Aging in 7 studies
nisoxetine: potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure
nisoxetine : A secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine was administered via the drinking water (5 mg/kg/day) for a period of two weeks to very young (day 25) and somewhat older (day 50) rats." | 1.30 | Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life. ( Bagli, M; Huether, G; Moll, GH; Rothenberger, A; Rüther, E; Wegerer, V, 1999) |
| "[3H]Nisoxetine ([3H]NIS) was used to measure uptake sites for norepinephrine (NE) in the locus coeruleus (LC) of humans." | 1.28 | Effect of age on [3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans. ( Ordway, GA; Tejani-Butt, SM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Leary, KT | 1 |
| Leslie, FM | 1 |
| Shirokawa, T | 1 |
| Ishida, Y | 1 |
| Isobe, K | 1 |
| Moore, TL | 1 |
| Schettler, SP | 1 |
| Killiany, RJ | 1 |
| Herndon, JG | 1 |
| Luebke, JI | 1 |
| Moss, MB | 1 |
| Rosene, DL | 1 |
| McReynolds, AM | 1 |
| Meyer, JS | 1 |
| Wegerer, V | 1 |
| Moll, GH | 2 |
| Bagli, M | 1 |
| Rothenberger, A | 2 |
| Rüther, E | 2 |
| Huether, G | 2 |
| Mehnert, C | 1 |
| Wicker, M | 1 |
| Bock, N | 1 |
| Tejani-Butt, SM | 1 |
| Ordway, GA | 1 |
7 other studies available for nisoxetine and Aging
| Article | Year |
|---|---|
Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Drug; Female; | 2003 |
Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aging; Animals; Clonidine; Fluoxetine; Fron | 2003 |
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; A | 2005 |
Effects of prenatal cocaine exposure on serotonin and norepinephrine transporter density in the rat brain.
Topics: Aging; Animals; Brain; Carrier Proteins; Cocaine; Female; Fluoxetine; Male; Membrane Glycoproteins; | 1998 |
Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Carrier Proteins; Fluoxetine; Growth; Membrane Gl | 1999 |
Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood.
Topics: Aging; Animals; Brain; Brain Stem; Carrier Proteins; Corpus Striatum; Dopamine Plasma Membrane Trans | 2000 |
Effect of age on [3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans.
Topics: Adult; Aged; Aging; Autoradiography; Biological Transport; Female; Fluoxetine; Humans; Locus Coerule | 1992 |