nisoldipine has been researched along with Muscle Contraction in 29 studies
Nisoldipine: A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
nisoldipine : A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, a calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intact muscle contractions were inhibited by 10(-6) M diltiazem, whereas greater levels were required to abolish contractions in skinned muscle fibers." | 3.66 | Mechanism of Ca++ antagonist-induced vasodilation. Intracellular actions. ( Saida, K; van Breemen, C, 1983) |
| "Ketanserin did not inhibit contractions of any vessels." | 1.28 | Inhibitory effects of nisoldipine on serotonin and potassium induced contractions of porcine coronary and femoral arteries. ( Kazda, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (44.83) | 18.7374 |
| 1990's | 14 (48.28) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imai, T | 2 |
| Tanaka, Y | 2 |
| Okamoto, T | 2 |
| Yamamoto, Y | 2 |
| Horinouchi, T | 1 |
| Tanaka, H | 2 |
| Koike, K | 2 |
| Shigenobu, K | 2 |
| Saida, K | 1 |
| van Breemen, C | 1 |
| Makita, Y | 1 |
| Kanmura, Y | 1 |
| Itoh, T | 3 |
| Suzuki, H | 1 |
| Kuriyama, H | 4 |
| Kazda, S | 3 |
| Garthoff, B | 2 |
| Meyer, H | 1 |
| Schlossmann, K | 1 |
| Stoepel, K | 1 |
| Towart, R | 1 |
| Vater, W | 1 |
| Wehinger, E | 1 |
| Balligand, JL | 1 |
| Godfraind, T | 2 |
| Zhou, BJ | 1 |
| Li, YS | 3 |
| Fu, SX | 3 |
| Watanabe, J | 1 |
| Horiguchi, S | 1 |
| Karibe, A | 1 |
| Keitoku, M | 1 |
| Takeuchi, M | 1 |
| Satoh, S | 2 |
| Takishima, T | 1 |
| Shirato, K | 1 |
| Sunman, W | 1 |
| Martin, G | 1 |
| Hair, WM | 1 |
| Sever, PS | 1 |
| Hughes, AD | 1 |
| Sasaki, H | 1 |
| Okabe, E | 1 |
| Chulia, T | 1 |
| Gonzalez, P | 1 |
| Del Rio, M | 1 |
| Tejerina, T | 1 |
| Higashino, R | 1 |
| Sato, R | 1 |
| Jin, H | 1 |
| Inoue, N | 1 |
| Fukuta, Y | 1 |
| Kurimoto, T | 1 |
| Tamaki, H | 1 |
| Yu, MF | 1 |
| Gorenne, I | 1 |
| Su, X | 1 |
| Moreland, RS | 1 |
| Kotlikoff, MI | 2 |
| Kim, BK | 1 |
| Mitsui, M | 1 |
| Karaki, H | 1 |
| Salomone, S | 1 |
| Dessy, C | 1 |
| Verhelst, B | 1 |
| Dion, R | 1 |
| Schoevaerts, JC | 1 |
| Worley, JF | 2 |
| Werner, G | 1 |
| Addicks, K | 1 |
| Fricke, U | 1 |
| Klaus, W | 1 |
| Sarram, M | 1 |
| Gielen, W | 1 |
| Yang, XP | 1 |
| Knorr, A | 1 |
| Takata, Y | 1 |
| Kato, H | 1 |
| Nelson, MT | 1 |
| Ueno, H | 1 |
| Yousif, FB | 1 |
| Bolger, GT | 1 |
| Ruzycky, A | 1 |
| Triggle, DJ | 1 |
| Sumimoto, K | 1 |
| Ren, LM | 1 |
| Jin, CJ | 1 |
| Saeed, M | 1 |
| Hartmann, A | 1 |
| Bing, RJ | 1 |
| Kubota, Y | 1 |
| Ito, Y | 1 |
| Yoshitomi, T | 1 |
1 review available for nisoldipine and Muscle Contraction
| Article | Year |
|---|---|
Calcium-induced calcium release mechanism in vascular smooth muscles--assessments based on contractions evoked in intact and saponin-treated skinned muscles.
Topics: Animals; Caffeine; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Glycerol; In Vi | 1985 |
28 other studies available for nisoldipine and Muscle Contraction
| Article | Year |
|---|---|
Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; Male; | 2002 |
Mechanism of Ca++ antagonist-induced vasodilation. Intracellular actions.
Topics: Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Ion Channels; Mesenteric Arterie | 1983 |
Effects of nifedipine derivatives on smooth muscle cells and neuromuscular transmission in the rabbit mesenteric artery.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Female; In Vitro Techniques; Male; Membrane Po | 1983 |
Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552).
Topics: Animals; Blood Coagulation; Calcium; Cats; Chemical Phenomena; Chemistry; Diuresis; Dogs; Female; Gu | 1980 |
Effect of nisoldipine on contractions evoked by endothelin-1 in human isolated distal and proximal coronary arteries and veins.
Topics: Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Endothelins; Humans; In Vitro Te | 1994 |
Effects of m-nisoldipine on contraction and 45Ca influx in isolated rat aorta.
Topics: Animals; Aorta, Thoracic; Biological Transport; Calcium; Female; Isomerism; Male; Muscle Contraction | 1994 |
Effects of ryanodine on development of myogenic response in rat small skeletal muscle arteries.
Topics: Animals; Arteries; Caffeine; Culture Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nisol | 1994 |
Effect of calcium antagonists on endothelin-induced contraction of isolated human resistance arteries: differences related to site of origin.
Topics: Adipose Tissue; Adult; Aged; Arteries; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endoth | 1993 |
Modification by hydroxyl radicals of functional reactivity in rabbit lingual artery.
Topics: Animals; Arteries; Caffeine; Endothelium, Vascular; Ferric Compounds; Ferrous Compounds; Fumarates; | 1993 |
Comparative study of elgodipine and nisoldipine on the contractile responses of various isolated blood vessels.
Topics: Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Female; Heart; In Vitro Techniques; Ma | 1995 |
Inhibitory effects of efonidipine hydrochloride on contraction induced by several vasoconstrictors in porcine coronary artery: comparison with effects of nifedipine and nisoldipine.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; C | 1997 |
Sodium hydrosulfite contractions of smooth muscle are calcium and myosin phosphorylation independent.
Topics: Alkaloids; Animals; Aorta, Thoracic; Benzophenanthridines; Caffeine; Calcium; Carbonyl Cyanide p-Tri | 1998 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Bl | 2001 |
The long-term inhibitory effect of a Ca2+ channel blocker, nisoldipine, on cytosolic Ca2+ and contraction in vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Selectivity scale of calcium antagonists in the human cardiovascular system based on in vitro studies.
Topics: Calcium; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Humans; In Vitro Techniques; Muscle | 1992 |
Dihydropyridine-sensitive single calcium channels in airway smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Sialic acid removal modulates the myocardial and vascular activity of calcium channel ligands.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Inhibitory effects of nisoldipine on serotonin and potassium induced contractions of porcine coronary and femoral arteries.
Topics: Animals; Coronary Vessels; Femoral Artery; In Vitro Techniques; Ketanserin; Muscle Contraction; Musc | 1991 |
Effects of m-nisoldipine on anoxia-potentiated histamine and acetylcholine-induced contractions of the porcine isolated coronary artery.
Topics: Acetylcholine; Animals; Coronary Vessels; Histamine Antagonists; Hypoxia; In Vitro Techniques; Indom | 1990 |
Interference of the calcium antagonist nisoldipine with the abnormal response of vessels from hypertensive rats to alpha-adrenergic stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Hypertension; In Vitro Techniques; Male; Muscle Contra | 1985 |
Effects of Bay K 8644 on the electrically evoked and KCl-evoked norepinephrine release and the corresponding contraction in isolated canine saphenous veins.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Ca2+ channel antagonist actions in bladder smooth muscle: comparative pharmacologic and [3H]nitrendipine binding studies.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Guinea Pigs; In | 1985 |
Mobilization of free Ca2+ measured during contraction-relaxation cycles in smooth muscle cells of the porcine coronary artery using quin2.
Topics: Acetylcholine; Aminoquinolines; Animals; Caffeine; Calcium; Calcium Channel Blockers; Coronary Vesse | 1986 |
[Cardiovascular action of m-nisoldipine in anaesthetized rabbits and guinea pigs].
Topics: Animals; Aorta; Blood Pressure; Coronary Circulation; Female; Guinea Pigs; Heart Rate; Hemodynamics; | 1988 |
Effect of nisoldipine on de-endothelialized large coronary artery in isolated working rabbit hearts.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Endothelium, Vascular; Heart; Histamine; In Vit | 1987 |
Mechanisms of the Ba2+-induced contraction in smooth muscle cells of the rabbit mesenteric artery.
Topics: Animals; Barium; Biomechanical Phenomena; Caffeine; Calcium; Contractile Proteins; Male; Mesenteric | 1987 |
Membrane and contractile properties of the dog ciliary muscle.
Topics: Animals; Carbachol; Dogs; Electric Stimulation; Evoked Potentials; Female; In Vitro Techniques; Isom | 1986 |