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nisoldipine and Left Ventricular Dysfunction

nisoldipine has been researched along with Left Ventricular Dysfunction in 7 studies

Nisoldipine: A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
nisoldipine : A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, a calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

Research Excerpts

ExcerptRelevanceReference
"The DEFIANT-I study (Doppler Flow and Echocardiography in Functional cardiac Insufficiency: Assessment of Nisoldipine Therapy) was a multicenter, multinational double-blind randomized study of the effects of the new calcium channel blocking drug nisoldipine on left ventricular (LV) size and function after acute myocardial infarction."9.07The DEFIANT study of left ventricular function and exercise performance after acute myocardial infarction. Doppler Flow and Echocardiology in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy Study Group. ( Lewis, BS; Poole-Wilson, PA, 1994)
"Nisoldipine is a dihydropyridine calcium entry blocker that inhibits contraction of vascular smooth muscle with a potency that is 2-3 times greater than its impact on myocardial contractility."6.39Why is nisoldipine a specific agent in ischemic left ventricular dysfunction? ( Knorr, AM, 1995)
"The DEFIANT-I study (Doppler Flow and Echocardiography in Functional cardiac Insufficiency: Assessment of Nisoldipine Therapy) was a multicenter, multinational double-blind randomized study of the effects of the new calcium channel blocking drug nisoldipine on left ventricular (LV) size and function after acute myocardial infarction."5.07The DEFIANT study of left ventricular function and exercise performance after acute myocardial infarction. Doppler Flow and Echocardiology in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy Study Group. ( Lewis, BS; Poole-Wilson, PA, 1994)
"Nisoldipine was found to improve both left ventricular systolic and diastolic function without activating the adrenergic system."2.39Clinical and therapeutic implications of chronic left ventricular dysfunction in coronary artery disease. ( Marini, A; Sheiban, I; Tonni, S; Trevi, G, 1995)
"Nisoldipine is a dihydropyridine calcium entry blocker that inhibits contraction of vascular smooth muscle with a potency that is 2-3 times greater than its impact on myocardial contractility."2.39Why is nisoldipine a specific agent in ischemic left ventricular dysfunction? ( Knorr, AM, 1995)
"Nisoldipine was administered to the hearts before 60 minutes of global ischemia."1.29Improvement of ischemic myocardial dysfunction by nisoldipine. ( Itakura, A; Saida, K; Umeda, M, 1994)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sheiban, I1
Tonni, S1
Marini, A1
Trevi, G1
Brunelli, C1
Parodi, O1
Sambuceti, G1
Corsiglia, L1
Rosa, GM1
Giorgetti, A1
Bezante, GP1
Nista, N1
Caponnetto, S1
Knorr, AM1
Rousseau, MF1
Melin, J1
Benedict, CR1
Ahn, S1
Raphaƫl, D1
Bornemann, M1
Pouleur, H1
Saida, K1
Umeda, M1
Itakura, A1
Lewis, BS1
Poole-Wilson, PA1
Romano, M1
Cardei, S1
de Arcangelis, E1
Monteforte, I1
Capaldo, M1
Muto, P1
Marchegiano, R1
Kilama, MO1
Condorelli, M1

Reviews

2 reviews available for nisoldipine and Left Ventricular Dysfunction

ArticleYear
Clinical and therapeutic implications of chronic left ventricular dysfunction in coronary artery disease.
    The American journal of cardiology, 1995, Apr-27, Volume: 75, Issue:13

    Topics: Chronic Disease; Coronary Circulation; Coronary Disease; Humans; Myocardial Contraction; Myocardial

1995
Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?
    The American journal of cardiology, 1995, Apr-27, Volume: 75, Issue:13

    Topics: Animals; Coronary Vessels; Depression, Chemical; Guinea Pigs; Heart; Membrane Potentials; Muscle, Sm

1995

Trials

4 trials available for nisoldipine and Left Ventricular Dysfunction

ArticleYear
Perfusional and metabolic effects of nisoldipine as shown by positron emission tomography after acute myocardial infarction.
    The American journal of cardiology, 1995, Apr-27, Volume: 75, Issue:13

    Topics: Adult; Coronary Circulation; Coronary Disease; Dobutamine; Echocardiography; Heart; Humans; Myocardi

1995
Effects of nisoldipine therapy on myocardial perfusion and neuro-hormonal status in patients with severe ischaemic left ventricular dysfunction.
    European heart journal, 1994, Volume: 15, Issue:7

    Topics: Arginine Vasopressin; Atrial Natriuretic Factor; Coronary Circulation; Double-Blind Method; Echocard

1994
The DEFIANT study of left ventricular function and exercise performance after acute myocardial infarction. Doppler Flow and Echocardiology in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy Study Group.
    Cardiovascular drugs and therapy, 1994, Volume: 8 Suppl 2

    Topics: Double-Blind Method; Echocardiography, Doppler; Exercise Test; Female; Heart Ventricles; Humans; Mal

1994
Effects of nisoldipine and/or enalapril on left ventricular function and exercise capacity in patients with recent anterior myocardial infarction and mild cardiac dysfunction.
    American heart journal, 1997, Volume: 133, Issue:3

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Drug Therapy, Combination

1997

Other Studies

1 other study available for nisoldipine and Left Ventricular Dysfunction

ArticleYear
Improvement of ischemic myocardial dysfunction by nisoldipine.
    Cardiovascular drugs and therapy, 1994, Volume: 8 Suppl 2

    Topics: Animals; Coronary Vessels; Disease Models, Animal; Heart; Heart Rate; L-Lactate Dehydrogenase; Male;

1994