nisoldipine has been researched along with Left Ventricular Dysfunction in 7 studies
Nisoldipine: A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
nisoldipine : A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, a calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The DEFIANT-I study (Doppler Flow and Echocardiography in Functional cardiac Insufficiency: Assessment of Nisoldipine Therapy) was a multicenter, multinational double-blind randomized study of the effects of the new calcium channel blocking drug nisoldipine on left ventricular (LV) size and function after acute myocardial infarction." | 9.07 | The DEFIANT study of left ventricular function and exercise performance after acute myocardial infarction. Doppler Flow and Echocardiology in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy Study Group. ( Lewis, BS; Poole-Wilson, PA, 1994) |
| "Nisoldipine is a dihydropyridine calcium entry blocker that inhibits contraction of vascular smooth muscle with a potency that is 2-3 times greater than its impact on myocardial contractility." | 6.39 | Why is nisoldipine a specific agent in ischemic left ventricular dysfunction? ( Knorr, AM, 1995) |
| "The DEFIANT-I study (Doppler Flow and Echocardiography in Functional cardiac Insufficiency: Assessment of Nisoldipine Therapy) was a multicenter, multinational double-blind randomized study of the effects of the new calcium channel blocking drug nisoldipine on left ventricular (LV) size and function after acute myocardial infarction." | 5.07 | The DEFIANT study of left ventricular function and exercise performance after acute myocardial infarction. Doppler Flow and Echocardiology in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy Study Group. ( Lewis, BS; Poole-Wilson, PA, 1994) |
| "Nisoldipine was found to improve both left ventricular systolic and diastolic function without activating the adrenergic system." | 2.39 | Clinical and therapeutic implications of chronic left ventricular dysfunction in coronary artery disease. ( Marini, A; Sheiban, I; Tonni, S; Trevi, G, 1995) |
| "Nisoldipine is a dihydropyridine calcium entry blocker that inhibits contraction of vascular smooth muscle with a potency that is 2-3 times greater than its impact on myocardial contractility." | 2.39 | Why is nisoldipine a specific agent in ischemic left ventricular dysfunction? ( Knorr, AM, 1995) |
| "Nisoldipine was administered to the hearts before 60 minutes of global ischemia." | 1.29 | Improvement of ischemic myocardial dysfunction by nisoldipine. ( Itakura, A; Saida, K; Umeda, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sheiban, I | 1 |
| Tonni, S | 1 |
| Marini, A | 1 |
| Trevi, G | 1 |
| Brunelli, C | 1 |
| Parodi, O | 1 |
| Sambuceti, G | 1 |
| Corsiglia, L | 1 |
| Rosa, GM | 1 |
| Giorgetti, A | 1 |
| Bezante, GP | 1 |
| Nista, N | 1 |
| Caponnetto, S | 1 |
| Knorr, AM | 1 |
| Rousseau, MF | 1 |
| Melin, J | 1 |
| Benedict, CR | 1 |
| Ahn, S | 1 |
| Raphaël, D | 1 |
| Bornemann, M | 1 |
| Pouleur, H | 1 |
| Saida, K | 1 |
| Umeda, M | 1 |
| Itakura, A | 1 |
| Lewis, BS | 1 |
| Poole-Wilson, PA | 1 |
| Romano, M | 1 |
| Cardei, S | 1 |
| de Arcangelis, E | 1 |
| Monteforte, I | 1 |
| Capaldo, M | 1 |
| Muto, P | 1 |
| Marchegiano, R | 1 |
| Kilama, MO | 1 |
| Condorelli, M | 1 |
2 reviews available for nisoldipine and Left Ventricular Dysfunction
| Article | Year |
|---|---|
Clinical and therapeutic implications of chronic left ventricular dysfunction in coronary artery disease.
Topics: Chronic Disease; Coronary Circulation; Coronary Disease; Humans; Myocardial Contraction; Myocardial | 1995 |
Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?
Topics: Animals; Coronary Vessels; Depression, Chemical; Guinea Pigs; Heart; Membrane Potentials; Muscle, Sm | 1995 |
4 trials available for nisoldipine and Left Ventricular Dysfunction
| Article | Year |
|---|---|
Perfusional and metabolic effects of nisoldipine as shown by positron emission tomography after acute myocardial infarction.
Topics: Adult; Coronary Circulation; Coronary Disease; Dobutamine; Echocardiography; Heart; Humans; Myocardi | 1995 |
Effects of nisoldipine therapy on myocardial perfusion and neuro-hormonal status in patients with severe ischaemic left ventricular dysfunction.
Topics: Arginine Vasopressin; Atrial Natriuretic Factor; Coronary Circulation; Double-Blind Method; Echocard | 1994 |
The DEFIANT study of left ventricular function and exercise performance after acute myocardial infarction. Doppler Flow and Echocardiology in Functional Cardiac Insufficiency: Assessment of Nisoldipine Therapy Study Group.
Topics: Double-Blind Method; Echocardiography, Doppler; Exercise Test; Female; Heart Ventricles; Humans; Mal | 1994 |
Effects of nisoldipine and/or enalapril on left ventricular function and exercise capacity in patients with recent anterior myocardial infarction and mild cardiac dysfunction.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Drug Therapy, Combination | 1997 |
1 other study available for nisoldipine and Left Ventricular Dysfunction
| Article | Year |
|---|---|
Improvement of ischemic myocardial dysfunction by nisoldipine.
Topics: Animals; Coronary Vessels; Disease Models, Animal; Heart; Heart Rate; L-Lactate Dehydrogenase; Male; | 1994 |