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nisoldipine and Epilepsy

nisoldipine has been researched along with Epilepsy in 2 studies

Nisoldipine: A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
nisoldipine : A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, a calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively)."7.69Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. ( Cipolla, G; Gatti, G; Heinig, R; Michelucci, R; Ochan, M; Passarelli, D; Perucca, E; Tassinari, CA, 1996)
"Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively)."3.69Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. ( Cipolla, G; Gatti, G; Heinig, R; Michelucci, R; Ochan, M; Passarelli, D; Perucca, E; Tassinari, CA, 1996)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Doyle, KM1
Kirby, BP1
Murphy, D1
Shaw, GG1
Michelucci, R1
Cipolla, G1
Passarelli, D1
Gatti, G1
Ochan, M1
Heinig, R1
Tassinari, CA1
Perucca, E1

Other Studies

2 other studies available for nisoldipine and Epilepsy

ArticleYear
Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo.
    Neuroscience letters, 2005, Jun-03, Volume: 380, Issue:3

    Topics: Amines; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System; Convuls

2005
Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy.
    Epilepsia, 1996, Volume: 37, Issue:11

    Topics: Adult; Contraindications; Delayed-Action Preparations; Drug Interactions; Epilepsy; Female; Humans;

1996