nipecotic acid has been researched along with Seizures in 12 studies
nipecotic acid: RN given refers to cpd without isomeric designation
nipecotic acid : A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0." | 3.73 | Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). ( Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR, 2006) |
| "The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seizures and be neurotoxic in mice was investigated." | 3.69 | Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats. ( Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P, 1996) |
| "Seizures were analyzed using the Lamberty & Klitgaard score and kindling was considered as established after at least three consecutive seizures of score 4 or 5." | 1.39 | Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats. ( Beleboni, RO; Cunha, AO; Dos Santos, WF; Gelfuso, EA; Liberato, JL; Lopes, NP; Mortari, MR, 2013) |
| "The age related audiogenic seizure susceptibility of DBA/2 mice is not related to an abnormality of neuronal GABA uptake." | 1.27 | Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice. ( Horton, RW; Prestwich, SA; Spyrou, NA, 1984) |
| "Pipecolic acid (PA) is an alicyclic amino acid and putative neurotransmitter which may modulate GABAergic transmission in the central nervous system." | 1.27 | Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA. ( Beitz, AJ; Larson, AA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, YC | 1 |
| Zhao, LX | 2 |
| Kim, TH | 1 |
| Je, SM | 1 |
| Kim, EK | 2 |
| Choi, H | 1 |
| Chae, WG | 1 |
| Park, M | 1 |
| Choi, J | 2 |
| Jahng, Y | 2 |
| Lee, ES | 2 |
| Dhanawat, M | 1 |
| Gupta, S | 1 |
| Mehta, DK | 1 |
| Das, R | 1 |
| Gelfuso, EA | 2 |
| Liberato, JL | 2 |
| Cunha, AO | 2 |
| Mortari, MR | 2 |
| Beleboni, RO | 1 |
| Lopes, NP | 1 |
| Dos Santos, WF | 2 |
| Napolitano, C | 1 |
| Scaglianti, M | 3 |
| Scalambra, E | 1 |
| Manfredini, S | 3 |
| Ferraro, L | 3 |
| Beggiato, S | 1 |
| Vertuani, S | 2 |
| Dalpiaz, A | 2 |
| Pavan, B | 2 |
| Vitali, F | 1 |
| Bortolotti, F | 1 |
| Biondi, C | 2 |
| Scatturin, A | 2 |
| Tanganelli, S | 2 |
| Prasad, P | 2 |
| Park, JG | 1 |
| Moon, YS | 1 |
| Basnet, A | 1 |
| Jeong, TC | 1 |
| Beleboni, Rde O | 1 |
| Coutinho-Netto, J | 1 |
| Spyrou, NA | 1 |
| Prestwich, SA | 1 |
| Horton, RW | 1 |
| Hinko, CN | 2 |
| Crider, AM | 2 |
| Kliem, MA | 1 |
| Steinmiller, CL | 1 |
| Seo, TH | 1 |
| Ho, B | 1 |
| Venkatarangan, P | 1 |
| el-Assadi, AA | 1 |
| Chang, H | 1 |
| Burns, CM | 1 |
| Tietz, EI | 1 |
| Andersen, PH | 1 |
| Klitgaard, H | 1 |
| Compagnone, D | 1 |
| Beitz, AJ | 1 |
| Larson, AA | 1 |
| Wood, JD | 1 |
12 other studies available for nipecotic acid and Seizures
| Article | Year |
|---|---|
Design and synthesis of anticonvulsive agents as gamma-vinyl GABA-based potential dual acting prodrugs and their biological activities.
Topics: Animals; Anticonvulsants; Bicuculline; Drug Design; Mice; Pentylenetetrazole; Picrotoxin; Prodrugs; | 2000 |
Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug.
Topics: Animals; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Esters; Hydrophobic and Hydroph | 2021 |
Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Uptake Inhib | 2013 |
Carnitine conjugate of nipecotic acid: a new example of dual prodrug.
Topics: Animals; Brain; Carnitine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mice; Nipe | 2009 |
Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.
Topics: Animals; Ascorbic Acid; Brain; Cell Line; Diclofenac; Humans; Male; Mice; Nipecotic Acids; Organic A | 2004 |
Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Isonipecotic Acids; Male; Mice; Nipec | 2004 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behav | 2006 |
Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Mi | 1984 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; | 1996 |
Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.
Topics: Animals; Ascorbic Acid; Biological Transport; Cell Line; Central Nervous System Agents; Diclofenac; | 2002 |
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picr | 1985 |
A comparison of prodrug esters of nipecotic acid.
Topics: Animals; Anticonvulsants; Bicuculline; Esters; GABA Antagonists; Male; Mice; Nipecotic Acids; Parasy | 1988 |