nipecotic acid has been researched along with Huntington Disease in 1 studies
nipecotic acid: RN given refers to cpd without isomeric designation
nipecotic acid : A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Putamen tissue from four cases of Huntington's disease showed a marked reduction in [3H]nipecotic acid binding." | 1.28 | [3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain. ( Czudek, C; Reynolds, GP, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Czudek, C | 1 |
| Reynolds, GP | 1 |
1 other study available for nipecotic acid and Huntington Disease
| Article | Year |
|---|---|
[3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain.
Topics: Aged; Aging; Binding Sites; Brain; Cadaver; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Hu | 1990 |