nipecotic acid has been researched along with Epilepsy in 4 studies
nipecotic acid: RN given refers to cpd without isomeric designation
nipecotic acid : A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tiagabine has comparable anticonvulsant action to carbamazepine in rats and has anticonvulsant effects in non-human primates supporting the potential use of inhibitors of GABA uptake as therapy for epilepsy." | 5.29 | The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. ( Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE, 1995) |
| "Pipecolic acid (PA) is an important biochemical marker for the diagnosis of peroxisomal disorders." | 3.81 | Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method. ( Barraco, GM; Boenzi, S; Catesini, G; Dionisi-Vici, C; Iacovone, F; Inglese, R; Manco, M; Muraca, M; Rizzo, C; Semeraro, M, 2015) |
| " To test whether GABA transport is compromised in both the forward (uptake) and reverse (heterotransport) direction in the sclerotic epileptic dentate gyrus, the physiological effects of microapplied GABA and nipecotic acid (NPA; a compound that induces heterotransport) were examined in granule cells in hippocampal slices from kainate (KA)-induced epileptic rats and patients with temporal lobe epilepsy (TLE)." | 3.71 | GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. ( Patrylo, PR; Spencer, DD; Williamson, A, 2001) |
| "Tiagabine has comparable anticonvulsant action to carbamazepine in rats and has anticonvulsant effects in non-human primates supporting the potential use of inhibitors of GABA uptake as therapy for epilepsy." | 1.29 | The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. ( Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Semeraro, M | 1 |
| Muraca, M | 1 |
| Catesini, G | 1 |
| Inglese, R | 1 |
| Iacovone, F | 1 |
| Barraco, GM | 1 |
| Manco, M | 1 |
| Boenzi, S | 1 |
| Dionisi-Vici, C | 1 |
| Rizzo, C | 1 |
| Smith, SE | 1 |
| Parvez, NS | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Pfeiffer, M | 1 |
| Draguhn, A | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Patrylo, PR | 1 |
| Spencer, DD | 1 |
| Williamson, A | 1 |
4 other studies available for nipecotic acid and Epilepsy
| Article | Year |
|---|---|
Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method.
Topics: Adolescent; Adult; Biomarkers; Calibration; Child; Child, Preschool; Chromatography, High Pressure L | 2015 |
The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Epilepsy; Female; G | 1995 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agoni | 1996 |
GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.
Topics: Animals; Biological Transport; Carrier Proteins; Dentate Gyrus; Electrophysiology; Epilepsy; Excitat | 2001 |