nintedanib has been researched along with Cytokine-Release-Syndrome* in 1 studies
1 other study(ies) available for nintedanib and Cytokine-Release-Syndrome
Article | Year |
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Pulmonary fibrosis and cytokine release syndrome after hyperactivation with sintilimab.
Immunotherapy-related adverse events (irAEs) are common immunotherapy-associated diseases. Severe pulmonary fibrosis with hypercytokinaemia has not been reported with programmed cell death 1 (PD-1) inhibitors. We describe a case of sintilimab-induced pulmonary fibrosis with cytokine storm induced in a 50-year-old patient with colon cancer refractory to second-line systemic chemotherapy.. Our patient developed hypercytokinaemia with elevated levels of interleukin (IL)-6 and IL-10 and pulmonary fibrosis, which differed from other irAEs. The patient benefited from a back-titrated regimen of methylprednisolone with the initial dosage of 2 mg/kg and anti-fibrotic effect of nintedanib and was successfully weaned from the ventilator.. This is the first report that a PD-1 inhibitor may have caused pulmonary fibrosis and a cytokine storm. This case indicates that the addition of nintedanib and glucocorticoid might possibly have potentially therapeutic effects of PD-1 induced pulmonary fibrosis and hypercytokinaemia. Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Colonic Neoplasms; Cytokine Release Syndrome; Glucocorticoids; Humans; Immunotherapy; Indoles; Male; Methylprednisolone; Middle Aged; Pulmonary Fibrosis | 2020 |