nintedanib and Corneal-Injuries

To compare the therapeutic effects of different forms of nintedanib ophthalmic preparations on neovascularization corneal alkali burns in rats.. NNTH had a stronger inhibitory effect on corneal neovascularization (CNV) in alkali-burned rats while reducing the level of inflammatory factors. NNTH had a longer drug duration of release than nanoformulations in vitro. Nintedanib at low concentrations (<8 μM) had no significant cytotoxicity to HCECs but significantly induced apoptosis and inhibited the expression of VEGFA and CD31 and the migration of HUVECs.. Nanomorphic thermoreversible hydrogel is superior among the nintedanib ophthalmic preparations, showing better inhibition of CNV in alkali-burned eyeballs and it blocked the migration and proangiogenic ability of HUVECs.

Topics: Alkalies; Animals; Burns, Chemical; Corneal Injuries; Corneal Neovascularization; Dexamethasone; Disease Models, Animal; Eye Burns; Human Umbilical Vein Endothelial Cells; Humans; Hydrogels; Neovascularization, Pathologic; Rats; Vascular Endothelial Growth Factor A