ningalin-b and Leukemia

ningalin-b has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for ningalin-b and Leukemia

Article	Year
Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors. Marine drugs, 2014, Oct-17, Volume: 12, Issue:10 In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells. Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Heterocyclic Compounds, 3-Ring; Humans; K562 Cells; Leukemia; Piperazine; Piperazines; Structure-Activity Relationship	2014

Article

Year

Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors.

Marine drugs, 2014, Oct-17, Volume: 12, Issue:10

In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.

Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Heterocyclic Compounds, 3-Ring; Humans; K562 Cells; Leukemia; Piperazine; Piperazines; Structure-Activity Relationship

2014