nimustine has been researched along with Glioma in 223 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 105 (47.09) | 18.7374 |
| 1990's | 73 (32.74) | 18.2507 |
| 2000's | 33 (14.80) | 29.6817 |
| 2010's | 10 (4.48) | 24.3611 |
| 2020's | 2 (0.90) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, T; Inoue, T; Saito, R; Sugiyama, S; Tominaga, T | 1 |
| Chonan, M; Kanamori, M; Nakasato, N; Osawa, SI; Saito, R; Suzuki, H; Tominaga, T; Watanabe, M | 1 |
| Ikuta, S; Maruyama, T; Muragaki, Y; Nitta, M | 1 |
| Atta, J; Franz, K; Lemercier, S; Rieger, J; Steinbach, JP; Sulzbacher, A; Thiepold, AL | 1 |
| Cui, XL; Li, HL; Lin, S; Zhang, JN | 1 |
| Ding, L; Gao, L; Lv, P; Qi, L; Wang, S; Wang, W; Xu, Y; Zhao, D; Zhong, Y | 1 |
| Dai, C; Dong, J; Huang, Q; Lan, Q; Li, M; Liu, B; Lu, Z; Ma, J; Ma, X; Xie, T | 1 |
| Endo, T; Inoue, T; Kawashima, R; Nonaka, H; Ogita, S; Saito, R; Sonoda, Y; Sugiyama, S; Sumiyoshi, A; Tominaga, T | 1 |
| Eisele, G; Happold, C; Linnebank, M; Roth, P; Steinbach, JP; Weller, M; Wick, W | 1 |
| Gong, F; Ji, SP; Li, AM; Tai, JL; Zhang, YP; Zheng, CQ | 1 |
| Fujioka, K; Inaba, N; Ishizawa, S; Kimura, M; Manome, Y; Shibasaki, T; Watanabe, M | 1 |
| Chen, ZP; Jiang, XB; Mu, YG; Sai, K; Shen, D; Yang, QY; Zhang, XH | 1 |
| Du, H; Hong, Y; Huang, H; Shen, G; Song, J; Wen, X; Xu, G; Yin, Y; Zhang, X | 1 |
| Christmann, M; Kaina, B; Meise, R; Tomicic, MT | 1 |
| Fujii, K; Hori, T; Kobayashi, I; Nagashima, T; Oka, H; Tanaka, S; Utsuki, S; Watanabe, T | 1 |
| Arai, H; Beppu, T; Fukuda, T; Kamada, K; Nakamura, R; Ogasawara, K; Ogawa, A; Oikawa, H; Takeda, M | 1 |
| Adachi, G; Inoue, O; Ishikawa, Y; Kakinohana, Y; Kin, S; Murayama, S; Ogawa, K; Saito, A; Toita, T; Yoshii, Y | 1 |
| Fukumoto, M; Hashimoto, N; Itoh, N; Kono, K; Murai, N; Myoumoto, A; Takahashi, JA; Ueba, T | 1 |
| Bamberg, M; Koch, R; Krauseneck, P; Müller, B; Weller, M | 1 |
| Asai, J; Chang, CW; Fujimoto, T; Nagashima, G; Suzuki, R | 1 |
| Baba, K; Fukami, T; Matsuda, M; Nakasu, S | 1 |
| Boiardi, A; Botturi, A; Broggi, G; Di Meco, F; Eoli, M; Lamperti, E; Salmaggi, A; Silvani, A; Solari, A | 1 |
| Bratengeier, K; Flentje, M; Kölbl, O; Ruprecht, K; Vince, GH; Vordermark, D | 1 |
| Fujii, K; Kobayashi, I; Oka, H; Tanaka, S; Utsuki, S; Yasui, Y | 1 |
| Shibui, S | 1 |
| Fujibayashi, Y; Furukawa, T; Kado, H; Kawai, H; Kubota, T; Nakagawa, T; Takamatsu, S; Toyohara, J; Yonekura, Y | 1 |
| Ido, K; Kubota, T; Matsuda, K; Nakagawa, T; Sakuma, T | 2 |
| Natsume, A; Wakabayashi, T; Yoshida, J | 1 |
| Adachi, G; Hyodo, A; Inoue, O; Iraha, S; Kakinohana, Y; Murayama, S; Ogawa, K; Saito, A; Sugimoto, K; Tamaki, W; Toita, T; Yoshii, Y | 1 |
| Fujiwara, T; Hosoda, K; Kawamura, A; Kohmura, E; Kondoh, T; Mizukawa, K; Sasayama, T; Tanaka, K | 1 |
| Hasegawa, A; Kamada, T; Mizoe, JE; Takagi, R; Takakura, K; Tsuji, H; Tsujii, H; Yanagi, T | 1 |
| Berrak, S; Koontz Webb, SE; Wolff, JE; Zhang, M | 1 |
| Arai, H; Konno, K; Murakami, N; Suzuki, Y; Takeda, N; Tanaka, R; Tanimura, K | 1 |
| Katakura, R; Kitahara, M; Mori, T; Sasaki, T; Suzuki, J | 2 |
| Mori, T; Sasaki, T; Sugiyama, S; Suzuki, J | 2 |
| Itagaki, T; Kaba, K; Morimura, T; Tani, E | 1 |
| Harada, K; Kiya, K; Okamoto, H; Uozumi, T | 1 |
| Asari, S; Doi, A; Fujiwara, T; Furuta, T; Matsumoto, K; Moriya, Y; Nakasone, S; Nishimoto, A; Ohnishi, R; Tabuchi, K | 1 |
| Allen, NJ; Clendenon, NR; Kaneko, S; Kartha, M | 1 |
| Hayakawa, T; Mogami, H; Nakata, Y; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T | 2 |
| Harada, K; Kiya, K; Uosumi, T | 1 |
| Kageyama, N; Kobayashi, T; Shibuya, N; Yoshida, J | 2 |
| Miki, Y; Nakamura, O; Nomura, K; Ohira, M; Shibui, S; Takakura, K; Watanabe, T | 1 |
| Handa, H; Teraura, T; Yamashita, J; Yumitori, K | 2 |
| Ha, YS; Handa, H; Otsuka, SI; Suda, K; Taki, W; Tokuriki, Y; Yamashita, J | 1 |
| Hokama, Y; Hori, T; Muraoka, K; Numata, H; Saito, Y; Takami, M | 1 |
| Fujiwara, T; Matsumoto, K; Nakasone, S; Nishimoto, A; Ohnishi, R; Tabuchi, K | 1 |
| Kohono, T; Matsutani, M; Nagashima, T | 1 |
| Iwasa, H; Kohno, T; Matsutani, M; Satoh, F; Takakura, K; Yamamoto, H | 1 |
| Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T | 5 |
| Muraoka, K | 1 |
| Abe, H; Aida, T; Iwakuma, T; Kaneko, S; Kashiwaba, T; Kitaoka, K; Sato, M; Tokuda, K; Tsuru, M; Ueno, K | 1 |
| Ishiwata, Y; Kuwabara, T; Kyuma, Y; Murai, M; Nishimura, S; Shinonaga, M; Yamashita, T | 1 |
| Inoue, I; Kageyama, N; Kanzaki, M; Nagata, M; Wakabayashi, T; Yoshida, J | 1 |
| Akanuma, A; Kohno, T; Maehara, T; Nakamura, O; Sano, K; Sato, F; Shitara, N; Takakura, K; Yamamoto, H | 1 |
| Nakamura, O; Nomura, K; Shibui, S; Watanabe, T | 1 |
| Hayakawa, T; Kato, A; Mogami, H; Nakata, Y; Ushio, Y; Yamada, K; Yoshida, T | 1 |
| Tanaka, R | 1 |
| Katakura, R; Mineura, K; Mori, T; Sasaki, T | 1 |
| Fujiwara, T; Honma, Y; Kuyama, H; Matsumoto, Y; Nagao, S; Ohkawa, M | 1 |
| Arai, Y; Kabuto, M; Kitai, R; Kobayashi, H; Kubota, T; Nakagawa, T | 1 |
| Imahori, T; Kasai, H; Kawamoto, K; Numa, Y; Tsuchida, T | 1 |
| Kreth, FW; Ostertag, CB; Warnke, PC | 1 |
| Kohda, K; Koyama, K; Mineura, K; Terashima, I; Watanabe, K | 1 |
| Felix, R; Golde, G; Gremmler, M; Löffel, J; Maier-Hauff, K; Mischel, M; Seebass, M; Stahl, H; Wust, P | 1 |
| Hyodo, A; Nose, T; Takada, K; Tsuboi, K; Yoshii, Y | 1 |
| Andoh, T; Hara, A; Murakawa, T; Niikawa, S; Sakai, N; Yamada, H; Zhang, W | 1 |
| Ikenaga, M; Izumi, I; Kohda, K; Kowada, M; Mineura, K; Watanabe, K | 1 |
| Fujita, H; Hotta, T; Ikenaga, M; Ishizaki, K; Isowa, G; Kiya, K; Kurisu, K; Mikami, T; Saito, Y; Uozumi, T | 1 |
| Kihara, S; Nakagawa, S; Shiraishi, T; Tabuchi, K | 1 |
| Cazzaniga, S; Charles, HC; Schold, SC; Sostman, HD | 1 |
| Hara, A; Kobayashi, H; Niikawa, S; Sakai, N; Yamada, H; Zhang, W | 1 |
| Kuratsu, J; Ushio, Y | 2 |
| Nakajima, Y; Ohnishi, T; Sasaki, T; Tanaka, M; Terasaki, T; Tsuji, A; Yamashima, T; Yamashita, J | 1 |
| Hotta, T; Ikenaga, M; Ishizaki, K; Isowa, G; Kiya, K; Kurisu, K; Mikami, T; Saito, Y; Uozumi, T | 1 |
| Hara, A; Mori, H; Niikawa, S; Sakai, N; Yamada, H; Yoshimi, N; Zhang, W | 1 |
| Izumi, I; Kowada, M; Mineura, K; Watanabe, K | 2 |
| Iwadate, Y; Namba, H; Saegusa, T; Sueyoshi, K | 1 |
| Krossnes, BK; Schem, BC | 1 |
| Kawamoto, K | 1 |
| Baillet, F; Capelle, L; Chauveinc, L; Chiras, J; Cornu, P; Delattre, JY; Faillot, T; Martin-Duverneuil, M; Mazeron, JJ; Poisson, M; Sola-Martinez, MT | 1 |
| Abe, H; Aida, T; Ikeda, J; Kaneko, S; Kashiwaba, T; Kawamoto, T; Mitsumori, K; Saitoh, H; Sawamura, Y | 1 |
| Hatakeyama, T; Kumon, Y; Nakagawa, K; Ohta, S; Sakaki, S; Zenke, K | 1 |
| Gomi, A; Hirai, H; Masuzawa, T; Ozawa, K; Sakai, R; Shinoda, S | 1 |
| Amemiya, Y; Hatake, K; Miura, Y; Miyata, T; Muroi, K; Saito, M | 1 |
| Abe, M; Nishimura, Y; Sasai, K; Shibamoto, Y; Takahashi, M; Tsutsui, K | 1 |
| Dichgans, J; Roth, W; Schmidt, C; Weller, M | 1 |
| Fukuchi, M; Kohda, K; Kowada, M; Mineura, K; Terashima, I | 1 |
| Asai, A; Kuchino, Y; Nagane, M; Nomura, K; Shibui, S | 1 |
| Aoyagi, M; Hirakawa, K; Ichimura, K; Nagashima, G; Niimi, Y; Ohno, K; Tamaki, M | 1 |
| Gomi, A; Ishikawa, T; Kuo, MT; Masuzawa, T | 1 |
| Gomi, A; Ishikawa, T; Kuo, MT; Masuzawa, T; Shinoda, S | 1 |
| Marchenko, SV | 1 |
| Hiasa, Y; Konishi, N; Nakamura, M; Sakaki, T; Tsunoda, S; Tsuzuki, T; Yabuno, T | 1 |
| Arita, K; Curiel, DT; Goldman, CK; Hama, S; Heike, Y; Kurisu, K; Naruse, I; Saijo, N; Takahashi, M; Yoshioka, H | 1 |
| Asai, A; Kuchino, Y; Nagane, M; Nomura, K; Oyama, H; Shibui, S | 1 |
| Horikoshi, T; Naganuma, H; Nukui, H; Ohashi, Y; Ueno, T | 1 |
| Ghulam Muhammad, AK; Isaka, T; Maruno, M; Nakagawa, H; Nakata, H; Ninomiya, H; Yoshimine, T | 1 |
| Weller, M; Winter, S | 1 |
| Amin, MR; Fujii, K; Hori, T; Kamitani, H; Nagashima, T; Oka, H; Tanaka, S; Watanabe, T | 1 |
| Kubo, O; Takakura, K | 1 |
| Kohshi, K | 1 |
| Abe, T; Hikawa, T; Hori, S; Mori, T | 1 |
| Mima, T; Mori, K; Mostafa, MG | 1 |
| Arai, H; Beppu, T; Hakozaki, S; Kubo, N; Ogawa, A; Suzuki, M; Wada, T; Yoshida, Y | 1 |
| Nakanishi, Y; Nomura, K; Shibui, S; Tanaka, M | 1 |
| Kajita, Y; Mizuno, M; Wakabayashi, T; Yoshida, J | 1 |
| Fukumoto, M; Hashimoto, N; Kono, K; Mori, H; Takahashi, JA; Ueba, T | 1 |
| Kito, A; Mizuno, M; Sugita, K; Wakabayashi, T; Yoshida, J | 1 |
| Fujiwara, T; Honma, Y; Matsumoto, Y; Mino, S; Nagao, S; Tsuchida, T | 1 |
| Hoshi, A; Kakuto, Y; Kayama, T; Nemoto, K; Ogawa, Y; Sakamoto, K; Takai, Y; Yamada, S; Yoshimoto, T | 1 |
| Koulousakis, A; Shimizu, K; Sturm, V; Yoshida, TK | 1 |
| Fujiwara, T; Matsumoto, Y; Nagao, S; Sasaoka, N; Tsuchida, T | 1 |
| Niikawa, S; Nozawa, Y; Sakai, N; Yamada, H; Zhang, W | 1 |
| Hyodo, A; Kobayashi, E; Komatsu, Y; Nose, T; Yamada, T; Yoshii, Y | 1 |
| Beuls, E; Koulousakis, A; Shimizu, K; Sturm, V; Yoshida, TK | 1 |
| Ishiwata, K; Kameyama, M; Katakura, R; Sato, K; Yoshimoto, T | 1 |
| Asai, A; Kuchino, Y; Matsutani, M; Nagane, M; Nomura, K; Shibui, S | 1 |
| Darling, JL; Hoffmann, O; Kraemer, HP; Nikkhah, G; Schachenmayr, W; Schönmayr, R; Tonn, JC | 1 |
| Fujita, T; Furuta, Y; Murasawa, A; Nakagawa, H; Nakajima, S; Nakamura, H; Niiyama, K; Shibata, H; Taki, T; Tsuruzono, K | 1 |
| Hotta, T; Kawamoto, K; Kiya, K; Kurisu, K; Mikami, T; Nakada, Y; Saito, Y; Uozumi, T | 1 |
| Matsutani, M; Nakamura, O; Nomura, K; Takakura, K | 1 |
| Katakura, R; Kitahara, M; Mashiyama, S; Sasaki, T; Suzuki, J; Takahashi, K | 2 |
| Daita, G; Fujita, T; Hodozuka, A; Okazaki, S; Sako, K; Takei, H; Yonemasu, Y | 1 |
| Kawamoto, K; Matsumura, H; Numa, Y | 1 |
| Hotta, T; Kawamoto, K; Kiya, K; Kurisu, K; Mikami, T; Saito, Y; Uozumi, T | 1 |
| Hirao, J; Hori, T; Muraoka, K; Nakajima, E; Nishiyama, M; Okamoto, H; Tabuchi, F; Tanaka, S; Tatsuhara, T | 1 |
| Roosen, K; Schachenmayr, W; Tonn, JC | 1 |
| Hotta, T; Kawamoto, K; Kiya, K; Kurisu, K; Mikami, T; Nakada, Y; Saito, Y; Uozumi, T; Yamada, K | 2 |
| Bodell, WJ | 1 |
| Katakura, R; Mashiyama, S; Sasaki, T; Suzuki, J; Takahashi, K; Yoshimoto, T | 1 |
| Dahl, O; Schem, BC | 1 |
| Fujita, H; Higano, S; Inugami, A; Kanno, I; Kato, T; Murakami, M; Ogawa, T; Shishido, F; Tomura, N; Uemura, K | 1 |
| Miyagami, M; Tsubokawa, T | 1 |
| Sasaoka, N | 1 |
| Heuser, K | 1 |
| Kraemer, HP; Schönmayr, R; Tonn, JC | 1 |
| Miyamachi, K | 1 |
| Tanaka, S | 1 |
| Shoin, K; Yamashima, T; Yamashita, J | 1 |
| Abe, H; Aida, T; Kaneko, S; Sugimoto, S; Tokuda, K | 1 |
| Maruo, K; Nakamura, O; Nomura, K; Takakura, K; Ueyama, Y | 3 |
| Mori, K; Moriyama, T; Moroki, J; Shibata, S; Tanaka, K | 2 |
| Akagi, K; Kawakami, K; Kawamoto, K; Kawamura, Y; Matsumura, H; Numa, Y; Ohyama, A; Oka, N | 1 |
| Ito, T; Kawakami, K; Kawamoto, K; Kawamura, Y; Matsumura, H; Ohyama, A; Oka, N | 1 |
| Kageyama, N; Kida, Y; Kobayashi, T; Shibuya, N; Tanaka, T | 1 |
| Aida, T; Bodell, WJ | 4 |
| Murakami, N; Onda, K; Suzuki, Y; Tanaka, R; Yamazaki, K | 1 |
| Enomoto, H; Kageyama, N; Yoshida, J | 1 |
| Handa, H; Hori, R; Iwakawa, S; Okumura, K; Okumura, T; Tokuriki, Y; Tsukamoto, T; Yamashita, J | 1 |
| Hondo, H; Sato, I; Suzuki, Y; Takeda, N; Tanaka, R | 1 |
| Kasahara, E; Miyagami, M; Tazoe, M; Tsubokawa, T | 1 |
| Hosoya, T; Nakai, O; Takahama, H; Takanashi, T; Yamada, K | 1 |
| Kowada, M; Mineura, K; Ogawa, T; Sasajima, T; Shishido, F; Suda, Y; Uemura, K | 1 |
| Bamberg, M; Budach, W; Sprengel, M; Strehl, K; Stuschke, M | 1 |
| Bock, WJ; Kiwit, JC; Lins, E; Roosen, N; Schirmer, M | 2 |
| Bock, WJ; Feinendegen, LE; Herzog, H; Kiwit, JC; Kuwert, T; Langen, KJ; Muzik, O; Roosen, N; Rota Kops, E | 1 |
| Fushimi, S; Ishino, Y; Itoh, Y; Kowada, M; Mineura, K | 1 |
| Fushimi, S; Ishino, Y; Kowada, M; Mineura, K; Sasajima, H; Sasaki, J | 3 |
| Hayashi, M; Ishii, H; Ishii, Y; Kawano, H; Nakatsugawa, S; Satoh, K | 1 |
| Nagashima, T; Takakura, K | 1 |
| Mabuchi, E; Matsui, Y; Mogami, H; Moriuchi, S; Park, K; Shimizu, K; Tamura, K; Yamada, M | 1 |
| Furuta, Y; Murasawa, A; Nakagawa, H; Nakajima, S; Nakajima, Y | 1 |
| Kageyama, N; Kito, A; Yoshida, J | 1 |
| Furuta, Y; Masaoka, T; Murasawa, A; Nakagawa, H; Nakajima, S; Nakamura, H; Niiyama, K; Shibata, H; Taki, T | 1 |
| Abe, H; Kitamura, K; Matsutani, M; Miwa, T; Nomura, K; Suzuki, J; Takakura, K; Takeuchi, K; Tanaka, R; Ushio, Y | 1 |
| Himuro, H; Inoue, N; Kaetsu, I; Kitamura, K; Kubo, O; Sakairi, M; Tajika, T; Tajika, Y; Tohyama, T; Yoshida, M | 1 |
| Ishizaki, R; Matsutani, M; Nakamura, O; Nomura, K; Shitara, N; Takakura, K | 1 |
| Jaksche, H; Loew, F; Papavero, L | 1 |
| Goya, T; Kaji, Y; Kinoshita, K; Kodama, T; Maruoka, N; Moriyama, T; Nonaka, A; Oyama, H; Shimauchi, M; Wakisaka, S | 1 |
| Kowada, M; Mineura, K; Ogawa, T; Shishido, F; Suda, Y; Uemura, K; Yasuda, T | 1 |
| Endo, Y; Matsutani, M; Nakamura, O; Nishikawa, K; Sasaki, T; Takakura, K; Tanaka, M; Uchida, H | 1 |
| Hirabuki, N; Kawai, R; Kozuka, T; Mitomo, M; Miura, T; Murayama, S; Usio, Y | 1 |
| Aida, T | 1 |
| Fushimi, S; Itoh, Y; Kowada, M; Mineura, K | 2 |
| Kanno, S; Kitahara, M; Kuwahara, K; Mashiyama, S; Sasaki, T; Sugiyama, S; Takahashi, K | 1 |
| Enkaku, F; Ito, H; Shoin, K; Yamamoto, S; Yamashima, T | 1 |
| Abe, H; Handa, H; Kageyama, N; Kitamura, K; Miwa, T; Mogami, H; Takakura, K; Takeuchi, K; Tanaka, R; Yamamoto, S | 1 |
| Enomoto, H; Kageyama, N; Kato, K; Kito, A; Wakabayashi, T; Yoshida, J | 1 |
| Hayakawa, T; Kato, A; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T | 2 |
| Tokuda, K | 1 |
| Berger, MS; Rosenblum, ML | 1 |
| Kageyama, N; Kida, Y; Kobayashi, T; Tanaka, T | 1 |
| Egawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Yoshida, T | 1 |
| Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T | 2 |
| Arita, N; Hayakawa, T; Mogami, H; Mori, S; Nagatani, M; Tzuu-Yuan, H; Ushio, Y; Yoshimine, T | 1 |
| Adachi, S; Anno, Y; Hori, T; Inagaki, H; Inoue, Y; Muraoka, K; Saito, Y; Sasahara, K | 1 |
| Kokunai, T; Matsumoto, S; Tamaki, N | 2 |
| Egawa, T; Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Yoshida, T | 1 |
| Genka, S; Kosugi, Y; Shitara, N; Takakura, K; Tsujita, Y; Wu, Y | 1 |
| Arai, K; Endoh, S; Horie, Y; Kuroki, T; Takaku, A | 1 |
| Katakura, R; Kitahara, M; Sasaki, T; Suzuki, J | 1 |
| Matsui, Y; Miyao, Y; Mogami, H; Okamoto, Y; Shimizu, K; Tsuda, N; Yamada, M | 1 |
| Inoue, I; Kageyama, N; Wakabayashi, T; Yoshida, J | 1 |
| Matsutani, M; Nagashima, T; Orii, H; Tamura, A | 1 |
| Hoshino, T; Kohno, T; Matsutani, M; Takakura, K | 1 |
8 review(s) available for nimustine and Glioma
| Article | Year |
|---|---|
Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review.
Topics: Convection; Drug Delivery Systems; Glioma; Humans; Neoplasm Recurrence, Local; Nimustine; Spinal Cord | 2020 |
A network meta-analysis: the overall and progression-free survival of glioma patients treated by different chemotherapeutic interventions combined with radiation therapy (RT).
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bayes Theorem; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Cisplatin; Dacarbazine; Disease-Free Survival; Eflornithine; Glioma; Humans; Mitolactol; Network Meta-Analysis; Nimustine; Probability; Randomized Controlled Trials as Topic; Snake Venoms; Temozolomide; Treatment Outcome; Vincristine | 2016 |
[Treatment for malignant glioma].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Glioma; Humans; Nimustine | 2005 |
[Glioma].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Drug Synergism; Genetic Therapy; Glioma; Humans; Interferon-beta; Nimustine; Radiotherapy; Temozolomide | 2006 |
[Hyperthermic treatment of malignant tumors. Possible application to the treatment of brain tumors].
Topics: Animals; Brain Neoplasms; Cobalt Radioisotopes; Culture Techniques; Electrocoagulation; Glioma; Haplorhini; Hot Temperature; Humans; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Rats; Sarcoma, Experimental | 1982 |
[Chemotherapy of brain tumors].
Topics: Blood-Brain Barrier; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therapy; Glioma; Humans; Nimustine | 1994 |
[Malignant brain tumor treatment and hyperbaric oxygenation].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Glioma; Humans; Hyperbaric Oxygenation; Nimustine | 2000 |
[Chemical modifiers in radiotherapy].
Topics: Brain Neoplasms; Bromodeoxyuridine; Combined Modality Therapy; Glioma; Humans; Immunologic Factors; Interferon Type I; Nimustine; Radiation-Sensitizing Agents | 1989 |
17 trial(s) available for nimustine and Glioma
| Article | Year |
|---|---|
Chemotherapy alleviates subacute recurrent glioma-associated refractory cerebral edema by downregulating vascular endothelial growth factor.
Topics: Adult; Aged; Brain Edema; Brain Neoplasms; Cisplatin; Dacarbazine; Down-Regulation; Female; Glioma; Humans; Leukopenia; Male; Middle Aged; Nimustine; Postoperative Complications; Temozolomide; Thrombocytopenia; Treatment Outcome; Vascular Endothelial Growth Factor A; Young Adult | 2014 |
A phase II study of radiotherapy after hyperbaric oxygenation combined with interferon-beta and nimustine hydrochloride to treat supratentorial malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Hyperbaric Oxygenation; Interferon-beta; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Nimustine; Radiotherapy Dosage; Survival Rate | 2003 |
Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Disease Progression; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Prognosis; Prospective Studies; Survival Analysis; Teniposide; Treatment Outcome | 2003 |
Local drug delivery in recurrent malignant gliomas.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Doxorubicin; Drug Delivery Systems; Drug Therapy, Combination; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Survival Rate; Treatment Outcome | 2005 |
Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Nimustine; Procarbazine; Radiotherapy; Survival Analysis; Treatment Outcome; Vincristine | 2006 |
Phase I/II clinical trial of carbon ion radiotherapy for malignant gliomas: combined X-ray radiotherapy, chemotherapy, and carbon ion radiotherapy.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carbon Radioisotopes; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Radiotherapy Dosage | 2007 |
Leukoencephalopathy associated with intra-arterial ACNU in patients with gliomas.
Topics: Adolescent; Adult; Aged; Brain; Brain Diseases; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Infant; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Recurrence; Tomography, X-Ray Computed | 1995 |
Intra-arterial mannitol infusion in the chemotherapy for malignant brain tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Cisplatin; Combined Modality Therapy; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Mannitol; Middle Aged; Nimustine; Survival Rate | 1993 |
Intra arterial chemotherapy with ACNU and radiotherapy in inoperable malignant gliomas.
Topics: Adult; Aged; Combined Modality Therapy; Drug Administration Schedule; Glioma; Humans; Infusions, Intra-Arterial; Middle Aged; Nimustine; Survival Rate | 1996 |
Phase II study of DTIC, ACNU, and vincristine combination chemotherapy for supratentorial malignant astrocytomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Child; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Radiation Dosage; Supratentorial Neoplasms; Treatment Outcome; Vincristine | 1996 |
Preliminary individual adjuvant therapy for gliomas based on the results of molecular biological analyses for drug-resistance genes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Brain Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioma; Humans; Immunohistochemistry; Middle Aged; Multidrug Resistance-Associated Proteins; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Prospective Studies; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis; Tumor Cells, Cultured | 2000 |
A phase II study of nimustine hydrochloride, cisplatin, and etoposide combination chemotherapy for supratentorial malignant gliomas.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Survival Analysis; Treatment Outcome | 2000 |
Intratumoral microinfusion of nimustine (ACNU) for recurrent glioma.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Child; Female; Glioma; Humans; Injections, Intralesional; Magnetic Resonance Imaging; Male; Middle Aged; Necrosis; Neoplasm Recurrence, Local; Nimustine; Oligodendroglioma; Prospective Studies | 2001 |
[Randomized controlled study on the effect of adjuvant immunotherapy with OK-432 on malignant gliomas].
Topics: Adult; Aged; Antineoplastic Agents; Biological Products; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Picibanil; Random Allocation | 1985 |
[Evaluation of ACNU alone and combined with tegafur as additions to radiotherapy of the treatment of malignant gliomas--a cooperative clinical trial].
Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Radiotherapy Dosage; Tegafur | 1985 |
Effects of ACNU and radiotherapy on malignant glioma.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Glioma; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nimustine; Nitrosourea Compounds | 1986 |
Randomized controlled study of the effect of adjuvant immunotherapy with Picibanil on 51 malignant gliomas.
Topics: Adult; Aged; Biological Products; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioma; Humans; Leukopenia; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Picibanil; Random Allocation; Skin Tests | 1987 |
198 other study(ies) available for nimustine and Glioma
| Article | Year |
|---|---|
Experience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Drug Resistance; Drug Resistant Epilepsy; Female; Follow-Up Studies; Glioma; Humans; Levetiracetam; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Neurosurgical Procedures; Nimustine; Nitriles; Pyridones; Radiotherapy, Adjuvant; Receptors, AMPA; Retrospective Studies; Temozolomide; Young Adult | 2020 |
[Nimustine hydrochloride/ranimustine efficacy and safety in glioma].
Topics: Antineoplastic Agents; Brain Neoplasms; Glioma; Humans; Nimustine; Nitrosourea Compounds | 2016 |
Prophylactic use of pegfilgrastim in patients treated with a nitrosourea and teniposide for recurrent glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Communicable Diseases; Disease-Free Survival; Female; Filgrastim; Germany; Glioma; Granulocyte Colony-Stimulating Factor; Humans; Leukopenia; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; Severity of Illness Index; Survival Rate; Teniposide | 2014 |
Hyperbaric oxygen therapy sensitizes nimustine treatment for glioma in mice.
Topics: Animals; Antineoplastic Agents; Biomarkers; Body Weight; Cell Line, Tumor; Disease Models, Animal; Glioma; Humans; Hyperbaric Oxygenation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Mice; Mice, Transgenic; Models, Biological; NF-kappa B; Nimustine; Signal Transduction; Tumor Burden; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2016 |
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models.
Topics: Animals; Antineoplastic Agents; Convection; Drug Delivery Systems; Glioma; Male; Nimustine; Rats; Rats, Inbred F344; Spinal Cord Neoplasms | 2017 |
ACNU-based chemotherapy for recurrent glioma in the temozolomide era.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Temozolomide | 2009 |
[Detection of O6-methylguanine-DNA methyltransferase promoter methylation in chemotherapy for glioma].
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Azacitidine; Brain Neoplasms; Cell Line, Tumor; CpG Islands; Dacarbazine; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Survival Rate; Temozolomide; Young Adult | 2009 |
Effect of inhibition of the ROCK isoform on RT2 malignant glioma cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Knockdown Techniques; Glioma; Humans; Immunoblotting; Isoenzymes; Nimustine; Rats; rho-Associated Kinases; RNA, Small Interfering; Transfection | 2010 |
[Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].
Topics: Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Child; Cisplatin; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Glioma; Humans; Infusions, Intravenous; Male; Nausea; Neutropenia; Nimustine; Temozolomide; Teniposide; Thrombocytopenia; Young Adult | 2011 |
An anti-transferrin receptor antibody enhanced the growth inhibitory effects of chemotherapeutic drugs on human glioma cells.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Glioma; Humans; Immunohistochemistry; Nimustine; Receptors, Transferrin | 2011 |
The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; DNA Repair; Down-Regulation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Glioma; Humans; Mice; Nimustine; Proto-Oncogene Proteins c-fos; Transcription Factor AP-1 | 2012 |
O6-methylguanine-DNA methyltranspherase gene expression in gliomas by means of real-time quantitative RT-PCR and clinical response to nitrosoureas.
Topics: Adult; Antineoplastic Agents; beta 2-Microglobulin; Brain Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Middle Aged; Neoplasm Recurrence, Local; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Survival Rate; Transcription, Genetic | 2003 |
Prospective trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Hyperbaric Oxygenation; Japan; Male; Middle Aged; Nimustine; Procarbazine; Prospective Studies; Supratentorial Neoplasms; Survival Rate; Vincristine | 2003 |
In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma.
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Cisplatin; Drug Synergism; Etoposide; Fibroblast Growth Factor 2; Glioma; Humans; Nimustine; Oligopeptides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Antisense; Signal Transduction; Tumor Cells, Cultured | 2003 |
[Role of thallium SPECT for evaluating the effect of maintenance chemotherapy against malignant gliomas].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Administration Schedule; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vincristine | 2003 |
Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas.
Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; Brain; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Immunohistochemistry; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Radiotherapy; Survival Analysis | 2004 |
Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma.
Topics: Antineoplastic Agents; Brain Neoplasms; Disease Progression; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Glioblastoma; Glioma; Humans; Neoplasm Recurrence, Local; Nimustine; Prognosis; Radiosurgery; Radiotherapy; Recurrence; Stereotaxic Techniques; Teniposide; Time Factors; Treatment Outcome | 2005 |
Down-regulation of O6-methylguanine-DNA methyltransferase gene expression in gliomas by platinum compounds.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Cisplatin; Down-Regulation; Female; Gene Expression Profiling; Glioma; Humans; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2005 |
Acquisition of resistance to antitumor alkylating agent ACNU: a possible target of positron emission tomography monitoring.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Resistance, Neoplasm; Fluorodeoxyglucose F18; Glioma; Nimustine; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Rats; Treatment Outcome | 2006 |
Gene expression profiles of 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU)-resistant C6 rat glioma cells.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression; Gene Expression Profiling; Glioma; Immunohistochemistry; Nimustine; Oligonucleotide Array Sequence Analysis; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
The combined effects of multiple chemotherapeutic agents for malignant glioma cells.
Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Cell Line, Tumor; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Synergism; Etoposide; Glioma; Humans; Models, Statistical; Nimustine; Vincristine | 2007 |
Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in human U251 malignant glioma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Drug Synergism; Glioma; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Male; Neoplasms, Experimental; Nimustine; Protein Kinases; Rats; Rats, Nude; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2007 |
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Cohort Studies; Data Interpretation, Statistical; Databases, Factual; Female; Glioblastoma; Glioma; Humans; Lomustine; Male; Nimustine; Nitrosourea Compounds; Reproducibility of Results; Selection Bias; Survival Analysis; Treatment Outcome | 2008 |
[Radiotherapy using bleomycin, ACNU, and vincristine for malignant brain tumors. Efficacy for tumor regression].
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bleomycin; Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Nimustine; Nitrosourea Compounds; Vincristine | 1984 |
[Combined effect of ACNU and 5-fluorouracil on spheroids of rat glioma cells].
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Glioma; Nimustine; Nitrosourea Compounds; Rats | 1984 |
[Lethal effect of X-ray and ACNU on cultured rat glioma cells in multicellular spheroids].
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Glioma; Nimustine; Nitrosourea Compounds; Rats | 1984 |
Preliminary study of the effects of vitamin A on antineoplastic activities of chemotherapeutic agents in glioma.
Topics: Animals; Antineoplastic Agents; Cell Survival; Glioma; Humans; In Vitro Techniques; Mice; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Vincristine; Vitamin A | 1980 |
[Comparative studies on anti-tumor effects of nitrosoureas, ACNU and MCNU, on experimental brain tumors (author's transl)].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Glioma; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds | 1981 |
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combination; Ependymoma; Fluorouracil; Glioma; Humans; Lymphoma; Meningeal Neoplasms; Meningioma; Nimustine; Nitrosourea Compounds; Oligodendroglioma; Picibanil | 1983 |
[Treatment schedule of combination using radiation and ACNU in the experimental brain tumors].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; DNA, Neoplasm; Drug Administration Schedule; Glioma; Male; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1983 |
[Chemotherapy of experimental meningeal gliomatosis].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain; Carmustine; Glioma; Male; Meningeal Neoplasms; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1984 |
Pharmacokinetics of a new water-soluble nitrosourea derivative (ACNU) in human gliomas.
Topics: Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Glioblastoma; Glioma; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Tissue Distribution | 1981 |
[Anti-tumor activity of ACNU against malignant glioma--a clinical application of in vitro sensitivity test of chemotherapeutic agent].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds | 1983 |
Intensive chemotherapy with autologous bone marrow rescue for recurrent malignant gliomas.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bone Marrow Transplantation; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Male; Neoplasm Recurrence, Local; Nimustine; Nitrosourea Compounds | 1984 |
[Treatment of brain tumor with phenobarbital and continuous infusion of ACNU into internal carotid artery].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carotid Artery, Internal; Drug Therapy, Combination; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Phenobarbital | 1983 |
Intra-arterial ACNU therapy for malignant brain tumors. Experimental studies and preliminary clinical results.
Topics: Adult; Animals; Brain Neoplasms; Cell Line; Female; Glioma; Humans; In Vitro Techniques; Injections, Intra-Arterial; Injections, Intravenous; Male; Mice; Middle Aged; Nimustine; Nitrosourea Compounds; Platelet Count; Radiography; Rats; Rats, Inbred Strains | 1983 |
[Study on postoperative local chemotherapy of malignant brain tumors using ACNU and PSK].
Topics: Adjuvants, Immunologic; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carotid Arteries; Drug Therapy, Combination; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Postoperative Period; Proteoglycans | 1983 |
[Effect of ACNU, a water-soluble nitrosourea, on cell cycle of cultured glioma cells--flow cytometric analysis].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Glioma; Humans; Mitosis; Nimustine; Nitrosourea Compounds; Rats | 1983 |
[Effects of phenobarbital on the metabolism of ACNU in vivo].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Glioma; Male; Nimustine; Nitrosourea Compounds; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
[Second-look operations and chemotherapy for malignant tumors of the brain].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Reoperation; Teniposide | 1983 |
[Meningeal gliomatosis models as a chemosensitivity assay system].
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Survival; Disease Models, Animal; Drug Resistance; Glioma; Male; Meningeal Neoplasms; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1984 |
[Enhanced effect of reserpine on growth-inhibitory action of ACNU on ACNU resistance C6 glioma].
Topics: Animals; Brain Neoplasms; DNA Repair; Drug Resistance; Drug Synergism; Glioma; Growth Inhibitors; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Reserpine | 1984 |
[ACNU delivery to malignant tumor tissue and serum--route of administration and combined use of phenobarbital].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain; Brain Neoplasms; Child, Preschool; Drug Therapy, Combination; Ependymoma; Female; Glioma; Humans; Injections, Intra-Arterial; Kinetics; Lymphoma; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Phenobarbital | 1983 |
[Evaluation of radiation immunochemotherapy in the treatment of malignant glioma. Combined use of ACNU, VCR and PS-K].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; Glioma; Humans; Middle Aged; Nimustine; Nitrosourea Compounds; Proteoglycans; Vincristine | 1983 |
Treatment of malignant brain tumours with ACNU and phenobarbital: continuous infusion of ACNU into internal carotid artery and systemic administration of phenobarbital.
Topics: Adult; Aged; Astrocytoma; Bone Marrow; Brain Neoplasms; Carotid Artery, Internal; Erythrocyte Count; Female; Glioma; Humans; Infusions, Intra-Arterial; Leukocyte Count; Lymphoma; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Phenobarbital; Tomography, X-Ray Computed | 1984 |
[Chemotherapy for experimental subarachnoid dissemination model of brain tumor].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioma; Injections, Intraperitoneal; Meningeal Neoplasms; Methotrexate; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Picibanil; Rats; Rats, Inbred Strains | 1984 |
[MCNU effectiveness on brain tumor. Part I: Antitumor activity in vitro on human glioma and neuroblastoma cell lines].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line; Cells, Cultured; DNA, Neoplasm; Flow Cytometry; Glioma; Humans; Mitosis; Neuroblastoma; Nimustine; Nitrosourea Compounds | 1984 |
[Synchronization chemoradiotherapy for malignant gliomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Nimustine; Nitrosourea Compounds; Teniposide; Vincristine | 1984 |
[Flow cytometric study of enhanced effect of anti-cancer drugs induced by nicardipine hydrochloride].
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; DNA, Neoplasm; Doxorubicin; Flow Cytometry; Glioma; Interphase; Methylnitrosourea; Nicardipine; Nifedipine; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Vincristine | 1984 |
[Development of ACNU-resistant meningeal gliomatosis models: establishment of resistant rat glioma subline against ACNU].
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Resistance; Glioma; Male; Meningeal Neoplasms; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1984 |
[Therapeutic effects of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and radiation on the rat glioma (author's transl)].
Topics: Animals; Brain Neoplasms; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Glioma; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Rats | 1981 |
Sensitivity to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) of glioma cells in vivo and in vitro.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line; Drug Evaluation, Preclinical; Glioma; Humans; Kinetics; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Rats | 1982 |
A comparison of intraarterial carboplatin and ACNU for the treatment of gliomas.
Topics: Adolescent; Adult; Aged; Carboplatin; Child; Drug Therapy; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Nimustine; Treatment Outcome | 1995 |
Experimental study of intraoperative local chemotherapy with fibrin glue containing nitrosourea for malignant gliomas.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy; Fibrin Tissue Adhesive; Glioma; Male; Nimustine; Rats; Rats, Wistar; Time Factors; Treatment Outcome | 1995 |
[Effective measures against side effects by increasing ACNU dose for malignant glioma: effects on digestive organs].
Topics: Adult; Aged; Anorexia; Brain Neoplasms; Drug Therapy, Combination; Female; Glioma; Granisetron; Granulocyte Colony-Stimulating Factor; Humans; Male; Middle Aged; Nausea; Nimustine; Vomiting | 1994 |
Long-term follow-up results of 175 patients with malignant glioma.
Topics: Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Follow-Up Studies; Glioma; Humans; Interferons; Nimustine; Radiotherapy, Adjuvant; Survival Rate; Treatment Outcome | 1994 |
Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines.
Topics: Alkylation; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Drug Synergism; Glioma; Guanine; HeLa Cells; Humans; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Phenols; Prohibitins; Rats; Tumor Cells, Cultured | 1995 |
[The use of an early postoperative interstitial-hyperthermia combination therapy in malignant gliomas].
Topics: Antineoplastic Agents; Brachytherapy; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Glioma; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Nimustine; Pilot Projects; Postoperative Care; Radiotherapy Dosage; Radiotherapy, Adjuvant; Retrospective Studies; Time Factors; Tomography, X-Ray Computed | 1995 |
Effect of interferon-gamma on ACNU-induced DNA damage and cytotoxicity in human glioblastoma cells.
Topics: Brain Neoplasms; Cell Line; Cell Survival; DNA Damage; Drug Synergism; Glioma; Humans; Interferon-gamma; Microscopy, Fluorescence; Nimustine; Tumor Cells, Cultured | 1993 |
Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Basal Ganglia; Brain Neoplasms; Cell Count; Cell Division; Culture Techniques; DNA Repair; DNA, Neoplasm; Drug Synergism; Glioma; Guanine; Male; Nimustine; Rats; Rats, Wistar | 1994 |
O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications.
Topics: Astrocytoma; Brain Neoplasms; Combined Modality Therapy; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Enzyme Induction; Glioblastoma; Glioma; Humans; Methyltransferases; Neoplasm Proteins; Neoplasm Recurrence, Local; Nimustine; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Tetrazolium Salts; Thiazoles | 1994 |
Induced expression and subcellular localization of the Bcl-2 protein in cultured glioma cells.
Topics: Blotting, Southern; Brain Neoplasms; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glioma; Humans; Immunohistochemistry; Microscopy, Confocal; Nimustine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 1994 |
Effects of therapy on the 1H NMR spectrum of a human glioma line.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Lactates; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nimustine; Tumor Cells, Cultured | 1994 |
A single cell gel electrophoresis technique for the detection of DNA damage induced by ACNU, an alkylating agent or irradiation in murine glioma cell lines.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; DNA Damage; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Glioma; Kinetics; Nimustine; Rats; Tumor Cells, Cultured; X-Rays | 1994 |
Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma.
Topics: Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Capillaries; Carrier Proteins; Cerebral Cortex; Drug Resistance; Fluorouracil; Glioma; Hippocampus; Male; Membrane Glycoproteins; Mesencephalon; Microscopy, Electron; Microscopy, Immunoelectron; Nimustine; Rats; Rats, Inbred F344; Sucrose; Tumor Cells, Cultured; Venules | 1993 |
Interrelationship between O6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosoureas in several glioma cell lines.
Topics: Animals; Drug Resistance; Glioma; Humans; Interferon-beta; Methyltransferases; Nimustine; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tumor Cells, Cultured | 1993 |
Identification of placental form of glutathione S-transferase in ACNU-resistant murine glioma cell lines.
Topics: Animals; Blotting, Northern; Blotting, Western; Drug Resistance; Glioma; Glutathione Transferase; Mice; Nimustine; Placenta; Tumor Cells, Cultured | 1993 |
Influence of O6-methylguanine-DNA methyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Female; Follow-Up Studies; Glioma; Humans; Male; Methyltransferases; Middle Aged; Neoplasms, Nerve Tissue; Nimustine; O(6)-Methylguanine-DNA Methyltransferase | 1993 |
Enhancement of ACNU treatment of the BT4An rat glioma by local brain hyperthermia and intra-arterial drug administration.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Glioma; Hyperthermia, Induced; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Nimustine; Random Allocation; Rats; Rats, Inbred Strains; Survival Rate | 1995 |
[Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents].
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Cycle; Cisplatin; Flow Cytometry; Glioma; Humans; Interferons; Nimustine; Prostaglandin D2; Tumor Cells, Cultured | 1995 |
A strategy for selective anti-cancer drug concentration increase in rat glioma tissue with Ca(2+)-channel blocker co-administration: calcium kinetics in intra-glioma arteriolar smooth muscle cells.
Topics: Animals; Antineoplastic Agents; Arterioles; Brain Neoplasms; Calcium; Calcium Channel Blockers; Diltiazem; Glioma; Kinetics; Male; Muscle, Smooth, Vascular; Nimustine; Rats; Rats, Wistar; Reference Values; Regional Blood Flow; Tumor Cells, Cultured | 1996 |
Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Cell Line; DNA Polymerase I; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Nimustine; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Therapy-related chronic myelomonocytic leukaemia with bone marrow eosinophilia associated with der(11)t(1;11)(q21;q14).
Topics: Antineoplastic Agents; Bone Marrow; Brain Neoplasms; Child; Chromosome Aberrations; Eosinophilia; Fatal Outcome; Glioma; Humans; Hydroxyurea; Karyotyping; Leukemia, Myelomonocytic, Chronic; Leukocyte Count; Lymphocyte Activation; Male; Nimustine | 1996 |
Comparison of accelerated hyperfractionated radiotherapy and conventional radiotherapy for supratentorial malignant glioma.
Topics: Adult; Antineoplastic Agents; Female; Glioma; Humans; Interferon-beta; Male; Middle Aged; Multivariate Analysis; Nimustine; Prognosis; Radiotherapy Dosage; Supratentorial Neoplasms; Survival Rate | 1997 |
Chemotherapy of human malignant glioma: prevention of efficacy by dexamethasone?
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Cell Cycle; Cell Survival; Cytarabine; Dexamethasone; Doxorubicin; Drug Interactions; Glioma; Humans; Methotrexate; Nimustine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Teniposide; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vincristine | 1997 |
[Study on potentiation of nitrosourea-cytotoxicity by DNA repair enzyme inhibitors in human brain tumor cells].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Glioma; Guanine; Humans; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Tumor Cells, Cultured | 1997 |
Application of antisense ribonucleic acid complementary to O6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant gliomas.
Topics: Animals; Antineoplastic Agents; Antisense Elements (Genetics); Drug Resistance, Neoplasm; Glioma; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Protein Biosynthesis; Rats; RNA, Complementary; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1997 |
Parenchymal damage in the territory of the anterior choroidal artery following supraophthalmic intracarotid administration of CDDP for treatment of malignant gliomas.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Carotid Arteries; Choroid Plexus; Cisplatin; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Retrospective Studies; Tomography, X-Ray Computed | 1997 |
Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Carrier Proteins; Cycloheximide; Dactinomycin; Glioma; Glutamate-Cysteine Ligase; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Nimustine; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; RNA, Messenger; Tumor Cells, Cultured | 1997 |
Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells.
Topics: Amino Acid Sequence; Animals; Antibodies; Antineoplastic Agents; Arsenates; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cisplatin; Doxorubicin; Drug Resistance, Multiple; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioma; Glutamate-Cysteine Ligase; Glutathione; Humans; Leukotriene C4; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Models, Biological; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Nimustine; Peptide Fragments; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
[Comprehensive therapy of malignant glioma of the brain].
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Glioma; Humans; Infant; Middle Aged; Nimustine; Radioimmunotherapy; Survival Analysis; Treatment Outcome | 1997 |
Drug resistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; DNA Nucleotidylexotransferase; Drug Resistance, Neoplasm; Ethylnitrosourea; Female; Glioma; Immunohistochemistry; Nimustine; Pregnancy; Rats; Rats, Wistar; Vincristine | 1998 |
Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells.
Topics: Adenoviridae; Antineoplastic Agents; Cell Death; Cyclin-Dependent Kinase Inhibitor p16; Drug Resistance, Neoplasm; G1 Phase; Gene Transfer Techniques; Genetic Vectors; Glioma; Humans; Nimustine; Tumor Cells, Cultured | 1998 |
Expression pattern of chemoresistance-related genes in human malignant brain tumors: a working knowledge for proper selection of anticancer drugs.
Topics: Antigens, CD; Antineoplastic Agents; Brain Neoplasms; Cisplatin; Doxorubicin; Etoposide; Genes, MDR; Glioma; Humans; Membrane Glycoproteins; Nimustine; RNA, Messenger; Tetraspanin 29; Tumor Cells, Cultured | 1999 |
Enhancing effect of electric stimulation on cytotoxicity of anticancer agents against rat and human glioma cells.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carboplatin; Cell Division; Electric Stimulation; Etoposide; Glioma; Humans; Nimustine; Rats; Tumor Cells, Cultured; Vincristine | 2000 |
Effectiveness of spray application of ACNU in the local control of malignant gliomas: report of two cases.
Topics: Aerosols; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Combinations; Fibrin Tissue Adhesive; Follow-Up Studies; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Postoperative Care; Tissue Adhesives | 2000 |
Poly(ADP-ribose) polymerase-independent potentiation of nitrosourea cytotoxicity by 3-aminobenzamide in human malignant glioma cells.
Topics: Benzamides; Binding Sites; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; G2 Phase; Glioma; Humans; Lomustine; Methylnitrosourea; Mitosis; Nimustine; Nitrosourea Compounds; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tumor Cells, Cultured | 2000 |
Treatment of malignant brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Nimustine; Prognosis; Radiosurgery; Survival Rate; Vincristine | 2000 |
The ability in adhesion and invasion of drug-resistant human glioma cells.
Topics: Animals; Brain Neoplasms; Cell Adhesion; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Extracellular Matrix Proteins; Flow Cytometry; Glioma; Humans; Matrix Metalloproteinases; Mice; Neoplasm Proteins; Neural Cell Adhesion Molecules; Nimustine; Tumor Cells, Cultured; Vincristine | 2000 |
Antitumor effect and peritumoral brain edema formation in relation to MX2, ACNU, and doxorubicin therapy: a comparative analysis using rodent models of gliomas.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Body Weight; Brain Edema; Brain Neoplasms; Carubicin; Disease Models, Animal; Doxorubicin; Glioma; Leukocyte Count; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Nimustine; Rats; Survival Rate | 2000 |
Radiotherapy combined with nimustine hydrochloride and etoposide for malignant gliomas: results of a pilot study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Disease-Free Survival; Etoposide; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Pilot Projects; Prognosis; Supratentorial Neoplasms | 2001 |
Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzylisoquinolines; Caspase Inhibitors; Cell Division; Central Nervous System Neoplasms; Genes, p53; Glioma; Humans; Nimustine; Oligopeptides; Tumor Cells, Cultured | 2002 |
Effectiveness of interferon-beta, ACNU, and radiation therapy in pediatric patients with brainstem glioma.
Topics: Adolescent; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Combined Modality Therapy; Female; Glioma; Humans; Interferon-beta; Magnetic Resonance Imaging; Male; Nimustine | 1992 |
[Intra-arterial chemotherapy with ACNU in the treatment of malignant gliomas].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Carotid Artery, Internal; Female; Glioblastoma; Glioma; Humans; Infant, Newborn; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Prognosis; Tomography, X-Ray Computed | 1992 |
Treatment results by uneven fractionated irradiation, low-dose rate telecobalt therapy as a boost, and intraoperative irradiation for malignant glioma.
Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Child; Child, Preschool; Cobalt Radioisotopes; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Necrosis; Nimustine; Prognosis; Radioisotope Teletherapy; Regression Analysis | 1992 |
Intrathecal chemotherapy with ACNU in a meningeal gliomatosis rat model.
Topics: Animals; Disease Models, Animal; Glioma; Injections, Spinal; Male; Meningeal Neoplasms; Nimustine; Rats; Rats, Wistar | 1992 |
[Quantitative analysis of glutathione and glutathione S-transferase in human brain tumors, C6 rat glioma cells and drug resistant C6 cells].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Drug Resistance; Glioma; Glutathione; Glutathione Transferase; Nimustine; Rats; Tumor Cells, Cultured; Vincristine | 1992 |
Enhancement of radiosensitivity by tamoxifen in C6 glioma cells.
Topics: Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Glioma; Humans; Nimustine; Protein Kinase C; Radiation-Sensitizing Agents; Tamoxifen; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1992 |
Malignancy and viability of intraparenchymal brain tumours: correlation between Gd-DTPA contrast MR images and proliferative potentials.
Topics: Brain; Brain Neoplasms; Cell Division; Cell Survival; Combined Modality Therapy; Contrast Media; Cranial Irradiation; Gadolinium DTPA; Glioma; Humans; Magnetic Resonance Imaging; Nimustine; Organometallic Compounds; Pentetic Acid; Premedication; Radiation Injuries | 1992 |
Intrathecal chemotherapy with ACNU for meningeal gliomatosis.
Topics: Animals; Drug Administration Schedule; Glioma; Injections, Spinal; Male; Meningeal Neoplasms; Nimustine; Rats; Rats, Inbred F344; Rats, Wistar | 1992 |
Modulation of BUdR labeling index in rat brain tumors following intracarotid ACNU administration.
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carotid Arteries; Cell Division; Dose-Response Relationship, Drug; Glioma; Injections, Intra-Arterial; Neoplasm Transplantation; Nimustine; Rats; Time Factors; Tumor Cells, Cultured | 1992 |
Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers.
Topics: Animals; Body Weight; Carbon Radioisotopes; Deoxyglucose; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Floxuridine; Fluorine Radioisotopes; Glioma; Groin; Male; Methionine; Neoplasm Proteins; Neoplasm Transplantation; Nimustine; Rats; Rats, Wistar; RNA, Neoplasm; Survival Rate; Thymidine; Tomography, Emission-Computed; Tritium | 1992 |
Expression of O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors.
Topics: Blotting, Northern; Brain Neoplasms; Cell Survival; DNA Probes; Drug Resistance; Glioma; Humans; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
The MTT assay for chemosensitivity testing of human tumors of the central nervous system. Part II: Evaluation of patient- and drug-specific variables.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Survival; Colony-Forming Units Assay; Coloring Agents; Drug Screening Assays, Antitumor; Glioma; Humans; Mitomycin; Mitoxantrone; Nimustine; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1992 |
[Treatment of malignant gliomas by selective intraarterial infusion chemotherapy with high-dose ACNU and autologous bone marrow transplantation--preliminary report].
Topics: Adolescent; Adult; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Transplantation, Autologous | 1991 |
Hypersensitivity of rat glioma sublines with acquired ACNU resistance to L-asparaginase.
Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Cell Division; Drug Resistance; Glioma; Nimustine; Rats; Tumor Cells, Cultured | 1991 |
[Drug sensitivity test against malignant gliomas].
Topics: Animals; Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Screening Assays, Antitumor; Glioma; Humans; Interferons; Mice; Mice, Inbred C57BL; Mitomycin; Mitomycins; Neoplasm Transplantation; Nimustine; Vincristine | 1990 |
Effects of X-irradiation alone and in combination with ACNU on human glioblastoma cells in vitro.
Topics: Cell Line; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Radiation; Glioma; Humans; Nimustine; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1990 |
Diffuse low-density areas in white matter on CT scans after intracarotid ACNU infusion--report of three cases.
Topics: Brain; Brain Neoplasms; Carotid Arteries; Female; Glioma; Humans; Infusions, Intra-Arterial; Middle Aged; Nimustine; Tomography, X-Ray Computed | 1990 |
[Multidisciplinary therapy using interferon and immunological evaluation for glioma patients: two-color analysis of T cell subsets].
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Interferons; Male; Middle Aged; Nimustine; Picibanil; Radiotherapy Dosage; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 1991 |
[Establishment of ACNU-resistant rat gliosarcoma cell lines and their characteristics].
Topics: Animals; Cell Separation; Drug Resistance; Drug Screening Assays, Antitumor; Glioma; Karyotyping; Microscopy, Electron; Mutation; Nimustine; Rats; Tumor Cells, Cultured | 1991 |
[Intrathecal distribution of ACNU by various modes of its administration analyzed by HPLC and autoradiography].
Topics: Animals; Autoradiography; Brain Neoplasms; Chromatography, High Pressure Liquid; Cisterna Magna; Dogs; Glioma; Injections, Intraventricular; Injections, Spinal; Nimustine; Perfusion | 1991 |
Brain necroses after intraarterial chemotherapy and irradiation of malignant gliomas--a complication of both ACNU and BCNU?
Topics: Brain; Brain Diseases; Brain Neoplasms; Carmustine; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Glioma; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Necrosis; Nimustine; Prospective Studies; Radiation Injuries | 1991 |
Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Doxorubicin; Drug Resistance; Etoposide; Glioma; Glutathione; Kinetics; Methionine Sulfoximine; Nimustine; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Vinblastine | 1991 |
Molecular dosimetry of sister chromatid exchange induction in 9L cells treated with 6-thioguanine.
Topics: Alkylating Agents; Animals; DNA Damage; Dose-Response Relationship, Drug; Ethylnitrosourea; Glioma; Nimustine; Rats; Sister Chromatid Exchange; Thioguanine; Tumor Cells, Cultured | 1991 |
[Effect of X-rays combined with ACNU and O6-ethylguanine on rat subcutaneous gliomas].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Combined Modality Therapy; Glioma; Guanine; Male; Neoplasm Transplantation; Nimustine; Rats; Rats, Inbred Strains; Skin Neoplasms; Tumor Cells, Cultured | 1991 |
Thermal enhancement of ACNU and potentiation of thermochemotherapy with ACNU by hypertonic glucose in the BT4An rat glioma.
Topics: Animals; Brain Neoplasms; Carmustine; Combined Modality Therapy; Drug Screening Assays, Antitumor; Drug Synergism; Glioma; Glucose; Hydrogen-Ion Concentration; Hyperthermia, Induced; Hypertonic Solutions; Neoplasm Transplantation; Nimustine; Rats; Rats, Inbred Strains; Retinal Diseases; Skin Neoplasms; Tumor Cells, Cultured | 1991 |
Cross-resistance patterns in ACNU-resistant glioma sublines in culture.
Topics: Animals; Brain Neoplasms; Clone Cells; Doxorubicin; Drug Resistance; Glioma; Glutathione; Hot Temperature; Nimustine; Phenotype; Radiation Tolerance; Rats; Rats, Inbred F344; Vinblastine | 1991 |
[The changes of cerebral blood flow and metabolism of normal brain tissue after surgery, radiation, and chemotherapy in brain tumor patients: evaluated by position emission tomography].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cerebrovascular Circulation; Child; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Glioma; Humans; Male; Middle Aged; Nimustine; Radiotherapy Dosage; Tegafur; Tomography, Emission-Computed | 1990 |
[Chemotherapy with ACNU and radiation therapy in malignant glioma in cerebral hemisphere of adult].
Topics: Adult; Brain Neoplasms; Combined Modality Therapy; Drug Evaluation; Female; Glioma; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Mannitol; Middle Aged; Nimustine; Remission Induction; Retrospective Studies; Survival Rate | 1990 |
[Chemosensitivity assays for malignant gliomas].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cisplatin; Drug Screening Assays, Antitumor; Glioma; Humans; Male; Nimustine; Rats; Rats, Inbred F344; Vincristine | 1990 |
[Chemotherapy in malignant gliomas].
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Combined Modality Therapy; Cytarabine; Follow-Up Studies; Glioma; Humans; Nimustine; Survival Rate; Teniposide | 1990 |
Sensitivity of human malignant intracranial tumors against MCNU in vitro in comparison to ACNU and BCNU.
Topics: Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Drug Screening Assays, Antitumor; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Tumor Cells, Cultured | 1990 |
[Chemotherapy responsiveness of brain tumors in subrenal capsule assay].
Topics: Animals; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Glioma; Male; Nimustine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Subrenal Capsule Assay; Tumor Cells, Cultured; Tumor Stem Cell Assay; Vincristine | 1990 |
[Application of interleukin 1 in the treatment of malignant gliomas with special reference to the experimental combination therapy with ACNU].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Glioma; Interferon Type I; Interleukin-1; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Nimustine; Tumor Cells, Cultured | 1990 |
Neurotoxicity of local administration of two nitrosoureas in malignant gliomas.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Glioma; Humans; Male; Middle Aged; Neurotoxins; Nimustine; Nitrosourea Compounds | 1990 |
Modification of tumor blood flow and enhancement of therapeutic effect of ACNU on experimental rat gliomas with angiotensin II.
Topics: Angiotensin II; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioma; Hypertension; Nimustine; Rats; Rats, Inbred Strains | 1990 |
Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro.
Topics: Animals; Glioma; Nimustine; Platelet-Derived Growth Factor; Pyrimidines; Suramin; Time Factors; Trapidil; Tumor Cells, Cultured | 1990 |
[Antineoplastic effect of Hu-IFN-beta and other anticancer drugs on malignant brain tumors in athymic nude mice].
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Ependymoma; Glioblastoma; Glioma; Interferon Type I; Mice; Mice, Inbred BALB C; Mice, Nude; Nimustine; Nitrosourea Compounds; Vincristine | 1985 |
[Effect of combined treatment of x-rays and ACNU on rat glioma cells in monolayer and multicellular spheroids].
Topics: Animals; Cell Survival; Cells, Cultured; Combined Modality Therapy; Cytological Techniques; Glioma; Necrosis; Nimustine; Nitrosourea Compounds; Radiation Effects; Rats | 1985 |
[Multidisciplinary therapy for gliomas. Experimental study using brain tumor-bearing rats and analytical study of clinical cases].
Topics: Animals; Astrocytoma; Biological Products; Brain Neoplasms; Cobalt Radioisotopes; Combined Modality Therapy; Glioma; Humans; Nimustine; Nitrosourea Compounds; Picibanil; Rats | 1986 |
[Flow cytometric studies of brain tumors--5: New sensitivity test of antineoplastic agents for brain tumors and its clinical application].
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Cell Cycle; Cell Survival; Colony-Forming Units Assay; Flow Cytometry; Fluorouracil; Glioma; Humans; Infant; Medulloblastoma; Mitomycin; Mitomycins; Nimustine; Nitrosourea Compounds; Rats; Tumor Stem Cell Assay | 1986 |
[In vitro response characteristics of brain tumor cell lines to hyperthermia].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line; Cells, Cultured; Glioma; Hot Temperature; Humans; Nimustine; Nitrosourea Compounds; Rats; Tumor Stem Cell Assay | 1986 |
[Interaction of human fibroblast interferon with chemotherapeutic agents and radiation of human gliomas in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Combined Modality Therapy; Doxorubicin; Female; Glioma; Interferon Type I; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Radiotherapy Dosage | 1986 |
[Enhancing effect of reserpine upon the cytotoxicity of ACNU on ACNU-resistant glioma cells].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Membrane Permeability; Cells, Cultured; Drug Resistance; Drug Synergism; Glioma; Nimustine; Nitrosourea Compounds; Rats; Reserpine | 1986 |
[Mechanism of cellular resistance to ACNU in rat brain tumor cell line].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; DNA Repair; Drug Resistance; Glioma; Nimustine; Nitrosourea Compounds; Rats; Sister Chromatid Exchange; Tumor Stem Cell Assay | 1986 |
[DNA content and sensitivity to ACNU of human glioma cell lines].
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Cell Line; DNA, Neoplasm; Female; Glioma; Humans; Male; Nimustine; Nitrosourea Compounds | 1986 |
The effectiveness of combination therapy with Hu IFN-beta and ACNU against malignant glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Glioma; Humans; Interferon Type I; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds | 1987 |
[Pharmacokinetics in intra-arterial ACNU therapy in malignant brain tumors].
Topics: Adolescent; Adult; Aged; Blood-Brain Barrier; Brain Neoplasms; Child; Female; Glioma; Humans; Injections, Intra-Arterial; Injections, Intravenous; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Tissue Distribution | 1987 |
[Mechanisms of cellular resistance to ACNU in cell lines derived from human brain tumors].
Topics: Brain Neoplasms; Drug Resistance; Glioma; Humans; Nimustine; Nitrosourea Compounds; Tumor Cells, Cultured | 1987 |
[Computed tomographic features of cerebral malignant glioma following treatment and regrowth. Tumor response to radiochemotherapy].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Child; Combined Modality Therapy; Follow-Up Studies; Glioma; Humans; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Tomography, X-Ray Computed; Vincristine | 1988 |
[Enhancement of the effect of X-irradiation against cultured human glioblastoma cells by pretreatment with ACNU].
Topics: Brain Neoplasms; Cell Survival; Glioma; Humans; Nimustine; Tumor Cells, Cultured | 1989 |
[Therapeutic efficacy of intracarotid infusion of 20% mannitol with ACNU in Fischer rats with intracerebrally implanted 9L gliosarcoma].
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Bromodeoxyuridine; Carotid Artery, Internal; Cell Division; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Glioma; Infusions, Intra-Arterial; Infusions, Parenteral; Male; Mannitol; Neoplasm Transplantation; Nimustine; Rats; Rats, Inbred F344 | 1989 |
[Intra-arterial chemotherapy of malignant glioma after osmotic blood-brain barrier disruption].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Evaluation Studies as Topic; Female; Fluorouracil; Glioma; Humans; Infusions, Intra-Arterial; Interferon Type I; Leukopenia; Male; Mannitol; Middle Aged; Nimustine; Osmotic Pressure; Remission Induction; Thrombocytopenia | 1989 |
[Radiochemotherapy-related changes in the brain parenchyma of glioma patients evaluated repeatedly by C15O2, C15O, 15O2, and 18F-fluorodeoxyglucose (FDG) PET].
Topics: Adolescent; Adult; Antineoplastic Agents; Brain; Brain Neoplasms; Carbon Radioisotopes; Cerebrovascular Circulation; Combined Modality Therapy; Deoxyglucose; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glioma; Humans; Male; Middle Aged; Nimustine; Oxygen Radioisotopes; Tegafur; Tomography, Emission-Computed | 1989 |
Treatment of high grade glioma xenografts with nitrosoureas in nude mice.
Topics: Animals; Carmustine; Glioblastoma; Glioma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Nimustine; Oligodendroglioma; Transplantation, Heterologous | 1989 |
Adjuvant intraarterial chemotherapy with nimustine in the management of World Health Organization Grade IV gliomas of the brain. Experience at the Department of Neurosurgery of Düsseldorf University.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Neoplasm Staging; Nimustine; Radiotherapy Dosage; World Health Organization | 1989 |
Early effects of intra-arterial chemotherapy in patients with brain tumours studied with PET: preliminary results.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Deoxy Sugars; Deoxyglucose; Female; Fluorine Radioisotopes; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Predictive Value of Tests; Prognosis; Tomography, Emission-Computed | 1989 |
Microspectrofluorometric evaluation of single- and double-stranded DNA in short-term cultured human glioma cells.
Topics: Adult; Brain Neoplasms; Child; DNA; DNA, Neoplasm; Female; Glioma; Humans; Infant; Male; Middle Aged; Nimustine; Polyploidy; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1989 |
[Chemotherapeutic strategy in rat brain tumor cells resistant to ACNU using an in vitro colony formation assay].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Nimustine; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
[A trial of ACNU and radiation therapy with sensitizing agents for malignant gliomas].
Topics: Acyclovir; Adolescent; Adult; Aged; Brain Neoplasms; Bromodeoxyuridine; Combined Modality Therapy; Evaluation Studies as Topic; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Radiation Injuries; Radiation-Sensitizing Agents; Radiotherapy Dosage; Remission Induction; Vidarabine | 1989 |
[Antitumor efficacy of FK 973 on malignant glioma cells].
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Doxorubicin; Drug Screening Assays, Antitumor; Glioma; Methotrexate; Mice; Mice, Inbred C3H; Nimustine; Oxazines | 1989 |
[Concentration of ACNU in a branch of middle cerebral artery, femoral vein and brain tissue by intracarotid or intravenous administration in a patient with recurrent glioblastoma].
Topics: Adult; Brain; Brain Neoplasms; Carotid Artery, Internal; Cerebral Arteries; Female; Femoral Vein; Glioma; Humans; Injections, Intra-Arterial; Injections, Intravenous; Neoplasm Recurrence, Local; Nimustine; Tissue Distribution | 1989 |
[Controlled multimodality treatment of brain stem gliomas].
Topics: Adolescent; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Interferon Type I; Male; Nimustine; Nitrosourea Compounds; Radiotherapy Dosage | 1987 |
[Treatment of malignant gliomas with high-dose ACNU and autologous bone marrow transplantation].
Topics: Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Transplantation, Autologous | 1988 |
Interactions of human fibroblast interferon with chemotherapeutic agents and radiation against human gliomas in nude mice.
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Doxorubicin; Female; Glioma; Interferon Type I; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds | 1986 |
[Circumvention of ACNU-resistance in rat glioma cells by pretreatment with O6-methylguanine].
Topics: Animals; Brain Neoplasms; Cell Survival; Drug Resistance; Drug Synergism; Enzyme Induction; Glioma; Guanine; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Intra-arterial chemotherapy with ACNU for the treatment of glioblastoma. Preliminary experience.
Topics: Adult; Brain Neoplasms; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine | 1986 |
[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Implants; Dysgerminoma; Ependymoma; Fluorouracil; Glioma; Humans; Medulloblastoma; Methylmethacrylates; Mitomycin; Mitomycins; Neoplasms, Germ Cell and Embryonal; Nimustine; Nitrosourea Compounds; Teratoma | 1986 |
[Treatment of autochthonous rat brain tumors with chemotherapy and radiotherapy].
Topics: Animals; Antineoplastic Agents; Avian Sarcoma Viruses; Brain Neoplasms; Carboxymethylcellulose Sodium; Combined Modality Therapy; Glioma; Nimustine; Nitrosourea Compounds; Poly I-C; Polylysine; Radiotherapy Dosage; Rats; Sarcoma, Avian; Vincristine | 1987 |
Intracarotid infusion of ACNU and BCNU as adjuvant therapy of malignant gliomas. Clinical aspects and critical considerations.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Carotid Arteries; Combined Modality Therapy; Follow-Up Studies; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Neoplasm Recurrence, Local; Nimustine; Nitrosourea Compounds; Oligodendroglioma | 1987 |
[AUFRAP therapy: combined modality treatment of malignant gliomas with intraarterial infusion of ACNU].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carotid Artery, Internal; Combined Modality Therapy; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Proteoglycans; Radiotherapy Dosage; Remission Induction; Tegafur; Uracil; Vitamin A | 1988 |
Early and late stage positron emission tomography (PET) studies on the haemocirculation and metabolism of seemingly normal brain tissue in patients with gliomas following radiochemotherapy.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Cerebrovascular Circulation; Child; Combined Modality Therapy; Female; Glioma; Humans; Male; Middle Aged; Nimustine; Tegafur; Tomography, Emission-Computed | 1988 |
[Response to antitumor agents of human transplantable glioma implanted into chorioallantoic membrane of chick embryo].
Topics: Allantois; Animals; Antineoplastic Agents; Brain Neoplasms; Chick Embryo; Chorion; Drug Screening Assays, Antitumor; Extraembryonic Membranes; Glioma; Humans; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds | 1988 |
[Intra-arterial ACNU chemotherapy of malignant glioma].
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Child; Female; Glioma; Humans; Infusions, Intra-Arterial; Male; Nimustine; Nitrosourea Compounds | 1988 |
[Mechanisms of cellular resistance to chloroethylnitrosourea in cell lines derived from human brain tumors].
Topics: Brain Neoplasms; Carmustine; Cell Line; DNA Damage; Drug Resistance; Glioma; Humans; Nimustine; Nitrosourea Compounds; Sister Chromatid Exchange; Tumor Cells, Cultured | 1988 |
In vitro damage of isolated DNA from two brain tumor cell lines induced by a water-soluble antitumor nitrosourea.
Topics: Animals; Brain Neoplasms; Cell Line; DNA Damage; DNA, Neoplasm; Glioma; In Vitro Techniques; Nimustine; Nitrosourea Compounds; Rats; Solubility; Water | 1988 |
[Biological basis for combined radio-chemotherapy in radioresistant tumors].
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Survival; Combined Modality Therapy; Fluorouracil; Glioma; Humans; Neoplasms; Nimustine; Prognosis; Radiation Tolerance | 1988 |
DNA lability induced by nimustine and ramustine in rat glioma cells.
Topics: Animals; Antineoplastic Agents; Base Sequence; Brain Neoplasms; Cell Line; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Glioma; Nimustine; Nitrosourea Compounds; Rats; Tumor Cells, Cultured | 1988 |
[Ring enhancement on CT scan associated with the local ACNU administration therapy following glioblastoma surgery].
Topics: Aged; Brain; Brain Neoplasms; Combined Modality Therapy; Diagnosis, Differential; Female; Glioma; Humans; Neoplasm Recurrence, Local; Nimustine; Radiographic Image Enhancement; Reoperation; Tomography, X-Ray Computed | 1988 |
[Analysis of DNA damage induced by nitrosourea derivatives in rat brain tumor cells using a sequencing procedure].
Topics: Animals; Antineoplastic Agents; Base Sequence; Brain Neoplasms; DNA Damage; DNA, Neoplasm; DNA, Satellite; Glioma; Nimustine; Nitrosourea Compounds; Rats | 1988 |
[Combination therapy with IFN-beta, ACNU and radiation (IAR) in malignant brain tumors].
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Child; Combined Modality Therapy; Female; Glioma; Humans; Interferon Type I; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Radiotherapy Dosage | 1986 |
[Overcoming of ACNU resistance in a subline of rat glioma in vitro and in vivo by reserpine].
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Resistance; Drug Synergism; Glioma; Meningeal Neoplasms; Nimustine; Nitrosourea Compounds; Rats; Reserpine | 1986 |
Enhanced effect of reserpine upon growth-inhibitory action of ACNU on ACNU-resistant C6 glioma.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Glioma; Male; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Reserpine | 1986 |
Combined effect of ACNU and 5-FU on rat glioma cells in spheroids and monolayer cultures.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cells, Cultured; Fluorouracil; Glioma; Nimustine; Nitrosourea Compounds; Rats | 1986 |
[Mechanism and overcoming of resistance in ACNU-resistant sublines of rat brain tumors].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Membrane Permeability; Drug Resistance; Glioma; Nicardipine; Nifedipine; Nimustine; Nitrosourea Compounds; Rats; Verapamil | 1986 |
[Experimental studies on induced hypertension chemotherapy of intracerebral inoculated gliomas in rats].
Topics: Angiotensin II; Animals; Antineoplastic Agents; Blood Pressure; Brain Neoplasms; Cerebrovascular Circulation; Glioma; Male; Nimustine; Nitrosourea Compounds; Rats | 1986 |
Resistance of tumor cells to chemotherapy.
Topics: Animals; Cell Line; Drug Resistance; Glioma; Nimustine; Nitrosourea Compounds; Rats | 1986 |
[The effect of hyperthermia and antitumor drugs on brain tumor cell lines].
Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line; Cisplatin; Combined Modality Therapy; Glioma; Humans; Hyperthermia, Induced; Naphthacenes; Nimustine; Nitrosourea Compounds; Rats | 1986 |
[Intrathecal ACNU for the treatment of a meningeal gliomatosis model].
Topics: Animals; Antineoplastic Agents; Body Weight; Glioma; Male; Meningeal Neoplasms; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1987 |
Modulation in vitro and in vivo of ACNU resistance in a subline of C6 glioma with reserpine.
Topics: Animals; Brain Neoplasms; Cell Line; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Glioma; Male; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Reserpine | 1987 |
[Studies on the mechanism of ACNU resistance in sublines of rat C6 glioma and 9L gliosarcoma in vitro].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cell Membrane Permeability; Drug Resistance; Glioma; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1986 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug Therapy, Combination; Glioma; Male; Nicardipine; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Reserpine; Trifluoperazine; Verapamil | 1986 |
[Intrathecal ACNU against malignant leptomeningeal tumors--toxicity and therapeutic effect in experimental animals].
Topics: Animals; Antineoplastic Agents; Arachnoid; Glioma; Meningeal Neoplasms; Nimustine; Nitrosourea Compounds; Pia Mater; Rats; Rats, Inbred Strains | 1986 |
Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(II) in human glial-derived cell lines.
Topics: Carmustine; Cell Line; Cell Survival; Cisplatin; DNA; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Humans; Mechlorethamine; Methylation; Nimustine; Nitrosourea Compounds; Sister Chromatid Exchange | 1987 |
Influence of modes of ACNU administration on tissue and blood drug concentration in malignant brain tumors.
Topics: Adenocarcinoma; Adolescent; Adult; Blood-Brain Barrier; Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Injections, Intra-Arterial; Injections, Intravenous; Lymphoma; Male; Meningioma; Middle Aged; Nimustine; Nitrosourea Compounds | 1987 |
[Anticancer drug induced sister chromatid exchange and correlation to cell survival in human brain tumor cells].
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Cisplatin; Glioma; Humans; Mechlorethamine; Nimustine; Nitrosourea Compounds; Sister Chromatid Exchange; Tumor Stem Cell Assay | 1987 |
Significance of DNA cross-links on 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3- nitrosourea (ACNU)-induced cytotoxicity against ACNU-sensitive and -resistant lines of 9L rat glioma cells.
Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Glioma; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344 | 1987 |
[Overcoming of ACNU resistance in an ACNU-resistant subline of rat C6 glioma in vivo through enhanced effect of ACNU by calmodulin inhibitor].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Calmodulin; Drug Resistance; Glioma; Male; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Trifluoperazine | 1987 |
Cell cycle perturbation of cultured C6 glioma cells following short-term contact with a low dose of ACNU.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Line; DNA, Neoplasm; Flow Cytometry; Glioma; Interphase; Kinetics; Mitosis; Nimustine; Nitrosourea Compounds; Rats | 1987 |
Specific induction of ACNU-resistance in V79 Chinese hamster cells and C6 rat glioma cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Resistance; Glioma; Mutation; Nimustine; Nitrosourea Compounds; Tumor Cells, Cultured | 1987 |
Experimental combination chemotherapy of ACNU and 5-FU against cultured glioma model (spheroid) and subcutaneous rat glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colony-Forming Units Assay; Disease Models, Animal; Fluorouracil; Glioma; Male; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Time Factors | 1987 |
The mechanism and overcoming of resistance in ACNU-resistant sublines of C6 and 9L rat glioma.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Membrane Permeability; Dinitrophenols; Drug Resistance; Glioma; Male; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reserpine | 1987 |
[Experimental studies on the treatment of recurrent gliomas].
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Glioma; Humans; Immunization, Passive; Interleukin-2; Killer Cells, Natural; Nimustine; Nitrosourea Compounds | 1987 |
[Combination therapy with HU IFN-beta and ACNU against malignant brain tumors, Part 1. Experimental study in vitro].
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Cycle; Cells, Cultured; Drug Synergism; Flow Cytometry; Glioma; Humans; Interferon Type I; Nimustine; Nitrosourea Compounds | 1985 |
[Regional blood flow of experimental brain tumors with special reference to effects of chemotherapy and radiotherapy].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Capillary Permeability; Disease Models, Animal; Glioma; Male; Nimustine; Nitrosourea Compounds; Rats; Regional Blood Flow; Tumor Stem Cell Assay | 1985 |
ACNU-resistant mutants of 9L rat glioma cell line. Isolation and preliminary characterization of these subclones.
Topics: Animals; Brain Neoplasms; Cell Line; Drug Resistance; Glioma; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred F344 | 1985 |
[Effects of anticancer drugs on multicellular spheroid of 9L rat brain tumor].
Topics: Aclarubicin; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Survival; Cells, Cultured; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Glioma; Naphthacenes; Nimustine; Nitrosourea Compounds; Rats; Tumor Stem Cell Assay | 1985 |