nimustine has been researched along with Astrocytoma, Grade IV in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (18.37) | 18.7374 |
| 1990's | 28 (28.57) | 18.2507 |
| 2000's | 34 (34.69) | 29.6817 |
| 2010's | 16 (16.33) | 24.3611 |
| 2020's | 2 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, T; Ichimura, K; Kawauchi, D; Kobayashi, T; Kondo, A; Nakano, T; Narita, Y; Sasaki, N; Satomi, K; Takahashi, M; Tomiyama, A; Uchida, E; Wada, K; Yamamuro, S; Yoshino, A | 1 |
| Bu, XY; Cheng, X; Kong, LF; Luo, JC; Qu, MQ; Wang, YW; Yan, ZY; Yang, DY; Zhao, YW | 1 |
| Bu, XY; Kong, LF; Luo, JC; Ma, CX; Qu, MQ; Wang, YW; Yan, ZY; Yang, DY; Zhao, YW; Zhou, ZL | 1 |
| Chen, B; Chen, L; Chen, X; Jiang, T; Li, S; Wang, J; Wang, L; Wang, Y; Wu, C; Zhang, X; Zhang, Z | 1 |
| Chonan, M; Jokura, H; Kanamori, M; Katakura, R; Kato, H; Kawagishi, J; Kawaguchi, T; Kayama, T; Kumabe, T; Mano, Y; Saito, R; Shibahara, I; Sonoda, Y; Tominaga, T; Watanabe, M; Yamashita, Y | 1 |
| Aasland, D; Berte, N; Christmann, M; Kaina, B; Kitzinger, R; Krämer, OH; Meise, R; Tomicic, MT | 1 |
| Ishikawa, E; Ishikawa, H; Matsuda, M; Matsumura, A; Mizumoto, M; Okumura, T; Sakurai, H; Takano, S; Tsuboi, K; Yamamoto, T | 1 |
| Matsumoto, T; Nakano, Y; Nishizawa, S; Soejima, Y; Urasaki, E; Yokota, A | 1 |
| Heo, DS; Jung, HW; Kim, CY; Kim, DG; Kim, DW; Kim, IH; Lee, SH; Paek, SH; Park, CK; Park, SH | 1 |
| Chernov, M; Hori, T; Iseki, H; Kubo, O; Muragaki, Y; Tajika, Y; Takakura, K | 1 |
| Glas, M; Herrlinger, U; Hundsberger, T; Kurzwelly, D; Nguyen-Huu, B; Rasch, K; Stuplich, M; Wiewrodt, D | 1 |
| Han, JH; Heo, DS; Jung, HW; Kim, CY; Kim, DG; Kim, DW; Kim, IH; Lee, SH; Paek, SH; Park, CK | 1 |
| Hashii, H; Hayashi, Y; Igaki, H; Kanemoto, A; Matsumura, A; Mizumoto, M; Nakayama, H; Oshiro, Y; Sakurai, H; Sugahara, S; Takano, S; Tokuuye, K; Tsuboi, K; Yamamoto, T | 1 |
| Inoue, T; Kanamori, M; Kumabe, T; Nakazato, Y; Sonoda, Y; Tominaga, T; Watanabe, M | 1 |
| Jung, S; Jung, TY; Kang, SS; Kim, IY; Kim, YH; Lee, KH; Moon, KS; Park, CS | 1 |
| Hamasaki, K; Kuratsu, J; Makino, K; Nakamura, H; Ueda, Y | 1 |
| Kondo, N; McKinnon, PJ; Mori, E; Nakase, H; Noda, T; Ohnishi, K; Ohnishi, T; Ono, K; Sakaki, T; Su, X; Takahashi, A | 1 |
| Bertalanffy, H; Bozinov, O; Kalk, JM; Krayenbühl, N; Sure, U; Woernle, CM | 1 |
| Ariga, T; Inoue, O; Iraha, S; Ishiuchi, S; Kakinohana, Y; Kasuya, G; Murayama, S; Ogawa, K; Saito, A; Toita, T; Watanabe, T; Yoshii, Y | 1 |
| Kumabe, T; Nagamatsu, K; Saito, R; Sonoda, Y; Tominaga, T; Watanabe, M | 1 |
| Hasegawa, M; Helleday, T; Kinashi, Y; Kondo, N; Masunaga, S; Mori, E; Noda, T; Ohnishi, T; Ono, K; Suzuki, M; Takahashi, A; Thompson, LH; Zdzienicka, MZ | 1 |
| Chen, ZP; Jiang, XB; Mu, YG; Sai, K; Shen, D; Yang, QY; Zhang, XH | 1 |
| Fujii, T; Saito, N; Takahashi, K; Tanaka, M; Todo, T; Tsuno, NH | 1 |
| Asai, A; Beppu, T; Fujimaki, T; Fukuda, H; Ito, T; Kayama, T; Kobayashi, H; Kobayashi, K; Kochi, M; Kumabe, T; Kuratsu, J; Maruyama, T; Minamida, Y; Mishima, K; Miyakita, Y; Mizusawa, J; Muragaki, Y; Nagane, M; Nakamura, H; Nakazato, Y; Narita, Y; Nishikawa, R; Nomura, K; Ogasawara, K; Sakurada, K; Sasaki, H; Sato, A; Sawamura, Y; Shibui, S; Sumi, M; Takahashi, H; Takahashi, J; Takano, S; Tanaka, K; Todo, T; Tominaga, T; Wakabayashi, T; Yamaki, T; Yazaki, T | 1 |
| Amano, T; Fukui, M; Ikezaki, K; Inamura, T; Inoha, S; Nakamizo, A; Ochi, H | 1 |
| Boiardi, A; Eoli, M; Erbetta, A; Fariselli, L; Salmaggi, A; Silvani, A | 1 |
| Matsumura, A; Nose, T; Takano, S; Tsuboi, K | 1 |
| Bang, JS; Bang, YJ; Choi, IS; Heo, DS; Jung, HW; Kim, DG; Kim, IH; Kim, NK; Kim, S; Kim, TY; Lee, SH; Paek, SH | 1 |
| Anda, T; Hayashi, T; Iseki, M; Kaminogo, M; Shabani, HK; Shibata, S; Tokunaga, Y; Tsunoda, K | 1 |
| Adachi, G; Inoue, O; Ishikawa, Y; Kakinohana, Y; Kin, S; Murayama, S; Ogawa, K; Saito, A; Toita, T; Yoshii, Y | 1 |
| Bamberg, M; Koch, R; Krauseneck, P; Müller, B; Weller, M | 1 |
| Kamiryo, T; Kochi, M; Shinojima, N; Shiraishi, S; Tada, K; Ushio, Y | 1 |
| Shibui, S | 1 |
| Mineta, T; Nakahara, Y; Okamoto, H; Shiraishi, T; Tabuchi, K; Ueda, S | 1 |
| Ernemann, U; Hahn, U; Ritz, R | 1 |
| Bratengeier, K; Flentje, M; Kölbl, O; Ruprecht, K; Vince, GH; Vordermark, D | 1 |
| Gwak, HS; Kim, JH; Kwon, AH; Lee, SH; Rhee, CH; Youn, SM | 1 |
| Weller, M | 1 |
| Abe, T; Miyagi, N; Ogo, E; Shigemori, M; Terasaki, M | 1 |
| Aoki, T; Fukui, T; Hashimoto, N; Hiraoka, M; Ishikawa, M; Matsui, K; Nakashima, Y; Oya, N; Takahashi, JA; Ueba, T | 1 |
| Flentje, M; Kölbl, O; Rieckmann, P; Roggendorf, W; Ruprecht, K; Vince, GH; Vordermark, D; Warmuth-Metz, M | 1 |
| Fukaya, R; Hirose, Y; Ikeda, E; Kawase, T; Takahashi, S | 1 |
| Chang, CC; Gondo, G; Hayashi, A; Ito, S; Kanno, H; Kyuma, Y; Nishimura, S; Ono, A; Sasaki, T; Sato, H; Shimizu, N; Tanaka, M; Yamamoto, I | 1 |
| Hasegawa, A; Kamada, T; Mizoe, JE; Takagi, R; Takakura, K; Tsuji, H; Tsujii, H; Yanagi, T | 1 |
| Berrak, S; Koontz Webb, SE; Wolff, JE; Zhang, M | 1 |
| Adler, JR; Jackson, PS; Lipani, JD; Sato, K; Soltys, SG | 1 |
| Kageyama, N; Kobayashi, T; Yoshida, J | 1 |
| Harada, K; Kiya, K; Uosumi, T | 1 |
| Kohno, T; Shitara, N; Takakura, K | 1 |
| Kageyama, N; Kobayashi, T; Shibuya, N; Yoshida, J | 1 |
| Iwadate, Y; Namba, H; Sueyoshi, K | 1 |
| Akai, F; Ioku, M; Iwasaki, H; Kaetsu, I; Kuroda, R; Nakatani, J; Uchiyama, T | 1 |
| Krossnes, BK; Mella, O; Roszinski, S; Schem, BC | 1 |
| Asai, A; Fujimaki, T; Matsutani, M; Nagashima, T; Nakamura, M; Nakamura, O; Tanaka, H; Tanaka, Y; Ueki, K | 1 |
| Fujita, H; Hotta, T; Ikenaga, M; Ishizaki, K; Isowa, G; Kiya, K; Kurisu, K; Mikami, T; Saito, Y; Uozumi, T | 1 |
| Hertel, A; Kiwit, JC; Matuschek, AE | 1 |
| Kajita, Y; Sugita, K; Wakabayashi, T; Yoshida, J | 1 |
| Kayama, T; Kumabe, T; Mizoi, K; Yoshimoto, T | 1 |
| Izumu, I; Kowada, M; Mineura, K; Watanabe, K | 1 |
| Kochi, M; Kuratsu, J; Mihara, Y; Seto, H; Takaki, S; Uemura, S; Ushio, Y | 1 |
| Abe, H; Aida, T; Ikeda, J; Kaneko, S; Kashiwaba, T; Kawamoto, T; Mitsumori, K; Saitoh, H; Sawamura, Y | 1 |
| Gomi, A; Hirai, H; Masuzawa, T; Ozawa, K; Sakai, R; Shinoda, S | 1 |
| Diete, S; Dietzmann, K; Kirches, E; von Bossanyi, P; Warich-Kirches, M | 1 |
| Aoki, H; Nakamura, M; Ohnishi, K; Ohnishi, T; Sakaki, T; Takahashi, A; Wang, X | 1 |
| Damian, MS; Leweke, F; Schachenmayr, W; Schindler, C | 1 |
| Flores, LG; Futami, S; Jinnouchi, S; Kawano, H; Kodama, T; Nagamachi, S; Nakahara, H; Ohnishi, T; Tamura, S; Wakisaka, S; Watanabe, K; Yokogami, K | 1 |
| Hirano, Y; Mineura, K; Mizoi, K; Tomura, N | 1 |
| Hori, S; Kawashima, H; Mori, T; Morikawa, N; Takeyama, M | 1 |
| Abe, T; Cole, SP; Hori, S; Koike, K; Kuwano, M; Mori, T; Nakagawa, M; Wakabayashi, Y | 1 |
| Asai, A; Kirino, T; Kuchino, Y; Narita, Y | 1 |
| Abe, T; Hori, S; Kawashima, H; Mori, T; Morikawa, N; Takeyama, M | 1 |
| Anders, K; Fahlbusch, R; Fietkau, R; Grabenbauer, GG; Krauseneck, P; Sauer, R; Schuchardt, U | 1 |
| Ikeda, J | 1 |
| Deininger, MH; Grote, E; Meyermann, R; Wickboldt, J | 1 |
| Goto, T; Iwasaki, T; Kimura, T; Kino, T; Kitamura, I; Kochii, M; Kuratsu, J; Nishi, T; Saito, Y; Shiraishi, S; Tada, K; Takeshima, H; Uemura, S; Ushio, Y; Yamamoto, K | 1 |
| Abe, H; Ikota, T; Iwasaki, Y; Ohkata, N; Sawamura, Y; Tashiro, T; Yamazaki, M | 1 |
| Fujiwara, T; Honma, Y; Matsumoto, Y; Mino, S; Nagao, S; Tsuchida, T | 1 |
| Capelle, L; Chatellier, G; Chiras, J; Cornu, P; Davila, L; Delattre, JY; Fauchon, F; Poisson, M; Vega, F | 1 |
| Akatsuka, K; Hokama, Y; Hori, T; Numata, H; Tabuchi, S; Takigawa, H; Tanaka, S; Watanabe, K | 1 |
| Hoshi, A; Kakuto, Y; Kayama, T; Nemoto, K; Ogawa, Y; Sakamoto, K; Takai, Y; Yamada, S; Yoshimoto, T | 1 |
| Fujita, T; Furuta, Y; Murasawa, A; Nakagawa, H; Nakajima, S; Nakamura, H; Niiyama, K; Shibata, H; Taki, T; Tsuruzono, K | 1 |
| Kagawa, Y; Miyagami, M; Tazoe, M; Tsubokawa, T | 1 |
| Andoh, T; Hirata, T; Miwa, Y; Nishimura, Y; Sakai, N; Shimizu, K; Yamada, H; Yanagawa, S | 1 |
| Abe, H; Aida, T; Ikoda, T; Itoh, T; Kaneko, S; Kashiwaba, T; Kawamoto, T; Sugimoto, S; Tokuda, K; Ueno, K | 1 |
| Maruo, K; Nakamura, O; Nomura, K; Takakura, K; Ueyama, Y | 1 |
| Cravioto, H; Kida, Y | 1 |
| Handa, Y; Hayashi, M; Ishikura, A; Itoh, H; Kabuto, M; Kawano, H; Kobayashi, H; Kubota, T; Yamamoto, S; Yamashima, T | 1 |
| Fields, WS; Iwata, K; Yung, WK | 1 |
| Bamberg, M; Budach, W; Sprengel, M; Strehl, K; Stuschke, M | 1 |
| Fukamachi, A; Kimurat, R; Naganuma, H; Nukui, H; Sasaki, A; Tasaka, K | 1 |
| Bock, WJ; Kiwit, JC; Lins, E; Roosen, N; Schirmer, M | 1 |
| Bock, WJ; Feinendegen, LE; Herzog, H; Kiwit, JC; Kuwert, T; Langen, KJ; Muzik, O; Roosen, N; Rota Kops, E | 1 |
| Kageyama, N; Kito, A; Yoshida, J | 1 |
| Furuta, Y; Masaoka, T; Murasawa, A; Nakagawa, H; Nakajima, S; Nakamura, H; Niiyama, K; Shibata, H; Taki, T | 1 |
| Koga, K; Nishikawa, K; Wakisaka, S; Watanabe, K | 1 |
| Kagawa, Y; Miyagami, M; Tsubokawa, T | 1 |
| Abe, H; Kitamura, K; Matsutani, M; Miwa, T; Nomura, K; Suzuki, J; Takakura, K; Takeuchi, K; Tanaka, R; Ushio, Y | 1 |
| Jaksche, H; Loew, F; Papavero, L | 1 |
2 review(s) available for nimustine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Cervical intramedullary glioblastoma: report of a long-term survival case and a review of the literature.
Topics: Antineoplastic Agents; Cervical Vertebrae; Diagnosis, Differential; Dose Fractionation, Radiation; Fatal Outcome; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Neurosurgical Procedures; Nimustine; Spinal Cord Neoplasms; Time Factors; Young Adult | 2008 |
[Standards and new developments in the chemotherapy of glioblastomas].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Cytarabine; Dacarbazine; Decanoic Acids; DNA Modification Methylases; Glioblastoma; Humans; Nimustine; Polyesters; Promoter Regions, Genetic; Temozolomide; Teniposide | 2005 |
22 trial(s) available for nimustine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Granulocyte-macrophage colony stimulating factor enhances efficacy of nimustine rendezvousing with temozolomide plus irradiation in patients with glioblastoma.
Topics: Brain Neoplasms; Glioblastoma; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Humans; Macrophage Colony-Stimulating Factor; Neutropenia; Nimustine; Temozolomide; Thrombocytopenia | 2023 |
Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Dexamethasone; Dose Fractionation, Radiation; Female; Glioblastoma; Glucocorticoids; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Middle Aged; Nimustine; Prednisolone; Proton Therapy; Protons; Radiation Injuries; Supratentorial Neoplasms; Survival Rate; Tumor Burden | 2010 |
Phase II trial of radiotherapy after hyperbaric oxygenation with multiagent chemotherapy (procarbazine, nimustine, and vincristine) for high-grade gliomas: long-term results.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dose Fractionation, Radiation; Female; Follow-Up Studies; Glioblastoma; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Multivariate Analysis; Nimustine; Procarbazine; Radiation Tolerance; Supratentorial Neoplasms; Vincristine; Young Adult | 2012 |
Human umbilical vein endothelial cell vaccine therapy in patients with recurrent glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cancer Vaccines; Chemotherapy, Adjuvant; Dacarbazine; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Immunotherapy, Active; Male; Middle Aged; Nimustine; Temozolomide | 2013 |
Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Glioblastoma; Humans; Male; Middle Aged; Nimustine; Procarbazine | 2013 |
Intra-arterial ACNU and carboplatin versus intravenous chemotherapy with cisplatin and BCNU in newly diagnosed patients with glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Cisplatin; Drug Administration Routes; Female; Glioblastoma; Humans; Injections, Intra-Arterial; Injections, Intravenous; Karnofsky Performance Status; Male; Middle Aged; Nimustine | 2002 |
Phase II study of chemotherapy with ACNU plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Nimustine; Survival Analysis | 2002 |
Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant glioma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Disease Progression; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Prognosis; Prospective Studies; Survival Analysis; Teniposide; Treatment Outcome | 2003 |
Randomized controlled trial on malignant brain tumors--activities of the Japan Clinical Oncology Group-Brain Tumor Study Group.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Glioblastoma; Humans; Nimustine; Procarbazine | 2004 |
Feasibility and response to 1-(4-amino-2-methyl-5-pyrimidynyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride chemotherapy with pre-treated procarbazine for elderly patients with newly diagnosed glioblastoma.
Topics: Aged; Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Benzylisoquinolines; Brain Neoplasms; Disease-Free Survival; Feasibility Studies; Female; Glioblastoma; Humans; Male; Middle Aged; Neutropenia; Nimustine; Procarbazine; Survival Analysis; Treatment Outcome; Vincristine | 2007 |
Phase II study of nimustine, carboplatin, vincristine, and interferon-beta with radiotherapy for glioblastoma multiforme: experience of the Kyoto Neuro-Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Drug Tolerance; Female; Glioblastoma; Humans; Interferon-beta; Male; Middle Aged; Nimustine; Vincristine | 2006 |
Phase I/II clinical trial of carbon ion radiotherapy for malignant gliomas: combined X-ray radiotherapy, chemotherapy, and carbon ion radiotherapy.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carbon Radioisotopes; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Radiotherapy Dosage | 2007 |
Radiation therapy combined with radiosensitizing agents for cerebral glioblastoma in adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Middle Aged; Nicardipine; Nimustine; Radiation-Sensitizing Agents; Survival Analysis; Vincristine | 1994 |
Long-term follow-up results of 175 patients with malignant glioma: importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Female; Follow-Up Studies; Glioblastoma; Humans; Infant; Interferon-beta; Male; Middle Aged; Nimustine; Postoperative Complications; Radiotherapy, Adjuvant; Survival Rate | 1994 |
Phase II study of DTIC, ACNU, and vincristine combination chemotherapy for supratentorial malignant astrocytomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Child; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Radiation Dosage; Supratentorial Neoplasms; Treatment Outcome; Vincristine | 1996 |
Therapeutic results of intra-arterial chemotherapy in patients with malignant glioma.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Humans; Injections, Intra-Arterial; Injections, Intravenous; Male; Middle Aged; Nimustine; Survival Analysis | 1998 |
Accelerated radiotherapy with concomitant ACNU/Ara-C for the treatment of malignant glioma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Cytarabine; Female; Glioblastoma; Humans; Male; Middle Aged; Nimustine; Radiotherapy; Survival Rate | 2000 |
Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma.
Topics: Adolescent; Adult; Aged; Aging; Antineoplastic Agents; Brain Neoplasms; Disease Progression; Female; Glioblastoma; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Middle Aged; Nimustine; Proportional Hazards Models; Prospective Studies; Survival Analysis | 2000 |
Treatment of malignant gliomas with surgery, intraarterial chemotherapy with ACNU and radiation therapy.
Topics: Adult; Aged; Astrocytoma; Chemotherapy, Adjuvant; Clinical Protocols; Combined Modality Therapy; Eye Diseases; Female; Glioblastoma; Humans; Infusions, Intra-Arterial; Male; Methylprednisolone; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Supratentorial Neoplasms; Survival Analysis | 1992 |
Preventive effects of interleukin 1 beta for ACNU-induced myelosuppression in malignant brain tumors: the experimental and preliminary clinical studies.
Topics: Aged; Agranulocytosis; Animals; Brain Neoplasms; Combined Modality Therapy; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Immunologic Factors; Interleukin-1; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Nimustine; Recombinant Proteins; Remission Induction; Thrombocytopenia; Transplantation, Heterologous; Vincristine | 1992 |
Intraoperative radiation therapy for malignant glioma.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Humans; Intraoperative Care; Life Tables; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Survival Rate | 1991 |
[Evaluation of ACNU alone and combined with tegafur as additions to radiotherapy of the treatment of malignant gliomas--a cooperative clinical trial].
Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Radiotherapy Dosage; Tegafur | 1985 |
74 other study(ies) available for nimustine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Lomustine and nimustine exert efficient antitumor effects against glioblastoma models with acquired temozolomide resistance.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Histones; Humans; Injections, Intraperitoneal; Lomustine; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Nimustine; Salvage Therapy; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2021 |
Enhanced antitumor effects of radiotherapy combined local nimustine delivery rendezvousing with oral temozolomide chemotherapy in glioblastoma patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Combined Modality Therapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Nimustine; Proportional Hazards Models; Quality of Life; Radiotherapy; Temozolomide; Tomography, X-Ray Computed; Treatment Outcome | 2018 |
Comparison of the clinical efficacy of temozolomide (TMZ) versus nimustine (ACNU)-based chemotherapy in newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Middle Aged; Nimustine; Survival Analysis; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2014 |
Treatment results of glioblastoma during the last 30 years in a single institute.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Craniotomy; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Hospitals, University; Humans; Japan; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Neuronavigation; Nimustine; Prognosis; Retrospective Studies; Temozolomide; Treatment Outcome | 2013 |
Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Nucleus; Comet Assay; Dacarbazine; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Proteins; Nimustine; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Signal Transduction; Temozolomide; Up-Regulation | 2015 |
Proton beam therapy with concurrent chemotherapy for glioblastoma multiforme: comparison of nimustine hydrochloride and temozolomide.
Topics: Adult; Aged; Antineoplastic Agents; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Nimustine; Proton Therapy; Retrospective Studies; Temozolomide; Treatment Outcome; Young Adult | 2016 |
Methylation status of the MGMT gene promoter fails to predict the clinical outcome of glioblastoma patients treated with ACNU plus cisplatin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Cisplatin; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Male; Middle Aged; Nimustine; Predictive Value of Tests; Promoter Regions, Genetic; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2009 |
Coincidence of central neurocytoma and multiple glioblastomas: a rare case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Lineage; Combined Modality Therapy; Cranial Irradiation; Electroencephalography; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Neoplasms, Multiple Primary; Neurocytoma; Neurosurgical Procedures; Nimustine; Tomography, X-Ray Computed; Vincristine | 2009 |
Nimustine (ACNU) plus teniposide (VM26) in recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Retrospective Studies; Teniposide | 2009 |
Preradiation chemotherapy with ACNU-CDDP in patients with newly diagnosed glioblastoma: a retrospective analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Dacarbazine; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Staging; Nimustine; Retrospective Studies; Salvage Therapy; Survival Analysis; Temozolomide | 2009 |
Long-term survivors of glioblastoma: clinical features and molecular analysis.
Topics: Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Protocols; Biomarkers, Tumor; Brain Neoplasms; Combined Modality Therapy; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Male; Middle Aged; Neurosurgical Procedures; Nimustine; Prognosis; Promoter Regions, Genetic; Radiotherapy; Retrospective Studies; Survival Rate; Time Factors; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2009 |
Changes of the O6-methylguanine-DNA methyltransferase promoter methylation and MGMT protein expression after adjuvant treatment in glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Immunohistochemistry; Male; Microsurgery; Middle Aged; Neoplasm Recurrence, Local; Neurosurgical Procedures; Nimustine; Polymerase Chain Reaction; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Reoperation; Temozolomide; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2010 |
Radiation-induced glioblastoma occurring 35 years after radiation therapy for medulloblastoma: case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Glioblastoma; Humans; Male; Medulloblastoma; Neoplasms, Second Primary; Neurosurgical Procedures; Nimustine; Procarbazine; Radiotherapy; Time Factors; Treatment Outcome; Vincristine | 2010 |
DNA ligase IV is a potential molecular target in ACNU sensitivity.
Topics: Animals; Antineoplastic Agents; Cell Line; DNA Breaks, Double-Stranded; DNA Helicases; DNA Ligase ATP; DNA Ligases; DNA Repair; Glioblastoma; Humans; Mice; Nimustine; Nuclear Proteins | 2010 |
Decreasing expression of the interleukin-13 receptor IL-13Ralpha2 in treated recurrent malignant gliomas.
Topics: Actins; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Exotoxins; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunotoxins; Interleukin-13; Interleukin-13 Receptor alpha2 Subunit; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Recombinant Fusion Proteins; RNA; Teniposide; Young Adult | 2010 |
Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride.
Topics: Adolescent; Antineoplastic Agents; Brain Stem Neoplasms; Cerebellar Neoplasms; Chemotherapy, Adjuvant; Convection; Cranial Irradiation; Drug Delivery Systems; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Neoplasm Recurrence, Local; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Nimustine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereotaxic Techniques | 2011 |
FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.
Topics: Animals; BRCA2 Protein; Cell Line; Dacarbazine; DNA Damage; DNA Repair; Down-Regulation; Fanconi Anemia; Gene Silencing; Glioblastoma; Humans; Mice; Models, Biological; Nimustine; Rad51 Recombinase; Recombination, Genetic; RNA, Small Interfering; Temozolomide | 2011 |
[Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].
Topics: Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Child; Cisplatin; Dacarbazine; Disease-Free Survival; Female; Glioblastoma; Glioma; Humans; Infusions, Intravenous; Male; Nausea; Neutropenia; Nimustine; Temozolomide; Teniposide; Thrombocytopenia; Young Adult | 2011 |
Suppression of Cdc2 dephosphorylation at the tyrosine 15 residue during nitrosourea-induced G2M phase arrest in glioblastoma cell lines.
Topics: Blotting, Western; CDC2 Protein Kinase; Cell Division; Flow Cytometry; G2 Phase; Glioblastoma; Humans; Nimustine; Phosphorylation; Tumor Cells, Cultured; Tyrosine | 2002 |
Anti-vascular endothelial growth factor antibody and nimustine as combined therapy: effects on tumour growth and angiogenesis in human glioblastoma xenografts.
Topics: Animals; Antibodies; Antineoplastic Combined Chemotherapy Protocols; Endothelial Growth Factors; Glioblastoma; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Nimustine; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2003 |
Relationship between expression of O6-methylguanine-DNA methyltransferase, glutathione-S-transferase pi in glioblastoma and the survival of the patients treated with nimustine hydrochloride: an immunohistochemical analysis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Drug Resistance, Neoplasm; Female; Glioblastoma; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Immunohistochemistry; Isoenzymes; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Retrospective Studies; Survival Rate | 2003 |
Prospective trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Hyperbaric Oxygenation; Japan; Male; Middle Aged; Nimustine; Procarbazine; Prospective Studies; Supratentorial Neoplasms; Survival Rate; Vincristine | 2003 |
Correlation between promoter hypermethylation of the O6-methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl)methyl
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; DNA Methylation; Female; Glioblastoma; Humans; Male; Middle Aged; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Retrospective Studies | 2004 |
Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Brain Neoplasms; Dexamethasone; Drug Resistance, Neoplasm; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation | 2004 |
[Glioblastoma multiforme of the optic nerve].
Topics: Antineoplastic Agents; Contrast Media; Diagnosis, Differential; Follow-Up Studies; Gadolinium DTPA; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nimustine; Optic Nerve; Optic Nerve Neoplasms; Teniposide; Time Factors | 2004 |
Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma.
Topics: Antineoplastic Agents; Brain Neoplasms; Disease Progression; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Glioblastoma; Glioma; Humans; Neoplasm Recurrence, Local; Nimustine; Prognosis; Radiosurgery; Radiotherapy; Recurrence; Stereotaxic Techniques; Teniposide; Time Factors; Treatment Outcome | 2005 |
ACNU-cisplatin continuous infusion chemotherapy as salvage therapy for recurrent glioblastomas: phase II study.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Cisplatin; Clinical Trials, Phase II as Topic; Cohort Studies; Drug Therapy, Combination; Female; Glioblastoma; Humans; In Vitro Techniques; Korea; Magnetic Resonance Imaging; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Salvage Therapy; Survival Analysis; Tomography, X-Ray Computed | 2005 |
Glioblastoma multiforme with oligodendroglial component (GBMO): favorable outcome after post-operative radiotherapy and chemotherapy with nimustine (ACNU) and teniposide (VM26).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Craniotomy; Disease Progression; Disease-Free Survival; Female; Glioblastoma; Humans; Life Tables; Male; Middle Aged; Nimustine; Oligodendroglia; Oligodendroglioma; Prognosis; Radiotherapy, Adjuvant; Survival Analysis; Teniposide; Treatment Outcome | 2006 |
Chromosome arm 1q gain associated with good response to chemotherapy in a malignant glioma. Case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chromosome Aberrations; Chromosomes, Human, Pair 1; Glioblastoma; Humans; Male; Nimustine; Peplomycin; Treatment Outcome; Vincristine | 2007 |
Collagen gel matrix assay as an in vitro chemosensitivity test for malignant astrocytic tumors.
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Carboplatin; Central Nervous System Neoplasms; Cisplatin; Collagen; Disease Progression; Disease-Free Survival; Drug Screening Assays, Antitumor; Etoposide; Female; Fibrin Foam; Follow-Up Studies; Glioblastoma; Humans; Japan; Karnofsky Performance Status; Male; Middle Aged; Nimustine; Sensitivity and Specificity; Survival Analysis; Tissue Adhesives; Treatment Outcome; Tumor Burden; Tumor Cells, Cultured | 2007 |
Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Cohort Studies; Data Interpretation, Statistical; Databases, Factual; Female; Glioblastoma; Glioma; Humans; Lomustine; Male; Nimustine; Nitrosourea Compounds; Reproducibility of Results; Selection Bias; Survival Analysis; Treatment Outcome | 2008 |
Survival following CyberKnife radiosurgery and hypofractionated radiotherapy for newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Nimustine; Radiosurgery; Radiotherapy; Retrospective Studies; Vincristine | 2008 |
Multimodality treatment of malignant glioma. Effect of chemotherapy with ACNU and immunotherapy with N-CWS.
Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Child; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds | 1984 |
Pharmacokinetics of a new water-soluble nitrosourea derivative (ACNU) in human gliomas.
Topics: Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Glioblastoma; Glioma; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Tissue Distribution | 1981 |
[Adjuvant immunotherapy with levamisole for malignant glioma].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Bromodeoxyuridine; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Glioblastoma; Humans; Levamisole; Male; Middle Aged; Nimustine; Nitrosourea Compounds; Vincristine | 1983 |
[Anti-tumor activity of ACNU against malignant glioma--a clinical application of in vitro sensitivity test of chemotherapeutic agent].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Nitrosourea Compounds | 1983 |
Intra-arterial ACNU and cisplatin chemotherapy for the treatment of glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Supratentorial Neoplasms; Survival Rate; Tomography, X-Ray Computed | 1995 |
Interstitial chemotherapy with biodegradable ACNU pellet for glioblastoma.
Topics: Adult; Aged; Animals; Biodegradation, Environmental; Brain Neoplasms; Drug Implants; Female; Glioblastoma; Humans; Lactates; Lactic Acid; Male; Middle Aged; Nimustine; Polyesters; Polymers; Rats; Rats, Wistar | 1994 |
Timing of hypertonic glucose and thermochemotherapy with 1-(4-amino-2-methylpyrimidine-5-yl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in the BT4An rat glioma: relation to intratumoral pH reduction and circulatory changes after glucose supply.
Topics: Animals; Antineoplastic Agents; Carmustine; Combined Modality Therapy; Drug Administration Schedule; Glioblastoma; Glucose Solution, Hypertonic; Hydrogen-Ion Concentration; Hyperthermia, Induced; Nimustine; Rats; Rats, Inbred Strains; Tumor Cells, Cultured | 1995 |
O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications.
Topics: Astrocytoma; Brain Neoplasms; Combined Modality Therapy; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Enzyme Induction; Glioblastoma; Glioma; Humans; Methyltransferases; Neoplasm Proteins; Neoplasm Recurrence, Local; Nimustine; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Tetrazolium Salts; Thiazoles | 1994 |
Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cisplatin; Drug Resistance; Glioblastoma; Humans; Immunoenzyme Techniques; Nimodipine; Nimustine; Phenotype; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
[Follow-up study of malignant astrocytomas showing complete response after initial treatment].
Topics: Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Nimustine; Prognosis; Radiography; Radiotherapy Dosage; Remission Induction | 1994 |
Characterization and chemosensitivity of two cell lines derived from human glioblastomas.
Topics: Animals; Brain Neoplasms; Drug Resistance; Ethylnitrosourea; Female; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Karyotyping; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasm Transplantation; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Occipital Lobe; Parietal Lobe; S100 Proteins; Tumor Cells, Cultured | 1993 |
Ventriculolumbar perfusion of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosou rea hydrochloride.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebellar Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Ependymoma; Female; Follow-Up Studies; Glioblastoma; Half-Life; Humans; Injections, Intraventricular; Injections, Spinal; Male; Medulloblastoma; Meningeal Neoplasms; Metabolic Clearance Rate; Neoplasm Recurrence, Local; Neuroectodermal Tumors; Nimustine; Prohibitins; Subarachnoid Space; Survival Rate | 1993 |
Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Southern; Cell Line; DNA Polymerase I; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Nimustine; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Immunohistochemical expression of P-glycoprotein and glutathione S-transferases in cerebral gliomas and response to chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Drug Resistance, Neoplasm; Glioblastoma; Glutathione Transferase; Humans; Immunohistochemistry; Isoenzymes; Karnofsky Performance Status; Nimustine; Teniposide | 1997 |
p53-independent WAF1 induction by ACNU in human glioblastoma cells.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression Regulation, Neoplastic; Genes, p53; Glioblastoma; Humans; Nimustine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Multidrug resistance in glioblastoma. Chemosensitivity testing and immunohistochemical demonstration of P-glycoprotein.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Neoplasms; Carmustine; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glioblastoma; Immunohistochemistry; Methotrexate; Mitoxantrone; Nimustine; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1998 |
[Evaluation of brain tumor by 99mTc-MIBI: comparison study with 201Tl and predictivity of therapeutic effect].
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Glioblastoma; Humans; Middle Aged; Nimustine; Predictive Value of Tests; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Thallium; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon | 1998 |
Pharmacokinetics of anticancer drugs in cerebrospinal fluid.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Administration Routes; Female; Glioblastoma; Humans; Injections, Spinal; Methotrexate; Nimustine; Perfusion | 1998 |
Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Child; Doxorubicin; Etoposide; Female; Gene Expression Regulation, Neoplastic; Genes, MDR; Glioblastoma; Humans; Male; Middle Aged; Nimustine; RNA, Messenger; RNA, Neoplasm; Vincristine | 1998 |
Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cisplatin; Dactinomycin; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Glioblastoma; Humans; Nimustine; Staurosporine; Tumor Cells, Cultured | 2000 |
Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Glioblastoma; Humans; Methotrexate; Nimustine; Valproic Acid | 2000 |
[Roles of p53 in chemotherapy of glioblastoma].
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cisplatin; Etoposide; Flow Cytometry; Glioblastoma; Nimustine; Paclitaxel; Polymerase Chain Reaction; Temperature; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Distinct radiochemotherapy protocols differentially influence cellular proliferation and expression of p53 and Bcl-2 in glioblastoma multiforme relapses in vivo.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers; Brain Neoplasms; Cell Division; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes; Genes, bcl-2; Glioblastoma; GTP-Binding Proteins; Humans; Ki-67 Antigen; Life Tables; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Nimustine; Protein Glutamine gamma Glutamyltransferase 2; Proto-Oncogene Proteins c-bcl-2; Radiotherapy, Adjuvant; Survival Analysis; Teniposide; Transglutaminases; Tumor Suppressor Protein p53 | 2000 |
[A case of spinal cord glioblastoma multiforme].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Glioblastoma; Humans; Immunotherapy, Adoptive; Killer Cells, Lymphokine-Activated; Neoplasm Recurrence, Local; Nimustine; Spinal Cord Neoplasms; Vincristine | 1992 |
[Intra-arterial chemotherapy with ACNU in the treatment of malignant gliomas].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Carotid Artery, Internal; Female; Glioblastoma; Glioma; Humans; Infant, Newborn; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Prognosis; Tomography, X-Ray Computed | 1992 |
Treatment results by uneven fractionated irradiation, low-dose rate telecobalt therapy as a boost, and intraoperative irradiation for malignant glioma.
Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Child; Child, Preschool; Cobalt Radioisotopes; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Necrosis; Nimustine; Prognosis; Radioisotope Teletherapy; Regression Analysis | 1992 |
[Treatment of malignant gliomas by selective intraarterial infusion chemotherapy with high-dose ACNU and autologous bone marrow transplantation--preliminary report].
Topics: Adolescent; Adult; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Transplantation, Autologous | 1991 |
Intra-arterial ACNU chemotherapy employing 20% mannitol osmotic blood-brain barrier disruption for malignant brain tumors.
Topics: Adolescent; Adult; Aged; Blood-Brain Barrier; Brain Neoplasms; Child; Electroencephalography; Female; Glioblastoma; Humans; Infusions, Intra-Arterial; Male; Mannitol; Middle Aged; Nimustine; Osmotic Pressure; Tomography, X-Ray Computed | 1990 |
[Combined postoperative radiotherapy and chemotherapy for malignant gliomas].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Nimustine; Proteoglycans; Retrospective Studies; Survival Rate; Vincristine | 1990 |
[Antineoplastic effect of Hu-IFN-beta and other anticancer drugs on malignant brain tumors in athymic nude mice].
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Ependymoma; Glioblastoma; Glioma; Interferon Type I; Mice; Mice, Inbred BALB C; Mice, Nude; Nimustine; Nitrosourea Compounds; Vincristine | 1985 |
Comparative study of chemotherapy and/or immunotherapy of established experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Combined Modality Therapy; Glioblastoma; Immunotherapy; Male; Nimustine; Nitrosourea Compounds; Propionibacterium acnes; Rats; Rats, Inbred Strains | 1985 |
[Evaluation of ACNU and 5-FU in the treatment of gliomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Glioblastoma; Humans; Male; Nimustine; Nitrosourea Compounds; Picibanil | 1986 |
In vitro effects of ACNU, BCNU, CDDP, and bleomycin on human glioma cells.
Topics: Antineoplastic Agents; Bleomycin; Brain Neoplasms; Carmustine; Cell Line; Cisplatin; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Nimustine; Tumor Cells, Cultured | 1988 |
Treatment of high grade glioma xenografts with nitrosoureas in nude mice.
Topics: Animals; Carmustine; Glioblastoma; Glioma; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Nimustine; Oligodendroglioma; Transplantation, Heterologous | 1989 |
Complete remission of recurrent glioblastoma multiforme following local infusions of lymphokine activated killer cells. Case report.
Topics: Adult; Brain Neoplasms; Combined Modality Therapy; Frontal Lobe; Glioblastoma; Humans; Immunization, Passive; Interferon Type I; Interleukin-2; Killer Cells, Natural; Male; Neoplasm Recurrence, Local; Nimustine; Parietal Lobe; Postoperative Complications; Recombinant Proteins | 1989 |
Adjuvant intraarterial chemotherapy with nimustine in the management of World Health Organization Grade IV gliomas of the brain. Experience at the Department of Neurosurgery of Düsseldorf University.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Neoplasm Staging; Nimustine; Radiotherapy Dosage; World Health Organization | 1989 |
Early effects of intra-arterial chemotherapy in patients with brain tumours studied with PET: preliminary results.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Deoxy Sugars; Deoxyglucose; Female; Fluorine Radioisotopes; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nimustine; Predictive Value of Tests; Prognosis; Tomography, Emission-Computed | 1989 |
[Controlled multimodality treatment of brain stem gliomas].
Topics: Adolescent; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Interferon Type I; Male; Nimustine; Nitrosourea Compounds; Radiotherapy Dosage | 1987 |
[Treatment of malignant gliomas with high-dose ACNU and autologous bone marrow transplantation].
Topics: Antineoplastic Agents; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Glioblastoma; Glioma; Humans; Male; Middle Aged; Nimustine; Transplantation, Autologous | 1988 |
[Radiotherapy of astrocytoma].
Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Combined Modality Therapy; Glioblastoma; Humans; Nimustine; Prognosis; Radiotherapy Dosage; Remission Induction | 1988 |
[ACNU delivery to malignant glioma tissue by osmotic blood brain barrier modification with intracarotid infusion of hyperosmoral mannitol].
Topics: Adult; Aged; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Cerebral Cortex; Combined Modality Therapy; Female; Glioblastoma; Humans; Infusions, Intra-Arterial; Male; Mannitol; Middle Aged; Nimustine; Nitrosourea Compounds; Osmolar Concentration | 1985 |
Intracarotid infusion of ACNU and BCNU as adjuvant therapy of malignant gliomas. Clinical aspects and critical considerations.
Topics: Astrocytoma; Brain Neoplasms; Carmustine; Carotid Arteries; Combined Modality Therapy; Follow-Up Studies; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Neoplasm Recurrence, Local; Nimustine; Nitrosourea Compounds; Oligodendroglioma | 1987 |