nimodipine and Stroke
nimodipine has been researched along with Stroke in 24 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Very Early Nimodipine Use in Stroke (VENUS) trial was designed to test the hypothesis that early treatment with nimodipine has a positive effect on survival and functional outcome after stroke." | 9.09 | Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial. ( de Haan , RJ; Horn, J; Limburg, M; Vermeulen, M, 2001) |
| "The treatment of vasospasms during endovascular stroke treatment (EST) with intra-arterial nimodipine (NM) is routinely performed." | 8.31 | Effect of intra-arterial nimodipine on iatrogenic vasospasms during endovascular stroke treatment - angiographic resolution and infarct growth in follow-up imaging. ( Bendszus, M; Chen, M; Do, TD; Jesser, J; Möhlenbruch, MA; Potreck, A; Schönenberger, S; Seker, F; Vollherbst, D; Weyland, CS, 2023) |
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 7.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| "A comparative study of pharmacodynamics and clinical efficacy of nimodipine, nifedipine and foridon in ischemic stroke (late recovery and residual period) was performed in 97 patients with ischemic stroke." | 7.71 | [Comparative clinico-pharmacological characteristics of nimodipine, nifedipine and foridon in the treatment of patients with ischemic stroke in late rehabilitative and residual periods]. ( Kurkova, KS; Svetyĭ, LI, 2002) |
| "Nifedipine and nimodipine, dihydropyridine calcium channel blockers, are commonly used as antihypertensive and antianginal agents in patients at risk for stroke." | 7.70 | Nifedipine and nimodipine competitively inhibit uridine kinase and orotidine-phosphate decarboxylase: theoretical relevance to poor outcome in stroke. ( Najarian, T; Traut, TW, 2000) |
| "INWEST enrolled acute ischaemic stroke patients within 24 h (n = 295) to the following groups: placebo (n = 100), 1 mg/h nimodipine (n = 101) or 2 mg/h nimodipine (n = 94)." | 5.10 | Effects of blood pressure lowering in the acute phase of total anterior circulation infarcts and other stroke subtypes. ( Ahmed, N; Wahlgren, NG, 2003) |
| "The Very Early Nimodipine Use in Stroke (VENUS) trial was designed to test the hypothesis that early treatment with nimodipine has a positive effect on survival and functional outcome after stroke." | 5.09 | Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial. ( de Haan , RJ; Horn, J; Limburg, M; Vermeulen, M, 2001) |
| "An observational study based on the data from the Intravenous Nimodipine West European Stroke Trial (INWEST)." | 5.09 | High initial blood pressure after acute stroke is associated with poor functional outcome. ( Ahmed, N; Wahlgren, G, 2001) |
| "The treatment of vasospasms during endovascular stroke treatment (EST) with intra-arterial nimodipine (NM) is routinely performed." | 4.31 | Effect of intra-arterial nimodipine on iatrogenic vasospasms during endovascular stroke treatment - angiographic resolution and infarct growth in follow-up imaging. ( Bendszus, M; Chen, M; Do, TD; Jesser, J; Möhlenbruch, MA; Potreck, A; Schönenberger, S; Seker, F; Vollherbst, D; Weyland, CS, 2023) |
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 3.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| "A comparative study of pharmacodynamics and clinical efficacy of nimodipine, nifedipine and foridon in ischemic stroke (late recovery and residual period) was performed in 97 patients with ischemic stroke." | 3.71 | [Comparative clinico-pharmacological characteristics of nimodipine, nifedipine and foridon in the treatment of patients with ischemic stroke in late rehabilitative and residual periods]. ( Kurkova, KS; Svetyĭ, LI, 2002) |
| "Nifedipine and nimodipine, dihydropyridine calcium channel blockers, are commonly used as antihypertensive and antianginal agents in patients at risk for stroke." | 3.70 | Nifedipine and nimodipine competitively inhibit uridine kinase and orotidine-phosphate decarboxylase: theoretical relevance to poor outcome in stroke. ( Najarian, T; Traut, TW, 2000) |
| "Male Sprague-Dawley rats under permanent middle cerebral artery occlusion (pMCAO) model, randomly assigned as: model, sham, nimodipine (0." | 3.11 | The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway. ( Fu, Y; Li, D; Liu, Q; Wang, H; Wang, W; Zhang, T; Zhang, Y, 2022) |
| "Nimodipine is a dihydropyridine calcium channel antagonist that blocks the flux of extracellular calcium through L-type, voltage-gated calcium channels." | 2.66 | Nimodipine Reappraised: An Old Drug With a Future. ( Carlson, AP; Hänggi, D; Macdonald, RL; Shuttleworth, CW, 2020) |
| "Aneurysmal subarachnoid hemorrhage (aSAH) represents 3% of all strokes in the US." | 2.58 | Investigational drugs for vasospasm after subarachnoid hemorrhage. ( Freeman, WD; Pizzi, MA; Tallarico, RT, 2018) |
| "In acute intracerebral hemorrhage the beneficial effect of recombinant coagulation factor VII found in a small study could not be proved in a large phase III trial." | 2.45 | [Pharmacotherapy of stroke]. ( Bereczki, D, 2009) |
| "Pediatric stroke is considered an infrequent complication of COVID-19." | 1.72 | Clinical improvement of a toddler with COVID-19 focal cerebral arteriopathy possibly due to intra-arterial nimodipine. ( Aharoni, S; Auriel, E; Avital, D; Bulkowstein, Y; Inbar, E; Konen, O; Nahum, E; Nevo, Y; Peretz, S; Perlow, E; Straussberg, R; Vig, LC, 2022) |
Research
Studies (24)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 6 (25.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zhao, X | 1 |
| Liu, J | 3 |
| Yang, L | 1 |
| Niu, Y | 1 |
| Ren, R | 1 |
| Su, C | 1 |
| Wang, Y | 2 |
| Chen, J | 1 |
| Ma, X | 1 |
| Avital, D | 1 |
| Peretz, S | 1 |
| Perlow, E | 1 |
| Konen, O | 1 |
| Inbar, E | 1 |
| Bulkowstein, Y | 1 |
| Nahum, E | 1 |
| Aharoni, S | 1 |
| Vig, LC | 1 |
| Nevo, Y | 1 |
| Auriel, E | 1 |
| Straussberg, R | 1 |
| Sun, C | 1 |
| Nie, G | 1 |
| Dong, Q | 1 |
| You, J | 1 |
| Li, Q | 1 |
| Li, M | 1 |
| Zhang, Y | 1 |
| Liu, Q | 1 |
| Zhang, T | 1 |
| Wang, H | 1 |
| Fu, Y | 1 |
| Wang, W | 1 |
| Li, D | 2 |
| Jesser, J | 1 |
| Potreck, A | 1 |
| Vollherbst, D | 1 |
| Seker, F | 1 |
| Chen, M | 1 |
| Schönenberger, S | 1 |
| Do, TD | 1 |
| Bendszus, M | 1 |
| Möhlenbruch, MA | 1 |
| Weyland, CS | 1 |
| Carlson, AP | 1 |
| Hänggi, D | 1 |
| Macdonald, RL | 1 |
| Shuttleworth, CW | 1 |
| Beez, T | 1 |
| Steiger, HJ | 1 |
| Etminan, N | 1 |
| Tallarico, RT | 1 |
| Pizzi, MA | 1 |
| Freeman, WD | 1 |
| Zhang, J | 1 |
| Zhang, C | 1 |
| Liu, M | 1 |
| Ehlert, A | 1 |
| Schmidt, C | 1 |
| Wölfer, J | 1 |
| Manthei, G | 1 |
| Jacobs, AH | 1 |
| Brüning, R | 1 |
| Heindel, W | 1 |
| Ringelstein, EB | 1 |
| Stummer, W | 1 |
| Pluta, RM | 1 |
| Hesselmann, V | 1 |
| Yau, WY | 1 |
| Chu, E | 1 |
| Lai, N | 1 |
| Bereczki, D | 1 |
| Ducros, A | 1 |
| Bousser, MG | 1 |
| Svetyĭ, LI | 1 |
| Kurkova, KS | 1 |
| Nucera, E | 1 |
| Schavino, D | 1 |
| Roncallo, C | 1 |
| de Pasquale, T | 1 |
| Buonomo, A | 1 |
| Pollastrini, E | 1 |
| Patriarca, G | 1 |
| Ahmed, N | 2 |
| Wahlgren, NG | 1 |
| Inzitari, D | 1 |
| Poggesi, A | 1 |
| Jiang, WJ | 1 |
| Du, B | 1 |
| Leung, TW | 1 |
| Xu, XT | 1 |
| Jin, M | 1 |
| Dong, KH | 1 |
| Horn, J | 1 |
| de Haan , RJ | 1 |
| Vermeulen, M | 1 |
| Limburg, M | 1 |
| Mittal, SR | 1 |
| Jain, A | 1 |
| Mathur, AK | 1 |
| Najarian, T | 1 |
| Traut, TW | 1 |
| Wahlgren, G | 1 |
| Lyden, PD | 1 |
Reviews
8 reviews available for nimodipine and Stroke
| Article | Year |
|---|---|
Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis.
Topics: Glasgow Coma Scale; Humans; Nimodipine; Stroke; Subarachnoid Hemorrhage; Treatment Outcome | 2022 |
Nimodipine Reappraised: An Old Drug With a Future.
Topics: Brain Injuries; Brain Injuries, Traumatic; Brain Ischemia; Calcium Channel Blockers; Humans; Nimodip | 2020 |
Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis.
Topics: Brain Damage, Chronic; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Hemorrhage; Dexamethasone | 2017 |
Investigational drugs for vasospasm after subarachnoid hemorrhage.
Topics: Animals; Brain Ischemia; Drug Design; Drugs, Investigational; Humans; Neuroprotective Agents; Nimodi | 2018 |
Calcium antagonists for acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Calcium; Calcium Channel Blockers; Fe | 2019 |
[Pharmacotherapy of stroke].
Topics: Acute Disease; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Hungary; N | 2009 |
Reversible cerebral vasoconstriction syndrome.
Topics: Age of Onset; Cerebral Angiography; Female; Humans; Male; Nimodipine; Sex Factors; Stroke; Subarachn | 2009 |
Calcium channel blockers and stroke.
Topics: Aged; Antihypertensive Agents; Atherosclerosis; Calcium Channel Blockers; Dementia, Vascular; Humans | 2005 |
Trials
4 trials available for nimodipine and Stroke
| Article | Year |
|---|---|
The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway.
Topics: Animals; Brain Ischemia; Chlorogenic Acid; Disease Models, Animal; Gallic Acid; Infarction, Middle C | 2022 |
Effects of blood pressure lowering in the acute phase of total anterior circulation infarcts and other stroke subtypes.
Topics: Acute-Phase Reaction; Administration, Oral; Aged; Aged, 80 and over; Antihypertensive Agents; Blood | 2003 |
Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Brain Ischemia; Calcium Channel | 2001 |
High initial blood pressure after acute stroke is associated with poor functional outcome.
Topics: Acute Disease; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clinical Tri | 2001 |
Other Studies
12 other studies available for nimodipine and Stroke
| Article | Year |
|---|---|
Beneficial effects of mijianchangpu decoction on ischemic stroke through components accessing to the brain based on network pharmacology.
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Gene Expression Regulation; Infarction, Middle Cereb | 2022 |
Clinical improvement of a toddler with COVID-19 focal cerebral arteriopathy possibly due to intra-arterial nimodipine.
Topics: Cerebral Arterial Diseases; Child; Child, Preschool; COVID-19; Humans; Nimodipine; SARS-CoV-2; Strok | 2022 |
Effect of intra-arterial nimodipine on iatrogenic vasospasms during endovascular stroke treatment - angiographic resolution and infarct growth in follow-up imaging.
Topics: Autonomic Nervous System Diseases; Brain Ischemia; Endovascular Procedures; Follow-Up Studies; Human | 2023 |
Comparison of pre- and post-ischemic treatment of telmisartan and nimodipine combination in experimentally induced cerebral ischemia.
Topics: Animals; Benzimidazoles; Benzoates; Brain Ischemia; Drug Combinations; Energy Metabolism; Excitatory | 2016 |
Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Infarction; Brain Ischemia; Drug Therapy, Combinat | 2016 |
Cannabis, serotonergic drug use and stroke in a 50-year-old woman.
Topics: Cannabis; Cerebral Angiography; Cognition Disorders; Female; Headache Disorders, Primary; Humans; Ma | 2015 |
[Comparative clinico-pharmacological characteristics of nimodipine, nifedipine and foridon in the treatment of patients with ischemic stroke in late rehabilitative and residual periods].
Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Female; Follow-Up Studies; Hemodynamics; Huma | 2002 |
Delayed-type allergy to oral nimodipine.
Topics: Administration, Oral; Aged; Allergens; Drug Eruptions; Drug Hypersensitivity; Follow-Up Studies; Hum | 2002 |
Symptomatic intracranial stenosis: cerebrovascular complications from elective stent placement.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon; Cerebral Hemorrhage; Female; Humans; Intracranial Art | 2007 |
Aggravation of sick sinus syndrome with precipitation of Stokes Adams attacks following nimodipine.
Topics: Adams-Stokes Syndrome; Aged; Electrocardiography; Female; Humans; Nimodipine; Sick Sinus Syndrome; S | 1998 |
Nifedipine and nimodipine competitively inhibit uridine kinase and orotidine-phosphate decarboxylase: theoretical relevance to poor outcome in stroke.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Cell Membrane; Humans; Neurons; Nife | 2000 |
Systematic review of nimodipine.
Topics: Animals; Humans; Meta-Analysis as Topic; Mice; Nimodipine; Rats; Stroke; Treatment Outcome | 2002 |