nimodipine has been researched along with Seizures in 42 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimodipine has been shown to have an inhibitory action on seizures and brain damage in rodents." | 7.81 | Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice. ( Cavalcanti, IM; Freitas, RM; Moreno, LC; Rolim, HM; Santos-Magalhães, NS; Satyal, P, 2015) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| " Its antiepileptic properties have been proved in various animal models, including pilocarpine-induced seizures in adult rats." | 7.73 | Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures. ( D'alva, MS; Fonteles, MM; Freitas, RM; Nascimento, VS; Oliveira, AA; Sousa, FC; Vasconcelos, SM, 2005) |
| " The aim of this study was to investigate the effects of the calcium channel blockers, nimodipine, nicardipine and amlodipine, on the brain free fatty acid (FFA) level in rats with chemically-induced seizures." | 7.70 | The influence of nimodipine, nicardipine and amlodipine on the brain free fatty acid level in rats with penicillin-induced seizures. ( Eraković, V; Kriz, J; Simonić, A; Varljen, J; Zupan, G, 1999) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 7.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| "The present work studied the effect of a calcium channel blocker (nimodipine) on rat behavioural changes and brain lesions observed after seizures induced by high doses of pilocarpine (400 mg/kg, s." | 7.69 | Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. ( Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS, 1997) |
| "The effects of the calcium channel antagonist, nimodipine, on picrotoxin-induced myoclonic (MYO) and generalized tonic-clonic (GTC) seizures were investigated in male and female rats." | 7.68 | The effect of nimodipine on picrotoxin-induced seizures. ( Thomas, J, 1990) |
| "Nimodipine has been shown to have an inhibitory action on seizures and brain damage in rodents." | 3.81 | Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice. ( Cavalcanti, IM; Freitas, RM; Moreno, LC; Rolim, HM; Santos-Magalhães, NS; Satyal, P, 2015) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| " Its antiepileptic properties have been proved in various animal models, including pilocarpine-induced seizures in adult rats." | 3.73 | Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures. ( D'alva, MS; Fonteles, MM; Freitas, RM; Nascimento, VS; Oliveira, AA; Sousa, FC; Vasconcelos, SM, 2005) |
| "Effect of nimodipine was studied alone and in combination with phenytoin and valproate in maximal electroshock seizures in rats." | 3.70 | Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1998) |
| "Nimodipine, a dihydropyridine derivative central nervous system (CNS) selective calcium channel blocker was studied at four different dosage schedules in five different models of seizures in rats." | 3.70 | Dose-finding study with nimodipine: a selective central nervous system calcium channel blocker on aminophylline induced seizure models in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1998) |
| " The aim of this study was to investigate the effects of the calcium channel blockers, nimodipine, nicardipine and amlodipine, on the brain free fatty acid (FFA) level in rats with chemically-induced seizures." | 3.70 | The influence of nimodipine, nicardipine and amlodipine on the brain free fatty acid level in rats with penicillin-induced seizures. ( Eraković, V; Kriz, J; Simonić, A; Varljen, J; Zupan, G, 1999) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 3.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| "Among three calcium channel inhibitors, only nicardipine (10-40 mg/kg) significantly inhibited clonic seizures induced by pentylenetetrazol administered at its CD97 (convulsive dose 97%) of 81 mg/kg, subcutaneously." | 3.69 | Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. ( Brudniak, T; Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z, 1996) |
| "The present work studied the effect of a calcium channel blocker (nimodipine) on rat behavioural changes and brain lesions observed after seizures induced by high doses of pilocarpine (400 mg/kg, s." | 3.69 | Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. ( Aguiar, LM; de Bruin, VM; de Pinho, RS; de Sousa, FC; Marinho, MM; Viana, GS, 1997) |
| ") potentiated the anticonvulsant properties of phenytoin, phenobarbital and valproate against audiogenic seizures in DBA/2 mice." | 3.68 | Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice. ( De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR, 1992) |
| "The effects of the calcium channel antagonist, nimodipine, on picrotoxin-induced myoclonic (MYO) and generalized tonic-clonic (GTC) seizures were investigated in male and female rats." | 3.68 | The effect of nimodipine on picrotoxin-induced seizures. ( Thomas, J, 1990) |
| "Nimodipine, a calcium channel blocker with high affinity for central dihydropyridine Ca2+ channels, produced a dose-dependent suppression of electrically induced seizures in the rabbit." | 3.67 | Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. ( Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM; Tally, PW; Yaksh, TL, 1986) |
| "Nimodipine, a dihydropyridine that interacts with a Ca++ channel-associated binding site, when delivered (30 to 150 micrograms/kg) intra-arterially (ia) to enflurane-anesthetized cats, produced a dose-dependent suppression of seizures evoked by pentylenetetrazol." | 3.67 | Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats. ( Anderson, RE; Ots, ME; Sundt, TM; Yaksh, TL, 1987) |
| " We report herein the influence of nimodipine, a selective central nervous system calcium channel blocker, in 60 rabbits with seizures that had been induced through ischemia, postischemia reperfusion, pentylenetetrazol, and bicuculline." | 3.67 | Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents. ( Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM, 1986) |
| "Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats." | 3.11 | Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022) |
| "The hypertension is only one manifestation of an underlying multifactorial, multisystem disorder, initiated early in pregnancy." | 2.41 | Management and monitoring of severe preeclampsia. ( Bolte, AC; Dekker, GA; van Geijn, HP, 2001) |
| "During the postpartum period, seizure is a significant concern." | 1.46 | Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage: A rare cause of postpartum seizure. ( Choi, YH; Lee, SH; Yun, SJ, 2017) |
| "Trimetazidine was administered orally in doses of 5, 10 and 20mg/kg (single dose) to observe its effect on the increasing current electroshock seizure (ICES) test in mice." | 1.36 | Trimetazidine exerts protection against increasing current electroshock seizure test in mice. ( Bharal, N; Jain, S; Mediratta, PK; Sharma, KK, 2010) |
| "Gabapentin has been shown to reduce paired-pulse inhibition in the dentate gyrus of the urethane-anesthetized rat and has been shown to block calcium channels, but its not known how these possible mechanisms relate to its antiepileptic effect." | 1.31 | The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine. ( Stringer, JL; Taylor, CP, 2000) |
| "Nimodipine pretreatment inhibited both the convulsive activity and the cerebral hypermetabolic responses to intraventricular endothelin." | 1.29 | Metabolic and neuroanatomical correlates of barrel-rolling and oculoclonic convulsions induced by intraventricular endothelin-1: a novel peptidergic signaling mechanism in visuovestibular and oculomotor regulation? ( Beninger, RJ; Espinosa, FJ; Gross, PM; Shaver, SW; Wainman, DS; Weaver, DF, 1993) |
| "Nimodipine did not affect convulsions elicited by strychnine." | 1.28 | The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions. ( Bolger, GT; O'Neill, SK, 1990) |
| "Nitrendipine was effective when given for two weeks but not after only two days' treatment." | 1.28 | Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment. ( Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Siarey, RJ; Whittington, MA, 1991) |
| "Seizures were induced with pentylenetetrazole in awake rats with chronically implanted EEG electrodes." | 1.28 | Diltiazem enhances and flunarizine inhibits nimodipine's antiseizure effects. ( Morón, MA; Stevens, CW; Yaksh, TL, 1989) |
| "In contrast, the severity of seizures produced by N-methyl-dl-aspartate (NMA) was increased by nitrendipine." | 1.27 | Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. ( Dolin, SJ; Halsey, MJ; Hunter, AB; Little, HJ, 1988) |
| "Verapamil significantly decreased seizure incidence and both it and flunarizine lowered mortality." | 1.27 | Calcium channel antagonists decrease the ethanol withdrawal syndrome. ( Dolin, SJ; Halsey, MJ; Little, HJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (23.81) | 18.7374 |
| 1990's | 16 (38.10) | 18.2507 |
| 2000's | 8 (19.05) | 29.6817 |
| 2010's | 7 (16.67) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Verdijk, JPAJ | 1 |
| Pottkämper, JCM | 1 |
| Verwijk, E | 1 |
| van Wingen, GA | 1 |
| van Putten, MJAM | 1 |
| Hofmeijer, J | 1 |
| van Waarde, JA | 1 |
| Cai, X | 1 |
| Bhattacharyya, S | 1 |
| Plitt, A | 1 |
| Raibagkar, P | 1 |
| LaBuzetta, JN | 1 |
| Schleicher, SM | 1 |
| Munshi, NC | 1 |
| Klein, JP | 1 |
| Moreno, LC | 1 |
| Cavalcanti, IM | 1 |
| Satyal, P | 1 |
| Santos-Magalhães, NS | 1 |
| Rolim, HM | 1 |
| Freitas, RM | 2 |
| Lee, SH | 1 |
| Yun, SJ | 1 |
| Choi, YH | 1 |
| Höcht, C | 1 |
| Lazarowski, A | 1 |
| Gonzalez, NN | 1 |
| Mayer, MA | 1 |
| Opezzo, JA | 1 |
| Taira, CA | 1 |
| Girardi, E | 1 |
| Jain, S | 1 |
| Bharal, N | 1 |
| Mediratta, PK | 1 |
| Sharma, KK | 1 |
| Chatterjee, N | 1 |
| Domoto-Reilly, K | 1 |
| Fecci, PE | 1 |
| Schwamm, LH | 1 |
| Singhal, AB | 1 |
| Corradini, I | 1 |
| Donzelli, A | 1 |
| Antonucci, F | 1 |
| Welzl, H | 1 |
| Loos, M | 1 |
| Martucci, R | 1 |
| De Astis, S | 1 |
| Pattini, L | 1 |
| Inverardi, F | 1 |
| Wolfer, D | 1 |
| Caleo, M | 1 |
| Bozzi, Y | 1 |
| Verderio, C | 1 |
| Frassoni, C | 1 |
| Braida, D | 1 |
| Clerici, M | 1 |
| Lipp, HP | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| Scorza, FA | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 1 |
| de Barros Viana, GS | 1 |
| Fureman, BE | 1 |
| Jinnah, HA | 1 |
| Hess, EJ | 1 |
| Nascimento, VS | 1 |
| D'alva, MS | 1 |
| Oliveira, AA | 1 |
| Vasconcelos, SM | 1 |
| Sousa, FC | 1 |
| Fonteles, MM | 1 |
| Koch, S | 1 |
| Gidal, BE | 1 |
| Wong, GK | 1 |
| Poon, WS | 1 |
| Haas, JS | 1 |
| Nowotny, T | 1 |
| Abarbanel, HD | 1 |
| van Luijtelaar, EL | 1 |
| Ates, N | 1 |
| Coenen, AM | 1 |
| Berg, M | 1 |
| Bruhn, T | 1 |
| Frandsen, A | 1 |
| Schousboe, A | 1 |
| Diemer, NH | 1 |
| Gross, PM | 1 |
| Beninger, RJ | 1 |
| Shaver, SW | 1 |
| Wainman, DS | 1 |
| Espinosa, FJ | 1 |
| Weaver, DF | 1 |
| Gasior, M | 1 |
| Kamiński, R | 1 |
| Brudniak, T | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Marinho, MM | 1 |
| de Bruin, VM | 1 |
| de Sousa, FC | 1 |
| Aguiar, LM | 1 |
| de Pinho, RS | 1 |
| Viana, GS | 1 |
| Balakrishnan, S | 2 |
| Pandhi, P | 2 |
| Bhargava, VK | 2 |
| Chakrabarti, A | 1 |
| Saini, HK | 1 |
| Garg, SK | 1 |
| Zapater, P | 1 |
| Javaloy, J | 1 |
| Román, JF | 1 |
| Vidal, MT | 1 |
| Horga, JF | 1 |
| Lanier, WL | 2 |
| Zupan, G | 1 |
| Eraković, V | 1 |
| Simonić, A | 1 |
| Kriz, J | 1 |
| Varljen, J | 1 |
| Stringer, JL | 1 |
| Taylor, CP | 1 |
| Bolte, AC | 1 |
| van Geijn, HP | 1 |
| Dekker, GA | 1 |
| De Sarro, GB | 1 |
| De Sarro, A | 1 |
| Trimarchi, GR | 1 |
| Nistico', G | 1 |
| Pontecorvo, MJ | 1 |
| Karbon, EW | 1 |
| Goode, S | 1 |
| Clissold, DB | 1 |
| Borosky, SA | 1 |
| Patch, RJ | 1 |
| Ferkany, JW | 1 |
| O'Neill, SK | 2 |
| Bolger, GT | 2 |
| Whittington, MA | 1 |
| Dolin, SJ | 3 |
| Patch, TL | 1 |
| Siarey, RJ | 1 |
| Butterworth, AR | 1 |
| Little, HJ | 3 |
| Thomas, J | 1 |
| Meyer, FB | 2 |
| Tally, PW | 2 |
| Anderson, RE | 4 |
| Sundt, TM | 4 |
| Yaksh, TL | 3 |
| Sharbrough, FW | 2 |
| Hunter, AB | 1 |
| Halsey, MJ | 2 |
| Morón, MA | 1 |
| Stevens, CW | 1 |
| Brandt, L | 1 |
| Andersson, KE | 1 |
| Ljunggren, B | 1 |
| Säveland, H | 1 |
| Ryman, T | 1 |
| Ots, ME | 1 |
| Steen, PA | 1 |
| Gisvold, SE | 1 |
| Milde, JH | 1 |
| Newberg, LA | 1 |
| Scheithauer, BW | 1 |
| Michenfelder, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596] | Phase 2 | 34 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nimodipine and Seizures
| Article | Year |
|---|---|
Management and monitoring of severe preeclampsia.
Topics: Adrenal Cortex Hormones; Antihypertensive Agents; Blood Pressure Determination; Female; Fetal Diseas | 2001 |
Cerebrovascular and cerebral effects of nimodipine--an update.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Coronary Vess | 1988 |
1 trial available for nimodipine and Seizures
| Article | Year |
|---|---|
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph | 2022 |
39 other studies available for nimodipine and Seizures
| Article | Year |
|---|---|
Management of Posterior Reversible Encephalopathy Syndrome Induced by Carfilzomib in a Patient With Multiple Myeloma.
Topics: Anticonvulsants; Antihypertensive Agents; Antineoplastic Agents; Biomarkers, Tumor; Bortezomib; Brai | 2016 |
Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice.
Topics: Animals; Anticonvulsants; Liposomes; Male; Mice; Nimodipine; Pilocarpine; Seizures; Stereotyped Beha | 2015 |
Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage: A rare cause of postpartum seizure.
Topics: Adult; Calcium Channel Blockers; Female; Humans; Magnetic Resonance Imaging; Neuroimaging; Nimodipin | 2017 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
Trimetazidine exerts protection against increasing current electroshock seizure test in mice.
Topics: Animals; Anticonvulsants; Calcium Channels; Dose-Response Relationship, Drug; Electroshock; Male; Mi | 2010 |
Licorice-associated reversible cerebral vasoconstriction with PRES.
Topics: Administration, Oral; Brain; Cerebral Angiography; Cerebrovascular Circulation; Cerebrovascular Diso | 2010 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Triggers of paroxysmal dyskinesia in the calcium channel mouse mutant tottering.
Topics: Animals; Anticonvulsants; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Sign | 2002 |
Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Behavior, Animal; Calcium Channel Blockers; Catalase; Corpus Striatum; Lipid | 2005 |
Phenytoin and cognitive decline.
Topics: Anticonvulsants; Area Under Curve; Calcium Channel Blockers; Cognition Disorders; Cytochrome P-450 E | 2005 |
Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage.
Topics: Cognition Disorders; Drug Interactions; Humans; Intracranial Aneurysm; Nimodipine; Phenytoin; Seizur | 2005 |
Spike-timing-dependent plasticity of inhibitory synapses in the entorhinal cortex.
Topics: Animals; Bicuculline; Calcium Channel Blockers; Calcium Channels, L-Type; Chelating Agents; Egtazic | 2006 |
Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Kainic acid-induced seizures and brain damage in the rat: role of calcium homeostasis.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Diseases; Calcium; Calcium Channels; Dantrolene; | 1995 |
Metabolic and neuroanatomical correlates of barrel-rolling and oculoclonic convulsions induced by intraventricular endothelin-1: a novel peptidergic signaling mechanism in visuovestibular and oculomotor regulation?
Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Calcium Channels; Endothelins; Glucose; | 1993 |
Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Clonazepam; Drug Interactions; Ethosuximide; Flu | 1996 |
Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats.
Topics: Animals; Atropine; Brain Diseases; Lithium; Male; Nimodipine; Pilocarpine; Rats; Rats, Wistar; Seizu | 1997 |
Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Drug Synergism; Electroshock; Female; Male; Nimo | 1998 |
Dose-finding study with nimodipine: a selective central nervous system calcium channel blocker on aminophylline induced seizure models in rats.
Topics: Aminophylline; Animals; Anticonvulsants; Calcium Channel Blockers; Dose-Response Relationship, Drug; | 1998 |
Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Clonazepam; Dihydropyr | 1998 |
Basic principles of cerebral protection in humans.
Topics: Adrenal Cortex Hormones; Anesthetics; Animals; Barbiturates; Blood Glucose; Blood Pressure; Body Tem | 1999 |
The influence of nimodipine, nicardipine and amlodipine on the brain free fatty acid level in rats with penicillin-induced seizures.
Topics: Amlodipine; Animals; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Fatty Acid | 1999 |
Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Male; | 1999 |
The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine.
Topics: Acetates; Amines; Animals; Anticonvulsants; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; C | 2000 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbr | 1991 |
The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment.
Topics: Adaptation, Psychological; Administration, Inhalation; Animals; Behavior, Animal; Bicuculline; Brain | 1991 |
The effect of nimodipine on picrotoxin-induced seizures.
Topics: Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Male; Nimodipine; Picro | 1990 |
Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker.
Topics: Animals; Catheterization; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; I | 1986 |
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Anticonvulsant activity of MK-801 and nimodipine alone and in combination against pentylenetetrazole and strychnine.
Topics: Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Dru | 1989 |
Diltiazem enhances and flunarizine inhibits nimodipine's antiseizure effects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diltiazem; Dose-Response Relationship, Drug; Electroence | 1989 |
Improvement of cortical perfusion, intracellular pH, and electrocorticography by nimodipine during transient focal cerebral ischemia.
Topics: Animals; Blood Flow Velocity; Cerebral Arteries; Cerebral Cortex; Electroencephalography; Hydrogen-I | 1989 |
Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats.
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Clonaz | 1987 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; | 1986 |
Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channel Blockers; Central Nervous System; Convulsants | 1986 |
Nimodipine improves outcome when given after complete cerebral ischemia in primates.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Drug Evaluation, Preclinical; Electroencep | 1985 |