nimodipine has been researched along with Rupture, Spontaneous in 44 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Rupture, Spontaneous: Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 213 patients with verified aneurysmal subarachnoid hemorrhage (SAH) of Grades I to III (Hunt and Hess classification) were enrolled in a double-blind placebo-controlled trial to determine the effect of intravenous nimodipine on delayed ischemic deterioration and computerized tomography (CT)-visualized infarcts after SAH and surgery." | 9.07 | Long-term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery. ( Heiskanen, O; Ohman, J; Servo, A, 1991) |
| "In patients with aneurysmal subarachnoid hemorrhage (SAH), delayed ischemic cerebral dysfunction (DID or symptomatic vasospasm) with subsequent fixed neurological dysfunction (FND) is a frequent and most feared complication induced by the hemorrhage." | 6.66 | Cerebral vasospasm and calcium channel blockade. Nimodipine treatment in patients with aneurysmal subarachnoid hemorrhage. ( Andersson, KE; Brandt, L; Ljunggren, B; Säveland, H; Vinge, E, 1986) |
| "A total of 213 patients with verified aneurysmal subarachnoid hemorrhage (SAH) of Grades I to III (Hunt and Hess classification) were enrolled in a double-blind placebo-controlled trial to determine the effect of intravenous nimodipine on delayed ischemic deterioration and computerized tomography (CT)-visualized infarcts after SAH and surgery." | 5.07 | Long-term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery. ( Heiskanen, O; Ohman, J; Servo, A, 1991) |
| "During recent years, the management of subarachnoid hemorrhage (SAH) has changed, resulting in an increase in early operations and routine administration of nimodipine." | 3.68 | Cerebral hemodynamics in subarachnoid hemorrhage evaluated by transcranial Doppler sonography. Part 1. Reliability of flow velocities in clinical management. ( Fahlbusch, R; Gönner, F; Laumer, R; Priem, R; Steinmeier, R; Vogtmann, T, 1993) |
| "Sixty-five patients with ruptured aneurysms were operated upon within 48 to 72 hours after subarachnoid hemorrhage (SAH) and were treated with a regimen of intra- and postoperative nimodipine for the prevention of symptomatic vasospasm." | 3.67 | Acute operation and preventive nimodipine improve outcome in patients with ruptured cerebral aneurysms. ( Auer, LM, 1984) |
| "The lipophilic calcium antagonist Nimodipine (Bayer Pharma , Wuppertal ) was administered during aneurysm operations in 40 patients with ruptured intracranial aneurysm." | 3.67 | Intraoperative topical nimodipine after aneurysm clipping. ( Auer, LM; Ito, Z; Suzuki, A; Yasui, N, 1984) |
| "During opiate anesthesia (standardized dosage of fentanyl) for operation of cerebral aneurysms after subarachnoid hemorrhage, different hemodynamic, respiratory, metabolic, and endocrine parameters were determined before (1 in Fig." | 3.67 | [Effect of the calcium antagonist nimodipine on hemodynamics, gas exchange and endocrine parameters in opiate anesthesia]. ( Adams, HA; Börner, U; Gips, H; Hempelmann, G; Marck, P; Müller, H; Otto, O, 1987) |
| "Nimodipine treatment was associated with a significant reduction of delayed ischemic deterioration (all operation group combined, nimodipine vs." | 2.66 | Timing of operation for ruptured supratentorial aneurysms: a prospective randomized study. ( Heiskanen, O; Ohman, J, 1989) |
| "In patients with aneurysmal subarachnoid hemorrhage (SAH), delayed ischemic cerebral dysfunction (DID or symptomatic vasospasm) with subsequent fixed neurological dysfunction (FND) is a frequent and most feared complication induced by the hemorrhage." | 2.66 | Cerebral vasospasm and calcium channel blockade. Nimodipine treatment in patients with aneurysmal subarachnoid hemorrhage. ( Andersson, KE; Brandt, L; Ljunggren, B; Säveland, H; Vinge, E, 1986) |
| "This process, known as cerebral vasospasm, is the most common cause of DCI after SAH." | 2.48 | Management of delayed cerebral ischemia after subarachnoid hemorrhage. ( Koenig, MA, 2012) |
| "Nimodipine infusion was started before surgery (1 mg/Kg/h)." | 2.38 | [Vasospasm, early surgery and nimodipine. A series of 120 consecutive cases of surgically treated ruptured aneurysm]. ( Creissard, P; Freger, P; Langlois, O; Proust, F; Rabehenoina, C; Tadie, M, 1992) |
| "Early surgery on cerebral aneurysms is advocated in order to prevent rebleeding and for early removal of blood clot from the basal cisterns." | 2.37 | [Vascular spasm and cerebral ischemia after meningeal hemorrhage caused by rupture of an aneurysm]. ( Van der Werf, AJ, 1986) |
| "Among the 141 patients with subarachnoid hemorrhage but not intracerebral or intraventricular hematoma, 16 made an unfavorable outcome, ie, 11% versus 56% among patients with intracerebral hematoma/intraventricular hematoma on preoperative computed tomography scan." | 1.28 | Unfavorable outcome following early surgical repair of ruptured cerebral aneurysms--a critical review of 238 patients. ( Auer, LM, 1991) |
| "The postoperative intracerebral hemorrhage occurred in 16 cases and seemed to be caused by one or more of the following events: cerebral infarction developed during the preoperative period, occlusion of the cerebral veins during the Sylvian dissection, cerebral retraction and/or sudden change of intracranial hemodynamics." | 1.28 | Surgery of intracranial aneurysms at Yonsei University: 780 cases. ( Lee, KC, 1991) |
| "Morbidity after aneurysmal subarachnoid hemorrhages is proceeding from many factors; ischemic etiology is underestimated and frequently thought to be vasospasm related only." | 1.28 | [Does nimodipine improve the outcome of perioperative complications of aneurysm rupture? Results of systematic treatment]. ( Ades, PE; Aesch, B; Buchet, S; Fabre, M; Jan, M; Lamotte, C; Rieant, JF, 1989) |
| "One nimodipine-treated patient with a preserved CO2 response, in whom operation was complicated, developed DID." | 1.27 | Prediction and prevention of delayed ischemic dysfunction after aneurysmal subarachnoid hemorrhage and early operation. ( Algotsson, L; Brandt, L; Ljunggren, B; Messeter, K; Romner, B; Ryding, E; Svendgaard, NA, 1987) |
| "The overall morbidity and mortality from aneurysmal subarachnoid hemorrhage have not changed significantly over the past 30 years in spite of great progress in surgical technology and diagnostic capabilities." | 1.27 | Current management of cerebral aneurysms: is it based on facts or myths? ( Ausman, JI; Diaz, FG; Fielding, AS; Malik, GM; Son, CS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (63.64) | 18.7374 |
| 1990's | 15 (34.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koenig, MA | 1 |
| Auer, LM | 4 |
| Ljunggren, B | 5 |
| Brandt, L | 5 |
| Säveland, H | 4 |
| Nilsson, PE | 1 |
| Cronqvist, S | 1 |
| Andersson, KE | 3 |
| Vinge, E | 2 |
| Suzuki, A | 1 |
| Yasui, N | 1 |
| Ito, Z | 1 |
| Laumer, R | 1 |
| Steinmeier, R | 1 |
| Gönner, F | 1 |
| Vogtmann, T | 1 |
| Priem, R | 1 |
| Fahlbusch, R | 1 |
| Langlois, O | 1 |
| Proust, F | 1 |
| Rabehenoina, C | 2 |
| Freger, P | 2 |
| Tadie, M | 2 |
| Creissard, P | 2 |
| Hillman, J | 3 |
| Bynke, O | 1 |
| Westergren, H | 1 |
| Mourier, KL | 1 |
| George, B | 1 |
| Raggueneau, JL | 1 |
| Tran Dinh, YR | 1 |
| Lot, G | 1 |
| Boissonnet, H | 1 |
| Cophignon, J | 1 |
| Romner, B | 4 |
| Ryman, T | 2 |
| Fodstad, H | 1 |
| Ohman, J | 2 |
| Servo, A | 1 |
| Heiskanen, O | 2 |
| Dorsch, NW | 2 |
| Lee, KC | 1 |
| Bracard, S | 1 |
| Picard, L | 1 |
| Marchal, JC | 1 |
| Ducrocq, X | 1 |
| Per, A | 1 |
| Czorny, A | 1 |
| Islak, C | 1 |
| Roy, D | 1 |
| Roland, J | 1 |
| Lepoire, J | 1 |
| Tettenborn, D | 1 |
| Dycka, J | 1 |
| Mathiesen, T | 1 |
| Lindquist, C | 1 |
| Sevrain, L | 1 |
| Hattab, N | 1 |
| Clavier, E | 1 |
| Thiebot, J | 1 |
| Laissy, JP | 1 |
| Childs, M | 2 |
| Riegel, B | 1 |
| Jomin, M | 3 |
| Fesard, P | 1 |
| Robiquet, P | 1 |
| Little, JM | 1 |
| Desbordes, JM | 1 |
| Ades, PE | 2 |
| Guggiari, M | 2 |
| Gulati, C | 1 |
| Fabre, M | 1 |
| Aesch, B | 1 |
| Rieant, JF | 1 |
| Buchet, S | 1 |
| Lamotte, C | 1 |
| Jan, M | 3 |
| Gilsbach, JM | 2 |
| Harders, AG | 2 |
| Frèrebeau, P | 2 |
| Janny, P | 2 |
| Peragut, JC | 1 |
| Philippon, J | 2 |
| Taquoi, G | 2 |
| Buchheit, F | 2 |
| Tremoulet, M | 1 |
| Besson, G | 1 |
| Houtteville, JP | 1 |
| Pecker, J | 1 |
| von Essen, C | 2 |
| Leszniewski, W | 2 |
| Oliver Abadal, B | 1 |
| Sagués Gabarró, F | 1 |
| Bartumeus Jené, F | 1 |
| Eggert, HR | 1 |
| Hornyak, ME | 1 |
| Johansson, I | 1 |
| Van der Werf, AJ | 1 |
| Grob, R | 1 |
| Dagreou, F | 1 |
| Rivierez, M | 1 |
| Viars, P | 1 |
| Tucker, WS | 1 |
| Messeter, K | 1 |
| Svendgaard, NA | 1 |
| Algotsson, L | 1 |
| Ryding, E | 1 |
| Müller, H | 1 |
| Marck, P | 1 |
| Gips, H | 1 |
| Börner, U | 1 |
| Otto, O | 1 |
| Adams, HA | 1 |
| Hempelmann, G | 1 |
| Schneider, GH | 1 |
| Auer, T | 1 |
| Ljunggren, BC | 1 |
| Brandt, JL | 1 |
| Säveland, HG | 1 |
| Stullken, EH | 1 |
| Johnston, WE | 1 |
| Prough, DS | 1 |
| Balestrieri, FJ | 1 |
| McWhorter, JM | 1 |
| Ausman, JI | 1 |
| Diaz, FG | 1 |
| Malik, GM | 1 |
| Fielding, AS | 1 |
| Son, CS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295] | Phase 3 | 49 participants (Actual) | Interventional | 2007-09-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for nimodipine and Rupture, Spontaneous
| Article | Year |
|---|---|
Management of delayed cerebral ischemia after subarachnoid hemorrhage.
Topics: Angioplasty, Balloon; Brain Ischemia; Calcium Channel Blockers; Cardiovascular Agents; Cerebral Angi | 2012 |
[Vasospasm, early surgery and nimodipine. A series of 120 consecutive cases of surgically treated ruptured aneurysm].
Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Female; Glasgow Coma Scale; Humans; Intracranial Aneury | 1992 |
[Value of the measurement of cerebral blood flow before and after diamox injection in predicting clinical vasospasm and final outcome in aneurysmal subarachnoid hemorrhage].
Topics: Acetazolamide; Cerebrovascular Circulation; Female; Humans; Intracranial Aneurysm; Male; Nimodipine; | 1991 |
Prevention and treatment of delayed ischemic dysfunction in patients with aneurysmal subarachnoid hemorrhage.
Topics: Brain Ischemia; Double-Blind Method; Humans; Intracranial Aneurysm; Meta-Analysis as Topic; Nimodipi | 1990 |
[Epidemiology of meningeal hemorrhage caused by aneurysmal rupture (report of 600 cases)].
Topics: Adult; Age Factors; Female; Follow-Up Studies; Glasgow Coma Scale; Health Surveys; Humans; Intracran | 1990 |
[Prevention of cerebral vasospasm caused by the rupture of intracranial aneurysms].
Topics: Cerebral Hemorrhage; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Nimodipine; Rupture, | 1988 |
Aneurysmal subarachnoid hemorrhage: prevention of delayed ischemic dysfunction with intravenous nimodipine.
Topics: Brain Ischemia; Clinical Trials as Topic; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; | 1987 |
[Vascular spasm and cerebral ischemia after meningeal hemorrhage caused by rupture of an aneurysm].
Topics: Brain Ischemia; Calcium Channel Blockers; Cerebral Angiography; Electroencephalography; Fibrin Fibri | 1986 |
14 trials available for nimodipine and Rupture, Spontaneous
| Article | Year |
|---|---|
Long-term effects of nimodipine on cerebral infarcts and outcome after aneurysmal subarachnoid hemorrhage and surgery.
Topics: Adolescent; Adult; Aged; Cause of Death; Cerebral Infarction; Double-Blind Method; Female; Humans; I | 1991 |
Prevention and treatment of delayed ischemic dysfunction in patients with aneurysmal subarachnoid hemorrhage.
Topics: Brain Ischemia; Double-Blind Method; Humans; Intracranial Aneurysm; Meta-Analysis as Topic; Nimodipi | 1990 |
Nimodipine for cerebral vasospasm after subarachnoid hemorrhage.
Topics: Administration, Oral; Clinical Trials as Topic; Humans; Infusions, Intravenous; Intracranial Aneurys | 1989 |
Reference: nimodipine in cerebral vasospasm.
Topics: Clinical Trials as Topic; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Nimodipine; Rup | 1989 |
[Intravenous nimodipine in the treatment of cerebral vasospasm following subarachnoid hemorrhage caused by aneurysm rupture: a comparative multicenter study].
Topics: Adult; Double-Blind Method; Female; Humans; Infusions, Intravenous; Intracranial Aneurysm; Ischemic | 1989 |
Timing of operation for ruptured supratentorial aneurysms: a prospective randomized study.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Circle of Willis; Evaluation Studies as Topic; Humans; Intr | 1989 |
[Curative action of intravenous nimodipine on cerebral vasospasm after aneurysm rupture].
Topics: Clinical Trials as Topic; Humans; Injections, Intravenous; Intracranial Aneurysm; Ischemic Attack, T | 1987 |
Therapeutic trial of intravenous nimodipine in patients with established cerebral vasospasm after rupture of intracranial aneurysms.
Topics: Adult; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypotension; Injections, Intravenous; | 1988 |
[Treatment of vasospasm in aneurysmal meningeal hemorrhage using intravenous nimodipine. Multicenter cooperative study].
Topics: Double-Blind Method; Female; Humans; Injections, Intravenous; Intracranial Aneurysm; Ischemic Attack | 1988 |
Aneurysmal subarachnoid hemorrhage: prevention of delayed ischemic dysfunction with intravenous nimodipine.
Topics: Brain Ischemia; Clinical Trials as Topic; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; | 1987 |
Cerebral vasospasm and calcium channel blockade. Nimodipine treatment in patients with aneurysmal subarachnoid hemorrhage.
Topics: Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Internal; Clinical Trials as Topic; Humans; | 1986 |
Prevention of vasospasm in subarachnoid haemorrhage. A controlled study with nimodipine.
Topics: Adolescent; Adult; Aged; Cerebral Angiography; Clinical Trials as Topic; Double-Blind Method; Humans | 1986 |
The relationship between timing of surgery and operative complications in aneurysmal subarachnoid hemorrhage.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Intracranial Aneurysm; Middle Aged; Nimodipin | 1987 |
Implications of nimodipine prophylaxis of cerebral vasospasm on anesthetic management during intracranial aneurysm clipping.
Topics: Anesthesia; Calcium Channel Blockers; Cerebral Hemorrhage; Cerebrovascular Circulation; Clinical Tri | 1985 |
24 other studies available for nimodipine and Rupture, Spontaneous
| Article | Year |
|---|---|
Acute operation and preventive nimodipine improve outcome in patients with ruptured cerebral aneurysms.
Topics: Adult; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Intraoperative Complications; Ische | 1984 |
Outcome in 60 consecutive patients treated with early aneurysm operation and intravenous nimodipine.
Topics: Adult; Combined Modality Therapy; Evaluation Studies as Topic; Female; Humans; Intracranial Aneurysm | 1984 |
Intraoperative topical nimodipine after aneurysm clipping.
Topics: Administration, Topical; Calcium Channel Blockers; Humans; Intracranial Aneurysm; Intraoperative Per | 1984 |
Cerebral hemodynamics in subarachnoid hemorrhage evaluated by transcranial Doppler sonography. Part 1. Reliability of flow velocities in clinical management.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brain Ischemia; Cerebral Arteries; | 1993 |
Nimodipine evoked dilation of cerebral arteries early during the development of late vasospasm in subarachnoid hemorrhage.
Topics: Aged; Cerebral Angiography; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Neurolo | 1991 |
Does nimodipine eliminate arterial hypertension as a prognostic risk factor in subarachnoid haemorrhage?
Topics: Adolescent; Adult; Aged; Female; Humans; Hypertension; Intracranial Aneurysm; Ischemic Attack, Trans | 1991 |
Advances in the management of victims struck by ruptured intracranial aneurysms.
Topics: Aged; History, 19th Century; History, 20th Century; History, Ancient; Humans; Intracranial Aneurysm; | 1990 |
Unfavorable outcome following early surgical repair of ruptured cerebral aneurysms--a critical review of 238 patients.
Topics: Aged; Cerebral Hemorrhage; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; | 1991 |
Subarachnoid haemorrhage.
Topics: Brain Ischemia; Humans; Intracranial Aneurysm; Nimodipine; Referral and Consultation; Rupture, Spont | 1991 |
Surgery of intracranial aneurysms at Yonsei University: 780 cases.
Topics: Brain Ischemia; Cerebral Hemorrhage; Humans; Hydrocephalus; Intracranial Aneurysm; Nimodipine; Posto | 1991 |
Role of angioplasty in the treatment of symptomatic vascular spasm occurring in the post-operative course of intracranial ruptured aneurysms.
Topics: Adult; Angiography; Angioplasty, Balloon; Circle of Willis; Female; Humans; Intracranial Aneurysm; I | 1990 |
Delayed brainstem ischemia following rupture of a basilar artery aneurysm and its reversal by nimodipine.
Topics: Adult; Basilar Artery; Brain Ischemia; Brain Stem; Female; Humans; Intracranial Aneurysm; Nimodipine | 1990 |
[The value of a computer tomography scanner and controlled arteriography in the study of the results of aneurysm surgery. A series of 100 consecutive cases].
Topics: Adult; Aged; Aneurysm; Angiography; Carotid Artery Diseases; Cerebral Angiography; Cerebral Hemorrha | 1990 |
Anesthetic management of a patient with a giant intracranial aneurysm.
Topics: Adult; Aminocaproic Acid; Anesthesia, General; Electrocardiography; Humans; Intracranial Aneurysm; I | 1989 |
[Does nimodipine improve the outcome of perioperative complications of aneurysm rupture? Results of systematic treatment].
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Ischemic Attack, | 1989 |
Morbidity and mortality after early aneurysm surgery--a prospective study with nimodipine prevention.
Topics: Adult; Aged; Brain Ischemia; Cerebral Arteries; Cerebral Hemorrhage; Cerebral Infarction; Combined M | 1989 |
Results of treatment for cerebral saccular aneurysms in a small neurosurgical unit--evaluation of early operation and nimodipine treatment.
Topics: Humans; Intracranial Aneurysm; Nimodipine; Rupture, Spontaneous; Subarachnoid Hemorrhage | 1988 |
Early aneurysm surgery: a 7 year clinical practice report.
Topics: Cerebral Angiography; Cerebrospinal Fluid Shunts; Humans; Hydrocephalus; Intracranial Aneurysm; Isch | 1988 |
Significance of "ultra-early" rebleeding in subarachnoid hemorrhage.
Topics: Female; Hematoma; Humans; Intracranial Aneurysm; Male; Mental Disorders; Middle Aged; Nervous System | 1988 |
Prediction and prevention of delayed ischemic dysfunction after aneurysmal subarachnoid hemorrhage and early operation.
Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Female; Humans; Intracranial Aneurysm; Male; Mid | 1987 |
[Effect of the calcium antagonist nimodipine on hemodynamics, gas exchange and endocrine parameters in opiate anesthesia].
Topics: Anesthesia, General; Cerebrovascular Circulation; Fentanyl; Hemodynamics; Hormones; Humans; Infusion | 1987 |
Computerized tomography and prognosis in early aneurysm surgery.
Topics: Cerebral Angiography; Follow-Up Studies; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; | 1986 |
Outcome in patients subjected to early aneurysm operation and intravenous nimodipine.
Topics: Adult; Aged; Follow-Up Studies; Humans; Infusions, Parenteral; Intracranial Aneurysm; Ischemic Attac | 1986 |
Current management of cerebral aneurysms: is it based on facts or myths?
Topics: Adult; Age Factors; Aged; Antifibrinolytic Agents; Cerebral Angiography; Humans; Hypotension, Contro | 1985 |