nimodipine has been researched along with Nervous System Disorders in 18 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 7.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| "Ten minutes of complete cerebral ischemia was produced in 26 dogs by temporary ligation of the aorta and the venae cavae." | 5.27 | Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischemia in the dog. ( Michenfelder, JD; Milde, JH; Newberg, LA; Steen, PA, 1984) |
| " In this study, the authors examined the effects of treatment with the NO donor molsidomine with regard to decreasing the incidence of spasm-related delayed brain infarctions and improving clinical outcome in patients with SAH." | 3.83 | Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study. ( Brüning, R; Ehlert, A; Heindel, W; Hesselmann, V; Jacobs, AH; Manthei, G; Pluta, RM; Ringelstein, EB; Schmidt, C; Stummer, W; Wölfer, J, 2016) |
| " In cell cultures, CgTx inhibited hypoxia-induced 45Ca accumulation and neuronal injury minimally, compared to the NMDA antagonist ketamine." | 3.68 | Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury. ( Clark, WM; Madden, KP; Marcoux, FW; Probert, AW; Rivier, J; Weber, ML; Zivin, JA, 1990) |
| "Nimodipine treatment was associated with a significant reduction of delayed ischemic deterioration (all operation group combined, nimodipine vs." | 2.66 | Timing of operation for ruptured supratentorial aneurysms: a prospective randomized study. ( Heiskanen, O; Ohman, J, 1989) |
| "Nimodipine is a 1,4-dihydropyridine-derivative Ca(2+)-channel blocker developed approximately 30 years ago." | 2.44 | Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies. ( Amenta, F; Lanari, A; Silvestrelli, G; Tomassoni, D; Traini, E, 2008) |
| "Nimodipine and aspirin were set as positive control separately." | 1.43 | Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats. ( Chen, B; Cheng, MH; Fan, BS; Shi, HQ; Tian, JS; Yu, JG; Zhang, Y, 2016) |
| "Nimodipine plus t-PA was not better than t-PA alone." | 1.28 | Tissue plasminogen activator plus glutamate antagonist improves outcome after embolic stroke. ( Mazzarella, V; Zivin, JA, 1991) |
| "Brain damage after resuscitation from cardiac arrest is believed to be related to calcium influx in ischaemic neurons and to postischaemic calcium-dependent vasospasm." | 1.28 | Nimodipine has no beneficial effect on neurological outcome in a cardiopulmonary arrest model in the rat. ( Bogaert, MG; Buylaert, WA; Calle, PA; De Ridder, L, 1990) |
| "Ten minutes of complete cerebral ischemia was produced in 26 dogs by temporary ligation of the aorta and the venae cavae." | 1.27 | Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischemia in the dog. ( Michenfelder, JD; Milde, JH; Newberg, LA; Steen, PA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Fiamingo, G | 1 |
| Canavero, I | 1 |
| Gastaldi, M | 1 |
| Coloberti, E | 1 |
| Buongarzone, G | 1 |
| Ghiotto, N | 1 |
| Bacila, A | 1 |
| Costa, A | 1 |
| Ravaglia, S | 1 |
| Anand, S | 1 |
| Goel, G | 1 |
| Gupta, V | 1 |
| Ehlert, A | 1 |
| Schmidt, C | 1 |
| Wölfer, J | 1 |
| Manthei, G | 1 |
| Jacobs, AH | 1 |
| Brüning, R | 1 |
| Heindel, W | 1 |
| Ringelstein, EB | 1 |
| Stummer, W | 1 |
| Pluta, RM | 1 |
| Hesselmann, V | 1 |
| Bridgeman, MB | 1 |
| Dalal, KS | 1 |
| Shi, HQ | 1 |
| Zhang, Y | 1 |
| Cheng, MH | 1 |
| Fan, BS | 1 |
| Tian, JS | 1 |
| Yu, JG | 1 |
| Chen, B | 1 |
| Wang, X | 1 |
| Wang, C | 1 |
| Yang, Y | 1 |
| Ni, J | 1 |
| Tomassoni, D | 1 |
| Lanari, A | 1 |
| Silvestrelli, G | 1 |
| Traini, E | 1 |
| Amenta, F | 1 |
| Emerick, GL | 1 |
| Peccinini, RG | 1 |
| de Oliveira, GH | 1 |
| Steen, PA | 1 |
| Newberg, LA | 1 |
| Milde, JH | 1 |
| Michenfelder, JD | 1 |
| Fisher, M | 1 |
| Jonas, S | 1 |
| Sacco, RL | 1 |
| Jones S [corrected to Jonas, S] | 1 |
| Rhee, RY | 1 |
| Gloviczki, P | 1 |
| Cambria, RA | 1 |
| Lowell, RC | 1 |
| Okazaki, H | 1 |
| Zivin, JA | 2 |
| Mazzarella, V | 1 |
| Madden, KP | 1 |
| Clark, WM | 1 |
| Marcoux, FW | 1 |
| Probert, AW | 1 |
| Weber, ML | 1 |
| Rivier, J | 1 |
| Calle, PA | 1 |
| Bogaert, MG | 1 |
| De Ridder, L | 1 |
| Buylaert, WA | 1 |
| Ohman, J | 1 |
| Heiskanen, O | 1 |
| Biller, J | 1 |
| Godersky, JC | 1 |
| Adams, HP | 1 |
| Hillman, J | 1 |
| von Essen, C | 1 |
| Leszniewski, W | 1 |
| Johansson, I | 1 |
| Allen, GS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436] | Phase 4 | 330 participants (Anticipated) | Interventional | 2016-08-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for nimodipine and Nervous System Disorders
| Article | Year |
|---|---|
HaNDL syndrome: a reversible cerebral vasoconstriction triggered by an infection? A case report and a case-based review.
Topics: Adult; Albumins; Calcium Channel Blockers; Epstein-Barr Virus Nuclear Antigens; Headache; Humans; Im | 2022 |
Nimodipine and its use in cerebrovascular disease: evidence from recent preclinical and controlled clinical studies.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; D | 2008 |
Prophylactic neuroprotection for cerebral ischemia.
Topics: Cerebrovascular Disorders; Coronary Artery Bypass; Endarterectomy, Carotid; Humans; Ischemic Attack, | 1994 |
Cerebral arterial spasm.
Topics: Blood Platelets; Calcium; Cerebral Arterial Diseases; Humans; Muscle Contraction; Nervous System Dis | 1985 |
1 trial available for nimodipine and Nervous System Disorders
| Article | Year |
|---|---|
Timing of operation for ruptured supratentorial aneurysms: a prospective randomized study.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Circle of Willis; Evaluation Studies as Topic; Humans; Intr | 1989 |
13 other studies available for nimodipine and Nervous System Disorders
| Article | Year |
|---|---|
Continuous intra-arterial dilatation with nimodipine and milrinone for refractory cerebral vasospasm.
Topics: Angioplasty, Balloon; Cerebral Angiography; Dilatation; Drug Resistance; Female; Humans; Infusions, | 2014 |
Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Infarction; Brain Ischemia; Drug Therapy, Combinat | 2016 |
Neurologic and psychiatric medications.
Topics: Alemtuzumab; Antibodies, Monoclonal, Humanized; Cyclopropanes; Dibenzazepines; Drug Therapy; Humans; | 2015 |
Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats.
Topics: Acute Disease; Analysis of Variance; Animals; Apoptosis; Aspirin; Blood Pressure; Cell Survival; Cel | 2016 |
New monocyte locomotion inhibitory factor analogs protect against cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Infarction, Middle Cerebral Artery; Interleukin-1 | 2017 |
Organophosphorus-induced delayed neuropathy: a simple and efficient therapeutic strategy.
Topics: Animals; Calcium; Calcium Channels; Calcium Gluconate; Carboxylic Ester Hydrolases; Chickens; Diseas | 2010 |
Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischemia in the dog.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascul | 1984 |
The effects of nimodipine on ischemic injury of the spinal cord during thoracic aortic cross-clamping.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Constriction; Dogs; Hyperemia; Laser-Doppler Flo | 1996 |
Tissue plasminogen activator plus glutamate antagonist improves outcome after embolic stroke.
Topics: Animals; Cerebrovascular Disorders; Dizocilpine Maleate; Drug Therapy, Combination; Excitatory Amino | 1991 |
Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Hypoxia; Injections; Ischemia; Ketamine | 1990 |
Nimodipine has no beneficial effect on neurological outcome in a cardiopulmonary arrest model in the rat.
Topics: Animals; Blood Pressure; Cell Survival; Coronary Disease; Disease Models, Animal; Electrocardiograph | 1990 |
Management of aneurysmal subarachnoid hemorrhage.
Topics: Aminocaproic Acid; Humans; Intracranial Aneurysm; Nervous System Diseases; Nicardipine; Nimodipine; | 1988 |
Significance of "ultra-early" rebleeding in subarachnoid hemorrhage.
Topics: Female; Hematoma; Humans; Intracranial Aneurysm; Male; Mental Disorders; Middle Aged; Nervous System | 1988 |