Page last updated: 2024-11-01

nimodipine and Neoplasms

nimodipine has been researched along with Neoplasms in 6 studies

Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study."9.08Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. ( Aguilar, JL; Costa, J; Gomar, C; Mazo, V; Roca, G; Vidal, F, 1996)
"We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study."5.08Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. ( Aguilar, JL; Costa, J; Gomar, C; Mazo, V; Roca, G; Vidal, F, 1996)
"Nimodipine was withdrawn in 5 patients during the first week of treatment due to intolerance (n = 3) or aggravation of the disease (n = 2)."2.67Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report. ( Flórez, J; Hurlé, MA; Maestre, JM; Santillán, R, 1994)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Piwnica-Worms, D1
Kesarwala, AH1
Pichler, A1
Prior, JL1
Sharma, V1
Santillán, R2
Maestre, JM1
Hurlé, MA2
Flórez, J2
Roca, G1
Aguilar, JL1
Gomar, C1
Mazo, V1
Costa, J1
Vidal, F1
Armijo, JA1
de los Mozos, R1

Reviews

2 reviews available for nimodipine and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease.
    Neuroimaging clinics of North America, 2006, Volume: 16, Issue:4

    Topics: Alzheimer Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Tran

2006

Trials

3 trials available for nimodipine and Neoplasms

ArticleYear
Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report.
    Pain, 1994, Volume: 58, Issue:1

    Topics: Administration, Oral; Adult; Aged; Analgesia; Drug Synergism; Drug Tolerance; Female; Humans; Inject

1994
Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment.
    Pain, 1996, Volume: 68, Issue:2-3

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Calcium Channel Blocker

1996
Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study.
    Pain, 1998, Volume: 76, Issue:1-2

    Topics: Aged; Analgesics, Opioid; Biotransformation; Calcium Channel Blockers; Double-Blind Method; Drug Syn

1998

Other Studies

1 other study available for nimodipine and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007