nimodipine has been researched along with Multiple Sclerosis in 3 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Excerpt | Relevance | Reference |
---|---|---|
"Nimodipine treatment attenuated clinical EAE and spinal cord degeneration and promoted remyelination." | 5.46 | Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. ( Ergün, S; Hell, JW; Jörg, S; Koeniger, T; Kuerten, S; Linker, RA; Schampel, A; Scholz, CJ; Volovitch, O; Wischmeyer, E; Wunsch, M, 2017) |
"Nimodipine treatment attenuated clinical EAE and spinal cord degeneration and promoted remyelination." | 1.46 | Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. ( Ergün, S; Hell, JW; Jörg, S; Koeniger, T; Kuerten, S; Linker, RA; Schampel, A; Scholz, CJ; Volovitch, O; Wischmeyer, E; Wunsch, M, 2017) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 2 (66.67) | 2.80 |
Authors | Studies |
---|---|
Enders, M | 1 |
Weier, A | 1 |
Chunder, R | 1 |
An, Y | 1 |
Bremm, F | 1 |
Feigenspan, A | 1 |
Buettner, C | 1 |
Ekici, AB | 1 |
Mingardo, E | 1 |
Odermatt, B | 1 |
Kuerten, S | 2 |
Denaroso, GE | 1 |
Smith, Z | 1 |
Angeliu, CG | 1 |
Cheli, VT | 1 |
Wang, C | 1 |
Paez, PM | 1 |
Schampel, A | 1 |
Volovitch, O | 1 |
Koeniger, T | 1 |
Scholz, CJ | 1 |
Jörg, S | 1 |
Linker, RA | 1 |
Wischmeyer, E | 1 |
Wunsch, M | 1 |
Hell, JW | 1 |
Ergün, S | 1 |
3 other studies available for nimodipine and Multiple Sclerosis
Article | Year |
---|---|
Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Encephalomyelitis | 2023 |
Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis.
Topics: Animals; Astrocytes; Calcium Channels; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experi | 2023 |
Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.
Topics: Animals; Apoptosis; Calcium Channels, L-Type; Cells, Cultured; Disease Models, Animal; Encephalomyel | 2017 |