nimodipine has been researched along with Infarction, Middle Cerebral Artery in 22 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to investigate the neuroprotective effects of 20(S)-ginsenoside Rg3 on focal cerebral ischemia in rats." | 7.73 | Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. ( Fu, F; Geng, M; Jiang, W; Jiang, Y; Liu, K; Tian, J; Wang, C; Yang, J, 2005) |
| "Nimodipine-treated animals were then matched with vehicle-treated controls for both study conditions." | 5.32 | Nimodipine does not affect the flow-metabolism couple in permanent cerebral ischemia. ( Burnett, MG; Gomi, S; Greenberg, JH; Karp, A, 2004) |
| "This study was conducted to investigate the neuroprotective effects of 20(S)-ginsenoside Rg3 on focal cerebral ischemia in rats." | 3.73 | Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. ( Fu, F; Geng, M; Jiang, W; Jiang, Y; Liu, K; Tian, J; Wang, C; Yang, J, 2005) |
| "Male Sprague-Dawley rats under permanent middle cerebral artery occlusion (pMCAO) model, randomly assigned as: model, sham, nimodipine (0." | 3.11 | The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway. ( Fu, Y; Li, D; Liu, Q; Wang, H; Wang, W; Zhang, T; Zhang, Y, 2022) |
| "Permanent cerebral ischemia is a consequence of prolonged cerebral artery occlusion that results in severe brain damage." | 1.72 | Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms. ( Chaichompoo, W; Oka, C; Sengking, J; Suksamrarn, A; Tocharus, C; Tocharus, J; Yawoot, N, 2022) |
| "Nimodipine and aspirin were set as positive control separately." | 1.43 | Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats. ( Chen, B; Cheng, MH; Fan, BS; Shi, HQ; Tian, JS; Yu, JG; Zhang, Y, 2016) |
| "A rat model of cerebral ischemia and reperfusion injury was established using the middle cerebral artery occlusion (MCAO) model." | 1.38 | Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats. ( Deng, YJ; Lu, JX; Lu, ZQ, 2012) |
| "Rats were subjected to transient middle cerebral artery occlusion (MCAO) model using the intraluminal thread." | 1.35 | Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. ( Chen, BY; Deng, CQ; Li, H; Liang, Y; Luo, XG; Zhang, SP, 2009) |
| "During the following 2 weeks, the cerebral vasospasm resolved with application of high-dose methyl prednisolone and nimodipine." | 1.32 | [Cerebral vasospasms with hemodynamic infarctions as a complication of HELLP syndrome]. ( Bloos, G; Harscher, S; Möller, U; Pfleiderer, SO; Terborg, C; Witte, OW, 2003) |
| "Nimodipine-treated animals were then matched with vehicle-treated controls for both study conditions." | 1.32 | Nimodipine does not affect the flow-metabolism couple in permanent cerebral ischemia. ( Burnett, MG; Gomi, S; Greenberg, JH; Karp, A, 2004) |
| "Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice." | 1.31 | [Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice]. ( Wang, PL; Wang, RD; Wei, EQ; Zeng, LH; Zhang, WP, 2001) |
| "Nimodipine pre-treatment immediately attenuated the inactivation of Na(+)-K+/Mg+2 ATPase (p < 0." | 1.31 | The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat. ( Cetinalp, E; Göçer, AI; Ildan, F; Isbir, T; Kaya, M; Polat, S; Tuna, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 8 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 2 |
| Ma, H | 1 |
| Huang, J | 1 |
| Yao, Z | 2 |
| Yu, J | 1 |
| Zhang, W | 2 |
| Zhang, L | 1 |
| Wang, Z | 1 |
| Zhuang, C | 1 |
| Zhao, X | 1 |
| Liu, J | 1 |
| Yang, L | 1 |
| Niu, Y | 1 |
| Ren, R | 1 |
| Su, C | 1 |
| Chen, J | 2 |
| Ma, X | 2 |
| Liu, ZJ | 1 |
| Wang, CP | 1 |
| Yang, B | 1 |
| Wang, N | 1 |
| Wang, Q | 1 |
| Gu, J | 1 |
| Tan, R | 1 |
| Sengking, J | 1 |
| Oka, C | 1 |
| Yawoot, N | 1 |
| Tocharus, J | 1 |
| Chaichompoo, W | 1 |
| Suksamrarn, A | 1 |
| Tocharus, C | 1 |
| Zhang, Y | 2 |
| Liu, Q | 1 |
| Zhang, T | 1 |
| Wang, H | 1 |
| Fu, Y | 1 |
| Wang, W | 1 |
| Li, D | 1 |
| Huang, S | 1 |
| Huang, Z | 1 |
| Fu, Z | 1 |
| Shi, Y | 1 |
| Dai, Q | 1 |
| Tang, S | 1 |
| Gu, Y | 1 |
| Xu, Y | 1 |
| Wu, X | 1 |
| Ren, F | 1 |
| Chen, X | 1 |
| Peng, X | 1 |
| Wu, L | 1 |
| Wu, H | 1 |
| Ou, Y | 1 |
| Lai, J | 1 |
| Wen, J | 1 |
| Jiang, Y | 2 |
| Hu, Q | 1 |
| Wang, J | 1 |
| Wei, S | 1 |
| Li, H | 2 |
| Larrosa-Campo, D | 1 |
| Ramon-Carbajo, C | 1 |
| Benavente-Fernandez, L | 1 |
| Alvarez-Escudero, R | 1 |
| Zeidan-Ramon, N | 1 |
| Calleja-Puerta, S | 1 |
| Pascual, J | 1 |
| Shi, HQ | 1 |
| Cheng, MH | 1 |
| Fan, BS | 1 |
| Tian, JS | 1 |
| Yu, JG | 1 |
| Chen, B | 1 |
| Wang, X | 1 |
| Wang, C | 2 |
| Yang, Y | 1 |
| Ni, J | 1 |
| Deng, CQ | 1 |
| Chen, BY | 1 |
| Zhang, SP | 1 |
| Liang, Y | 1 |
| Luo, XG | 1 |
| Koskinen, LO | 1 |
| Olivecrona, M | 1 |
| Rodling-Wahlström, M | 1 |
| Naredi, S | 1 |
| Babu, CS | 1 |
| Ramanathan, M | 1 |
| Lu, ZQ | 1 |
| Deng, YJ | 1 |
| Lu, JX | 1 |
| Bell, KF | 1 |
| Bent, RJ | 1 |
| Meese-Tamuri, S | 1 |
| Ali, A | 1 |
| Forder, JP | 1 |
| Aarts, MM | 1 |
| Zeng, LH | 1 |
| Zhang, WP | 1 |
| Wang, RD | 1 |
| Wang, PL | 1 |
| Wei, EQ | 1 |
| Harscher, S | 1 |
| Witte, OW | 1 |
| Möller, U | 1 |
| Bloos, G | 1 |
| Pfleiderer, SO | 1 |
| Terborg, C | 1 |
| Gomi, S | 1 |
| Burnett, MG | 1 |
| Karp, A | 1 |
| Greenberg, JH | 1 |
| Tian, J | 1 |
| Fu, F | 1 |
| Geng, M | 1 |
| Yang, J | 1 |
| Jiang, W | 1 |
| Liu, K | 1 |
| Zhu, D | 1 |
| Li, R | 1 |
| Liu, G | 1 |
| Hua, W | 1 |
| Ildan, F | 1 |
| Göçer, AI | 1 |
| Tuna, M | 1 |
| Polat, S | 1 |
| Kaya, M | 1 |
| Isbir, T | 1 |
| Cetinalp, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study on the Treatment of Hypertensive Cerebral Hemorrhage With Panax Notoginseng Saponins[NCT02999048] | Phase 4 | 90 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for nimodipine and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway.
Topics: Animals; Brain Ischemia; Chlorogenic Acid; Disease Models, Animal; Gallic Acid; Infarction, Middle C | 2022 |
21 other studies available for nimodipine and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.
Topics: Administration, Oral; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dru | 2021 |
Beneficial effects of mijianchangpu decoction on ischemic stroke through components accessing to the brain based on network pharmacology.
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Gene Expression Regulation; Infarction, Middle Cereb | 2022 |
[Protective effect and mechanism of Ershiwuwei Zhenzhu Pills on cerebral apoplexy rats].
Topics: Animals; Caspase 3; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Interleukin-6; Ischem | 2022 |
Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Topics: Animals; bcl-2-Associated X Protein; Benzylisoquinolines; Brain Ischemia; Calcium; Calcium Channels; | 2022 |
A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies.
Topics: Animals; Drug Carriers; Drug Delivery Systems; Drug Stability; Emulsions; Female; Infarction, Middle | 2020 |
Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway.
Topics: Animals; Apoptosis; Brain Ischemia; China; Flavones; Infarction, Middle Cerebral Artery; Inflammatio | 2020 |
l-Borneol ameliorates cerebral ischaemia by downregulating the mitochondrial calcium uniporter-induced apoptosis cascade in pMCAO rats.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channels; Camphanes; Disease Models, Animal; Dose-Respon | 2021 |
[Diagnosis of stroke due to cocaine and its complications].
Topics: Adult; Aphasia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Hemi | 2013 |
Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats.
Topics: Acute Disease; Analysis of Variance; Animals; Apoptosis; Aspirin; Blood Pressure; Cell Survival; Cel | 2016 |
New monocyte locomotion inhibitory factor analogs protect against cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Infarction, Middle Cerebral Artery; Interleukin-1 | 2017 |
Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspase Inhibitors; Female; Infarction, Middle Cerebral A | 2009 |
Prostacyclin treatment normalises the MCA flow velocity in nimodipine-resistant cerebral vasospasm after aneurysmal subarachnoid haemorrhage: a pilot study.
Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Arteries; Cerebrovascular Circula | 2009 |
Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Calcium Channel Blockers; Glutamate-Ammonia Ligase | 2011 |
Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats.
Topics: Aloe; Animals; Brain Ischemia; Caspase 3; Cerebral Cortex; Gene Expression Regulation, Enzymologic; | 2012 |
Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Infarction; Calcium Channel Blockers; Calcium-C | 2013 |
[Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice].
Topics: Animals; Brain; Brain Ischemia; Chromones; Dexamethasone; Infarction, Middle Cerebral Artery; Leukot | 2001 |
[Cerebral vasospasms with hemodynamic infarctions as a complication of HELLP syndrome].
Topics: Adult; Cesarean Section; Diagnostic Imaging; Dose-Response Relationship, Drug; Female; Follow-Up Stu | 2003 |
Nimodipine does not affect the flow-metabolism couple in permanent cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signalin | 2004 |
Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Chemistry; Brain Ischemia; Calcium Chan | 2005 |
Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells.
Topics: Animals; Astrocytes; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Enzyme Activation; | 1999 |
The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat.
Topics: Animals; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Cerebral Cortex; Energy Metabolism; Infarction, Middl | 2001 |