nimodipine has been researched along with Hypotension in 19 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimodipine improves outcomes following aneurysmal subarachnoid hemorrhage (aSAH) and current guidelines suggest that patients with aSAH receive nimodipine for 21 days." | 8.31 | Comparison of nimodipine formulations and administration techniques via enteral feeding tubes in patients with aneurysmal subarachnoid hemorrhage: A multicenter retrospective cohort study. ( Almohaish, S; Ammar, AA; Ammar, MA; Armahizer, MJ; Barra, ME; Barthol, CA; Binning, MJ; Blunck, JR; Brophy, GM; Brown, CS; Burgess, SV; Buschur, PL; Cantin, A; Clark, SL; Cook, AM; Delucilla, L; Fox, N; Hamilton, LA; Hefny, FR; Hintze, TD; Kaupp, K; Keegan, SP; Mahmoud, LN; Mahmoud, SH; Naydin, S; Ngan, Z; Owusu-Guha, J; Panos, NG; Perreault, MM; Peters, DM; Rowe, AS; Sandler, M; Shewmaker, J; Tesoro, EP; Traeger, J; Wieruszewski, ED, 2023) |
| "Nimodipine is recommended to prevent delayed cerebral ischemia in patients with spontaneous subarachnoid hemorrhage (SAH)." | 8.31 | Blood Pressure Changes in Association with Nimodipine Therapy in Patients with Spontaneous Subarachnoid Hemorrhage. ( Altmann, K; Beer, R; Helbok, R; Ianosi, BA; Kindl, P; Kofler, M; Lindner, A; Pfausler, B; Putnina, L; Rass, V; Schiefecker, AJ, 2023) |
| "Oral nimodipine is used for prophylaxis and treatment of delayed cerebral ischemia in patients with aneurysmal or perimesencephalic subarachnoid hemorrhage (SAH)." | 7.91 | Incidence of Arterial Hypotension in Patients Receiving Peroral or Continuous Intra-arterial Nimodipine After Aneurysmal or Perimesencephalic Subarachnoid Hemorrhage. ( Bele, S; Dettmer, K; Eissnert, C; Graf, B; Gruber, M; Kieninger, M; Knott, I; Oefner, PJ; Tuemmler, S; Wendl, C, 2019) |
| "To determine adherence to nimodipine administration in patients admitted with aneurysmal subarachnoid hemorrhage (aSAH)." | 7.91 | Poor Utilization of Nimodipine in Aneurysmal Subarachnoid Hemorrhage. ( Clark, SL; Hajizadeh Barfejani, A; Rabinstein, AA; Wijdicks, EFM, 2019) |
| " In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate." | 7.72 | Easily reversible hypoxemia and hypotension induced by nimodipine. ( Copetti, R; Gerloni, R, 2004) |
| "In a pilot study of 6 patients with subarachnoid hemorrhage caused by a ruptured intracranial (grade IV (Hunt and Hess) aneurysm the hemodynamics and plasma-nimodipine concentrations have been observed during a 3-week period of treatment." | 7.67 | Nimodipine treatment of subarachnoid hemorrhage. ( Jakobsen, P; Jensen, F; Laursen, J; Mikkelsen, E, 1988) |
| "Nimodipine improves outcomes following aneurysmal subarachnoid hemorrhage (aSAH) and current guidelines suggest that patients with aSAH receive nimodipine for 21 days." | 4.31 | Comparison of nimodipine formulations and administration techniques via enteral feeding tubes in patients with aneurysmal subarachnoid hemorrhage: A multicenter retrospective cohort study. ( Almohaish, S; Ammar, AA; Ammar, MA; Armahizer, MJ; Barra, ME; Barthol, CA; Binning, MJ; Blunck, JR; Brophy, GM; Brown, CS; Burgess, SV; Buschur, PL; Cantin, A; Clark, SL; Cook, AM; Delucilla, L; Fox, N; Hamilton, LA; Hefny, FR; Hintze, TD; Kaupp, K; Keegan, SP; Mahmoud, LN; Mahmoud, SH; Naydin, S; Ngan, Z; Owusu-Guha, J; Panos, NG; Perreault, MM; Peters, DM; Rowe, AS; Sandler, M; Shewmaker, J; Tesoro, EP; Traeger, J; Wieruszewski, ED, 2023) |
| "Nimodipine is recommended to prevent delayed cerebral ischemia in patients with spontaneous subarachnoid hemorrhage (SAH)." | 4.31 | Blood Pressure Changes in Association with Nimodipine Therapy in Patients with Spontaneous Subarachnoid Hemorrhage. ( Altmann, K; Beer, R; Helbok, R; Ianosi, BA; Kindl, P; Kofler, M; Lindner, A; Pfausler, B; Putnina, L; Rass, V; Schiefecker, AJ, 2023) |
| "Oral nimodipine is used for prophylaxis and treatment of delayed cerebral ischemia in patients with aneurysmal or perimesencephalic subarachnoid hemorrhage (SAH)." | 3.91 | Incidence of Arterial Hypotension in Patients Receiving Peroral or Continuous Intra-arterial Nimodipine After Aneurysmal or Perimesencephalic Subarachnoid Hemorrhage. ( Bele, S; Dettmer, K; Eissnert, C; Graf, B; Gruber, M; Kieninger, M; Knott, I; Oefner, PJ; Tuemmler, S; Wendl, C, 2019) |
| "To determine adherence to nimodipine administration in patients admitted with aneurysmal subarachnoid hemorrhage (aSAH)." | 3.91 | Poor Utilization of Nimodipine in Aneurysmal Subarachnoid Hemorrhage. ( Clark, SL; Hajizadeh Barfejani, A; Rabinstein, AA; Wijdicks, EFM, 2019) |
| " In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate." | 3.72 | Easily reversible hypoxemia and hypotension induced by nimodipine. ( Copetti, R; Gerloni, R, 2004) |
| "To determine the incidence of induced systemic hypotension in patients after aneurysmal subarachnoid haemorrhage (SAH) and nimodipine treatment 87 consecutive cases were reviewed." | 3.69 | Hypotensive effect of nimodipine during treatment for aneurysmal subarachnoid haemorrhage. ( Chioléro, R; de Tribolet, N; Porchet, F, 1995) |
| "In a pilot study of 6 patients with subarachnoid hemorrhage caused by a ruptured intracranial (grade IV (Hunt and Hess) aneurysm the hemodynamics and plasma-nimodipine concentrations have been observed during a 3-week period of treatment." | 3.67 | Nimodipine treatment of subarachnoid hemorrhage. ( Jakobsen, P; Jensen, F; Laursen, J; Mikkelsen, E, 1988) |
| "Nimodipine treatment resulted in a statistically significant reduction in systolic BP (SBP) and diastolic BP (DBP) from baseline compared with placebo during the first few days." | 2.69 | Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. ( Ahmed, N; Näsman, P; Wahlgren, NG, 2000) |
| "Large-vessel cerebral vasospasm has been challenged as the sole causal mechanism; new hypotheses now focus on the early brain injury, microcirculatory dysfunction, impaired autoregulation, and spreading depolarization." | 2.53 | Management of delayed cerebral ischemia after subarachnoid hemorrhage. ( Francoeur, CL; Mayer, SA, 2016) |
| "Outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved over the last decades." | 2.49 | SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials. ( Cusimano, MD; Etminan, N; Hanggi, D; Hasan, D; Ilodigwe, D; Jaja, B; Lantigua, H; Le Roux, P; Lo, B; Louffat-Olivares, A; Macdonald, RL; Mayer, S; Molyneux, A; Quinn, A; Schenk, T; Schweizer, TA; Singh, J; Spears, J; Todd, M; Torner, J; Vergouwen, MD; Wong, GK, 2013) |
| "To determine if the age of packed red blood cells (PRBCs) is associated with adverse events or outcomes in patients with subarachnoid haemorrhage (SAH)." | 1.37 | Packed red blood cell age does not impact adverse events or outcomes after subarachnoid haemorrhage. ( Ault, ML; Duran, IM; Liebling, SM; Naidech, AM, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Mahmoud, SH | 1 |
| Hefny, FR | 1 |
| Panos, NG | 1 |
| Delucilla, L | 1 |
| Ngan, Z | 1 |
| Perreault, MM | 1 |
| Hamilton, LA | 1 |
| Rowe, AS | 1 |
| Buschur, PL | 1 |
| Owusu-Guha, J | 1 |
| Almohaish, S | 1 |
| Sandler, M | 1 |
| Armahizer, MJ | 1 |
| Barra, ME | 1 |
| Cook, AM | 1 |
| Barthol, CA | 1 |
| Hintze, TD | 1 |
| Cantin, A | 1 |
| Traeger, J | 1 |
| Blunck, JR | 1 |
| Shewmaker, J | 1 |
| Burgess, SV | 1 |
| Kaupp, K | 1 |
| Brown, CS | 1 |
| Clark, SL | 2 |
| Wieruszewski, ED | 1 |
| Tesoro, EP | 1 |
| Ammar, AA | 1 |
| Ammar, MA | 1 |
| Binning, MJ | 1 |
| Naydin, S | 1 |
| Fox, N | 1 |
| Peters, DM | 1 |
| Mahmoud, LN | 1 |
| Keegan, SP | 1 |
| Brophy, GM | 1 |
| Rass, V | 1 |
| Kindl, P | 1 |
| Lindner, A | 1 |
| Kofler, M | 1 |
| Altmann, K | 1 |
| Putnina, L | 1 |
| Ianosi, BA | 1 |
| Schiefecker, AJ | 1 |
| Beer, R | 1 |
| Pfausler, B | 1 |
| Helbok, R | 1 |
| Chen, CJ | 1 |
| Turnage, C | 1 |
| Sokolowski, JD | 1 |
| Kumar, JS | 1 |
| Kalani, MY | 1 |
| Park, MS | 1 |
| Kieninger, M | 1 |
| Gruber, M | 1 |
| Knott, I | 1 |
| Dettmer, K | 1 |
| Oefner, PJ | 1 |
| Bele, S | 1 |
| Wendl, C | 1 |
| Tuemmler, S | 1 |
| Graf, B | 1 |
| Eissnert, C | 1 |
| Hajizadeh Barfejani, A | 1 |
| Rabinstein, AA | 1 |
| Wijdicks, EFM | 1 |
| Mitra, R | 1 |
| Dube, SK | 1 |
| Jain, V | 1 |
| Macdonald, RL | 1 |
| Jaja, B | 1 |
| Cusimano, MD | 1 |
| Etminan, N | 1 |
| Hanggi, D | 1 |
| Hasan, D | 1 |
| Ilodigwe, D | 1 |
| Lantigua, H | 1 |
| Le Roux, P | 1 |
| Lo, B | 1 |
| Louffat-Olivares, A | 1 |
| Mayer, S | 1 |
| Molyneux, A | 1 |
| Quinn, A | 1 |
| Schweizer, TA | 1 |
| Schenk, T | 1 |
| Spears, J | 1 |
| Todd, M | 1 |
| Torner, J | 1 |
| Vergouwen, MD | 1 |
| Wong, GK | 1 |
| Singh, J | 1 |
| Justin, A | 1 |
| Sathishkumar, M | 1 |
| Sudheer, A | 1 |
| Shanthakumari, S | 1 |
| Ramanathan, M | 1 |
| Francoeur, CL | 1 |
| Mayer, SA | 1 |
| Bekker, A | 2 |
| Haile, M | 2 |
| Li, YS | 2 |
| Galoyan, S | 2 |
| Garcia, E | 1 |
| Quartermain, D | 2 |
| Kamer, A | 1 |
| Blanck, T | 2 |
| Naidech, AM | 1 |
| Liebling, SM | 1 |
| Duran, IM | 1 |
| Ault, ML | 1 |
| Cohen, BH | 1 |
| Gerloni, R | 1 |
| Copetti, R | 1 |
| Porchet, F | 1 |
| Chioléro, R | 1 |
| de Tribolet, N | 1 |
| Radhakrishnan, D | 1 |
| Menon, DK | 1 |
| Cunitz, G | 1 |
| Ahmed, N | 1 |
| Näsman, P | 1 |
| Wahlgren, NG | 1 |
| Jan, M | 1 |
| Buchheit, F | 1 |
| Tremoulet, M | 1 |
| Laursen, J | 1 |
| Jensen, F | 1 |
| Mikkelsen, E | 1 |
| Jakobsen, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inter- and Intra-Observer Variability in Transcranial Doppler (TCD) Technique in Neurocritical Care Patients[NCT04583163] | 12 participants (Anticipated) | Observational | 2020-09-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nimodipine and Hypotension
| Article | Year |
|---|---|
SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials.
Topics: Antioxidants; Brain Infarction; Calcium Channel Blockers; Critical Care; Dioxanes; Drug Therapy, Com | 2013 |
Management of delayed cerebral ischemia after subarachnoid hemorrhage.
Topics: Brain Ischemia; Calcium Channel Blockers; Disease Management; Humans; Hyponatremia; Hypotension; Hyp | 2016 |
3 trials available for nimodipine and Hypotension
| Article | Year |
|---|---|
Haemodynamic effects of intravenous nimodipine following aneurysmal subarachnoid haemorrhage: implications for monitoring.
Topics: Adult; Aged; Calcium Channel Blockers; Cardiac Catheterization; Hemodynamics; Humans; Hypotension; I | 1997 |
Effect of intravenous nimodipine on blood pressure and outcome after acute stroke.
Topics: Acute Disease; Administration, Oral; Blood Pressure; Brain Damage, Chronic; Brain Ischemia; Calcium | 2000 |
Therapeutic trial of intravenous nimodipine in patients with established cerebral vasospasm after rupture of intracranial aneurysms.
Topics: Adult; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypotension; Injections, Intravenous; | 1988 |
14 other studies available for nimodipine and Hypotension
| Article | Year |
|---|---|
Comparison of nimodipine formulations and administration techniques via enteral feeding tubes in patients with aneurysmal subarachnoid hemorrhage: A multicenter retrospective cohort study.
Topics: Calcium Channel Blockers; Enteral Nutrition; Humans; Hypotension; Nimodipine; Retrospective Studies; | 2023 |
Blood Pressure Changes in Association with Nimodipine Therapy in Patients with Spontaneous Subarachnoid Hemorrhage.
Topics: Blood Pressure; Brain Ischemia; Cerebral Infarction; Humans; Hypotension; Nimodipine; Norepinephrine | 2023 |
Dangers of outpatient nimodipine use after spontaneous subarachnoid hemorrhage in accordance with the Comprehensive Stroke Center guidelines.
Topics: Aged; Brain Ischemia; Calcium Channel Blockers; Humans; Hypotension; Male; Nimodipine; Outpatients; | 2018 |
Incidence of Arterial Hypotension in Patients Receiving Peroral or Continuous Intra-arterial Nimodipine After Aneurysmal or Perimesencephalic Subarachnoid Hemorrhage.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Femal | 2019 |
Poor Utilization of Nimodipine in Aneurysmal Subarachnoid Hemorrhage.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Drug Administration Sch | 2019 |
Isolated diastolic hypotension: A unique complication of intra-arterial nimodipine infusion!!
Topics: Aged; Angiography, Digital Subtraction; Anterior Cerebral Artery; Blood Pressure; Diastole; Electroc | 2020 |
Non-hypotensive dose of telmisartan and nimodipine produced synergistic neuroprotective effect in cerebral ischemic model by attenuating brain cytokine levels.
Topics: Animals; Benzimidazoles; Benzoates; Brain; Brain Ischemia; Cytokines; Drug Synergism; Drug Therapy, | 2014 |
Nimodipine prevents memory impairment caused by nitroglycerin-induced hypotension in adult mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Calcium Channel Blockers; Cerebrovasc | 2009 |
Packed red blood cell age does not impact adverse events or outcomes after subarachnoid haemorrhage.
Topics: Adult; Aged; Blood Preservation; Cerebral Infarction; Coma; Erythrocyte Aging; Erythrocyte Transfusi | 2011 |
Nimodipine-induced hypotension but not nitroglycerin-induced hypotension preserves long- and short-term memory in adult mice.
Topics: Animals; Avoidance Learning; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cer | 2012 |
Easily reversible hypoxemia and hypotension induced by nimodipine.
Topics: Aged; Aged, 80 and over; Calcium Gluconate; Emergency Service, Hospital; Female; Follow-Up Studies; | 2004 |
Hypotensive effect of nimodipine during treatment for aneurysmal subarachnoid haemorrhage.
Topics: Administration, Oral; Adult; Aged; Aneurysm, Ruptured; Blood Pressure; Brain; Calcium Channel Blocke | 1995 |
Early management of head injury.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiaz | 1997 |
Nimodipine treatment of subarachnoid hemorrhage.
Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Drug Administration Schedule; Female; Humans; Hy | 1988 |