nimodipine has been researched along with Heart Arrest in 19 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred fifty-five consecutive patients resuscitated after out-of-hospital ventricular fibrillation by a physician-manned advanced life support unit were randomly assigned to receive nimodipine or placebo at a dosage of 10 micrograms/kg as an intravenous injection immediately after restoration of spontaneous circulation, followed by an infusion of 0." | 9.06 | Nimodipine after resuscitation from out-of-hospital ventricular fibrillation. A placebo-controlled, double-blind, randomized trial. ( Kajaste, S; Kaste, M; Kinnunen, A; Nikki, P; Roine, RO; Sarna, S, 1990) |
| "The presence of cerebral infarcts, leukoaraiosis, atrophy, and edema on ultra-low-field MRI was assessed in 88 community volunteers and 52 cardiac arrest survivors enrolled in a placebo-controlled, randomized, double-blind trial of nimodipine in out-of-hospital ventricular fibrillation." | 5.07 | Magnetic resonance imaging findings associated with cardiac arrest. ( Erkinjuntti, T; Kaste, M; Raininko, R; Roine, RO; Ylikoski, A, 1993) |
| "Placebo-controlled, randomized, double-blind trial of nimodipine compared with placebo in out-of-hospital ventricular fibrillation." | 5.07 | Neuropsychological sequelae of cardiac arrest. ( Kajaste, S; Kaste, M; Roine, RO, 1993) |
| "One hundred fifty-five consecutive patients resuscitated after out-of-hospital ventricular fibrillation by a physician-manned advanced life support unit were randomly assigned to receive nimodipine or placebo at a dosage of 10 micrograms/kg as an intravenous injection immediately after restoration of spontaneous circulation, followed by an infusion of 0." | 5.06 | Nimodipine after resuscitation from out-of-hospital ventricular fibrillation. A placebo-controlled, double-blind, randomized trial. ( Kajaste, S; Kaste, M; Kinnunen, A; Nikki, P; Roine, RO; Sarna, S, 1990) |
| "This study presents 39 out-of-hospital cardiac arrests resuscitated with success." | 2.67 | Early effects of nimodipine on intracranial and cerebral perfusion pressures in cerebral anoxia after out-of-hospital cardiac arrest. ( Bancalari, G; Garcia-Darennes, F; Gaussorgues, P; Gueugniaud, PY; Petit, P; Robert, D; Roux, H, 1990) |
| "Patients suffering from critical illnesses like cardiac arrest with resuscitation and hypovolemic shock often are in need of medication." | 2.41 | [Pharmacology in critical illness]. ( Buylaert, WA, 2001) |
| " In these experiments, we started the administration of nimodipine before the induction of global brain ischemia, used 2 different dosage regimens and provided prolonged drug administration after restoration of cerebral blood flow in order to create optimal circumstances for a cerebroprotective effect to be detected." | 1.29 | Pharmacological influences on cardiopulmonary arrest-related brain damage in the rat. ( Calle, PA, 1993) |
| "Brain damage after resuscitation from cardiac arrest is believed to be related to calcium influx in ischaemic neurons and to postischaemic calcium-dependent vasospasm." | 1.28 | Nimodipine has no beneficial effect on neurological outcome in a cardiopulmonary arrest model in the rat. ( Bogaert, MG; Buylaert, WA; Calle, PA; De Ridder, L, 1990) |
| "Nimodipine was given as a bolus injection followed by a maintenance infusion." | 1.27 | Influence of cardiopulmonary resuscitation on plasma concentrations of nimodipine in the dog. ( Buylaert, WA; Calle, PA; Huyghens, LP; Rosseel, MT, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 11 (57.89) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, Y | 1 |
| Zacharias, E | 1 |
| Hoff, P | 1 |
| Tegtmeier, F | 1 |
| Nash, SD | 1 |
| Patt, MV | 1 |
| Schindler, I | 1 |
| Steltzer, H | 1 |
| Weindlmayr-Goettel, M | 1 |
| Steinbereithner, K | 1 |
| Roine, RO | 4 |
| Raininko, R | 1 |
| Erkinjuntti, T | 1 |
| Ylikoski, A | 1 |
| Kaste, M | 4 |
| Kajaste, S | 2 |
| Calle, PA | 4 |
| Buylaert, WA | 5 |
| Tateishi, A | 2 |
| Scheller, MS | 2 |
| Drummond, JC | 2 |
| Zornow, MH | 2 |
| Grafe, MR | 2 |
| Fleischer, JE | 2 |
| Shapiro, HM | 2 |
| Bogaert, MG | 3 |
| De Ridder, L | 2 |
| Gueugniaud, PY | 1 |
| Gaussorgues, P | 1 |
| Garcia-Darennes, F | 1 |
| Bancalari, G | 1 |
| Roux, H | 1 |
| Robert, D | 1 |
| Petit, P | 1 |
| Kinnunen, A | 2 |
| Nikki, P | 2 |
| Sarna, S | 1 |
| Huyghens, LP | 2 |
| Corne, L | 1 |
| Rosseel, MT | 2 |
| Prough, DS | 1 |
| Furberg, CD | 1 |
| Forsman, M | 1 |
| Aarseth, HP | 1 |
| Nordby, HK | 1 |
| Skulberg, A | 1 |
| Steen, PA | 2 |
| Gisvold, SE | 1 |
| Milde, JH | 1 |
| Newberg, LA | 1 |
| Scheithauer, BW | 1 |
| Lanier, WL | 1 |
| Michenfelder, JD | 1 |
1 review available for nimodipine and Heart Arrest
| Article | Year |
|---|---|
[Pharmacology in critical illness].
Topics: Adrenergic Agonists; Anesthetics, Intravenous; Animals; Calcium Channel Blockers; Cardiopulmonary Re | 2001 |
5 trials available for nimodipine and Heart Arrest
| Article | Year |
|---|---|
Magnetic resonance imaging findings associated with cardiac arrest.
Topics: Adult; Age Factors; Aged; Atrophy; Brain Edema; Cerebral Infarction; Double-Blind Method; Female; He | 1993 |
Neuropsychological sequelae of cardiac arrest.
Topics: Adult; Aged; Aged, 80 and over; Cognition; Depressive Disorder; Double-Blind Method; Female; Heart A | 1993 |
Early effects of nimodipine on intracranial and cerebral perfusion pressures in cerebral anoxia after out-of-hospital cardiac arrest.
Topics: Cerebrovascular Circulation; Heart Arrest; Humans; Hypoxia, Brain; Intracranial Pressure; Middle Age | 1990 |
Nimodipine after resuscitation from out-of-hospital ventricular fibrillation. A placebo-controlled, double-blind, randomized trial.
Topics: Aged; Brain Ischemia; Double-Blind Method; Female; Heart Arrest; Humans; Male; Middle Aged; Nimodipi | 1990 |
Effects of nimodipine on cerebral blood flow and cerebrospinal fluid pressure after cardiac arrest: correlation with neurologic outcome.
Topics: Aged; Cerebrospinal Fluid Pressure; Cerebrovascular Circulation; Consciousness; Female; Heart Arrest | 1989 |
13 other studies available for nimodipine and Heart Arrest
| Article | Year |
|---|---|
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Dizocilpine Maleate; Flunarizine; Glyburid | 1995 |
Sinus arrest after nimodipine treatment for a head injury.
Topics: Adult; Arrhythmia, Sinus; Electrocardiography; Heart Arrest; Humans; Ischemic Attack, Transient; Mal | 1994 |
Nimodipine after circulatory arrest: effects on oxygen delivery and consumption.
Topics: Animals; Blood Gas Analysis; Cardiopulmonary Resuscitation; Combined Modality Therapy; Disease Model | 1994 |
Pharmacological influences on cardiopulmonary arrest-related brain damage in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Butylene Glycols; Carotid Arteries; Heart Arrest; Liga | 1993 |
Failure of nimodipine to improve neurologic outcome after eighteen minutes of cardiac arrest in the cat.
Topics: Animals; Cats; Central Nervous System Diseases; Electroencephalography; Heart Arrest; Hemodynamics; | 1991 |
Nimodipine decreases resuscitability in a cardiopulmonary arrest model in the rat.
Topics: Animals; Central Nervous System Diseases; Heart Arrest; Nimodipine; Rats; Rats, Inbred Strains; Resu | 1991 |
Nimodipine has no beneficial effect on neurological outcome in a cardiopulmonary arrest model in the rat.
Topics: Animals; Blood Pressure; Cell Survival; Coronary Disease; Disease Models, Animal; Electrocardiograph | 1990 |
Plasma concentrations and haemodynamic effects of nimodipine in patients resuscitated after cardiac arrest.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Ethanol; Female; Heart Arrest; Heart Rate; Hemodynam | 1989 |
Nimodipine does not improve neurologic outcome after 14 minutes of cardiac arrest in cats.
Topics: Animals; Brain; Cats; Central Nervous System Diseases; Electroencephalography; Heart Arrest; Nimodip | 1989 |
Influence of cardiopulmonary resuscitation on plasma concentrations of nimodipine in the dog.
Topics: Animals; Antipyrine; Blood Pressure; Body Temperature; Dogs; Female; Heart Arrest; Male; Nimodipine; | 1987 |
Nimodipine and the "no-reflow phenomenon"--experimental triumph, clinical failure?
Topics: Cerebrovascular Circulation; Heart Arrest; Humans; Nimodipine; Reperfusion Injury | 1989 |
Safety and efficacy of nimodipine in resuscitation of patients outside hospital.
Topics: Community Health Services; Heart Arrest; Humans; Nimodipine; Resuscitation; Safety | 1987 |
Nimodipine improves outcome when given after complete cerebral ischemia in primates.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Drug Evaluation, Preclinical; Electroencep | 1985 |