nimodipine has been researched along with Epilepsy in 19 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To analyze the effect of nimodipine in patients with intractable epilepsy." | 9.08 | Nimodipine as an add-on therapy for intractable epilepsy. ( Cascino, GD; Gorman, DA; Ivnik, RJ; Meyer, FB; O'Fallon, WM; Sharbrough, FW; So, EL; Whisnant, JP; Windschitl, WL, 1995) |
| "To evaluate efficacy and safety of the calcium channel antagonist nimodipine in dogs with idiopathic epilepsy." | 9.08 | Nimodipine for treatment of idiopathic epilepsy in dogs. ( Goetze, L; Kroll, RA; Longshore, RC; O'Brien, DP; Simpson, ST, 1997) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "To analyze the effect of nimodipine in patients with intractable epilepsy." | 5.08 | Nimodipine as an add-on therapy for intractable epilepsy. ( Cascino, GD; Gorman, DA; Ivnik, RJ; Meyer, FB; O'Fallon, WM; Sharbrough, FW; So, EL; Whisnant, JP; Windschitl, WL, 1995) |
| "To evaluate efficacy and safety of the calcium channel antagonist nimodipine in dogs with idiopathic epilepsy." | 5.08 | Nimodipine for treatment of idiopathic epilepsy in dogs. ( Goetze, L; Kroll, RA; Longshore, RC; O'Brien, DP; Simpson, ST, 1997) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.89 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Hasan, M; Marson, AG; Pulman, J, 2013) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.81 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Baillie, N; Chaisewikul, R; Marson, AG, 2001) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of 3-mercaptopropionic acid (MP), and possible participation of P-glycoprotein in this model of epilepsy." | 3.74 | Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. ( Auzmendi, J; Bramuglia, GF; Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Opezzo, JA; Taira, CA, 2007) |
| "The present work studied the effect of calcium channel blocker (nimodipine) on epileptic seizures elicited by electrical stimulation of somatosensory cortex in young rats exposed to hypoxia." | 3.73 | Partial effect of nimodipine on evoked epileptic seizures in young rats. ( Maresová, D, 2006) |
| "Employing the immunocytochemical analysis, we observed the alterations of Substance P-Immune Reaction (SP-IR) positive neurons of the cerebral cortex, hippocampus and amygdala in rats suffering from epilepsy induced by Penicillin (PEN)." | 3.69 | [Alterations of substance P-immune reaction positive neurons of cerebral tissues in epileptic rats]. ( Ruan, X; Wei, Y; Zhu, C; Zou, X, 1997) |
| "Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats." | 3.11 | Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022) |
| "3." | 2.67 | Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients. ( Baasch, H; Barzaghi, N; Caresia, L; Galimberti, CA; Gatti, G; Manni, R; Mück, W; Parietti, L; Tartara, A; Zucca, C, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Verdijk, JPAJ | 1 |
| Pottkämper, JCM | 1 |
| Verwijk, E | 1 |
| van Wingen, GA | 1 |
| van Putten, MJAM | 1 |
| Hofmeijer, J | 1 |
| van Waarde, JA | 1 |
| Hasan, M | 1 |
| Pulman, J | 1 |
| Marson, AG | 2 |
| Wang, P | 1 |
| Wang, WP | 1 |
| Wang, HX | 1 |
| Fan, YH | 1 |
| Höcht, C | 2 |
| Lazarowski, A | 2 |
| Gonzalez, NN | 2 |
| Mayer, MA | 1 |
| Opezzo, JA | 2 |
| Taira, CA | 2 |
| Girardi, E | 2 |
| Escribano, AB | 1 |
| Peña, E | 1 |
| Barbosa, A | 1 |
| Fernández, C | 1 |
| Corradini, I | 1 |
| Donzelli, A | 1 |
| Antonucci, F | 1 |
| Welzl, H | 1 |
| Loos, M | 1 |
| Martucci, R | 1 |
| De Astis, S | 1 |
| Pattini, L | 1 |
| Inverardi, F | 1 |
| Wolfer, D | 1 |
| Caleo, M | 1 |
| Bozzi, Y | 1 |
| Verderio, C | 1 |
| Frassoni, C | 1 |
| Braida, D | 1 |
| Clerici, M | 1 |
| Lipp, HP | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| Scorza, FA | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 1 |
| de Barros Viana, GS | 1 |
| Auzmendi, J | 1 |
| Bramuglia, GF | 1 |
| Maresová, D | 1 |
| Trembly, B | 1 |
| Meyer, FB | 1 |
| Cascino, GD | 1 |
| Whisnant, JP | 1 |
| Sharbrough, FW | 1 |
| Ivnik, RJ | 1 |
| Gorman, DA | 1 |
| Windschitl, WL | 1 |
| So, EL | 1 |
| O'Fallon, WM | 1 |
| O'Brien, DP | 1 |
| Simpson, ST | 1 |
| Longshore, RC | 1 |
| Kroll, RA | 1 |
| Goetze, L | 1 |
| Zou, X | 2 |
| Ruan, X | 2 |
| Wei, Y | 1 |
| Zhu, C | 1 |
| Zhou, S | 1 |
| Cai, Q | 1 |
| Niespodziany, I | 1 |
| Klitgaard, H | 1 |
| Margineanu, DG | 1 |
| Chaisewikul, R | 1 |
| Baillie, N | 1 |
| Tartara, A | 1 |
| Galimberti, CA | 1 |
| Manni, R | 1 |
| Parietti, L | 1 |
| Zucca, C | 1 |
| Baasch, H | 1 |
| Caresia, L | 1 |
| Mück, W | 1 |
| Barzaghi, N | 1 |
| Gatti, G | 1 |
| Lu, YM | 1 |
| Zhang, JT | 1 |
| Zhao, FQ | 1 |
| Li, F | 1 |
| Otomo, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596] | Phase 2 | 34 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nimodipine and Epilepsy
| Article | Year |
|---|---|
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Drug Therapy, Combination; Epilepsy; Flu | 2013 |
Clinical potential for the use of neuroprotective agents. A brief overview.
Topics: Animals; Brain Diseases; Brain Injuries; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular D | 1995 |
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Epilepsy; Flunarizine; Humans; Nifedipin | 2001 |
4 trials available for nimodipine and Epilepsy
| Article | Year |
|---|---|
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph | 2022 |
Nimodipine as an add-on therapy for intractable epilepsy.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Humans; | 1995 |
Nimodipine for treatment of idiopathic epilepsy in dogs.
Topics: Animals; Calcium Channel Blockers; Dog Diseases; Dogs; Epilepsy; Female; Male; Nimodipine; Prospecti | 1997 |
Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients.
Topics: Adult; Anticonvulsants; Drug Interactions; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Ma | 1991 |
12 other studies available for nimodipine and Epilepsy
| Article | Year |
|---|---|
Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats.
Topics: Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein | 2008 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
Puerpera with dyspnoea and epileptic seizure.
Topics: Adult; Calcium Channel Blockers; Cerebrovascular Disorders; Coronary Angiography; Dyspnea; Epilepsy; | 2013 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2007 |
Partial effect of nimodipine on evoked epileptic seizures in young rats.
Topics: Air Pressure; Animals; Calcium Channel Blockers; Electric Stimulation; Epilepsy; Hypoxia; Male; Nimo | 2006 |
[Alterations of substance P-immune reaction positive neurons of cerebral tissues in epileptic rats].
Topics: Amygdala; Animals; Calcium Channel Blockers; Cerebral Cortex; Epilepsy; Female; Hippocampus; Male; N | 1997 |
[Antiepileptic effects of nimodipine on penicillin-induced seizures in rats].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Epilepsy; Female; Male; Nimodipine; Penicillins; | 1997 |
Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices.
Topics: Animals; Anticonvulsants; Cadmium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Ep | 2001 |
Effects of nimodipine on l-glutamate-induced seizures and Ca2+ influx in hippocampus in freely moving rats.
Topics: Animals; Biological Transport, Active; Calcium; Electroencephalography; Epilepsy; Glutamates; Hippoc | 1991 |
[Nervous disease & Ca antagonist].
Topics: Calcium Channel Blockers; Cerebral Infarction; Cerebrovascular Disorders; Epilepsy; Flunarizine; Hum | 1990 |