nimodipine has been researched along with Diabetic Neuropathies in 5 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with nimodipine (20 mg kg-1) from week 6 onwards significantly increased the sciatic nerve blood flow as compared to placebo-treated diabetic BB/Wor rats." | 1.29 | Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. ( Biessels, G; Bravenboer, B; de Wildt, DJ; Gispen, WH; Kappelle, AC; Traber, J; van Buren, T, 1994) |
| "Treatment with nimodipine restored the reduced presynaptic responsiveness independent of the postsynaptic adrenergic hyporesponsiveness." | 1.29 | Effects of nimodipine on sciatic nerve blood flow and vasa nervorum responsiveness in the diabetic rat. ( Biessels, GJ; De Wildt, DJ; Erkelens, DW; Gispen, WH; Kappelle, AC; Van Buren, T, 1993) |
| " Intraperitoneal treatment with the Ca2+ channel blocker, nimodipine, from week 4 onwards, in a dosage of 10 mg kg-1 or 20 mg kg-1 intraperitoneally per 48 h, resulted in a significant increase in sensory and motor nerve conduction velocity whereas treatment with 5 mg kg-1 intraperitoneally per 48 h was not effective." | 1.29 | Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat. ( Bravenboer, B; Erkelens, DW; Gispen, WH; Kappelle, AC; Traber, J; van Buren, T, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gispen, WH | 4 |
| Hamers, FP | 1 |
| Kappelle, AC | 3 |
| Biessels, G | 1 |
| Bravenboer, B | 2 |
| van Buren, T | 3 |
| Traber, J | 2 |
| de Wildt, DJ | 2 |
| Biessels, GJ | 1 |
| Erkelens, DW | 2 |
| Ristic, H | 1 |
| Wiley, JW | 1 |
| Hall, KE | 1 |
| Sima, AA | 1 |
1 review available for nimodipine and Diabetic Neuropathies
| Article | Year |
|---|---|
Calcium and neuronal dysfunction in peripheral nervous system.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cisplatin; Diabetic Neuropathie | 1994 |
4 other studies available for nimodipine and Diabetic Neuropathies
| Article | Year |
|---|---|
Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat.
Topics: Animals; Autonomic Nervous System; Blood Glucose; Blood Pressure; Body Weight; Diabetic Neuropathies | 1994 |
Effects of nimodipine on sciatic nerve blood flow and vasa nervorum responsiveness in the diabetic rat.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experi | 1993 |
Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat.
Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 1993 |
Failure of nimodipine to prevent or correct the long-term nerve conduction defect and increased neuronal Ca(2+)-currents in the diabetic BB/W-rat.
Topics: Animals; Blood Glucose; Body Weight; Calcium; Calcium Channel Blockers; Cohort Studies; Diabetic Neu | 1996 |