nimodipine has been researched along with Cerebral Malaria in 3 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human cerebral malaria (HCM) is a life-threatening complication caused by Plasmodium falciparum infection that continues to be a major global health problem despite optimal anti-malarial treatment." | 5.39 | Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria. ( Carvalho, LJ; Clemmer, L; Frangos, JA; Martins, YC; Ong, PK; Orjuela-Sánchez, P; Zanini, GM, 2013) |
| "Brain hemodynamics in cerebral malaria (CM) is poorly understood, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increased blood flow in large arteries." | 5.36 | Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. ( Cabrales, P; Carvalho, LJ; Frangos, JA; Meays, D; Zanini, GM, 2010) |
| "Human cerebral malaria (HCM) is a life-threatening complication caused by Plasmodium falciparum infection that continues to be a major global health problem despite optimal anti-malarial treatment." | 1.39 | Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria. ( Carvalho, LJ; Clemmer, L; Frangos, JA; Martins, YC; Ong, PK; Orjuela-Sánchez, P; Zanini, GM, 2013) |
| "Brain hemodynamics in cerebral malaria (CM) is poorly understood, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increased blood flow in large arteries." | 1.36 | Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. ( Cabrales, P; Carvalho, LJ; Frangos, JA; Meays, D; Zanini, GM, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martins, YC | 1 |
| Clemmer, L | 1 |
| Orjuela-Sánchez, P | 1 |
| Zanini, GM | 2 |
| Ong, PK | 1 |
| Frangos, JA | 2 |
| Carvalho, LJ | 2 |
| Desruisseaux, MS | 1 |
| Machado, FS | 1 |
| Weiss, LM | 1 |
| Tanowitz, HB | 1 |
| Golightly, LM | 1 |
| Cabrales, P | 1 |
| Meays, D | 1 |
3 other studies available for nimodipine and Cerebral Malaria
| Article | Year |
|---|---|
Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria.
Topics: Administration, Intravenous; Animals; Antihypertensive Agents; Antimalarials; Artemisinins; Artesuna | 2013 |
Cerebral malaria: a vasculopathy.
Topics: Animals; Artemether; Artemisinins; Humans; Malaria, Cerebral; Mice; Nimodipine; Plasmodium berghei; | 2010 |
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.
Topics: Animals; Artemether; Artemisinins; Arterioles; Body Temperature; Cell Adhesion; Cerebrovascular Circ | 2010 |