nimodipine has been researched along with Cerebral Infarction, Middle Cerebral Artery in 22 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to investigate the neuroprotective effects of 20(S)-ginsenoside Rg3 on focal cerebral ischemia in rats." | 7.73 | Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. ( Fu, F; Geng, M; Jiang, W; Jiang, Y; Liu, K; Tian, J; Wang, C; Yang, J, 2005) |
| "Nimodipine-treated animals were then matched with vehicle-treated controls for both study conditions." | 5.32 | Nimodipine does not affect the flow-metabolism couple in permanent cerebral ischemia. ( Burnett, MG; Gomi, S; Greenberg, JH; Karp, A, 2004) |
| "This study was conducted to investigate the neuroprotective effects of 20(S)-ginsenoside Rg3 on focal cerebral ischemia in rats." | 3.73 | Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. ( Fu, F; Geng, M; Jiang, W; Jiang, Y; Liu, K; Tian, J; Wang, C; Yang, J, 2005) |
| "Male Sprague-Dawley rats under permanent middle cerebral artery occlusion (pMCAO) model, randomly assigned as: model, sham, nimodipine (0." | 3.11 | The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway. ( Fu, Y; Li, D; Liu, Q; Wang, H; Wang, W; Zhang, T; Zhang, Y, 2022) |
| "Permanent cerebral ischemia is a consequence of prolonged cerebral artery occlusion that results in severe brain damage." | 1.72 | Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms. ( Chaichompoo, W; Oka, C; Sengking, J; Suksamrarn, A; Tocharus, C; Tocharus, J; Yawoot, N, 2022) |
| "Nimodipine and aspirin were set as positive control separately." | 1.43 | Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats. ( Chen, B; Cheng, MH; Fan, BS; Shi, HQ; Tian, JS; Yu, JG; Zhang, Y, 2016) |
| "A rat model of cerebral ischemia and reperfusion injury was established using the middle cerebral artery occlusion (MCAO) model." | 1.38 | Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats. ( Deng, YJ; Lu, JX; Lu, ZQ, 2012) |
| "Rats were subjected to transient middle cerebral artery occlusion (MCAO) model using the intraluminal thread." | 1.35 | Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. ( Chen, BY; Deng, CQ; Li, H; Liang, Y; Luo, XG; Zhang, SP, 2009) |
| "During the following 2 weeks, the cerebral vasospasm resolved with application of high-dose methyl prednisolone and nimodipine." | 1.32 | [Cerebral vasospasms with hemodynamic infarctions as a complication of HELLP syndrome]. ( Bloos, G; Harscher, S; Möller, U; Pfleiderer, SO; Terborg, C; Witte, OW, 2003) |
| "Nimodipine-treated animals were then matched with vehicle-treated controls for both study conditions." | 1.32 | Nimodipine does not affect the flow-metabolism couple in permanent cerebral ischemia. ( Burnett, MG; Gomi, S; Greenberg, JH; Karp, A, 2004) |
| "Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice." | 1.31 | [Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice]. ( Wang, PL; Wang, RD; Wei, EQ; Zeng, LH; Zhang, WP, 2001) |
| "Nimodipine pre-treatment immediately attenuated the inactivation of Na(+)-K+/Mg+2 ATPase (p < 0." | 1.31 | The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat. ( Cetinalp, E; Göçer, AI; Ildan, F; Isbir, T; Kaya, M; Polat, S; Tuna, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 8 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 2 |
| Ma, H | 1 |
| Huang, J | 1 |
| Yao, Z | 2 |
| Yu, J | 1 |
| Zhang, W | 2 |
| Zhang, L | 1 |
| Wang, Z | 1 |
| Zhuang, C | 1 |
| Zhao, X | 1 |
| Liu, J | 1 |
| Yang, L | 1 |
| Niu, Y | 1 |
| Ren, R | 1 |
| Su, C | 1 |
| Chen, J | 2 |
| Ma, X | 2 |
| Liu, ZJ | 1 |
| Wang, CP | 1 |
| Yang, B | 1 |
| Wang, N | 1 |
| Wang, Q | 1 |
| Gu, J | 1 |
| Tan, R | 1 |
| Sengking, J | 1 |
| Oka, C | 1 |
| Yawoot, N | 1 |
| Tocharus, J | 1 |
| Chaichompoo, W | 1 |
| Suksamrarn, A | 1 |
| Tocharus, C | 1 |
| Zhang, Y | 2 |
| Liu, Q | 1 |
| Zhang, T | 1 |
| Wang, H | 1 |
| Fu, Y | 1 |
| Wang, W | 1 |
| Li, D | 1 |
| Huang, S | 1 |
| Huang, Z | 1 |
| Fu, Z | 1 |
| Shi, Y | 1 |
| Dai, Q | 1 |
| Tang, S | 1 |
| Gu, Y | 1 |
| Xu, Y | 1 |
| Wu, X | 1 |
| Ren, F | 1 |
| Chen, X | 1 |
| Peng, X | 1 |
| Wu, L | 1 |
| Wu, H | 1 |
| Ou, Y | 1 |
| Lai, J | 1 |
| Wen, J | 1 |
| Jiang, Y | 2 |
| Hu, Q | 1 |
| Wang, J | 1 |
| Wei, S | 1 |
| Li, H | 2 |
| Larrosa-Campo, D | 1 |
| Ramon-Carbajo, C | 1 |
| Benavente-Fernandez, L | 1 |
| Alvarez-Escudero, R | 1 |
| Zeidan-Ramon, N | 1 |
| Calleja-Puerta, S | 1 |
| Pascual, J | 1 |
| Shi, HQ | 1 |
| Cheng, MH | 1 |
| Fan, BS | 1 |
| Tian, JS | 1 |
| Yu, JG | 1 |
| Chen, B | 1 |
| Wang, X | 1 |
| Wang, C | 2 |
| Yang, Y | 1 |
| Ni, J | 1 |
| Deng, CQ | 1 |
| Chen, BY | 1 |
| Zhang, SP | 1 |
| Liang, Y | 1 |
| Luo, XG | 1 |
| Koskinen, LO | 1 |
| Olivecrona, M | 1 |
| Rodling-Wahlström, M | 1 |
| Naredi, S | 1 |
| Babu, CS | 1 |
| Ramanathan, M | 1 |
| Lu, ZQ | 1 |
| Deng, YJ | 1 |
| Lu, JX | 1 |
| Bell, KF | 1 |
| Bent, RJ | 1 |
| Meese-Tamuri, S | 1 |
| Ali, A | 1 |
| Forder, JP | 1 |
| Aarts, MM | 1 |
| Zeng, LH | 1 |
| Zhang, WP | 1 |
| Wang, RD | 1 |
| Wang, PL | 1 |
| Wei, EQ | 1 |
| Harscher, S | 1 |
| Witte, OW | 1 |
| Möller, U | 1 |
| Bloos, G | 1 |
| Pfleiderer, SO | 1 |
| Terborg, C | 1 |
| Gomi, S | 1 |
| Burnett, MG | 1 |
| Karp, A | 1 |
| Greenberg, JH | 1 |
| Tian, J | 1 |
| Fu, F | 1 |
| Geng, M | 1 |
| Yang, J | 1 |
| Jiang, W | 1 |
| Liu, K | 1 |
| Zhu, D | 1 |
| Li, R | 1 |
| Liu, G | 1 |
| Hua, W | 1 |
| Ildan, F | 1 |
| Göçer, AI | 1 |
| Tuna, M | 1 |
| Polat, S | 1 |
| Kaya, M | 1 |
| Isbir, T | 1 |
| Cetinalp, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study on the Treatment of Hypertensive Cerebral Hemorrhage With Panax Notoginseng Saponins[NCT02999048] | Phase 4 | 90 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for nimodipine and Cerebral Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway.
Topics: Animals; Brain Ischemia; Chlorogenic Acid; Disease Models, Animal; Gallic Acid; Infarction, Middle C | 2022 |
21 other studies available for nimodipine and Cerebral Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.
Topics: Administration, Oral; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dru | 2021 |
Beneficial effects of mijianchangpu decoction on ischemic stroke through components accessing to the brain based on network pharmacology.
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Gene Expression Regulation; Infarction, Middle Cereb | 2022 |
[Protective effect and mechanism of Ershiwuwei Zhenzhu Pills on cerebral apoplexy rats].
Topics: Animals; Caspase 3; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Interleukin-6; Ischem | 2022 |
Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Topics: Animals; bcl-2-Associated X Protein; Benzylisoquinolines; Brain Ischemia; Calcium; Calcium Channels; | 2022 |
A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies.
Topics: Animals; Drug Carriers; Drug Delivery Systems; Drug Stability; Emulsions; Female; Infarction, Middle | 2020 |
Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway.
Topics: Animals; Apoptosis; Brain Ischemia; China; Flavones; Infarction, Middle Cerebral Artery; Inflammatio | 2020 |
l-Borneol ameliorates cerebral ischaemia by downregulating the mitochondrial calcium uniporter-induced apoptosis cascade in pMCAO rats.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channels; Camphanes; Disease Models, Animal; Dose-Respon | 2021 |
[Diagnosis of stroke due to cocaine and its complications].
Topics: Adult; Aphasia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Hemi | 2013 |
Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats.
Topics: Acute Disease; Analysis of Variance; Animals; Apoptosis; Aspirin; Blood Pressure; Cell Survival; Cel | 2016 |
New monocyte locomotion inhibitory factor analogs protect against cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Infarction, Middle Cerebral Artery; Interleukin-1 | 2017 |
Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspase Inhibitors; Female; Infarction, Middle Cerebral A | 2009 |
Prostacyclin treatment normalises the MCA flow velocity in nimodipine-resistant cerebral vasospasm after aneurysmal subarachnoid haemorrhage: a pilot study.
Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Arteries; Cerebrovascular Circula | 2009 |
Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergetics.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Calcium Channel Blockers; Glutamate-Ammonia Ligase | 2011 |
Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats.
Topics: Aloe; Animals; Brain Ischemia; Caspase 3; Cerebral Cortex; Gene Expression Regulation, Enzymologic; | 2012 |
Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Infarction; Calcium Channel Blockers; Calcium-C | 2013 |
[Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice].
Topics: Animals; Brain; Brain Ischemia; Chromones; Dexamethasone; Infarction, Middle Cerebral Artery; Leukot | 2001 |
[Cerebral vasospasms with hemodynamic infarctions as a complication of HELLP syndrome].
Topics: Adult; Cesarean Section; Diagnostic Imaging; Dose-Response Relationship, Drug; Female; Follow-Up Stu | 2003 |
Nimodipine does not affect the flow-metabolism couple in permanent cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signalin | 2004 |
Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Chemistry; Brain Ischemia; Calcium Chan | 2005 |
Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells.
Topics: Animals; Astrocytes; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Enzyme Activation; | 1999 |
The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat.
Topics: Animals; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Cerebral Cortex; Energy Metabolism; Infarction, Middl | 2001 |