nimodipine has been researched along with Brain Swelling in 26 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the mechanism and type of acute infectious brain edema induced by injection of pertussis bacilli (PB) in rat neocortex, to study the neuroprotective effect of non-competitive antagonist of N-methl-D-aspartate (NMDA) receptor (MK-801) and antagonist of Ca(2+) channels (nimodipine) on brain edema, and to investigate the relationship between percentage of water content and cytosolic free calcium concentration ([Ca(2+) ](i)) in synaptosomes or content of Evans Blue (EB)." | 9.10 | Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats. ( Cao, MH; Chen, LH; Liu, LX; Liu, YS; Yang, YJ, 2003) |
| "To study the effect of nimodipine (Nim) on infectious brain edema (BE)." | 7.69 | Effect of nimodipine on infectious brain edema in rabbits. ( Tao, YG; Wen, FQ; Yu, PL; Zhang, BL, 1996) |
| "The effect of nimodipine pretreatment on CBF and brain edema was studied in conscious rats subjected to 2." | 7.68 | Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J; Wang, XJ, 1990) |
| "Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i." | 7.68 | Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J, 1990) |
| "A novel transient middle cerebral artery (MCA) occlusion model in the rat was used to evaluate the effect of nimodipine on brain edema and mortality." | 7.68 | Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model. ( Hara, H; Kogure, K; Nagasawa, H; Onodera, H, 1990) |
| "Nimodipine was admenistred to show its effect on the PB induced brain edema." | 5.30 | [Protective effects of nimodipine on brain edema induced by pertussis bacilli in rats]. ( Cao, M; Chen, L; Yang, Y, 1997) |
| "To explore the mechanism and type of acute infectious brain edema induced by injection of pertussis bacilli (PB) in rat neocortex, to study the neuroprotective effect of non-competitive antagonist of N-methl-D-aspartate (NMDA) receptor (MK-801) and antagonist of Ca(2+) channels (nimodipine) on brain edema, and to investigate the relationship between percentage of water content and cytosolic free calcium concentration ([Ca(2+) ](i)) in synaptosomes or content of Evans Blue (EB)." | 5.10 | Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats. ( Cao, MH; Chen, LH; Liu, LX; Liu, YS; Yang, YJ, 2003) |
| "The presence of cerebral infarcts, leukoaraiosis, atrophy, and edema on ultra-low-field MRI was assessed in 88 community volunteers and 52 cardiac arrest survivors enrolled in a placebo-controlled, randomized, double-blind trial of nimodipine in out-of-hospital ventricular fibrillation." | 5.07 | Magnetic resonance imaging findings associated with cardiac arrest. ( Erkinjuntti, T; Kaste, M; Raininko, R; Roine, RO; Ylikoski, A, 1993) |
| "To study the effect of nimodipine (Nim) on infectious brain edema (BE)." | 3.69 | Effect of nimodipine on infectious brain edema in rabbits. ( Tao, YG; Wen, FQ; Yu, PL; Zhang, BL, 1996) |
| "The effect of nimodipine pretreatment on CBF and brain edema was studied in conscious rats subjected to 2." | 3.68 | Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J; Wang, XJ, 1990) |
| "Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i." | 3.68 | Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J, 1990) |
| "A novel transient middle cerebral artery (MCA) occlusion model in the rat was used to evaluate the effect of nimodipine on brain edema and mortality." | 3.68 | Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model. ( Hara, H; Kogure, K; Nagasawa, H; Onodera, H, 1990) |
| "Treatment with the calcium entry blocker nimodipine is recommended as effective therapy for cerebral ischemia due to cerebral vasospasm or cerebral thrombosis." | 3.68 | [Effect of calcium antagonist nimodipine and induced hypertension on cerebral vessel reactivities, cerebral blood flow, cerebral edema and infarction in cats with one hour middle-cerebral-artery occlusion]. ( Ishida, T; Sakaki, T; Sasaoka, Y; Thunoda, S; Utsumi, S, 1990) |
| "Acute cerebral hypoxia causes rapid calcium shifts leading to neuronal damage and death." | 2.90 | Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia. ( Douaud, G; Ezra, M; Garry, P; Kelly, M; Lamb, C; Okell, TW; Pattinson, KT; Rowland, MJ; Westbrook, J; Winkler, A; Wise, RG, 2019) |
| "Treatment of progressing or acute cerebral ischemia is aimed at prevention of infarction in areas of the brain that are still viable." | 2.38 | Medical management of acute cerebral ischemia in the elderly. ( Biller, J; Love, BB, 1991) |
| "Nimodipine has a protective action on brain injury by blocking a series of pathological reactions induced by neuronal calcium overload, and by reducing the spasm of brain vessels and improving cerebral blood flow." | 1.32 | Therapeutic effect of nimodipine on experimental brain injury. ( Wang, ZG; Yang, SY, 2003) |
| "Nimodipine was admenistred to show its effect on the PB induced brain edema." | 1.30 | [Protective effects of nimodipine on brain edema induced by pertussis bacilli in rats]. ( Cao, M; Chen, L; Yang, Y, 1997) |
| "Nimodipine was given at a dose of 1 mg/kg 1 hour before and 2 hours after the cold lesion." | 1.29 | Proposed toxic oxidant inhibitors fail to reduce brain edema. ( Bulkley, GB; Hedlund, BE; Judy, KD; Long, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (69.23) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Hawkes, MA | 1 |
| Hlavnicka, AA | 1 |
| Wainsztein, NA | 1 |
| Rowland, MJ | 1 |
| Ezra, M | 1 |
| Winkler, A | 1 |
| Garry, P | 1 |
| Lamb, C | 1 |
| Kelly, M | 1 |
| Okell, TW | 1 |
| Westbrook, J | 1 |
| Wise, RG | 1 |
| Douaud, G | 1 |
| Pattinson, KT | 1 |
| Gan'shina, TS | 1 |
| Kim, GA | 1 |
| Gnezdilova, AV | 1 |
| Kurdiumov, IN | 1 |
| Mirzoian, RS | 1 |
| Konopacka, A | 1 |
| Konopacki, FA | 1 |
| Albrecht, J | 1 |
| Ismailoglu, O | 1 |
| Atilla, P | 1 |
| Palaoglu, S | 1 |
| Cakar, N | 1 |
| Yasar, U | 1 |
| Kilinc, K | 1 |
| Kaptanoglu, E | 1 |
| Chen, LH | 1 |
| Liu, LX | 1 |
| Yang, YJ | 1 |
| Liu, YS | 1 |
| Cao, MH | 1 |
| Yang, SY | 1 |
| Wang, ZG | 1 |
| Roda, JM | 1 |
| Carceller, F | 1 |
| Díez-Tejedor, E | 1 |
| Avendaño, C | 1 |
| Judy, KD | 1 |
| Bulkley, GB | 1 |
| Hedlund, BE | 1 |
| Long, DM | 1 |
| De Jong, GI | 1 |
| Van der Zee, EA | 1 |
| Bohus, B | 1 |
| Luiten, PG | 1 |
| Roine, RO | 1 |
| Raininko, R | 1 |
| Erkinjuntti, T | 1 |
| Ylikoski, A | 1 |
| Kaste, M | 1 |
| Wen, FQ | 1 |
| Zhang, BL | 1 |
| Yu, PL | 1 |
| Tao, YG | 1 |
| Chen, L | 1 |
| Cao, M | 1 |
| Yang, Y | 1 |
| Morgan, MK | 1 |
| Sekhon, LH | 1 |
| Finfer, S | 1 |
| Grinnell, V | 1 |
| Li, G | 1 |
| Liu, Y | 1 |
| Olson, JE | 1 |
| Biller, J | 1 |
| Love, BB | 1 |
| Sakaki, T | 2 |
| Tsunoda, S | 1 |
| Morimoto, T | 1 |
| Hara, H | 3 |
| Nagasawa, H | 3 |
| Kogure, K | 3 |
| Gaab, MR | 2 |
| Höllerhage, HG | 1 |
| Walter, GF | 1 |
| Hocheder, M | 1 |
| Haubitz, I | 1 |
| Jacewicz, M | 2 |
| Brint, S | 2 |
| Tanabe, J | 2 |
| Wang, XJ | 1 |
| Pulsinelli, WA | 2 |
| Onodera, H | 1 |
| Ishida, T | 1 |
| Sasaoka, Y | 1 |
| Thunoda, S | 1 |
| Utsumi, S | 1 |
| Poch, B | 1 |
| Heller, V | 1 |
| Kostron, H | 1 |
| Grunert, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MRI Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations - A Prospective Preliminary Study[NCT03995823] | 50 participants (Anticipated) | Observational | 2019-07-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nimodipine and Brain Swelling
| Article | Year |
|---|---|
Medical management of acute cerebral ischemia in the elderly.
Topics: Acute Disease; Aged; Brain Edema; Brain Ischemia; Fibrinolytic Agents; Humans; Nimodipine; Reperfusi | 1991 |
3 trials available for nimodipine and Brain Swelling
| Article | Year |
|---|---|
Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia.
Topics: Adult; Brain Edema; Calcium; Calcium Channel Blockers; Calcium Signaling; Female; Humans; Hypoxia, B | 2019 |
Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats.
Topics: Acute Disease; Analysis of Variance; Animals; Blood-Brain Barrier; Bordetella pertussis; Brain Edema | 2003 |
Magnetic resonance imaging findings associated with cardiac arrest.
Topics: Adult; Age Factors; Aged; Atrophy; Brain Edema; Cerebral Infarction; Double-Blind Method; Female; He | 1993 |
22 other studies available for nimodipine and Brain Swelling
| Article | Year |
|---|---|
Reversible Cerebral Vasoconstriction Syndrome Responsive to Intravenous Milrinone.
Topics: Adult; Angiography, Digital Subtraction; Aphasia, Broca; Brain Edema; Cerebral Hemorrhage; Computed | 2020 |
[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].
Topics: Amlodipine; Animals; Animals, Outbred Strains; Brain; Brain Edema; Brain Injuries; Brain Ischemia; L | 2014 |
Protein kinase G is involved in ammonia-induced swelling of astrocytes.
Topics: Ammonia; Animals; Astrocytes; Brain Edema; Calcium Channel Blockers; Calcium Channels, L-Type; Calci | 2009 |
The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Drug Combinations; Lipid Peroxi | 2012 |
Therapeutic effect of nimodipine on experimental brain injury.
Topics: Animals; Biopsy, Needle; Brain Edema; Brain Injuries; Calcium Channel Blockers; Disease Models, Anim | 2003 |
Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia.
Topics: Animals; Blood Pressure; Brain Edema; Calcium Channel Blockers; Carotid Artery, External; Cerebral A | 1995 |
Proposed toxic oxidant inhibitors fail to reduce brain edema.
Topics: Allopurinol; Animals; Brain Edema; Brain Injuries; Calcium; Cats; Cerebral Cortex; Cerebral Infarcti | 1994 |
Reversed alterations of hippocampal parvalbumin and protein kinase C-gamma immunoreactivity after stroke in spontaneously hypertensive stroke-prone rats.
Topics: Aging; Animals; Brain; Brain Edema; Calcium; Cerebrovascular Disorders; Hippocampus; Male; Nimodipin | 1993 |
Effect of nimodipine on infectious brain edema in rabbits.
Topics: Animals; Bordetella Infections; Bordetella pertussis; Brain; Brain Edema; Calcium; Calcium Channel B | 1996 |
[Protective effects of nimodipine on brain edema induced by pertussis bacilli in rats].
Topics: Animals; Blood-Brain Barrier; Bordetella pertussis; Brain Edema; Calcium Channel Blockers; Female; M | 1997 |
Delayed neurological deterioration following resection of arteriovenous malformations of the brain.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Aneurysm; Anticoagulants; Antihypertensive Agents; Asp | 1999 |
Calcium/calmodulin-modulated chloride and taurine conductances in cultured rat astrocytes.
Topics: Animals; Astrocytes; Brain Edema; Calcium; Calcium Channel Blockers; Calmodulin; Cells, Cultured; Ch | 2002 |
The influence of the calcium antagonist nimodipine and induced hypertension on the behavior of the cerebral pial arteries, the blood-brain barrier, cerebral edema, and cerebral infarction in cats with one-hour occlusion of the middle cerebral artery.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cats; Cerebral Arteries; Cerebral Infarction; Female; Int | 1991 |
Nimodipine attenuates both ischaemia-induced brain oedema and mortality in a rat novel transient middle cerebral artery occlusion model.
Topics: Animals; Autoradiography; Body Water; Brain; Brain Edema; Calcium; Cerebral Arteries; Constriction, | 1990 |
Brain edema, autoregulation, and calcium antagonism. An experimental study with nimodipine.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Edema; Brain Injuries; Calcium; Cerebrovascular | 1990 |
Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Male; Nimodipine; Premedication; | 1990 |
Nimodipine prevents postischemic brain damage in the early phase of focal cerebral ischemia.
Topics: Animals; Brain; Brain Edema; Calcium Radioisotopes; Cerebral Arteries; Constriction; Ischemic Attack | 1990 |
Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia.
Topics: Animals; Blood Pressure; Blood Volume; Brain Edema; Brain Ischemia; Cerebral Infarction; Male; Nimod | 1990 |
Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model.
Topics: Animals; Autoradiography; Brain Edema; Brain Ischemia; Calcium Radioisotopes; Cerebral Arteries; Dis | 1990 |
[Effect of calcium antagonist nimodipine and induced hypertension on cerebral vessel reactivities, cerebral blood flow, cerebral edema and infarction in cats with one hour middle-cerebral-artery occlusion].
Topics: Animals; Blood Pressure; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Infarction; | 1990 |
Oxygen tension, oxygen metabolism, and microcirculation in vasogenic brain edema.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Ketamine; Male; | 1990 |
Calcium entry blocker effects on ischemic brain damage after severe head injury.
Topics: Brain Edema; Craniocerebral Trauma; Drug Evaluation; Humans; Intracranial Pressure; Nimodipine; Pilo | 1990 |