nimodipine has been researched along with Brain Injuries in 38 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimodipine treatment provides SAH patients with short-term neurological benefits." | 5.72 | Nimodipine Attenuates Early Brain Injury by Protecting the Glymphatic System After Subarachnoid Hemorrhage in Mice. ( Cui, X; Hou, C; Li, J; Liu, Q; Ren, W; Wang, B; Wang, W; Yang, X; Zhang, H, 2022) |
| "Traumatic subarachnoid hemorrhage is a common finding following traumatic brain injury." | 5.35 | Experimental subarachnoid hemorrhage in the rat: influences of nimodipine. ( Brinker, T; Herrmann, B; Samii, M; Thomas, S, 2008) |
| "Cerebral vasospasm is one of the frequent complications that can occur following subarachnoid hemorrhage (SAH)." | 3.01 | Cerebral Vasospasm: Practical Review of Diagnosis and Management. ( Artico, M; Berger, JM; Caramuta, M; Longhitano, Y; Maconi, A; Piccolella, F; Romenskaya, T; Saviano, A; Savioli, G; Taurone, S; Zanza, C, 2023) |
| "Aneurysmal subarachnoid hemorrhage (aSAH) is a severe subtype of stroke occurring at a relatively young age with a significant socioeconomic impact." | 2.82 | Therapeutic Approaches for Cerebrovascular Dysfunction After Aneurysmal Subarachnoid Hemorrhage: An Update and Future Perspectives. ( Grasso, G; Torregrossa, F, 2022) |
| "Treatment with nimodipine dramatically reduces the effects of brain damage induced by injection of PB." | 2.70 | Changes of neuronal calcium channel following brain damage induced by injection of pertussis bacilli in rats. ( Cao, M; Chen, L; Liu, L; Yang, Y, 2002) |
| "Nimodipine was well tolerated and there were few adverse reactions; means of systolic and diastolic blood pressures and the intracranial pressure did not differ between the groups." | 2.67 | A trial of the effect of nimodipine on outcome after head injury. ( Bailey, I; Bell, A; Gray, J; Gullan, R; Heiskanan, O; Marks, PV; Marsh, H; Mendelow, DA; Murray, G; Ohman, J, 1991) |
| "Nimodipine is a dihydropyridine calcium channel antagonist that blocks the flux of extracellular calcium through L-type, voltage-gated calcium channels." | 2.66 | Nimodipine Reappraised: An Old Drug With a Future. ( Carlson, AP; Hänggi, D; Macdonald, RL; Shuttleworth, CW, 2020) |
| "Nimodipine treatment provides SAH patients with short-term neurological benefits." | 1.72 | Nimodipine Attenuates Early Brain Injury by Protecting the Glymphatic System After Subarachnoid Hemorrhage in Mice. ( Cui, X; Hou, C; Li, J; Liu, Q; Ren, W; Wang, B; Wang, W; Yang, X; Zhang, H, 2022) |
| "Moreover, MN-08 also alleviated cerebral vasospasm in a cisterna magna single-injection model in rabbits." | 1.51 | The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models. ( Guo, B; Han, Y; Ju, J; Li, N; Li, S; Liu, Z; Luo, F; Mak, S; Sun, Y; Wang, Y; Wu, L; Yang, X; Zhang, G; Zhang, Z; Zhou, Q; Zhu, Z, 2019) |
| "Female mice received whole brain irradiation (WBI) and were treated with saline, nimodipine, hUC-MSCs, or hUC-MSCs combined with nimodipine." | 1.43 | Neuroprotective effects of human umbilical cord-derived mesenchymal stromal cells combined with nimodipine against radiation-induced brain injury through inhibition of apoptosis. ( Duan, HF; Li, T; Liu, J; Liu, Y; Lu, Y; Qin, YR; Wang, GH; Wu, XB, 2016) |
| "Traumatic subarachnoid hemorrhage is a common finding following traumatic brain injury." | 1.35 | Experimental subarachnoid hemorrhage in the rat: influences of nimodipine. ( Brinker, T; Herrmann, B; Samii, M; Thomas, S, 2008) |
| " The animals were treated with either one of the drugs at previously defined relevant dosage or control." | 1.33 | Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine. ( Gahm, C; Holmin, S; Mathiesen, T; Rudehill, S, 2005) |
| "Nimodipine has a protective action on brain injury by blocking a series of pathological reactions induced by neuronal calcium overload, and by reducing the spasm of brain vessels and improving cerebral blood flow." | 1.32 | Therapeutic effect of nimodipine on experimental brain injury. ( Wang, ZG; Yang, SY, 2003) |
| "Group 3 (n = 10) received head trauma and intravenous (IV) 2 microgr/kg nimodipine." | 1.31 | Effects of nimodipine and magnesium sulfate on endogenous antioxidant levels in brain tissue after experimental head trauma. ( Ak, A; Duman, A; Oğun, CO; Ustün, ME; Vatansev, H, 2001) |
| "This may represent an advantage in the treatment of hypertension with risk of brain damage." | 1.31 | Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats. ( Amenta, F; Sabbatini, M; Tomassoni, D, 2001) |
| "Pretreatment with nimodipine markedly prevented mice from delayed encephalopathy after CO poisoning." | 1.31 | Protective effect of nimodipine against cerebral injury induced by subacute carbon monoxide intoxication in mice. ( Yang, JQ; Zhou, QX, 2001) |
| "Nimodipine was given at a dose of 1 mg/kg 1 hour before and 2 hours after the cold lesion." | 1.29 | Proposed toxic oxidant inhibitors fail to reduce brain edema. ( Bulkley, GB; Hedlund, BE; Judy, KD; Long, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 14 (36.84) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 6 (15.79) | 24.3611 |
| 2020's | 6 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, C | 1 |
| Liu, Q | 2 |
| Zhang, H | 1 |
| Wang, W | 1 |
| Wang, B | 1 |
| Cui, X | 1 |
| Li, J | 1 |
| Ren, W | 1 |
| Yang, X | 2 |
| Torregrossa, F | 1 |
| Grasso, G | 1 |
| Romenskaya, T | 1 |
| Longhitano, Y | 1 |
| Piccolella, F | 1 |
| Berger, JM | 1 |
| Artico, M | 1 |
| Taurone, S | 1 |
| Maconi, A | 1 |
| Saviano, A | 1 |
| Caramuta, M | 1 |
| Savioli, G | 1 |
| Zanza, C | 1 |
| Yang, Y | 2 |
| Li, H | 1 |
| Xu, Y | 2 |
| Xie, J | 1 |
| Shi, Z | 1 |
| Huang, J | 1 |
| Cheng, J | 1 |
| Chen, S | 2 |
| Zhao, X | 1 |
| Li, S | 2 |
| Zhang, Z | 3 |
| Cai, J | 1 |
| He, B | 1 |
| Lin, WJ | 1 |
| Shen, Q | 1 |
| Li, Y | 1 |
| Tang, Y | 2 |
| Carlson, AP | 1 |
| Hänggi, D | 1 |
| Macdonald, RL | 1 |
| Shuttleworth, CW | 1 |
| Roelz, R | 1 |
| Schubach, F | 1 |
| Coenen, VA | 1 |
| Jenkner, C | 1 |
| Scheiwe, C | 1 |
| Grauvogel, J | 1 |
| Niesen, WD | 1 |
| Urbach, H | 1 |
| Taschner, C | 1 |
| Seufert, J | 1 |
| Kätzler, J | 1 |
| Beck, J | 1 |
| Reinacher, PC | 1 |
| Luo, F | 1 |
| Wu, L | 1 |
| Zhu, Z | 1 |
| Liu, Z | 1 |
| Guo, B | 1 |
| Li, N | 2 |
| Ju, J | 1 |
| Zhou, Q | 1 |
| Mak, S | 1 |
| Han, Y | 1 |
| Sun, Y | 1 |
| Wang, Y | 1 |
| Zhang, G | 1 |
| Tang, H | 1 |
| Shi, Q | 1 |
| Guo, J | 1 |
| Shang, E | 1 |
| Duan, JA | 1 |
| Gan'shina, TS | 1 |
| Kim, GA | 1 |
| Gnezdilova, AV | 1 |
| Kurdiumov, IN | 1 |
| Mirzoian, RS | 1 |
| Wang, GH | 1 |
| Liu, Y | 1 |
| Wu, XB | 1 |
| Lu, Y | 1 |
| Liu, J | 1 |
| Qin, YR | 1 |
| Li, T | 1 |
| Duan, HF | 1 |
| Thomas, S | 1 |
| Herrmann, B | 1 |
| Samii, M | 1 |
| Brinker, T | 1 |
| Bie, XD | 1 |
| Han, J | 1 |
| Dai, HB | 1 |
| Ismailoglu, O | 1 |
| Atilla, P | 1 |
| Palaoglu, S | 2 |
| Cakar, N | 1 |
| Yasar, U | 1 |
| Kilinc, K | 2 |
| Kaptanoglu, E | 1 |
| Chen, L | 1 |
| Liu, L | 1 |
| Cao, M | 1 |
| Yang, SY | 1 |
| Wang, ZG | 1 |
| Gahm, C | 1 |
| Holmin, S | 1 |
| Rudehill, S | 1 |
| Mathiesen, T | 1 |
| Trembly, B | 1 |
| Kakarieka, A | 2 |
| Braakman, R | 2 |
| Schakel, EH | 2 |
| Hans, P | 1 |
| Triffaux, M | 1 |
| Bonhomme, V | 1 |
| Born, JD | 1 |
| Damas, F | 1 |
| Maertens de Noordhout, A | 1 |
| Judy, KD | 1 |
| Bulkley, GB | 1 |
| Hedlund, BE | 1 |
| Long, DM | 1 |
| Hinson, J | 1 |
| Lambert, DC | 1 |
| LeVere, TE | 1 |
| Sattler, R | 1 |
| Tymianski, M | 1 |
| Feyaz, I | 1 |
| Hafner, M | 1 |
| Tator, CH | 1 |
| Murray, GD | 1 |
| Teasdale, GM | 1 |
| Schmitz, H | 1 |
| Sui, J | 1 |
| Xiong, Y | 1 |
| Zhang, C | 1 |
| Ustün, ME | 1 |
| Duman, A | 1 |
| Oğun, CO | 1 |
| Vatansev, H | 1 |
| Ak, A | 1 |
| Ercan, M | 1 |
| Inci, S | 1 |
| Aypar, U | 1 |
| Sabbatini, M | 1 |
| Tomassoni, D | 1 |
| Amenta, F | 1 |
| Zhang, X | 1 |
| Liu, E | 1 |
| Liu, X | 1 |
| Dai, Q | 1 |
| Yang, JQ | 1 |
| Zhou, QX | 1 |
| Shen, G | 1 |
| Zhou, Y | 1 |
| Xu, M | 1 |
| Liu, B | 1 |
| Teasdale, G | 1 |
| Bailey, I | 2 |
| Bell, A | 2 |
| Gray, J | 2 |
| Gullan, R | 2 |
| Heiskanan, O | 2 |
| Marks, PV | 2 |
| Marsh, H | 2 |
| Mendelow, DA | 2 |
| Murray, G | 2 |
| Ohman, J | 1 |
| Gaab, MR | 2 |
| Höllerhage, HG | 1 |
| Walter, GF | 1 |
| Hocheder, M | 1 |
| Haubitz, I | 1 |
| Poch, B | 1 |
| Heller, V | 1 |
| Archer, DP | 1 |
| Pappius, HM | 1 |
| Kostron, H | 1 |
| Rumpl, E | 1 |
| Stampfl, G | 1 |
| Russegger, L | 1 |
| Grunert, V | 1 |
5 reviews available for nimodipine and Brain Injuries
| Article | Year |
|---|---|
Therapeutic Approaches for Cerebrovascular Dysfunction After Aneurysmal Subarachnoid Hemorrhage: An Update and Future Perspectives.
Topics: Brain Injuries; Brain Ischemia; Cerebral Infarction; Humans; Nimodipine; Quality of Life; Subarachno | 2022 |
Cerebral Vasospasm: Practical Review of Diagnosis and Management.
Topics: Brain Injuries; Humans; Nimodipine; Subarachnoid Hemorrhage; Treatment Outcome; Vasospasm, Intracran | 2023 |
Nimodipine Reappraised: An Old Drug With a Future.
Topics: Brain Injuries; Brain Injuries, Traumatic; Brain Ischemia; Calcium Channel Blockers; Humans; Nimodip | 2020 |
Clinical potential for the use of neuroprotective agents. A brief overview.
Topics: Animals; Brain Diseases; Brain Injuries; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular D | 1995 |
Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Calcium Channel Blockers; Female; Gl | 1996 |
8 trials available for nimodipine and Brain Injuries
| Article | Year |
|---|---|
Stereotactic cisternal lavage in patients with aneurysmal subarachnoid hemorrhage with urokinase and nimodipine for the prevention of secondary brain injury (SPLASH): study protocol for a randomized controlled trial.
Topics: Aortic Aneurysm, Abdominal; Blood Vessel Prosthesis Implantation; Brain Injuries; Endovascular Proce | 2021 |
Changes of neuronal calcium channel following brain damage induced by injection of pertussis bacilli in rats.
Topics: Analysis of Variance; Animals; Bordetella pertussis; Brain Injuries; Calcium; Calcium Channel Blocke | 2002 |
[Classification of head injuries based on computerized tomography: prognostic value].
Topics: Adolescent; Adult; Aged; Brain Injuries; Humans; Middle Aged; Nimodipine; Prognosis; Prospective Stu | 1995 |
Clinical significance of the finding of subarachnoid blood on CT scan after head injury.
Topics: Adult; Brain Damage, Chronic; Brain Injuries; Disability Evaluation; Dose-Response Relationship, Dru | 1994 |
A multicenter trial of the efficacy of nimodipine on outcome after severe head injury. The European Study Group on Nimodipine in Severe Head Injury.
Topics: Adult; Brain Injuries; Female; Humans; Male; Nimodipine; Placebos; Radiography; Subarachnoid Hemorrh | 1994 |
Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Calcium Channel Blockers; Female; Gl | 1996 |
A randomized trial of nimodipine in severe head injury: HIT I. British/Finnish Co-operative Head Injury Trial Group.
Topics: Adult; Brain Injuries; Female; Follow-Up Studies; Humans; Intracranial Pressure; Male; Motor Activit | 1992 |
A trial of the effect of nimodipine on outcome after head injury.
Topics: Adult; Blood Pressure; Brain Damage, Chronic; Brain Injuries; Double-Blind Method; Female; Follow-Up | 1991 |
26 other studies available for nimodipine and Brain Injuries
| Article | Year |
|---|---|
Nimodipine Attenuates Early Brain Injury by Protecting the Glymphatic System After Subarachnoid Hemorrhage in Mice.
Topics: Animals; Brain; Brain Injuries; Glymphatic System; Humans; Mice; Nimodipine; Rats; Rats, Sprague-Daw | 2022 |
Notch Signaling Mediates Radiation-Induced Smooth Muscle Cell Hypermuscularization and Cerebral Vasculopathy.
Topics: Animals; Brain Injuries; Cerebrovascular Disorders; Esters; Mice; Myocytes, Smooth Muscle; Nimodipin | 2022 |
The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models.
Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; HEK293 Cells; Hum | 2019 |
Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats.
Topics: Amino Acids; Animals; Antioxidants; Apigenin; Brain; Brain Injuries; Brain Ischemia; CA1 Region, Hip | 2014 |
[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].
Topics: Amlodipine; Animals; Animals, Outbred Strains; Brain; Brain Edema; Brain Injuries; Brain Ischemia; L | 2014 |
Neuroprotective effects of human umbilical cord-derived mesenchymal stromal cells combined with nimodipine against radiation-induced brain injury through inhibition of apoptosis.
Topics: Animals; Apoptosis; Astrocytes; beta-Globins; Body Weight; Brain Injuries; Cell Count; Cell Differen | 2016 |
Experimental subarachnoid hemorrhage in the rat: influences of nimodipine.
Topics: Animals; Brain Injuries; Disease Models, Animal; Fibrinolytic Agents; Glial Fibrillary Acidic Protei | 2008 |
Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats.
Topics: Adenosine Triphosphatases; Animals; Brain; Brain Injuries; Chalcone; Disease Models, Animal; Malondi | 2010 |
The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Drug Combinations; Lipid Peroxi | 2012 |
Therapeutic effect of nimodipine on experimental brain injury.
Topics: Animals; Biopsy, Needle; Brain Edema; Brain Injuries; Calcium Channel Blockers; Disease Models, Anim | 2003 |
Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Brain Injuries; Calcium Channel Blockers; Cell | 2005 |
Control of drug-resistant epilepsy after head injury with intravenous nimodipine.
Topics: Brain Injuries; Drug Therapy, Combination; Electroencephalography; Epilepsy, Generalized; Female; Hu | 1994 |
Proposed toxic oxidant inhibitors fail to reduce brain edema.
Topics: Allopurinol; Animals; Brain Edema; Brain Injuries; Calcium; Cats; Cerebral Cortex; Cerebral Infarcti | 1994 |
Recovery of function after brain damage: differential effects of blocking calcium uptake during the recovery of a learned behavior and the performance of the recovered behavior following neocortical brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Calcium; Calcium Channel Blockers; Cerebral Cortex; L | 1996 |
Voltage-sensitive calcium channels mediate calcium entry into cultured mammalian sympathetic neurons following neurite transection.
Topics: Animals; Brain Injuries; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Membr | 1996 |
[Therapeutic effects of nimodipine on learning and memory of rats with traumatic brain injury].
Topics: Animals; Avoidance Learning; Brain Injuries; Calcium Channel Blockers; Female; Male; Memory Disorder | 1997 |
Effects of nimodipine and magnesium sulfate on endogenous antioxidant levels in brain tissue after experimental head trauma.
Topics: Analysis of Variance; Animals; Antioxidants; Blood Pressure; Brain; Brain Injuries; Carbon Dioxide; | 2001 |
Nimodipine attenuates lipid peroxidation during the acute phase of head trauma in rats.
Topics: Acute-Phase Reaction; Animals; Brain Injuries; Disease Models, Animal; Female; Free Radicals; Lipid | 2001 |
Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Brain Injuries; Calcium Channel Blockers; D | 2001 |
Changes in and effective factors of microtubule-associated protein 2 in traumatic neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cold Temperature; Fluorescent Antibody Techniq | 2001 |
Protective effect of nimodipine against cerebral injury induced by subacute carbon monoxide intoxication in mice.
Topics: Animals; Avoidance Learning; Brain; Brain Injuries; Calcium Channel Blockers; Carbon Monoxide Poison | 2001 |
Effects of nimodipine on changes of endothelin after head injury in rabbits.
Topics: Animals; Brain; Brain Injuries; Calcium Channel Blockers; Craniocerebral Trauma; Endothelins; Nimodi | 2001 |
Brain edema, autoregulation, and calcium antagonism. An experimental study with nimodipine.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Edema; Brain Injuries; Calcium; Cerebrovascular | 1990 |
Oxygen tension, oxygen metabolism, and microcirculation in vasogenic brain edema.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Ketamine; Male; | 1990 |
Effects of two dihydropyridine calcium channel blockers on cerebral metabolism and blood flow in traumatized rat brain.
Topics: Animals; Blood Glucose; Brain; Brain Injuries; Calcium; Calcium Channel Blockers; Cerebrovascular Ci | 1986 |
Treatment of cerebral vasospasm following severe head injury with the calcium influx blocker nimodipine.
Topics: Adolescent; Adult; Aged; Brain Injuries; Calcium Channel Blockers; Cerebral Angiography; Electroence | 1985 |