nimodipine has been researched along with Brain Edema in 26 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the mechanism and type of acute infectious brain edema induced by injection of pertussis bacilli (PB) in rat neocortex, to study the neuroprotective effect of non-competitive antagonist of N-methl-D-aspartate (NMDA) receptor (MK-801) and antagonist of Ca(2+) channels (nimodipine) on brain edema, and to investigate the relationship between percentage of water content and cytosolic free calcium concentration ([Ca(2+) ](i)) in synaptosomes or content of Evans Blue (EB)." | 9.10 | Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats. ( Cao, MH; Chen, LH; Liu, LX; Liu, YS; Yang, YJ, 2003) |
| "To study the effect of nimodipine (Nim) on infectious brain edema (BE)." | 7.69 | Effect of nimodipine on infectious brain edema in rabbits. ( Tao, YG; Wen, FQ; Yu, PL; Zhang, BL, 1996) |
| "The effect of nimodipine pretreatment on CBF and brain edema was studied in conscious rats subjected to 2." | 7.68 | Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J; Wang, XJ, 1990) |
| "Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i." | 7.68 | Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J, 1990) |
| "A novel transient middle cerebral artery (MCA) occlusion model in the rat was used to evaluate the effect of nimodipine on brain edema and mortality." | 7.68 | Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model. ( Hara, H; Kogure, K; Nagasawa, H; Onodera, H, 1990) |
| "Nimodipine was admenistred to show its effect on the PB induced brain edema." | 5.30 | [Protective effects of nimodipine on brain edema induced by pertussis bacilli in rats]. ( Cao, M; Chen, L; Yang, Y, 1997) |
| "To explore the mechanism and type of acute infectious brain edema induced by injection of pertussis bacilli (PB) in rat neocortex, to study the neuroprotective effect of non-competitive antagonist of N-methl-D-aspartate (NMDA) receptor (MK-801) and antagonist of Ca(2+) channels (nimodipine) on brain edema, and to investigate the relationship between percentage of water content and cytosolic free calcium concentration ([Ca(2+) ](i)) in synaptosomes or content of Evans Blue (EB)." | 5.10 | Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats. ( Cao, MH; Chen, LH; Liu, LX; Liu, YS; Yang, YJ, 2003) |
| "The presence of cerebral infarcts, leukoaraiosis, atrophy, and edema on ultra-low-field MRI was assessed in 88 community volunteers and 52 cardiac arrest survivors enrolled in a placebo-controlled, randomized, double-blind trial of nimodipine in out-of-hospital ventricular fibrillation." | 5.07 | Magnetic resonance imaging findings associated with cardiac arrest. ( Erkinjuntti, T; Kaste, M; Raininko, R; Roine, RO; Ylikoski, A, 1993) |
| "To study the effect of nimodipine (Nim) on infectious brain edema (BE)." | 3.69 | Effect of nimodipine on infectious brain edema in rabbits. ( Tao, YG; Wen, FQ; Yu, PL; Zhang, BL, 1996) |
| "The effect of nimodipine pretreatment on CBF and brain edema was studied in conscious rats subjected to 2." | 3.68 | Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J; Wang, XJ, 1990) |
| "Focal cerebral infarction and edema were measured in rats (Wistar, Fisher 344, and spontaneously hypertensive strains) pretreated with nimodipine (2 micrograms/kg/min i." | 3.68 | Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia. ( Brint, S; Jacewicz, M; Pulsinelli, WA; Tanabe, J, 1990) |
| "A novel transient middle cerebral artery (MCA) occlusion model in the rat was used to evaluate the effect of nimodipine on brain edema and mortality." | 3.68 | Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model. ( Hara, H; Kogure, K; Nagasawa, H; Onodera, H, 1990) |
| "Treatment with the calcium entry blocker nimodipine is recommended as effective therapy for cerebral ischemia due to cerebral vasospasm or cerebral thrombosis." | 3.68 | [Effect of calcium antagonist nimodipine and induced hypertension on cerebral vessel reactivities, cerebral blood flow, cerebral edema and infarction in cats with one hour middle-cerebral-artery occlusion]. ( Ishida, T; Sakaki, T; Sasaoka, Y; Thunoda, S; Utsumi, S, 1990) |
| "Acute cerebral hypoxia causes rapid calcium shifts leading to neuronal damage and death." | 2.90 | Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia. ( Douaud, G; Ezra, M; Garry, P; Kelly, M; Lamb, C; Okell, TW; Pattinson, KT; Rowland, MJ; Westbrook, J; Winkler, A; Wise, RG, 2019) |
| "Treatment of progressing or acute cerebral ischemia is aimed at prevention of infarction in areas of the brain that are still viable." | 2.38 | Medical management of acute cerebral ischemia in the elderly. ( Biller, J; Love, BB, 1991) |
| "Nimodipine has a protective action on brain injury by blocking a series of pathological reactions induced by neuronal calcium overload, and by reducing the spasm of brain vessels and improving cerebral blood flow." | 1.32 | Therapeutic effect of nimodipine on experimental brain injury. ( Wang, ZG; Yang, SY, 2003) |
| "Nimodipine was admenistred to show its effect on the PB induced brain edema." | 1.30 | [Protective effects of nimodipine on brain edema induced by pertussis bacilli in rats]. ( Cao, M; Chen, L; Yang, Y, 1997) |
| "Nimodipine was given at a dose of 1 mg/kg 1 hour before and 2 hours after the cold lesion." | 1.29 | Proposed toxic oxidant inhibitors fail to reduce brain edema. ( Bulkley, GB; Hedlund, BE; Judy, KD; Long, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (69.23) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Hawkes, MA | 1 |
| Hlavnicka, AA | 1 |
| Wainsztein, NA | 1 |
| Rowland, MJ | 1 |
| Ezra, M | 1 |
| Winkler, A | 1 |
| Garry, P | 1 |
| Lamb, C | 1 |
| Kelly, M | 1 |
| Okell, TW | 1 |
| Westbrook, J | 1 |
| Wise, RG | 1 |
| Douaud, G | 1 |
| Pattinson, KT | 1 |
| Gan'shina, TS | 1 |
| Kim, GA | 1 |
| Gnezdilova, AV | 1 |
| Kurdiumov, IN | 1 |
| Mirzoian, RS | 1 |
| Konopacka, A | 1 |
| Konopacki, FA | 1 |
| Albrecht, J | 1 |
| Ismailoglu, O | 1 |
| Atilla, P | 1 |
| Palaoglu, S | 1 |
| Cakar, N | 1 |
| Yasar, U | 1 |
| Kilinc, K | 1 |
| Kaptanoglu, E | 1 |
| Chen, LH | 1 |
| Liu, LX | 1 |
| Yang, YJ | 1 |
| Liu, YS | 1 |
| Cao, MH | 1 |
| Yang, SY | 1 |
| Wang, ZG | 1 |
| Roda, JM | 1 |
| Carceller, F | 1 |
| Díez-Tejedor, E | 1 |
| Avendaño, C | 1 |
| Judy, KD | 1 |
| Bulkley, GB | 1 |
| Hedlund, BE | 1 |
| Long, DM | 1 |
| De Jong, GI | 1 |
| Van der Zee, EA | 1 |
| Bohus, B | 1 |
| Luiten, PG | 1 |
| Roine, RO | 1 |
| Raininko, R | 1 |
| Erkinjuntti, T | 1 |
| Ylikoski, A | 1 |
| Kaste, M | 1 |
| Wen, FQ | 1 |
| Zhang, BL | 1 |
| Yu, PL | 1 |
| Tao, YG | 1 |
| Chen, L | 1 |
| Cao, M | 1 |
| Yang, Y | 1 |
| Morgan, MK | 1 |
| Sekhon, LH | 1 |
| Finfer, S | 1 |
| Grinnell, V | 1 |
| Li, G | 1 |
| Liu, Y | 1 |
| Olson, JE | 1 |
| Biller, J | 1 |
| Love, BB | 1 |
| Sakaki, T | 2 |
| Tsunoda, S | 1 |
| Morimoto, T | 1 |
| Hara, H | 3 |
| Nagasawa, H | 3 |
| Kogure, K | 3 |
| Gaab, MR | 2 |
| Höllerhage, HG | 1 |
| Walter, GF | 1 |
| Hocheder, M | 1 |
| Haubitz, I | 1 |
| Jacewicz, M | 2 |
| Brint, S | 2 |
| Tanabe, J | 2 |
| Wang, XJ | 1 |
| Pulsinelli, WA | 2 |
| Onodera, H | 1 |
| Ishida, T | 1 |
| Sasaoka, Y | 1 |
| Thunoda, S | 1 |
| Utsumi, S | 1 |
| Poch, B | 1 |
| Heller, V | 1 |
| Kostron, H | 1 |
| Grunert, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MRI Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations - A Prospective Preliminary Study[NCT03995823] | 50 participants (Anticipated) | Observational | 2019-07-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nimodipine and Brain Edema
| Article | Year |
|---|---|
Medical management of acute cerebral ischemia in the elderly.
Topics: Acute Disease; Aged; Brain Edema; Brain Ischemia; Fibrinolytic Agents; Humans; Nimodipine; Reperfusi | 1991 |
3 trials available for nimodipine and Brain Edema
| Article | Year |
|---|---|
Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia.
Topics: Adult; Brain Edema; Calcium; Calcium Channel Blockers; Calcium Signaling; Female; Humans; Hypoxia, B | 2019 |
Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats.
Topics: Acute Disease; Analysis of Variance; Animals; Blood-Brain Barrier; Bordetella pertussis; Brain Edema | 2003 |
Magnetic resonance imaging findings associated with cardiac arrest.
Topics: Adult; Age Factors; Aged; Atrophy; Brain Edema; Cerebral Infarction; Double-Blind Method; Female; He | 1993 |
22 other studies available for nimodipine and Brain Edema
| Article | Year |
|---|---|
Reversible Cerebral Vasoconstriction Syndrome Responsive to Intravenous Milrinone.
Topics: Adult; Angiography, Digital Subtraction; Aphasia, Broca; Brain Edema; Cerebral Hemorrhage; Computed | 2020 |
[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].
Topics: Amlodipine; Animals; Animals, Outbred Strains; Brain; Brain Edema; Brain Injuries; Brain Ischemia; L | 2014 |
Protein kinase G is involved in ammonia-induced swelling of astrocytes.
Topics: Ammonia; Animals; Astrocytes; Brain Edema; Calcium Channel Blockers; Calcium Channels, L-Type; Calci | 2009 |
The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Drug Combinations; Lipid Peroxi | 2012 |
Therapeutic effect of nimodipine on experimental brain injury.
Topics: Animals; Biopsy, Needle; Brain Edema; Brain Injuries; Calcium Channel Blockers; Disease Models, Anim | 2003 |
Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia.
Topics: Animals; Blood Pressure; Brain Edema; Calcium Channel Blockers; Carotid Artery, External; Cerebral A | 1995 |
Proposed toxic oxidant inhibitors fail to reduce brain edema.
Topics: Allopurinol; Animals; Brain Edema; Brain Injuries; Calcium; Cats; Cerebral Cortex; Cerebral Infarcti | 1994 |
Reversed alterations of hippocampal parvalbumin and protein kinase C-gamma immunoreactivity after stroke in spontaneously hypertensive stroke-prone rats.
Topics: Aging; Animals; Brain; Brain Edema; Calcium; Cerebrovascular Disorders; Hippocampus; Male; Nimodipin | 1993 |
Effect of nimodipine on infectious brain edema in rabbits.
Topics: Animals; Bordetella Infections; Bordetella pertussis; Brain; Brain Edema; Calcium; Calcium Channel B | 1996 |
[Protective effects of nimodipine on brain edema induced by pertussis bacilli in rats].
Topics: Animals; Blood-Brain Barrier; Bordetella pertussis; Brain Edema; Calcium Channel Blockers; Female; M | 1997 |
Delayed neurological deterioration following resection of arteriovenous malformations of the brain.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Aneurysm; Anticoagulants; Antihypertensive Agents; Asp | 1999 |
Calcium/calmodulin-modulated chloride and taurine conductances in cultured rat astrocytes.
Topics: Animals; Astrocytes; Brain Edema; Calcium; Calcium Channel Blockers; Calmodulin; Cells, Cultured; Ch | 2002 |
The influence of the calcium antagonist nimodipine and induced hypertension on the behavior of the cerebral pial arteries, the blood-brain barrier, cerebral edema, and cerebral infarction in cats with one-hour occlusion of the middle cerebral artery.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cats; Cerebral Arteries; Cerebral Infarction; Female; Int | 1991 |
Nimodipine attenuates both ischaemia-induced brain oedema and mortality in a rat novel transient middle cerebral artery occlusion model.
Topics: Animals; Autoradiography; Body Water; Brain; Brain Edema; Calcium; Cerebral Arteries; Constriction, | 1990 |
Brain edema, autoregulation, and calcium antagonism. An experimental study with nimodipine.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Edema; Brain Injuries; Calcium; Cerebrovascular | 1990 |
Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Male; Nimodipine; Premedication; | 1990 |
Nimodipine prevents postischemic brain damage in the early phase of focal cerebral ischemia.
Topics: Animals; Brain; Brain Edema; Calcium Radioisotopes; Cerebral Arteries; Constriction; Ischemic Attack | 1990 |
Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia.
Topics: Animals; Blood Pressure; Blood Volume; Brain Edema; Brain Ischemia; Cerebral Infarction; Male; Nimod | 1990 |
Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model.
Topics: Animals; Autoradiography; Brain Edema; Brain Ischemia; Calcium Radioisotopes; Cerebral Arteries; Dis | 1990 |
[Effect of calcium antagonist nimodipine and induced hypertension on cerebral vessel reactivities, cerebral blood flow, cerebral edema and infarction in cats with one hour middle-cerebral-artery occlusion].
Topics: Animals; Blood Pressure; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Infarction; | 1990 |
Oxygen tension, oxygen metabolism, and microcirculation in vasogenic brain edema.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Ketamine; Male; | 1990 |
Calcium entry blocker effects on ischemic brain damage after severe head injury.
Topics: Brain Edema; Craniocerebral Trauma; Drug Evaluation; Humans; Intracranial Pressure; Nimodipine; Pilo | 1990 |