nimodipine has been researched along with Brain Damage, Chronic in 23 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In view of our negative results with the calcium antagonist nimodipine as a cerebroprotective agent in a cardiopulmonary resuscitation model in the rat, we examined the protective effects of nimodipine in the four-vessel (carotid and vertebral) occlusion model, a model of global brain ischemia without important cardiovascular depression." | 7.68 | Failure of nimodipine to prevent brain damage in a global brain ischemia model in the rat. ( Buylaert, WA; Calle, PA; De Ridder, LI; Paridaens, K, 1993) |
| "In view of our negative results with the calcium antagonist nimodipine as a cerebroprotective agent in a cardiopulmonary resuscitation model in the rat, we examined the protective effects of nimodipine in the four-vessel (carotid and vertebral) occlusion model, a model of global brain ischemia without important cardiovascular depression." | 3.68 | Failure of nimodipine to prevent brain damage in a global brain ischemia model in the rat. ( Buylaert, WA; Calle, PA; De Ridder, LI; Paridaens, K, 1993) |
| " The results of this experiment support this hypothesis by demonstrating that the calcium entry blocker nimodipine, which prevents trauma-induced retrograde amnesia in a 1-trial passive learning situation, will also facilitate the recovery of pre-operatively learned brightness discrimination in rats with visual neocortical injuries." | 3.67 | Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine. ( Brugler, T; Gray-Silva, S; LeVere, TE; Sandin, M, 1989) |
| "Nimodipine treatment resulted in a statistically significant reduction in systolic BP (SBP) and diastolic BP (DBP) from baseline compared with placebo during the first few days." | 2.69 | Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. ( Ahmed, N; Näsman, P; Wahlgren, NG, 2000) |
| "Nimodipine was well tolerated and there were few adverse reactions; means of systolic and diastolic blood pressures and the intracranial pressure did not differ between the groups." | 2.67 | A trial of the effect of nimodipine on outcome after head injury. ( Bailey, I; Bell, A; Gray, J; Gullan, R; Heiskanan, O; Marks, PV; Marsh, H; Mendelow, DA; Murray, G; Ohman, J, 1991) |
| "Nimodipine has no consistent effect on brain oxygen consumption or cortical ATP or phosphocreatine levels, although the ischemia-induced fall of brain ATP levels in gerbils or the lowering of intracellular brain pH in rabbits with focal cerebral ischemia were antagonized by the drug." | 2.38 | Pharmacological basis for the use of nimodipine in central nervous system disorders. ( Schuurman, T; Scriabine, A; Traber, J, 1989) |
| "Nimodipine was given twice daily by subcutaneous injections." | 1.34 | Calcium antagonism in neonatal rats with kaolin-induced hydrocephalus. ( Del Bigio, MR; Khan, OH; McPhee, LC; Moddemann, LN, 2007) |
| "Nimodipine did not enhance recovery on any of the behavioral measures." | 1.28 | Neurological correlates of unilateral and bilateral "strokes" of the middle cerebral artery in the rat. ( Andersen, AB; Andersen, CS; Finger, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 15 (65.22) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beez, T | 1 |
| Steiger, HJ | 1 |
| Etminan, N | 1 |
| Soppi, V | 1 |
| Karamanakos, PN | 1 |
| Koivisto, T | 1 |
| Kurki, MI | 1 |
| Vanninen, R | 1 |
| Jaaskelainen, JE | 1 |
| Rinne, J | 1 |
| Yang, J | 1 |
| Zhao, X | 1 |
| Zhou, Q | 1 |
| Jiang, Q | 1 |
| Khan, OH | 1 |
| McPhee, LC | 1 |
| Moddemann, LN | 1 |
| Del Bigio, MR | 1 |
| Pickard, JD | 1 |
| Walker, V | 1 |
| Brandt, L | 1 |
| Zygmunt, S | 1 |
| Smythe, J | 1 |
| Vilkki, J | 2 |
| Ahola, K | 1 |
| Holst, P | 1 |
| Ohman, J | 2 |
| Servo, A | 1 |
| Heiskanen, O | 1 |
| Kakarieka, A | 2 |
| Braakman, R | 1 |
| Schakel, EH | 1 |
| Nyakas, C | 1 |
| Buwalda, B | 1 |
| Markel, E | 1 |
| Korte, SM | 1 |
| Luiten, PG | 1 |
| McCulloch, J | 1 |
| Ozyurt, E | 1 |
| Park, CK | 1 |
| Nehls, DG | 1 |
| Teasdale, GM | 2 |
| Graham, DI | 1 |
| Calle, PA | 1 |
| Paridaens, K | 1 |
| De Ridder, LI | 1 |
| Buylaert, WA | 1 |
| Steen, PA | 1 |
| Auer, RN | 1 |
| Anderson, LG | 1 |
| Mathiesen, T | 1 |
| Edner, G | 1 |
| Murray, GD | 1 |
| Schmitz, H | 1 |
| Hauerberg, J | 1 |
| Rosenørn, J | 1 |
| Skriver, EB | 1 |
| Ahmed, N | 1 |
| Näsman, P | 1 |
| Wahlgren, NG | 1 |
| Matula, C | 1 |
| Schoeggl, A | 1 |
| Andersen, CS | 1 |
| Andersen, AB | 1 |
| Finger, S | 1 |
| Bailey, I | 1 |
| Bell, A | 1 |
| Gray, J | 1 |
| Gullan, R | 1 |
| Heiskanan, O | 1 |
| Marks, PV | 1 |
| Marsh, H | 1 |
| Mendelow, DA | 1 |
| Murray, G | 1 |
| Isaacson, RL | 1 |
| Scriabine, A | 1 |
| Schuurman, T | 1 |
| Traber, J | 1 |
| LeVere, TE | 1 |
| Brugler, T | 1 |
| Sandin, M | 1 |
| Gray-Silva, S | 1 |
4 reviews available for nimodipine and Brain Damage, Chronic
| Article | Year |
|---|---|
Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis.
Topics: Brain Damage, Chronic; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Hemorrhage; Dexamethasone | 2017 |
Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Calcium Channel Blockers; Female; Gl | 1996 |
Cerebral protection before, during and after neurosurgical procedures.
Topics: Amino Acids; Brain Damage, Chronic; Calcium Channel Blockers; Clinical Trials as Topic; Cognition Di | 2000 |
Pharmacological basis for the use of nimodipine in central nervous system disorders.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Damage, Chronic; Brain Ischemia; Cen | 1989 |
7 trials available for nimodipine and Brain Damage, Chronic
| Article | Year |
|---|---|
A randomized outcome study of enteral versus intravenous nimodipine in 171 patients after acute aneurysmal subarachnoid hemorrhage.
Topics: Administration, Oral; Adult; Aged; Brain Damage, Chronic; Calcium Channel Blockers; Cerebral Angiogr | 2012 |
Prediction of psychosocial recovery after head injury with cognitive tests and neurobehavioral ratings.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Cognition Disorders; Discrimination Learning; Female | 1994 |
Clinical significance of the finding of subarachnoid blood on CT scan after head injury.
Topics: Adult; Brain Damage, Chronic; Brain Injuries; Disability Evaluation; Dose-Response Relationship, Dru | 1994 |
Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Calcium Channel Blockers; Female; Gl | 1996 |
Effect of intravenous nimodipine on blood pressure and outcome after acute stroke.
Topics: Acute Disease; Administration, Oral; Blood Pressure; Brain Damage, Chronic; Brain Ischemia; Calcium | 2000 |
Cognitive flexibility and mental programming after closed head injuries and anterior or posterior cerebral excisions.
Topics: Adolescent; Adult; Aged; Attention; Brain Damage, Chronic; Brain Neoplasms; Cognition Disorders; Fem | 1992 |
A trial of the effect of nimodipine on outcome after head injury.
Topics: Adult; Blood Pressure; Brain Damage, Chronic; Brain Injuries; Double-Blind Method; Female; Follow-Up | 1991 |
13 other studies available for nimodipine and Brain Damage, Chronic
| Article | Year |
|---|---|
Effects of nimodipine and fructose-1,6-diphosphate on cerebral damage in carbon monoxide poisoning mice.
Topics: Animals; Brain Damage, Chronic; Calcium Channel Blockers; Carbon Monoxide Poisoning; Dose-Response R | 2003 |
Calcium antagonism in neonatal rats with kaolin-induced hydrocephalus.
Topics: Animals; Animals, Newborn; Brain; Brain Damage, Chronic; Calcium Channel Blockers; Calcium Channels; | 2007 |
Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Brain Damage, Chronic; Cerebral Ventricles; Dexamethasone; Di | 1994 |
Life-spanning behavioural and adrenal dysfunction induced by prenatal hypoxia in the rat is prevented by the calcium antagonist nimodipine.
Topics: Adrenal Insufficiency; Aging; Anemia; Animals; Behavior, Animal; Brain Damage, Chronic; Corticostero | 1994 |
Glutamate receptor antagonists in experimental focal cerebral ischaemia.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cats; Caudate Nucleus; Cerebral Cortex; Cerebral Inf | 1993 |
Failure of nimodipine to prevent brain damage in a global brain ischemia model in the rat.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Hippocampus; Male; Nimodipine; Rats; Rats, Wistar | 1993 |
Are we wasting talent and resources?
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Humans; Nimodipine; Rats; Research | 1993 |
Hypoglycaemic brain damage: effect of a dihydropyridine calcium channel antagonist in rats.
Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Calcium Channel Blockers; Calcium C | 1996 |
Traumatic intracerebral lesions without extracerebral haematoma in 218 patients.
Topics: Adult; Brain Concussion; Brain Damage, Chronic; Calcium Channel Blockers; Cerebral Hemorrhage; Combi | 1995 |
Does nimodipine influence sex difference in outcome after aneurysmal subarachnoid haemorrhage?
Topics: Administration, Oral; Adolescent; Adult; Aged; Aneurysm, Ruptured; Brain Damage, Chronic; Brain Isch | 1996 |
Neurological correlates of unilateral and bilateral "strokes" of the middle cerebral artery in the rat.
Topics: Animals; Arousal; Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Cerebrovascular Disorders; | 1991 |
Brain plasticity after damage.
Topics: Animals; Brain Damage, Chronic; Choline; Hippocampus; Hypoxia, Brain; Metyrapone; Neuronal Plasticit | 1990 |
Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine.
Topics: Amnesia; Amnesia, Retrograde; Animals; Brain Damage, Chronic; Discrimination Learning; Dose-Response | 1989 |