nimodipine has been researched along with Aura in 19 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To analyze the effect of nimodipine in patients with intractable epilepsy." | 9.08 | Nimodipine as an add-on therapy for intractable epilepsy. ( Cascino, GD; Gorman, DA; Ivnik, RJ; Meyer, FB; O'Fallon, WM; Sharbrough, FW; So, EL; Whisnant, JP; Windschitl, WL, 1995) |
| "To evaluate efficacy and safety of the calcium channel antagonist nimodipine in dogs with idiopathic epilepsy." | 9.08 | Nimodipine for treatment of idiopathic epilepsy in dogs. ( Goetze, L; Kroll, RA; Longshore, RC; O'Brien, DP; Simpson, ST, 1997) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "To analyze the effect of nimodipine in patients with intractable epilepsy." | 5.08 | Nimodipine as an add-on therapy for intractable epilepsy. ( Cascino, GD; Gorman, DA; Ivnik, RJ; Meyer, FB; O'Fallon, WM; Sharbrough, FW; So, EL; Whisnant, JP; Windschitl, WL, 1995) |
| "To evaluate efficacy and safety of the calcium channel antagonist nimodipine in dogs with idiopathic epilepsy." | 5.08 | Nimodipine for treatment of idiopathic epilepsy in dogs. ( Goetze, L; Kroll, RA; Longshore, RC; O'Brien, DP; Simpson, ST, 1997) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.89 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Hasan, M; Marson, AG; Pulman, J, 2013) |
| " Similarly, there is no convincing evidence to support the use of nifedipine or nimodipine as add-on treatments for epilepsy." | 4.81 | Calcium antagonists as an add-on therapy for drug-resistant epilepsy. ( Baillie, N; Chaisewikul, R; Marson, AG, 2001) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of 3-mercaptopropionic acid (MP), and possible participation of P-glycoprotein in this model of epilepsy." | 3.74 | Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. ( Auzmendi, J; Bramuglia, GF; Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Opezzo, JA; Taira, CA, 2007) |
| "The present work studied the effect of calcium channel blocker (nimodipine) on epileptic seizures elicited by electrical stimulation of somatosensory cortex in young rats exposed to hypoxia." | 3.73 | Partial effect of nimodipine on evoked epileptic seizures in young rats. ( Maresová, D, 2006) |
| "Employing the immunocytochemical analysis, we observed the alterations of Substance P-Immune Reaction (SP-IR) positive neurons of the cerebral cortex, hippocampus and amygdala in rats suffering from epilepsy induced by Penicillin (PEN)." | 3.69 | [Alterations of substance P-immune reaction positive neurons of cerebral tissues in epileptic rats]. ( Ruan, X; Wei, Y; Zhu, C; Zou, X, 1997) |
| "Recently, seizure-induced cyclooxygenase (COX)-mediated postictal vasoconstriction, accompanied by cerebral hypoperfusion and hypoxia, has been identified as a candidate mechanism in experimentally induced seizures in rats." | 3.11 | Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ( Hofmeijer, J; Pottkämper, JCM; van Putten, MJAM; van Waarde, JA; van Wingen, GA; Verdijk, JPAJ; Verwijk, E, 2022) |
| "3." | 2.67 | Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients. ( Baasch, H; Barzaghi, N; Caresia, L; Galimberti, CA; Gatti, G; Manni, R; Mück, W; Parietti, L; Tartara, A; Zucca, C, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Verdijk, JPAJ | 1 |
| Pottkämper, JCM | 1 |
| Verwijk, E | 1 |
| van Wingen, GA | 1 |
| van Putten, MJAM | 1 |
| Hofmeijer, J | 1 |
| van Waarde, JA | 1 |
| Hasan, M | 1 |
| Pulman, J | 1 |
| Marson, AG | 2 |
| Wang, P | 1 |
| Wang, WP | 1 |
| Wang, HX | 1 |
| Fan, YH | 1 |
| Höcht, C | 2 |
| Lazarowski, A | 2 |
| Gonzalez, NN | 2 |
| Mayer, MA | 1 |
| Opezzo, JA | 2 |
| Taira, CA | 2 |
| Girardi, E | 2 |
| Escribano, AB | 1 |
| Peña, E | 1 |
| Barbosa, A | 1 |
| Fernández, C | 1 |
| Corradini, I | 1 |
| Donzelli, A | 1 |
| Antonucci, F | 1 |
| Welzl, H | 1 |
| Loos, M | 1 |
| Martucci, R | 1 |
| De Astis, S | 1 |
| Pattini, L | 1 |
| Inverardi, F | 1 |
| Wolfer, D | 1 |
| Caleo, M | 1 |
| Bozzi, Y | 1 |
| Verderio, C | 1 |
| Frassoni, C | 1 |
| Braida, D | 1 |
| Clerici, M | 1 |
| Lipp, HP | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| Scorza, FA | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| Cavalheiro, EA | 1 |
| de Barros Viana, GS | 1 |
| Auzmendi, J | 1 |
| Bramuglia, GF | 1 |
| Maresová, D | 1 |
| Trembly, B | 1 |
| Meyer, FB | 1 |
| Cascino, GD | 1 |
| Whisnant, JP | 1 |
| Sharbrough, FW | 1 |
| Ivnik, RJ | 1 |
| Gorman, DA | 1 |
| Windschitl, WL | 1 |
| So, EL | 1 |
| O'Fallon, WM | 1 |
| O'Brien, DP | 1 |
| Simpson, ST | 1 |
| Longshore, RC | 1 |
| Kroll, RA | 1 |
| Goetze, L | 1 |
| Zou, X | 2 |
| Ruan, X | 2 |
| Wei, Y | 1 |
| Zhu, C | 1 |
| Zhou, S | 1 |
| Cai, Q | 1 |
| Niespodziany, I | 1 |
| Klitgaard, H | 1 |
| Margineanu, DG | 1 |
| Chaisewikul, R | 1 |
| Baillie, N | 1 |
| Tartara, A | 1 |
| Galimberti, CA | 1 |
| Manni, R | 1 |
| Parietti, L | 1 |
| Zucca, C | 1 |
| Baasch, H | 1 |
| Caresia, L | 1 |
| Mück, W | 1 |
| Barzaghi, N | 1 |
| Gatti, G | 1 |
| Lu, YM | 1 |
| Zhang, JT | 1 |
| Zhao, FQ | 1 |
| Li, F | 1 |
| Otomo, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| StudY of Effect of Nimodipine and Acetaminophen on Postictal Symptoms After ECT[NCT04028596] | Phase 2 | 34 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nimodipine and Aura
| Article | Year |
|---|---|
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Drug Therapy, Combination; Epilepsy; Flu | 2013 |
Clinical potential for the use of neuroprotective agents. A brief overview.
Topics: Animals; Brain Diseases; Brain Injuries; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular D | 1995 |
Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Topics: Anticonvulsants; Calcium Channel Blockers; Drug Resistance; Epilepsy; Flunarizine; Humans; Nifedipin | 2001 |
4 trials available for nimodipine and Aura
| Article | Year |
|---|---|
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE).
Topics: Acetaminophen; Animals; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalograph | 2022 |
Nimodipine as an add-on therapy for intractable epilepsy.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Humans; | 1995 |
Nimodipine for treatment of idiopathic epilepsy in dogs.
Topics: Animals; Calcium Channel Blockers; Dog Diseases; Dogs; Epilepsy; Female; Male; Nimodipine; Prospecti | 1997 |
Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients.
Topics: Adult; Anticonvulsants; Drug Interactions; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Ma | 1991 |
12 other studies available for nimodipine and Aura
| Article | Year |
|---|---|
Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats.
Topics: Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein | 2008 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
Puerpera with dyspnoea and epileptic seizure.
Topics: Adult; Calcium Channel Blockers; Cerebrovascular Disorders; Coronary Angiography; Dyspnea; Epilepsy; | 2013 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2007 |
Partial effect of nimodipine on evoked epileptic seizures in young rats.
Topics: Air Pressure; Animals; Calcium Channel Blockers; Electric Stimulation; Epilepsy; Hypoxia; Male; Nimo | 2006 |
[Alterations of substance P-immune reaction positive neurons of cerebral tissues in epileptic rats].
Topics: Amygdala; Animals; Calcium Channel Blockers; Cerebral Cortex; Epilepsy; Female; Hippocampus; Male; N | 1997 |
[Antiepileptic effects of nimodipine on penicillin-induced seizures in rats].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Epilepsy; Female; Male; Nimodipine; Penicillins; | 1997 |
Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices.
Topics: Animals; Anticonvulsants; Cadmium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Ep | 2001 |
Effects of nimodipine on l-glutamate-induced seizures and Ca2+ influx in hippocampus in freely moving rats.
Topics: Animals; Biological Transport, Active; Calcium; Electroencephalography; Epilepsy; Glutamates; Hippoc | 1991 |
[Nervous disease & Ca antagonist].
Topics: Calcium Channel Blockers; Cerebral Infarction; Cerebrovascular Disorders; Epilepsy; Flunarizine; Hum | 1990 |