nimodipine has been researched along with Aneurysm, Ruptured in 34 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Aneurysm, Ruptured: The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the cost-effectiveness ratio of nimodipine administration after aneurysmal subarachnoid hemorrhage (SAH) and surgery." | 9.09 | Cost-effectiveness analysis of nimodipine treatment after aneurysmal subarachnoid hemorrhage and surgery. ( Karinen, P; Koivukangas, J; Koivukangas, P; Ohinmaa, A; Ohman, J, 1999) |
| "Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality." | 6.80 | NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage. ( Aldrich, F; Diringer, MN; Etminan, N; Faleck, HJ; Hänggi, D; Hoh, BL; Macdonald, RL; Mayer, SA; Miller, M; Mocco, J; Steiger, HJ; Strange, P, 2015) |
| "To assess the cost-effectiveness ratio of nimodipine administration after aneurysmal subarachnoid hemorrhage (SAH) and surgery." | 5.09 | Cost-effectiveness analysis of nimodipine treatment after aneurysmal subarachnoid hemorrhage and surgery. ( Karinen, P; Koivukangas, J; Koivukangas, P; Ohinmaa, A; Ohman, J, 1999) |
| "Between August 2001 and January 2004 we treated nine acute subarachnoid hemorrhage (SAH) patients with a combination of stents and platinum coils." | 3.73 | [Stenting plus coiling: dangerous or helpful?]. ( Dörfler, A; Forsting, M; Gizewski, E; Stolke, D; Wanke, I, 2005) |
| "To determine the incidence of induced systemic hypotension in patients after aneurysmal subarachnoid haemorrhage (SAH) and nimodipine treatment 87 consecutive cases were reviewed." | 3.69 | Hypotensive effect of nimodipine during treatment for aneurysmal subarachnoid haemorrhage. ( Chioléro, R; de Tribolet, N; Porchet, F, 1995) |
| "The study evaluated the effectiveness of the combination of nimodipine and cyclosporine A vs nimodipine alone in the prevention of delayed neurologic deficit in 82 (31 plus 51) patients in whom intracranial aneurysms were clipped within 72 h after subarachnoid haemorrhage." | 3.68 | A strategy for analyzing multiple parameters with application to aneurysmal SAH patients all of them clipped but treated with and without cyclosporine. ( Andrychowski, J; Barczewska, M; Bojarski, P; Dziewiecki, C; Pastuszko, M; Ryba, M, 1993) |
| "Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality." | 2.80 | NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage. ( Aldrich, F; Diringer, MN; Etminan, N; Faleck, HJ; Hänggi, D; Hoh, BL; Macdonald, RL; Mayer, SA; Miller, M; Mocco, J; Steiger, HJ; Strange, P, 2015) |
| "Early treatment of ruptured aneurysms is advocated; delayed intervention complicates the treatment strategy leading to significant vasospasm and poor prognosis." | 2.58 | Coadjuvant Treatment of Vasospasm in Ruptured Unsecured Cerebral Aneurysms with Aggressive Angioplasty, Intra-Arterial Nimodipine, and Aneurysm Embolization. ( Chen, CC; Chen, CT; Hsieh, PC; Yi-Chou Wang, A, 2018) |
| "Among patients with symptomatic cerebral vasospasm around 1/3 fully recover in 1/3 of cases persistent neurological deficit remains and 1/3 of the patients die." | 2.41 | [Cerebral vasospasm after subarachnoid hemorrhage. Current possibilities of prevention and treatment]. ( Danilewicz, B; Stachura, K, 2002) |
| "Nimodipine infusion was started before surgery (1 mg/Kg/h)." | 2.38 | [Vasospasm, early surgery and nimodipine. A series of 120 consecutive cases of surgically treated ruptured aneurysm]. ( Creissard, P; Freger, P; Langlois, O; Proust, F; Rabehenoina, C; Tadie, M, 1992) |
| "The current management of subarachnoid hemorrhage (SAH) in the urban Chinese population remains unclear and the relevant literature is still lacking." | 1.91 | Current management of subarachnoid hemorrhage in a northern urban Chinese population: a multi-center surveillance study. ( Cheng, GJ; Li, RM; Lv, L; Ma, N; Zhang, JF; Zhang, L; Zhang, WS, 2023) |
| "Background and Purpose- Delayed cerebral infarction (DCI) is an important cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH)." | 1.56 | Impact of Stereotactic Ventriculocisternostomy on Delayed Cerebral Infarction and Outcome After Subarachnoid Hemorrhage. ( Bardutzky, J; Beck, J; Buttler, J; Coenen, VA; Csok, I; Egger, K; Grauvogel, J; Niesen, WD; Reinacher, PC; Roelz, R; Rohr, E; Sajonz, B; Schaefer, JH; Scheiwe, C; Shah, MJ; Steiert, C, 2020) |
| "Twenty (20) patients with SAH were treated after their ruptured aneurysms had been secured." | 1.39 | Acupuncture for cerebral vasospasm after subarachnoid hemorrhage: a retrospective case-control study. ( Bae, HS; Cho, SY; Kim, GK; Ko, CN; Koh, JS; Lee, IW; Lee, SH; Park, JM; Park, SU, 2013) |
| "Nimodipine is an established drug in the treatment of symptomatic subarachnoid haemorrhage." | 1.29 | Nimodipine levels in breast milk. ( Tonks, AM, 1995) |
| "Nimodipine infusion was started before surgery." | 1.29 | Causes of morbidity and mortality after ruptured aneurysm surgery in a series of 230 patients. The importance of control angiography. ( Creissard, P; Freger, P; Hannequin, D; Langlois, O; Proust, F, 1995) |
| "Nimodipine was administered in 231 (84%) of the 275 patients." | 1.29 | Which are the major determinants for outcome in aneurysmal subarachnoid hemorrhage? A prospective total management study from a strictly unselected series. ( Brandt, L; Säveland, H, 1994) |
| "Early hydrocephalus is a risk factor of shunt-dependent late hydrocephalus (SDHC)." | 1.29 | Shunt-dependent hydrocephalus after subarachnoid haemorrhage and aneurysm surgery: timing of surgery is not a risk factor. ( Hernesniemi, J; Kari, A; Luukkonen, M; Niskanen, M; Puranen, M; Tapaninaho, A; Vapalahti, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (52.94) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 11 (32.35) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, JF | 1 |
| Ma, N | 1 |
| Zhang, WS | 1 |
| Cheng, GJ | 1 |
| Lv, L | 1 |
| Zhang, L | 1 |
| Li, RM | 1 |
| Cottenceau, V | 1 |
| Poutier, B | 1 |
| Gariel, F | 1 |
| Sauvage, N | 1 |
| Petit, L | 1 |
| Carrie, C | 1 |
| Biais, M | 1 |
| Roelz, R | 1 |
| Schaefer, JH | 1 |
| Scheiwe, C | 1 |
| Sajonz, B | 1 |
| Csok, I | 1 |
| Steiert, C | 1 |
| Buttler, J | 1 |
| Rohr, E | 1 |
| Grauvogel, J | 1 |
| Shah, MJ | 1 |
| Egger, K | 1 |
| Niesen, WD | 1 |
| Bardutzky, J | 1 |
| Beck, J | 1 |
| Coenen, VA | 1 |
| Reinacher, PC | 1 |
| Chen, CT | 2 |
| Chen, CC | 2 |
| Wang, AY | 1 |
| Wu, YM | 1 |
| Chin, SC | 1 |
| Hsieh, PC | 2 |
| Yeap, MC | 1 |
| Hsu, SY | 1 |
| Lin, YJ | 1 |
| Lawton, MT | 1 |
| Vates, GE | 1 |
| Sánchez Arguiano, J | 1 |
| Hernández-Hernández, MA | 1 |
| Jáuregui Solórzano, RA | 1 |
| Maldonado-Vega, S | 1 |
| González Mandly, A | 1 |
| Burón Mediavilla, J | 1 |
| Yi-Chou Wang, A | 1 |
| Hänggi, D | 1 |
| Etminan, N | 1 |
| Macdonald, RL | 1 |
| Steiger, HJ | 2 |
| Mayer, SA | 1 |
| Aldrich, F | 1 |
| Diringer, MN | 1 |
| Hoh, BL | 1 |
| Mocco, J | 1 |
| Strange, P | 1 |
| Faleck, HJ | 1 |
| Miller, M | 1 |
| Konczalla, J | 1 |
| Brawanski, N | 1 |
| Platz, J | 1 |
| Senft, C | 1 |
| Kashefiolasl, S | 1 |
| Seifert, V | 2 |
| Tang, W | 1 |
| Feng, H | 1 |
| Chen, Z | 1 |
| Miu, H | 1 |
| Pan, J | 1 |
| Lin, J | 1 |
| Zhu, G | 1 |
| Sun, LQ | 1 |
| Slivka, AP | 1 |
| Ko, CN | 1 |
| Lee, IW | 1 |
| Cho, SY | 1 |
| Lee, SH | 1 |
| Park, SU | 1 |
| Koh, JS | 1 |
| Park, JM | 1 |
| Kim, GK | 1 |
| Bae, HS | 1 |
| Chalouhi, N | 1 |
| Jabbour, P | 1 |
| Ibrahim, I | 1 |
| Starke, RM | 1 |
| Younes, P | 1 |
| El Hage, G | 1 |
| Samaha, E | 1 |
| Wanke, I | 1 |
| Gizewski, E | 1 |
| Dörfler, A | 1 |
| Stolke, D | 1 |
| Forsting, M | 1 |
| Tonks, AM | 1 |
| Proust, F | 2 |
| Hannequin, D | 1 |
| Langlois, O | 2 |
| Freger, P | 2 |
| Creissard, P | 2 |
| Säveland, H | 1 |
| Brandt, L | 1 |
| Fritschi, J | 1 |
| Seiler, RW | 1 |
| Boecher-Schwarz, HG | 1 |
| Ungersboeck, K | 1 |
| Ulrich, P | 1 |
| Fries, G | 1 |
| Wild, A | 1 |
| Perneczky, A | 1 |
| Weir, B | 1 |
| MacDonald, L | 1 |
| Tapaninaho, A | 1 |
| Hernesniemi, J | 1 |
| Vapalahti, M | 1 |
| Niskanen, M | 1 |
| Kari, A | 1 |
| Luukkonen, M | 1 |
| Puranen, M | 1 |
| Ryba, M | 1 |
| Pastuszko, M | 1 |
| Dziewiecki, C | 1 |
| Andrychowski, J | 1 |
| Bojarski, P | 1 |
| Barczewska, M | 1 |
| Porchet, F | 1 |
| Chioléro, R | 1 |
| de Tribolet, N | 1 |
| Lindsberg, PJ | 1 |
| Ohman, J | 2 |
| Lehto, T | 1 |
| Karjalainen-Lindsberg, ML | 1 |
| Paetau, A | 1 |
| Wuorimaa, T | 1 |
| Carpén, O | 1 |
| Kaste, M | 1 |
| Meri, S | 1 |
| Hauerberg, J | 1 |
| Rosenørn, J | 1 |
| Skriver, EB | 1 |
| Findlay, JM | 1 |
| Deagle, GM | 1 |
| Dorsch, NW | 1 |
| Stroobandt, G | 1 |
| Lambert, O | 1 |
| Menard, E | 1 |
| Karinen, P | 1 |
| Koivukangas, P | 1 |
| Ohinmaa, A | 1 |
| Koivukangas, J | 1 |
| Carvi y Nievas, MN | 1 |
| Stachura, K | 1 |
| Danilewicz, B | 1 |
| Rabehenoina, C | 1 |
| Tadie, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Evaluation of Effectiveness and Safety of the CorPath® GRX System in Endovascular Embolization Procedures of Cerebral Aneurysms[NCT04236856] | 120 participants (Actual) | Interventional | 2020-08-21 | Completed | |||
| Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After subarachNoid Hemorrhage: Phase I/IIa Multicenter, Controlled, Randomized, Open Label, Dose Escalation, Safety, Tolerability, and Pharmacokinectic Study Comparing EG-1962 and Nimod[NCT01893190] | Phase 1/Phase 2 | 73 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| IVIG in Acute Ischemic Stroke: A Pilot Study[NCT01628055] | Phase 1 | 0 participants (Actual) | Interventional | 2013-03-31 | Withdrawn (stopped due to difficult recruitment and new black box warning for IVIG) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for nimodipine and Aneurysm, Ruptured
| Article | Year |
|---|---|
Subarachnoid Hemorrhage.
Topics: Adolescent; Aneurysm, Ruptured; Angiography; Brain; Calcium Channel Blockers; Endovascular Procedure | 2017 |
Coadjuvant Treatment of Vasospasm in Ruptured Unsecured Cerebral Aneurysms with Aggressive Angioplasty, Intra-Arterial Nimodipine, and Aneurysm Embolization.
Topics: Adult; Aged; Aneurysm, Ruptured; Angioplasty; Combined Modality Therapy; Embolization, Therapeutic; | 2018 |
Cerebral vasospasm.
Topics: Aneurysm, Ruptured; Blood Pressure; Blood Volume; Brain Ischemia; Catheterization; Cerebral Infarcti | 1993 |
[Neurosurgical therapy of subarachnoid hemorrhage. Microsurgical techniques--early postoperative nimodipine administration].
Topics: Aged; Aneurysm, Ruptured; Combined Modality Therapy; Drug Administration Schedule; Humans; Intracran | 1993 |
The effect and management of delayed vasospasm after aneurysmal subarachnoid hemorrhage.
Topics: Aneurysm, Ruptured; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Humans; Isch | 1998 |
The association of tranexamic acid and nimodipine in the pre-operative treatment of ruptured intracranial aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Antifibrinolytic Agents; Antihypertensive Agents | 1998 |
Poor-grade subarachnoid hemorrhage patients: the use of nimodipine and other optional treatments.
Topics: Aneurysm, Ruptured; Clinical Trials as Topic; Humans; Intracranial Aneurysm; Nimodipine; Subarachnoi | 1999 |
[Cerebral vasospasm after subarachnoid hemorrhage. Current possibilities of prevention and treatment].
Topics: Aneurysm, Ruptured; Humans; Neuroprotective Agents; Nimodipine; Pregnatrienes; Subarachnoid Hemorrha | 2002 |
[Vasospasm, early surgery and nimodipine. A series of 120 consecutive cases of surgically treated ruptured aneurysm].
Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Female; Glasgow Coma Scale; Humans; Intracranial Aneury | 1992 |
3 trials available for nimodipine and Aneurysm, Ruptured
| Article | Year |
|---|---|
NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage.
Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Calcium Channel Blockers; Clinical Protocols; Delayed-A | 2015 |
Causes of morbidity and mortality following intracranial aneurysm rupture.
Topics: Adult; Aged; Aneurysm, Ruptured; Angioplasty, Balloon; Cause of Death; Employment; Female; Glasgow C | 1998 |
Cost-effectiveness analysis of nimodipine treatment after aneurysmal subarachnoid hemorrhage and surgery.
Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Combined Modality Therapy; Cost-Benefit Analysis; Doubl | 1999 |
22 other studies available for nimodipine and Aneurysm, Ruptured
| Article | Year |
|---|---|
Current management of subarachnoid hemorrhage in a northern urban Chinese population: a multi-center surveillance study.
Topics: Aged; Aneurysm, Ruptured; Case-Control Studies; Female; Humans; Intracranial Aneurysm; Middle Aged; | 2023 |
May levosimendan be safe and effective in refractory vasospasm despite adequate treatment with repeated angiography and milrinone infusion after subarachnoid haemorrhage?
Topics: Aneurysm, Ruptured; Cardiotonic Agents; Cerebral Angiography; Cerebrospinal Fluid Leak; Computed Tom | 2019 |
Impact of Stereotactic Ventriculocisternostomy on Delayed Cerebral Infarction and Outcome After Subarachnoid Hemorrhage.
Topics: Aged; Aneurysm, Ruptured; Cerebral Infarction; Female; Fibrinolytic Agents; Humans; Intracranial Ane | 2020 |
Early strategy of scepter XC balloon angioplasty and simultaneous Nimodipine infusion for vasospasm following ruptured aneurysm.
Topics: Adult; Aged; Aneurysm, Ruptured; Angioplasty, Balloon; Computed Tomography Angiography; Female; Huma | 2020 |
Stellate ganglion block as rescue therapy in refractory vasospasm after subarachnoid hemorrhage.
Topics: Anesthetics, Local; Aneurysm, Ruptured; Arm; Bupivacaine; Humans; Intracranial Aneurysm; Middle Aged | 2019 |
In brief: nimodipine oral solution (Nymalize).
Topics: Administration, Oral; Aneurysm, Ruptured; Calcium Channel Blockers; Drug Approval; Humans; Intracran | 2013 |
Aneurysm Location as a Prognostic Outcome Factor After Subarachnoid Hemorrhage From Internal Carotid Artery Aneurysms and Potential Impact for Further Experimental Subarachnoid Hemorrhage Models.
Topics: Adult; Aged; Aneurysm, Ruptured; Carotid Artery Diseases; Female; Humans; Male; Middle Aged; Multiva | 2016 |
Microsurgical treatment of ruptured intracranial aneurysm: a 120-case analysis.
Topics: Adult; Aged; Aneurysm, Ruptured; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Mic | 2011 |
Sensitivity of computed tomography angiography vs catheter angiography in the detection of a ruptured intracranial infectious aneurysm in a pregnant woman.
Topics: Adult; Aneurysm, Infected; Aneurysm, Ruptured; Anti-Bacterial Agents; Anticonvulsants; Brain; Cathet | 2012 |
Acupuncture for cerebral vasospasm after subarachnoid hemorrhage: a retrospective case-control study.
Topics: Acupuncture Therapy; Adult; Aged; Aneurysm, Ruptured; Case-Control Studies; Cerebral Angiography; Co | 2013 |
Surgical treatment of ruptured anterior circulation aneurysms: comparison of pterional and supraorbital keyhole approaches.
Topics: Anesthesia, General; Aneurysm, Ruptured; Calcium Channel Blockers; Female; Glasgow Outcome Scale; Hu | 2013 |
[Stenting plus coiling: dangerous or helpful?].
Topics: Acute Disease; Aneurysm, Ruptured; Angiography, Digital Subtraction; Aspirin; Calcium Channel Blocke | 2005 |
Nimodipine levels in breast milk.
Topics: Adult; Aneurysm, Ruptured; Cesarean Section; Combined Modality Therapy; Female; Humans; Milk, Human; | 1995 |
Causes of morbidity and mortality after ruptured aneurysm surgery in a series of 230 patients. The importance of control angiography.
Topics: Adolescent; Adult; Aged; Aneurysm, Ruptured; Brain Ischemia; Cerebral Angiography; Cerebral Hemorrha | 1995 |
Which are the major determinants for outcome in aneurysmal subarachnoid hemorrhage? A prospective total management study from a strictly unselected series.
Topics: Adult; Aged; Aneurysm, Ruptured; Brain Ischemia; Cause of Death; Disability Evaluation; Female; Foll | 1994 |
Current pattern of in-hospital aneurysmal rebleeds. Analysis of a series treated with individually timed surgery and intravenous nimodipine.
Topics: Adult; Aged; Aneurysm, Ruptured; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Neurologi | 1994 |
Transcranial Doppler diagnosis of cerebral vasospasm following subarachnoid haemorrhage: correlation and analysis of results in relation to the age of patients.
Topics: Adult; Age Factors; Aged; Aneurysm, Ruptured; Blood Flow Velocity; Cerebrovascular Circulation; Dose | 1994 |
Shunt-dependent hydrocephalus after subarachnoid haemorrhage and aneurysm surgery: timing of surgery is not a risk factor.
Topics: Adult; Aneurysm, Ruptured; Cerebrospinal Fluid Shunts; Combined Modality Therapy; Female; Humans; Hy | 1993 |
A strategy for analyzing multiple parameters with application to aneurysmal SAH patients all of them clipped but treated with and without cyclosporine.
Topics: Adult; Aged; Aneurysm, Ruptured; Cyclosporine; Drug Therapy, Combination; Female; Glasgow Coma Scale | 1993 |
Hypotensive effect of nimodipine during treatment for aneurysmal subarachnoid haemorrhage.
Topics: Administration, Oral; Adult; Aged; Aneurysm, Ruptured; Blood Pressure; Brain; Calcium Channel Blocke | 1995 |
Complement activation in the central nervous system following blood-brain barrier damage in man.
Topics: Adult; Aneurysm, Ruptured; Anti-Inflammatory Agents; Betamethasone; Blood-Brain Barrier; Brain; Chem | 1996 |
Does nimodipine influence sex difference in outcome after aneurysmal subarachnoid haemorrhage?
Topics: Administration, Oral; Adolescent; Adult; Aged; Aneurysm, Ruptured; Brain Damage, Chronic; Brain Isch | 1996 |