Page last updated: 2024-11-01

nimodipine and Anesthesia

nimodipine has been researched along with Anesthesia in 11 studies

Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
" Drug-drug interactions are further implicated through this study."1.29Cerebral blood flow effects of sumatriptan in drug combinations in the baboon model. ( Dormehl, IC; Hugo, N; Oliver, DW, 1995)
"The nimodipine-induced increase in vascular conductance in the skeletal muscles showed regional variation; the effect was most pronounced in the cheek muscles, followed by the muscles of the chest, abdominal, trunk and gluteal regions."1.27Nimodipine-induced changes in the distribution of carotid blood flow and cardiac output in pentobarbitone-anaesthetized pigs. ( Duncker, DJ; Heiligers, J; Mylecharane, EJ; Saxena, PR; Verdouw, PD, 1986)
" using a cumulative dosing regimen in conscious (6, 24 and 60 micrograms/kg) and anesthetized (6 and 60 micrograms/kg) rats."1.27Effects of nimodipine on cerebral blood flow in conscious rat. ( Flaim, SF; Kanda, K, 1986)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's4 (36.36)18.2507
2000's1 (9.09)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pasternak, JJ1
Lanier, WL1
Lin, X1
Guolin, W1
Jun-tian, Z1
Taylor, DG1
Kowalski, TE1
Dormehl, IC1
Oliver, DW1
Hugo, N1
Stånge, K1
Lagerkranser, M1
Sollevi, A1
Karlsson, B1
Fredriksson, SA1
Sellström, A1
Algers, G1
Gross, PM1
Zochodne, DW1
Wainman, DS1
Ho, LT1
Espinosa, FJ1
Weaver, DF1
Wauquier, A1
Melis, W1
Janssen, PA1
Duncker, DJ1
Heiligers, J1
Mylecharane, EJ1
Saxena, PR1
Verdouw, PD1
Stullken, EH1
Johnston, WE1
Prough, DS1
Balestrieri, FJ1
McWhorter, JM1
Kanda, K1
Flaim, SF1

Reviews

1 review available for nimodipine and Anesthesia

ArticleYear
Neuroanesthesiology update.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:2

    Topics: Anesthesia; Anesthesiology; Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Electroenceph

2010

Trials

1 trial available for nimodipine and Anesthesia

ArticleYear
Implications of nimodipine prophylaxis of cerebral vasospasm on anesthetic management during intracranial aneurysm clipping.
    Journal of neurosurgery, 1985, Volume: 62, Issue:2

    Topics: Anesthesia; Calcium Channel Blockers; Cerebral Hemorrhage; Cerebrovascular Circulation; Clinical Tri

1985

Other Studies

9 other studies available for nimodipine and Anesthesia

ArticleYear
Intracellular calcium involved in the long-term potentiation induced by securinine in dentate gyrus of anesthetized rats.
    Planta medica, 2002, Volume: 68, Issue:8

    Topics: Alkaloids; Anesthesia; Animals; Azepines; Calcium; Calcium Channel Blockers; Dentate Gyrus; Drug Int

2002
Comparison of calcium channel inhibitors on vagal heart rate responses elicited by arterial baroreceptor reflexes in anesthetized dogs.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:2

    Topics: Acetylcholine; Anesthesia; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Heart Rate; In Vitro

1984
Cerebral blood flow effects of sumatriptan in drug combinations in the baboon model.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:9

    Topics: Acetazolamide; Anesthesia; Anesthetics; Animals; Calcium; Calcium Channel Blockers; Cerebrovascular

1995
Nimodipine does not affect the cerebral autoregulatory response in the anesthetized pig.
    Journal of neurosurgical anesthesiology, 1994, Volume: 6, Issue:2

    Topics: Anesthesia; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Fentanyl; Homeostasis; Nimo

1994
The protective effect of nimodipine, a calcium antagonist, and its influence on soman clearance in the anaesthetized rabbit.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:2

    Topics: Acetylcholinesterase; Anesthesia; Animals; Calcium; Cholinesterases; Gas Chromatography-Mass Spectro

1994
Intraventricular endothelin-1 uncouples the blood flow: metabolism relationship in periventricular structures of the rat brain: involvement of L-type calcium channels.
    Neuropeptides, 1992, Volume: 22, Issue:3

    Topics: Anesthesia; Animals; Brain; Calcium Channels; Caudate Nucleus; Cerebrovascular Circulation; Deoxyglu

1992
Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia.
    Neuropharmacology, 1989, Volume: 28, Issue:8

    Topics: Anesthesia; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Electromyogra

1989
Nimodipine-induced changes in the distribution of carotid blood flow and cardiac output in pentobarbitone-anaesthetized pigs.
    British journal of pharmacology, 1986, Volume: 89, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Carotid Arteries; Heart Rate; Nimodipine; Pento

1986
Effects of nimodipine on cerebral blood flow in conscious rat.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: Anesthesia; Animals; Calcium Channel Blockers; Cerebrovascular Circulation; Coronary Circulation; Ma

1986