Page last updated: 2024-11-01

nimodipine and Anasarca

nimodipine has been researched along with Anasarca in 5 studies

Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Research Excerpts

ExcerptRelevanceReference
" In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis."3.80Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014)
" Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h."3.71Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002)
" The 5-HT2 receptor-antagonistic properties of AHR-16303B were demonstrated by inhibition of (a) [3H]ketanserin binding to rat cerebral cortical membranes (IC50 = 165 nM); (b) 5-hydroxytryptamine (5-HT)-induced foot edema in rats (minimum effective dose, (MED) = 0."3.68AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels. ( Appell, KC; Barrett, RJ; Kilpatrick, BF; Nolan, JC; Proakis, AG; Walsh, DA, 1991)
" The physical compatibility, pharmacokinetic, and vascular irritability studies showed that, in comparison to the commercially available NIM injections, NIM-EPC-SGC-MMs presented better physical compatibility, the same pharmacokinetic profile, and less risk of local vascular irritation and phlebitis."1.38Nimodipine-loaded mixed micelles: formulation, compatibility, pharmacokinetics, and vascular irritability study. ( Gong, T; Jiang, Y; Ren, C; Song, X; Sun, X; Zhang, Q; Zhang, Z, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Song, X1
Jiang, Y1
Ren, C1
Sun, X1
Zhang, Q1
Gong, T1
Zhang, Z1
Zhu, JJ1
Xu, YQ1
He, JH1
Yu, HP1
Huang, CJ1
Gao, JM1
Dong, QX1
Xuan, YX1
Li, CQ1
Sharma, HS2
Winkler, T2
Stålberg, E1
Badgaiyan, RD1
Gordh, T1
Westman, J1
Barrett, RJ1
Appell, KC1
Kilpatrick, BF1
Proakis, AG1
Nolan, JC1
Walsh, DA1

Other Studies

5 other studies available for nimodipine and Anasarca

ArticleYear
Nimodipine-loaded mixed micelles: formulation, compatibility, pharmacokinetics, and vascular irritability study.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: Animals; Drug Stability; Ear; Edema; Glycocholic Acid; Hydrogen-Ion Concentration; Male; Micelles; N

2012
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease

2014
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
    Muscle & nerve. Supplement, 2002, Volume: 11

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I

2002
An L-type calcium channel blocker, nimodipine influences trauma induced spinal cord conduction and axonal injury in the rat.
    Acta neurochirurgica. Supplement, 2003, Volume: 86

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Diffuse Axonal Injury; Edema; Evoked Po

2003
AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:1

    Topics: Animals; Atrial Function; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Calci

1991