nimodipine has been researched along with Alcoholism in 8 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty three patients with chronic alcoholism of stage II with secondary affective disorders (anxiety, subdepression) and actualization of pathological drive for alcohol in remission period were divided into 3 groups: patients were treated with nimodipine (90 mg/day during 10 days), patients were treated with nifedipine (45 mg/day during 10 days) and patients of control group (they received a placebo for 10 days)." | 5.11 | [The efficacy of calcium channel blockers in the treatment of affective disorders and pathologic drive for alcohol in patients with alcoholism in the remission period]. ( Burakov, AM; Grinenko, AIa; Karandashova, GF; Krupitskiĭ, EM; Priputina, LS; Romanova, TN; Slavina, TIu; Vostrikov, VV, 2004) |
| "Nimodipine pretreatment attenuated the perceived similarity of ketamine effects to ethanol as well as ketamine-induced euphoria and sedation." | 2.70 | Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. ( Burakov, AM; Fletcher, J; Grinenko, AY; Grinenko, NI; Krupitsky, EM; Krystal, JH; Petrakis, IL; Romanova, TN, 2001) |
| " Chronic nimodipine dosing in cocaine-dependent individuals is now needed to confirm its efficacy in the treatment of cocaine dependence." | 2.68 | The effects of nimodipine on the EEG of substance abusers. ( Guo, X; Herning, RI; Lange, WR, 1995) |
| " Chronic administration of nimodipine may alleviate the cognitive deficits observed in substance abusers during abstinence and prevent treatment relapse." | 2.68 | Nimodipine improves information processing in substance abusers. ( Guo, X; Herning, RI; Lange, WR, 1995) |
| "When nimodipine was given before the motor task learning and ethanol after the practice sessions, the tolerance to the ataxic effect of ethanol was increased." | 1.31 | Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance. ( Little, HJ; Smith, JW, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krupitskiĭ, EM | 1 |
| Burakov, AM | 2 |
| Priputina, LS | 1 |
| Vostrikov, VV | 1 |
| Romanova, TN | 2 |
| Karandashova, GF | 1 |
| Slavina, TIu | 1 |
| Grinenko, AIa | 1 |
| Herning, RI | 2 |
| Guo, X | 2 |
| Lange, WR | 2 |
| Rossetti, ZL | 1 |
| Isola, D | 1 |
| De Vry, J | 1 |
| Fadda, F | 1 |
| Smith, JW | 1 |
| Little, HJ | 3 |
| Holt, JD | 1 |
| Watson, WP | 1 |
| Krupitsky, EM | 1 |
| Grinenko, NI | 1 |
| Grinenko, AY | 1 |
| Fletcher, J | 1 |
| Petrakis, IL | 1 |
| Krystal, JH | 1 |
| Dolin, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department[NCT04260607] | Phase 3 | 2 participants (Actual) | Interventional | 2020-01-14 | Terminated (stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for nimodipine and Alcoholism
| Article | Year |
|---|---|
[The efficacy of calcium channel blockers in the treatment of affective disorders and pathologic drive for alcohol in patients with alcoholism in the remission period].
Topics: Adult; Alcoholism; Calcium Channel Blockers; Double-Blind Method; Drive; Humans; Mood Disorders; Nif | 2004 |
The effects of nimodipine on the EEG of substance abusers.
Topics: Adult; Alcoholism; Analysis of Variance; Cocaine; Double-Blind Method; Electroencephalography; Heroi | 1995 |
Nimodipine improves information processing in substance abusers.
Topics: Adult; Alcoholism; Analysis of Variance; Cocaine; Double-Blind Method; Electroencephalography; Evoke | 1995 |
Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists.
Topics: Adult; Affect; Alcoholism; Anxiety; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Ty | 2001 |
4 other studies available for nimodipine and Alcoholism
| Article | Year |
|---|---|
Effects of nimodipine on extracellular dopamine levels in the rat nucleus accumbens in ethanol withdrawal.
Topics: Alcoholism; Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dopam | 1999 |
Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance.
Topics: 2-Amino-5-phosphonovalerate; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Ataxia; | 2000 |
Studies on a model of long term alcohol drinking.
Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Calcium; Calcium Channel | 2001 |
Are changes in neuronal calcium channels involved in ethanol tolerance?
Topics: Alcoholism; Animals; Behavior, Animal; Brain; Calcium Channels; Dose-Response Relationship, Drug; Dr | 1989 |