Page last updated: 2024-11-01

nimodipine and Aging

nimodipine has been researched along with Aging in 63 studies

Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Forty patients aged 65-80 with minor-medium signs of brain aging were treated for 6 months with daily 90 mg doses of nimodipine."9.07[Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine]. ( Albano, O; Cassiano, MA; Centonze, V; Cirillo, L; Di Bari, M; Massaro, C; Polito, BM; Russo, P, 1992)
" In a multicenter, placebo-controlled, double-blind clinical study in 178 elderly patients with cognitive decline, nimodipine, a calcium antagonist was found to be a therapeutically effective agent in the treatment of old age dementias."9.06Nimodipine in the treatment of old age dementias. ( Aguglia, E; Azzarelli, O; Balsano, F; Ban, TA; Caglieris, N; Capurso, A; Marigliano, V; Morey, L; Sterlicchio, M; Tomasi, NA, 1990)
"Nimodipine, a 1,4-dihydropyridine calcium channel blocker, has been shown to enhance learning in aging rats, rabbits, and monkeys."7.69Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits. ( Disterhoft, JF; Kowalska, M, 1994)
" Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits."7.68Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990)
"Curcumin has neuroprotective effect and could enhance memory."5.39Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. ( Cheng, YF; Guo, L; Li, JM; Liu, YS; Wu, QW; Xie, YS; Zhang, J, 2013)
"Forty patients aged 65-80 with minor-medium signs of brain aging were treated for 6 months with daily 90 mg doses of nimodipine."5.07[Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine]. ( Albano, O; Cassiano, MA; Centonze, V; Cirillo, L; Di Bari, M; Massaro, C; Polito, BM; Russo, P, 1992)
" In a multicenter, placebo-controlled, double-blind clinical study in 178 elderly patients with cognitive decline, nimodipine, a calcium antagonist was found to be a therapeutically effective agent in the treatment of old age dementias."5.06Nimodipine in the treatment of old age dementias. ( Aguglia, E; Azzarelli, O; Balsano, F; Ban, TA; Caglieris, N; Capurso, A; Marigliano, V; Morey, L; Sterlicchio, M; Tomasi, NA, 1990)
"To determine whether aging alters cardiac calcium dose responses or dihydropyridine receptor density or affinity, we performed (a) calcium (Ca2+) dose-response studies (3-5 mM) in Langendorff perfused hearts from 12 mature (4-7 month) and 12 old (23-27 month) Fischer 344 rats, and (b) quantitative autoradiography experiments with 3H-nimodipine (50-3,000 pM) in 20-microns tissue sections containing the compact AV node from hearts of eight mature and eight old F344 rats."3.69Responses to calcium and binding of 3H-nimodipine in the atrioventricular node, atria, and ventricles of mature and old male Fischer 344 rats. ( Capili, H; Kusumoto, FM; Schwartz, JB; Sniezek, MJ, 1995)
"Sustained high levels of corticosterone (CORT), one of the major stress-induced hormones in the rat, were suggested as generating 'accelerated brain aging' and were shown to induce both specific brain changes in the hippocampus and learning impairments in young and middle-aged Fischer-344 rats."3.69Nimodipine's protection against corticosterone-induced morphological changes in the hippocampus of young rats. ( Dachir, S; Kadar, T; Levy, A; Robinzon, B, 1997)
" Cellular properties were studied before and after bath application of the dihydropyridine L-type calcium channel antagonist nimodipine in aging and young rabbit hippocampal CA1 pyramidal cells in vitro."3.68Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner. ( Black, JP; Disterhoft, JF; Moyer, JR; Thompson, LT, 1992)
" Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits."3.68Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990)
" for 6 days), however, resulted in pronounced differences in AUC and Cmax between elderly and young subjects when the same doses were given."2.68The influence of age on the pharmacokinetics of nimodipine. ( Breuel, HP; Kuhlmann, J; Mück, W, 1996)
" Concomitant administration of cimetidine produced an approximate doubling of the bioavailability of nimodipine."2.39Nimodipine. Potential for drug-drug interactions in the elderly. ( Ahr, G; Kuhlmann, J; Mück, W, 1995)
" Earlier studies indicated that chronic administration of nimodipine revealed a protective effect in the occurrence of strokes in SHR-SP rats, yielding a decreased mortality rate."2.39Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains. ( de Jong, GI; Luiten, PG; Schuurman, T, 1994)
"Nimodipine has no consistent effect on brain oxygen consumption or cortical ATP or phosphocreatine levels, although the ischemia-induced fall of brain ATP levels in gerbils or the lowering of intracellular brain pH in rabbits with focal cerebral ischemia were antagonized by the drug."2.38Pharmacological basis for the use of nimodipine in central nervous system disorders. ( Schuurman, T; Scriabine, A; Traber, J, 1989)
"Aging is associated with cognitive decline and memory loss in humans."1.91Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons. ( Critch, TNRHY; Flynn, CM; Ghosh, S; Hell, JW; Lee, A; Man, KNM; Maziar, A; Qin, T; Rajani, V; Reinhardt, C; Yuan, Q, 2023)
"Pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (POCD)."1.48Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats. ( Bao, Y; Gao, F; Guo, Y; Huo, S; Li, Y; Wang, Q; Wang, X; Xin, X; Yin, C; Zhang, Q, 2018)
"Curcumin has neuroprotective effect and could enhance memory."1.39Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. ( Cheng, YF; Guo, L; Li, JM; Liu, YS; Wu, QW; Xie, YS; Zhang, J, 2013)
"Nimodipine treatment decreased cortical high voltage spindles (HVSs) in aged rats, but did not prevent the diminution of spontaneous locomotor activity."1.30Chronic nimodipine and acute metrifonate treatment decreases age-related cortical high voltage spindles in rats. ( Björklund, M; Jäkälä, P; Koivisto, E; Riekkinen, P; Schmidt, B, 1997)
"Nimodipine-treated rats performed better than vehicle-treated, aged-matched controls in all the test series, making more correct choices every time a new series was initiated."1.30Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. ( Batuecas, A; Bogónez, E; Bollati, A; Centeno, C; Hernández, M; Pereira, R; Pulido, JA; Satrústegui, J, 1998)
" These results suggest that SAM rapidly undergoes neurochemical changes which are considered to be part of the normal aging process, and these changes were attenuated by chronic administration of nimodipine."1.29Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine. ( Kabuto, H; Mori, A; Murakami, M; Sawada, S; Yokoi, I, 1995)
" Intraperitoneal treatment with the Ca2+ channel blocker, nimodipine, from week 4 onwards, in a dosage of 10 mg kg-1 or 20 mg kg-1 intraperitoneally per 48 h, resulted in a significant increase in sensory and motor nerve conduction velocity whereas treatment with 5 mg kg-1 intraperitoneally per 48 h was not effective."1.29Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat. ( Bravenboer, B; Erkelens, DW; Gispen, WH; Kappelle, AC; Traber, J; van Buren, T, 1993)
"Nimodipine did, however, enhance performance of rats during the first and second probe trials of reversal training."1.29Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine. ( Fanelli, RJ; McMonagle-Strucko, K, 1993)
" In conclusion, the present study suggests that there is an altered Ca++ homeostasis in the SAMP8 brain that is effectively attenuated by chronic administration of nimodipine and nicardipine."1.29Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine. ( Kimura, R; Ohkura, T; Suzuki, M; Uchida, S; Yamada, S; Yamaguchi, M; Yamamoto, M, 1996)
" These data indicate that chronic administration of nimodipine enables granular cells in the dentate gyrus to maintain its number of synaptic contacts during the aging process."1.28Synaptic plasticity in the dentate gyrus of aged rats is altered after chronic nimodipine application. ( Buwalda, B; de Jong, GI; Luiten, PG; Schuurman, T, 1992)
" We now conclude that chronic administration of nimodipine delays the formation of microvascular deposits up to the age of 30 months."1.28Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application. ( de Jong, GI; Luiten, PG; Traber, J, 1992)
"Nimodipine-treated as well as parathyroidectomied animals showed significantly fewer hypertensive cerebral lesions."1.28Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine. ( Kazda, S; Lenz, P; Luckhaus, G; Stasch, JP, 1990)

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.17)18.7374
1990's49 (77.78)18.2507
2000's3 (4.76)29.6817
2010's8 (12.70)24.3611
2020's1 (1.59)2.80

Authors

AuthorsStudies
Maziar, A1
Critch, TNRHY1
Ghosh, S1
Rajani, V1
Flynn, CM1
Qin, T1
Reinhardt, C1
Man, KNM1
Lee, A1
Hell, JW1
Yuan, Q1
Zhang, Q1
Li, Y1
Bao, Y1
Yin, C1
Xin, X1
Guo, Y1
Gao, F1
Huo, S1
Wang, X1
Wang, Q1
Debette, S1
Wolf, C1
Lambert, JC1
Crivello, F1
Soumaré, A1
Zhu, YC1
Schilling, S1
Dufouil, C1
Mazoyer, B1
Amouyel, P1
Tzourio, C1
Elbaz, A1
Hopp, SC1
D'Angelo, HM1
Royer, SE1
Kaercher, RM1
Adzovic, L1
Wenk, GL1
Shen, AN2
Cummings, C2
Pope, D2
Hoffman, D2
Newland, MC2
Arnold, M1
Lu, CB1
Hamilton, JB1
Powell, AD1
Toescu, EC1
Vreugdenhil, M1
Barua, NU1
Miners, JS1
Bienemann, AS1
Wyatt, MJ1
Welser, K1
Tabor, AB1
Hailes, HC1
Love, S1
Gill, SS1
Cheng, YF1
Guo, L1
Xie, YS1
Liu, YS1
Zhang, J1
Wu, QW1
Li, JM1
Power, JM1
Wu, WW1
Sametsky, E1
Oh, MM1
Disterhoft, JF8
Veng, LM1
Mesches, MH1
Browning, MD1
Rajasekaran, S1
Venkatadass, K1
Naresh Babu, J1
Ganesh, K1
Shetty, AP1
Mervis, RF1
Kuntz, N1
Burton, D1
Dvorak, R1
Tandon, R1
Hoover, L1
Wood, MS1
Solomon, PR1
Kabuto, H2
Yokoi, I2
Mori, A1
Murakami, M1
Sawada, S1
Mück, W2
Ahr, G1
Kuhlmann, J2
Fischhof, PK1
Fanelli, RJ2
McCarthy, RT1
Chisholm, J1
Moyer, JR4
Thompson, LT4
Gispen, WH5
Hamers, FP1
Luiten, PG10
de Jong, GI5
Schuurman, T5
Traber, J7
Nyakas, C5
Buwalda, B4
Kramers, RJ1
Zhang, JT1
Naber, R1
Markel, E1
Korte, SM1
Kowalska, M1
Van der Zee, EA2
Bohus, B1
Kappelle, AC1
Bravenboer, B1
van Buren, T1
Erkelens, DW1
McMonagle-Strucko, K1
de Jonge, MC1
Douma, BR2
Kusumoto, FM1
Capili, H1
Sniezek, MJ1
Schwartz, JB1
Yamada, S1
Uchida, S1
Ohkura, T1
Kimura, R1
Yamaguchi, M1
Suzuki, M1
Yamamoto, M1
Mogul, DJ1
Hartmann, H1
Eckert, A1
Velbinger, K1
Rewsin, M1
Müller, WE1
Stuiver, BT1
Bakker, R1
Breuel, HP1
Dachir, S1
Kadar, T1
Robinzon, B1
Levy, A1
Meneses, A2
Terrón, JA1
Ibarra, M1
Hong, E2
Inada, K1
Namba, Y1
Ogawa, N1
Riekkinen, P1
Schmidt, B1
Jäkälä, P1
Koivisto, E1
Björklund, M1
Alvarez, XA1
Laredo, M1
Corzo, D1
Fernández-Novoa, L1
Mouzo, R1
Perea, JE1
Daniele, D1
Cacabelos, R1
Araki, T1
Kato, H1
Shuto, K1
Itoyama, Y1
Paróczai, M1
Kiss, B1
Kárpáti, E1
Batuecas, A1
Pereira, R1
Centeno, C1
Pulido, JA1
Hernández, M1
Bollati, A1
Bogónez, E1
Satrústegui, J1
Kanowski, S1
Black, JP1
Centonze, V1
Massaro, C1
Polito, BM1
Cassiano, MA1
Di Bari, M1
Russo, P1
Cirillo, L1
Albano, O1
Van der Zee, CE1
Brakkee, JH1
Deyo, RA2
Aldenhoff, J1
Bär, PR1
Ban, TA1
Morey, L1
Aguglia, E1
Azzarelli, O1
Balsano, F1
Marigliano, V1
Caglieris, N1
Sterlicchio, M1
Capurso, A1
Tomasi, NA1
Horváth, E1
Lenz, P1
Luckhaus, G1
Stasch, JP1
Kazda, S1
Gelmers, HJ1
Hennerici, M1
Scriabine, A1
Straube, KT1

Reviews

12 reviews available for nimodipine and Aging

ArticleYear
Nimodipine. Potential for drug-drug interactions in the elderly.
    Drugs & aging, 1995, Volume: 6, Issue:3

    Topics: Aged; Aging; Drug Interactions; Humans; Nimodipine; Risk Factors

1995
The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Alzheimer Disease; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Hippocampus;

1994
Calcium and neuronal dysfunction in peripheral nervous system.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cisplatin; Diabetic Neuropathie

1994
Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Calcium; Calcium Channel Blockers; Cal

1994
Calcium antagonists in aging brain.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Animals; Behavior, Animal; Brain; Calcium; Male; Neurons; Nimodipine; Rats; Rats, Wistar

1994
[Altered calcium homeostasis in brain aging and senile dementia, new approach to treat Alzheimer's disease].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:9

    Topics: Aging; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dementia; Humans; Learni

1993
Nimodipine: cognition, aging, and degeneration.
    Clinical neuropharmacology, 1993, Volume: 16 Suppl 1

    Topics: Aging; Animals; Calcium; Cognition; Homeostasis; Humans; Nerve Degeneration; Nimodipine

1993
Neuronal plasticity and function.
    Clinical neuropharmacology, 1993, Volume: 16 Suppl 1

    Topics: Adult; Aging; Animals; Humans; Neuronal Plasticity; Neurons; Nimodipine

1993
Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus.
    Life sciences, 1996, Volume: 59, Issue:5-6

    Topics: Action Potentials; Aging; Animals; Calcium; Calcium Channel Blockers; Conditioning, Classical; Hippo

1996
Aging, dementia and calcium metabolism.
    Journal of neural transmission. Supplementum, 1998, Volume: 54

    Topics: Aged; Aging; Alzheimer Disease; Animals; Brain; Calcium; Calcium Channel Blockers; Dementia, Vascula

1998
CNS and PNS effects of nimodipine.
    Journal of neural transmission. Supplementum, 1990, Volume: 31

    Topics: Aging; Animals; Brain; Calcium; Cell Survival; Humans; Neuronal Plasticity; Nimodipine; Peripheral N

1990
Pharmacological basis for the use of nimodipine in central nervous system disorders.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:7

    Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Damage, Chronic; Brain Ischemia; Cen

1989

Trials

7 trials available for nimodipine and Aging

ArticleYear
Divergent neuroprotective effects of nimodipine in PDD and MID provide indirect evidence of disturbances in Ca2+ homeostasis in dementia.
    Methods and findings in experimental and clinical pharmacology, 1993, Volume: 15, Issue:8

    Topics: Aged; Aged, 80 and over; Aging; Calcium; Cognition; Dementia; Dementia, Multi-Infarct; Double-Blind

1993
The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Alzheimer Disease; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Hippocampus;

1994
The influence of age on the pharmacokinetics of nimodipine.
    International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:7

    Topics: Adult; Aged; Aging; Area Under Curve; Biological Availability; Calcium Channel Blockers; Electrocard

1996
Citicoline improves memory performance in elderly subjects.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:3

    Topics: Aged; Aging; Blood Pressure; Cross-Over Studies; Cytidine Diphosphate Choline; Dose-Response Relatio

1997
[Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine].
    La Clinica terapeutica, 1992, Volume: 140, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Brain; Dementia; Drug Tolerance; Female; Humans; Male; Nimodipine; P

1992
Nimodipine in the treatment of old age dementias.
    Progress in neuro-psychopharmacology & biological psychiatry, 1990, Volume: 14, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Blood Pressure; Dementia; Double-Blind Method; El

1990
Effect of nimodipine on acute ischemic stroke. Pooled results from five randomized trials.
    Stroke, 1990, Volume: 21, Issue:12 Suppl

    Topics: Aged; Aging; Brain Ischemia; Cerebrovascular Disorders; Double-Blind Method; Female; Humans; Male; M

1990

Other Studies

45 other studies available for nimodipine and Aging

ArticleYear
Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons.
    Cerebral cortex (New York, N.Y. : 1991), 2023, 02-07, Volume: 33, Issue:4

    Topics: Aged; Aging; Animals; Calcium Channels, L-Type; Hippocampus; Humans; Nimodipine; Piriform Cortex; Py

2023
Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats.
    BMC anesthesiology, 2018, 04-16, Volume: 18, Issue:1

    Topics: Aging; Animals; Apoptosis; Calcineurin; Calcium Channel Blockers; Cognition Disorders; Disease Model

2018
Abdominal obesity and lower gray matter volume: a Mendelian randomization study.
    Neurobiology of aging, 2014, Volume: 35, Issue:2

    Topics: Aged; Aging; Anthropometry; Body Mass Index; Brain; Cerebral Infarction; Cohort Studies; Female; Hip

2014
Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism.
    Neuroscience, 2014, Nov-07, Volume: 280

    Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dantrolene; Gene Expression; Hip

2014
A bout analysis reveals age-related methylmercury neurotoxicity and nimodipine neuroprotection.
    Behavioural brain research, 2016, 09-15, Volume: 311

    Topics: Aging; Animals; Brain; Calcium Channel Blockers; Cohort Studies; Conditioning, Operant; Disease Susc

2016
Aging, motor function, and sensitivity to calcium channel blockers: An investigation using chronic methylmercury exposure.
    Behavioural brain research, 2016, 12-15, Volume: 315

    Topics: Aging; Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug;

2016
Effect of ageing on CA3 interneuron sAHP and gamma oscillations is activity-dependent.
    Neurobiology of aging, 2011, Volume: 32, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2011
Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.
    Journal of Alzheimer's disease : JAD, 2012, Volume: 32, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antigens, Nuclear; Calcium Channel Blocker

2012
Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice.
    Neurochemical research, 2013, Volume: 38, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Antioxidants; Calcium Channel Blockers; Curcumin; Elect

2013
Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Aug-15, Volume: 22, Issue:16

    Topics: Action Potentials; Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Fema

2002
Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment.
    Brain research. Molecular brain research, 2003, Feb-20, Volume: 110, Issue:2

    Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium-Calmod

2003
Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs : Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2008, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Aging; Calcium Channel Blockers; Child; Contrast Media; Diffusion; Female; Gadoli

2008
Structural-functional correlates of neuroprotection in the aging rabbit by a calcium channel blocker. Nimodipine reverses neocortical dendritic atrophy and improves memory retention.
    Annals of the New York Academy of Sciences, 1995, Sep-15, Volume: 765

    Topics: Aging; Animals; Atrophy; Blinking; Calcium Channel Blockers; Dendrites; Dose-Response Relationship,

1995
Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine.
    Mechanisms of ageing and development, 1995, Apr-21, Volume: 80, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Administration, Oral; Aging; Animals; Brain; Calcium

1995
Neuropharmacology of nimodipine: from single channels to behavior.
    Annals of the New York Academy of Sciences, 1994, Dec-15, Volume: 747

    Topics: Aging; Amyloid beta-Peptides; Animals; Behavior, Animal; Calcium; Cells, Cultured; Dementia; Female;

1994
Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: effects of nitrite-induced prenatal hypoxia and nimodipine treatment.
    Neuroscience, 1994, Volume: 59, Issue:3

    Topics: Acetylcholinesterase; Aging; Animals; Cerebral Cortex; Female; Fetal Hypoxia; Hippocampus; Immunohis

1994
Nimodipine accelerates the postnatal development of parvalbumin and S-100 beta immunoreactivity in the rat brain.
    Brain research. Developmental brain research, 1994, Apr-15, Volume: 78, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Calcium-Binding Proteins; Female; Immunohistochemistry; Ner

1994
Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentration-dependent manner.
    Hippocampus, 1994, Volume: 4, Issue:1

    Topics: Action Potentials; Aging; Animals; Cadmium; Cadmium Chloride; Calcium; Calcium Channels; Chlorides;

1994
Life-spanning behavioural and adrenal dysfunction induced by prenatal hypoxia in the rat is prevented by the calcium antagonist nimodipine.
    The European journal of neuroscience, 1994, May-01, Volume: 6, Issue:5

    Topics: Adrenal Insufficiency; Aging; Anemia; Animals; Behavior, Animal; Brain Damage, Chronic; Corticostero

1994
Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits.
    Experimental neurology, 1994, Volume: 127, Issue:1

    Topics: Acoustic Stimulation; Aging; Animals; Blinking; Conditioning, Classical; Dose-Response Relationship,

1994
Reversed alterations of hippocampal parvalbumin and protein kinase C-gamma immunoreactivity after stroke in spontaneously hypertensive stroke-prone rats.
    Stroke, 1993, Volume: 24, Issue:12

    Topics: Aging; Animals; Brain; Brain Edema; Calcium; Cerebrovascular Disorders; Hippocampus; Male; Nimodipin

1993
Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat.
    British journal of pharmacology, 1993, Volume: 108, Issue:3

    Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies;

1993
Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:4

    Topics: Aging; Animals; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Implants; Male;

1993
Neuroprotection against NMDA induced cell death in rat nucleus basalis by Ca2+ antagonist nimodipine, influence of aging and developmental drug treatment.
    Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 1995, Volume: 4, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Calcium Channel Blockers; Cell Count; Cell Death; Functional L

1995
Responses to calcium and binding of 3H-nimodipine in the atrioventricular node, atria, and ventricles of mature and old male Fischer 344 rats.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Atrioventricular Node; Autoradiography; Binding, Competitive;

1995
Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Mice;

1996
Down-regulation of free intracellular calcium in dissociated brain cells of aged mice and rats.
    Life sciences, 1996, Volume: 59, Issue:5-6

    Topics: Aging; Animals; Brain; Calcimycin; Calcium; Calcium Channel Blockers; Down-Regulation; Female; Homeo

1996
In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection.
    Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 1996, Volume: 5, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug;

1996
Nimodipine's protection against corticosterone-induced morphological changes in the hippocampus of young rats.
    Brain research, 1997, Feb-14, Volume: 748, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Calcium Channel Blockers; Corticosterone; Hippocampus

1997
Effects of nimodipine on learning in normotensive and spontaneously hypertensive rats.
    Behavioural brain research, 1997, Volume: 85, Issue:1

    Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Conditioning, Operant; Heart

1997
The effects of chronic administration of nimodipine on age-related changes in nitric oxide and its synthase in senescence-accelerated mouse brain.
    Biochemistry and molecular biology international, 1997, Volume: 41, Issue:4

    Topics: Age Factors; Aging; Animals; Brain; Calcium Channel Blockers; Cerebral Cortex; Mice; Mice, Inbred AK

1997
Chronic nimodipine and acute metrifonate treatment decreases age-related cortical high voltage spindles in rats.
    Psychopharmacology, 1997, Volume: 129, Issue:1

    Topics: Aging; Animals; Calcium Channel Blockers; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism

1997
Age-related changes in [3H]nimodipine and [3H]rolipram binding in the rat brain.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Binding Sites; Brain; Calcium

1997
Spontaneously hypertensive rats: a potential model to identify drugs for treatment of learning disorders.
    Hypertension (Dallas, Tex. : 1979), 1998, Volume: 31, Issue:4

    Topics: Aging; Analysis of Variance; Animals; Blood Pressure; Calcium Channel Blockers; Cognition Disorders;

1998
Effect of RGH-2716 on learning and memory deficits of young and aged rats in water-labyrinth.
    Brain research bulletin, 1998, Mar-15, Volume: 45, Issue:5

    Topics: Aging; Amnesia, Retrograde; Animals; Diazepam; Learning Disabilities; Male; Maze Learning; Memory; M

1998
Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis.
    European journal of pharmacology, 1998, Jun-05, Volume: 350, Issue:2-3

    Topics: Aging; Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Calcium; Calcium Channel Block

1998
Synaptic plasticity in the dentate gyrus of aged rats is altered after chronic nimodipine application.
    Brain research, 1992, Nov-20, Volume: 596, Issue:1-2

    Topics: Aging; Animals; Ethanol; Hippocampus; Male; Neuronal Plasticity; Nimodipine; Phosphotungstic Acid; R

1992
Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application.
    Mechanisms of ageing and development, 1992, Jul-15, Volume: 64, Issue:3

    Topics: Aging; Animals; Basement Membrane; Blood Pressure; Brain; Fibrosis; Male; Microcirculation; Microsco

1992
Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner.
    Journal of neurophysiology, 1992, Volume: 68, Issue:6

    Topics: Action Potentials; Aging; Animals; Electrophysiology; In Vitro Techniques; Membrane Potentials; Neur

1992
Putative neurotrophic factors and functional recovery from peripheral nerve damage in the rat.
    British journal of pharmacology, 1991, Volume: 103, Issue:1

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Anticonvulsants; Female; Hypophysectomy; Melanocyte-Sti

1991
Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning.
    Brain research, 1990, Dec-03, Volume: 535, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
[Calcium antagonists for the aging brain].
    Zahntechnik (Zurich, Switzerland), 1991, Volume: 48, Issue:5

    Topics: Aging; Animals; Brain Diseases; Calcium Channel Blockers; Nimodipine; Rats

1991
Effects of early onset of nimodipine treatment on microvascular integrity in the aging rat brain.
    Stroke, 1990, Volume: 21, Issue:12 Suppl

    Topics: Aging; Animals; Brain; Male; Microcirculation; Microscopy, Electron; Nimodipine; Rats; Rats, Inbred

1990
Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine.
    Stroke, 1990, Volume: 21, Issue:12 Suppl

    Topics: Aging; Animals; Brain; Calcium; Cerebrovascular Disorders; Creatinine; Hypertension; Kidney; Male; M

1990
Nimodipine facilitates associative learning in aging rabbits.
    Science (New York, N.Y.), 1989, Feb-10, Volume: 243, Issue:4892

    Topics: Aging; Animals; Association Learning; Calcium; Learning; Nimodipine; Rabbits; Vasodilator Agents

1989