nimodipine and Aging
nimodipine has been researched along with Aging in 63 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty patients aged 65-80 with minor-medium signs of brain aging were treated for 6 months with daily 90 mg doses of nimodipine." | 9.07 | [Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine]. ( Albano, O; Cassiano, MA; Centonze, V; Cirillo, L; Di Bari, M; Massaro, C; Polito, BM; Russo, P, 1992) |
| " In a multicenter, placebo-controlled, double-blind clinical study in 178 elderly patients with cognitive decline, nimodipine, a calcium antagonist was found to be a therapeutically effective agent in the treatment of old age dementias." | 9.06 | Nimodipine in the treatment of old age dementias. ( Aguglia, E; Azzarelli, O; Balsano, F; Ban, TA; Caglieris, N; Capurso, A; Marigliano, V; Morey, L; Sterlicchio, M; Tomasi, NA, 1990) |
| "Nimodipine, a 1,4-dihydropyridine calcium channel blocker, has been shown to enhance learning in aging rats, rabbits, and monkeys." | 7.69 | Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits. ( Disterhoft, JF; Kowalska, M, 1994) |
| " Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits." | 7.68 | Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990) |
| "Curcumin has neuroprotective effect and could enhance memory." | 5.39 | Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. ( Cheng, YF; Guo, L; Li, JM; Liu, YS; Wu, QW; Xie, YS; Zhang, J, 2013) |
| "Forty patients aged 65-80 with minor-medium signs of brain aging were treated for 6 months with daily 90 mg doses of nimodipine." | 5.07 | [Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine]. ( Albano, O; Cassiano, MA; Centonze, V; Cirillo, L; Di Bari, M; Massaro, C; Polito, BM; Russo, P, 1992) |
| " In a multicenter, placebo-controlled, double-blind clinical study in 178 elderly patients with cognitive decline, nimodipine, a calcium antagonist was found to be a therapeutically effective agent in the treatment of old age dementias." | 5.06 | Nimodipine in the treatment of old age dementias. ( Aguglia, E; Azzarelli, O; Balsano, F; Ban, TA; Caglieris, N; Capurso, A; Marigliano, V; Morey, L; Sterlicchio, M; Tomasi, NA, 1990) |
| "To determine whether aging alters cardiac calcium dose responses or dihydropyridine receptor density or affinity, we performed (a) calcium (Ca2+) dose-response studies (3-5 mM) in Langendorff perfused hearts from 12 mature (4-7 month) and 12 old (23-27 month) Fischer 344 rats, and (b) quantitative autoradiography experiments with 3H-nimodipine (50-3,000 pM) in 20-microns tissue sections containing the compact AV node from hearts of eight mature and eight old F344 rats." | 3.69 | Responses to calcium and binding of 3H-nimodipine in the atrioventricular node, atria, and ventricles of mature and old male Fischer 344 rats. ( Capili, H; Kusumoto, FM; Schwartz, JB; Sniezek, MJ, 1995) |
| "Sustained high levels of corticosterone (CORT), one of the major stress-induced hormones in the rat, were suggested as generating 'accelerated brain aging' and were shown to induce both specific brain changes in the hippocampus and learning impairments in young and middle-aged Fischer-344 rats." | 3.69 | Nimodipine's protection against corticosterone-induced morphological changes in the hippocampus of young rats. ( Dachir, S; Kadar, T; Levy, A; Robinzon, B, 1997) |
| " Cellular properties were studied before and after bath application of the dihydropyridine L-type calcium channel antagonist nimodipine in aging and young rabbit hippocampal CA1 pyramidal cells in vitro." | 3.68 | Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner. ( Black, JP; Disterhoft, JF; Moyer, JR; Thompson, LT, 1992) |
| " Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits." | 3.68 | Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990) |
| " for 6 days), however, resulted in pronounced differences in AUC and Cmax between elderly and young subjects when the same doses were given." | 2.68 | The influence of age on the pharmacokinetics of nimodipine. ( Breuel, HP; Kuhlmann, J; Mück, W, 1996) |
| " Concomitant administration of cimetidine produced an approximate doubling of the bioavailability of nimodipine." | 2.39 | Nimodipine. Potential for drug-drug interactions in the elderly. ( Ahr, G; Kuhlmann, J; Mück, W, 1995) |
| " Earlier studies indicated that chronic administration of nimodipine revealed a protective effect in the occurrence of strokes in SHR-SP rats, yielding a decreased mortality rate." | 2.39 | Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains. ( de Jong, GI; Luiten, PG; Schuurman, T, 1994) |
| "Nimodipine has no consistent effect on brain oxygen consumption or cortical ATP or phosphocreatine levels, although the ischemia-induced fall of brain ATP levels in gerbils or the lowering of intracellular brain pH in rabbits with focal cerebral ischemia were antagonized by the drug." | 2.38 | Pharmacological basis for the use of nimodipine in central nervous system disorders. ( Schuurman, T; Scriabine, A; Traber, J, 1989) |
| "Aging is associated with cognitive decline and memory loss in humans." | 1.91 | Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons. ( Critch, TNRHY; Flynn, CM; Ghosh, S; Hell, JW; Lee, A; Man, KNM; Maziar, A; Qin, T; Rajani, V; Reinhardt, C; Yuan, Q, 2023) |
| "Pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (POCD)." | 1.48 | Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats. ( Bao, Y; Gao, F; Guo, Y; Huo, S; Li, Y; Wang, Q; Wang, X; Xin, X; Yin, C; Zhang, Q, 2018) |
| "Curcumin has neuroprotective effect and could enhance memory." | 1.39 | Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. ( Cheng, YF; Guo, L; Li, JM; Liu, YS; Wu, QW; Xie, YS; Zhang, J, 2013) |
| "Nimodipine treatment decreased cortical high voltage spindles (HVSs) in aged rats, but did not prevent the diminution of spontaneous locomotor activity." | 1.30 | Chronic nimodipine and acute metrifonate treatment decreases age-related cortical high voltage spindles in rats. ( Björklund, M; Jäkälä, P; Koivisto, E; Riekkinen, P; Schmidt, B, 1997) |
| "Nimodipine-treated rats performed better than vehicle-treated, aged-matched controls in all the test series, making more correct choices every time a new series was initiated." | 1.30 | Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. ( Batuecas, A; Bogónez, E; Bollati, A; Centeno, C; Hernández, M; Pereira, R; Pulido, JA; Satrústegui, J, 1998) |
| " These results suggest that SAM rapidly undergoes neurochemical changes which are considered to be part of the normal aging process, and these changes were attenuated by chronic administration of nimodipine." | 1.29 | Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine. ( Kabuto, H; Mori, A; Murakami, M; Sawada, S; Yokoi, I, 1995) |
| " Intraperitoneal treatment with the Ca2+ channel blocker, nimodipine, from week 4 onwards, in a dosage of 10 mg kg-1 or 20 mg kg-1 intraperitoneally per 48 h, resulted in a significant increase in sensory and motor nerve conduction velocity whereas treatment with 5 mg kg-1 intraperitoneally per 48 h was not effective." | 1.29 | Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat. ( Bravenboer, B; Erkelens, DW; Gispen, WH; Kappelle, AC; Traber, J; van Buren, T, 1993) |
| "Nimodipine did, however, enhance performance of rats during the first and second probe trials of reversal training." | 1.29 | Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine. ( Fanelli, RJ; McMonagle-Strucko, K, 1993) |
| " In conclusion, the present study suggests that there is an altered Ca++ homeostasis in the SAMP8 brain that is effectively attenuated by chronic administration of nimodipine and nicardipine." | 1.29 | Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine. ( Kimura, R; Ohkura, T; Suzuki, M; Uchida, S; Yamada, S; Yamaguchi, M; Yamamoto, M, 1996) |
| " These data indicate that chronic administration of nimodipine enables granular cells in the dentate gyrus to maintain its number of synaptic contacts during the aging process." | 1.28 | Synaptic plasticity in the dentate gyrus of aged rats is altered after chronic nimodipine application. ( Buwalda, B; de Jong, GI; Luiten, PG; Schuurman, T, 1992) |
| " We now conclude that chronic administration of nimodipine delays the formation of microvascular deposits up to the age of 30 months." | 1.28 | Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application. ( de Jong, GI; Luiten, PG; Traber, J, 1992) |
| "Nimodipine-treated as well as parathyroidectomied animals showed significantly fewer hypertensive cerebral lesions." | 1.28 | Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine. ( Kazda, S; Lenz, P; Luckhaus, G; Stasch, JP, 1990) |
Research
Studies (63)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.17) | 18.7374 |
| 1990's | 49 (77.78) | 18.2507 |
| 2000's | 3 (4.76) | 29.6817 |
| 2010's | 8 (12.70) | 24.3611 |
| 2020's | 1 (1.59) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Maziar, A | 1 |
| Critch, TNRHY | 1 |
| Ghosh, S | 1 |
| Rajani, V | 1 |
| Flynn, CM | 1 |
| Qin, T | 1 |
| Reinhardt, C | 1 |
| Man, KNM | 1 |
| Lee, A | 1 |
| Hell, JW | 1 |
| Yuan, Q | 1 |
| Zhang, Q | 1 |
| Li, Y | 1 |
| Bao, Y | 1 |
| Yin, C | 1 |
| Xin, X | 1 |
| Guo, Y | 1 |
| Gao, F | 1 |
| Huo, S | 1 |
| Wang, X | 1 |
| Wang, Q | 1 |
| Debette, S | 1 |
| Wolf, C | 1 |
| Lambert, JC | 1 |
| Crivello, F | 1 |
| Soumaré, A | 1 |
| Zhu, YC | 1 |
| Schilling, S | 1 |
| Dufouil, C | 1 |
| Mazoyer, B | 1 |
| Amouyel, P | 1 |
| Tzourio, C | 1 |
| Elbaz, A | 1 |
| Hopp, SC | 1 |
| D'Angelo, HM | 1 |
| Royer, SE | 1 |
| Kaercher, RM | 1 |
| Adzovic, L | 1 |
| Wenk, GL | 1 |
| Shen, AN | 2 |
| Cummings, C | 2 |
| Pope, D | 2 |
| Hoffman, D | 2 |
| Newland, MC | 2 |
| Arnold, M | 1 |
| Lu, CB | 1 |
| Hamilton, JB | 1 |
| Powell, AD | 1 |
| Toescu, EC | 1 |
| Vreugdenhil, M | 1 |
| Barua, NU | 1 |
| Miners, JS | 1 |
| Bienemann, AS | 1 |
| Wyatt, MJ | 1 |
| Welser, K | 1 |
| Tabor, AB | 1 |
| Hailes, HC | 1 |
| Love, S | 1 |
| Gill, SS | 1 |
| Cheng, YF | 1 |
| Guo, L | 1 |
| Xie, YS | 1 |
| Liu, YS | 1 |
| Zhang, J | 1 |
| Wu, QW | 1 |
| Li, JM | 1 |
| Power, JM | 1 |
| Wu, WW | 1 |
| Sametsky, E | 1 |
| Oh, MM | 1 |
| Disterhoft, JF | 8 |
| Veng, LM | 1 |
| Mesches, MH | 1 |
| Browning, MD | 1 |
| Rajasekaran, S | 1 |
| Venkatadass, K | 1 |
| Naresh Babu, J | 1 |
| Ganesh, K | 1 |
| Shetty, AP | 1 |
| Mervis, RF | 1 |
| Kuntz, N | 1 |
| Burton, D | 1 |
| Dvorak, R | 1 |
| Tandon, R | 1 |
| Hoover, L | 1 |
| Wood, MS | 1 |
| Solomon, PR | 1 |
| Kabuto, H | 2 |
| Yokoi, I | 2 |
| Mori, A | 1 |
| Murakami, M | 1 |
| Sawada, S | 1 |
| Mück, W | 2 |
| Ahr, G | 1 |
| Kuhlmann, J | 2 |
| Fischhof, PK | 1 |
| Fanelli, RJ | 2 |
| McCarthy, RT | 1 |
| Chisholm, J | 1 |
| Moyer, JR | 4 |
| Thompson, LT | 4 |
| Gispen, WH | 5 |
| Hamers, FP | 1 |
| Luiten, PG | 10 |
| de Jong, GI | 5 |
| Schuurman, T | 5 |
| Traber, J | 7 |
| Nyakas, C | 5 |
| Buwalda, B | 4 |
| Kramers, RJ | 1 |
| Zhang, JT | 1 |
| Naber, R | 1 |
| Markel, E | 1 |
| Korte, SM | 1 |
| Kowalska, M | 1 |
| Van der Zee, EA | 2 |
| Bohus, B | 1 |
| Kappelle, AC | 1 |
| Bravenboer, B | 1 |
| van Buren, T | 1 |
| Erkelens, DW | 1 |
| McMonagle-Strucko, K | 1 |
| de Jonge, MC | 1 |
| Douma, BR | 2 |
| Kusumoto, FM | 1 |
| Capili, H | 1 |
| Sniezek, MJ | 1 |
| Schwartz, JB | 1 |
| Yamada, S | 1 |
| Uchida, S | 1 |
| Ohkura, T | 1 |
| Kimura, R | 1 |
| Yamaguchi, M | 1 |
| Suzuki, M | 1 |
| Yamamoto, M | 1 |
| Mogul, DJ | 1 |
| Hartmann, H | 1 |
| Eckert, A | 1 |
| Velbinger, K | 1 |
| Rewsin, M | 1 |
| Müller, WE | 1 |
| Stuiver, BT | 1 |
| Bakker, R | 1 |
| Breuel, HP | 1 |
| Dachir, S | 1 |
| Kadar, T | 1 |
| Robinzon, B | 1 |
| Levy, A | 1 |
| Meneses, A | 2 |
| Terrón, JA | 1 |
| Ibarra, M | 1 |
| Hong, E | 2 |
| Inada, K | 1 |
| Namba, Y | 1 |
| Ogawa, N | 1 |
| Riekkinen, P | 1 |
| Schmidt, B | 1 |
| Jäkälä, P | 1 |
| Koivisto, E | 1 |
| Björklund, M | 1 |
| Alvarez, XA | 1 |
| Laredo, M | 1 |
| Corzo, D | 1 |
| Fernández-Novoa, L | 1 |
| Mouzo, R | 1 |
| Perea, JE | 1 |
| Daniele, D | 1 |
| Cacabelos, R | 1 |
| Araki, T | 1 |
| Kato, H | 1 |
| Shuto, K | 1 |
| Itoyama, Y | 1 |
| Paróczai, M | 1 |
| Kiss, B | 1 |
| Kárpáti, E | 1 |
| Batuecas, A | 1 |
| Pereira, R | 1 |
| Centeno, C | 1 |
| Pulido, JA | 1 |
| Hernández, M | 1 |
| Bollati, A | 1 |
| Bogónez, E | 1 |
| Satrústegui, J | 1 |
| Kanowski, S | 1 |
| Black, JP | 1 |
| Centonze, V | 1 |
| Massaro, C | 1 |
| Polito, BM | 1 |
| Cassiano, MA | 1 |
| Di Bari, M | 1 |
| Russo, P | 1 |
| Cirillo, L | 1 |
| Albano, O | 1 |
| Van der Zee, CE | 1 |
| Brakkee, JH | 1 |
| Deyo, RA | 2 |
| Aldenhoff, J | 1 |
| Bär, PR | 1 |
| Ban, TA | 1 |
| Morey, L | 1 |
| Aguglia, E | 1 |
| Azzarelli, O | 1 |
| Balsano, F | 1 |
| Marigliano, V | 1 |
| Caglieris, N | 1 |
| Sterlicchio, M | 1 |
| Capurso, A | 1 |
| Tomasi, NA | 1 |
| Horváth, E | 1 |
| Lenz, P | 1 |
| Luckhaus, G | 1 |
| Stasch, JP | 1 |
| Kazda, S | 1 |
| Gelmers, HJ | 1 |
| Hennerici, M | 1 |
| Scriabine, A | 1 |
| Straube, KT | 1 |
Reviews
12 reviews available for nimodipine and Aging
| Article | Year |
|---|---|
Nimodipine. Potential for drug-drug interactions in the elderly.
Topics: Aged; Aging; Drug Interactions; Humans; Nimodipine; Risk Factors | 1995 |
The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging.
Topics: Aging; Alzheimer Disease; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Hippocampus; | 1994 |
Calcium and neuronal dysfunction in peripheral nervous system.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cisplatin; Diabetic Neuropathie | 1994 |
Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains.
Topics: Aging; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Calcium; Calcium Channel Blockers; Cal | 1994 |
Calcium antagonists in aging brain.
Topics: Aging; Animals; Behavior, Animal; Brain; Calcium; Male; Neurons; Nimodipine; Rats; Rats, Wistar | 1994 |
[Altered calcium homeostasis in brain aging and senile dementia, new approach to treat Alzheimer's disease].
Topics: Aging; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dementia; Humans; Learni | 1993 |
Nimodipine: cognition, aging, and degeneration.
Topics: Aging; Animals; Calcium; Cognition; Homeostasis; Humans; Nerve Degeneration; Nimodipine | 1993 |
Neuronal plasticity and function.
Topics: Adult; Aging; Animals; Humans; Neuronal Plasticity; Neurons; Nimodipine | 1993 |
Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus.
Topics: Action Potentials; Aging; Animals; Calcium; Calcium Channel Blockers; Conditioning, Classical; Hippo | 1996 |
Aging, dementia and calcium metabolism.
Topics: Aged; Aging; Alzheimer Disease; Animals; Brain; Calcium; Calcium Channel Blockers; Dementia, Vascula | 1998 |
CNS and PNS effects of nimodipine.
Topics: Aging; Animals; Brain; Calcium; Cell Survival; Humans; Neuronal Plasticity; Nimodipine; Peripheral N | 1990 |
Pharmacological basis for the use of nimodipine in central nervous system disorders.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Damage, Chronic; Brain Ischemia; Cen | 1989 |
Trials
7 trials available for nimodipine and Aging
| Article | Year |
|---|---|
Divergent neuroprotective effects of nimodipine in PDD and MID provide indirect evidence of disturbances in Ca2+ homeostasis in dementia.
Topics: Aged; Aged, 80 and over; Aging; Calcium; Cognition; Dementia; Dementia, Multi-Infarct; Double-Blind | 1993 |
The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging.
Topics: Aging; Alzheimer Disease; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Hippocampus; | 1994 |
The influence of age on the pharmacokinetics of nimodipine.
Topics: Adult; Aged; Aging; Area Under Curve; Biological Availability; Calcium Channel Blockers; Electrocard | 1996 |
Citicoline improves memory performance in elderly subjects.
Topics: Aged; Aging; Blood Pressure; Cross-Over Studies; Cytidine Diphosphate Choline; Dose-Response Relatio | 1997 |
[Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine].
Topics: Aged; Aged, 80 and over; Aging; Brain; Dementia; Drug Tolerance; Female; Humans; Male; Nimodipine; P | 1992 |
Nimodipine in the treatment of old age dementias.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Blood Pressure; Dementia; Double-Blind Method; El | 1990 |
Effect of nimodipine on acute ischemic stroke. Pooled results from five randomized trials.
Topics: Aged; Aging; Brain Ischemia; Cerebrovascular Disorders; Double-Blind Method; Female; Humans; Male; M | 1990 |
Other Studies
45 other studies available for nimodipine and Aging
| Article | Year |
|---|---|
Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons.
Topics: Aged; Aging; Animals; Calcium Channels, L-Type; Hippocampus; Humans; Nimodipine; Piriform Cortex; Py | 2023 |
Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats.
Topics: Aging; Animals; Apoptosis; Calcineurin; Calcium Channel Blockers; Cognition Disorders; Disease Model | 2018 |
Abdominal obesity and lower gray matter volume: a Mendelian randomization study.
Topics: Aged; Aging; Anthropometry; Body Mass Index; Brain; Cerebral Infarction; Cohort Studies; Female; Hip | 2014 |
Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism.
Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dantrolene; Gene Expression; Hip | 2014 |
A bout analysis reveals age-related methylmercury neurotoxicity and nimodipine neuroprotection.
Topics: Aging; Animals; Brain; Calcium Channel Blockers; Cohort Studies; Conditioning, Operant; Disease Susc | 2016 |
Aging, motor function, and sensitivity to calcium channel blockers: An investigation using chronic methylmercury exposure.
Topics: Aging; Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; | 2016 |
Effect of ageing on CA3 interneuron sAHP and gamma oscillations is activity-dependent.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2011 |
Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antigens, Nuclear; Calcium Channel Blocker | 2012 |
Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Antioxidants; Calcium Channel Blockers; Curcumin; Elect | 2013 |
Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro.
Topics: Action Potentials; Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Fema | 2002 |
Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment.
Topics: Aging; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium-Calmod | 2003 |
Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs : Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs.
Topics: Adolescent; Adult; Aging; Calcium Channel Blockers; Child; Contrast Media; Diffusion; Female; Gadoli | 2008 |
Structural-functional correlates of neuroprotection in the aging rabbit by a calcium channel blocker. Nimodipine reverses neocortical dendritic atrophy and improves memory retention.
Topics: Aging; Animals; Atrophy; Blinking; Calcium Channel Blockers; Dendrites; Dose-Response Relationship, | 1995 |
Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Administration, Oral; Aging; Animals; Brain; Calcium | 1995 |
Neuropharmacology of nimodipine: from single channels to behavior.
Topics: Aging; Amyloid beta-Peptides; Animals; Behavior, Animal; Calcium; Cells, Cultured; Dementia; Female; | 1994 |
Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: effects of nitrite-induced prenatal hypoxia and nimodipine treatment.
Topics: Acetylcholinesterase; Aging; Animals; Cerebral Cortex; Female; Fetal Hypoxia; Hippocampus; Immunohis | 1994 |
Nimodipine accelerates the postnatal development of parvalbumin and S-100 beta immunoreactivity in the rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Calcium-Binding Proteins; Female; Immunohistochemistry; Ner | 1994 |
Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentration-dependent manner.
Topics: Action Potentials; Aging; Animals; Cadmium; Cadmium Chloride; Calcium; Calcium Channels; Chlorides; | 1994 |
Life-spanning behavioural and adrenal dysfunction induced by prenatal hypoxia in the rat is prevented by the calcium antagonist nimodipine.
Topics: Adrenal Insufficiency; Aging; Anemia; Animals; Behavior, Animal; Brain Damage, Chronic; Corticostero | 1994 |
Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits.
Topics: Acoustic Stimulation; Aging; Animals; Blinking; Conditioning, Classical; Dose-Response Relationship, | 1994 |
Reversed alterations of hippocampal parvalbumin and protein kinase C-gamma immunoreactivity after stroke in spontaneously hypertensive stroke-prone rats.
Topics: Aging; Animals; Brain; Brain Edema; Calcium; Cerebrovascular Disorders; Hippocampus; Male; Nimodipin | 1993 |
Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat.
Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 1993 |
Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine.
Topics: Aging; Animals; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Implants; Male; | 1993 |
Neuroprotection against NMDA induced cell death in rat nucleus basalis by Ca2+ antagonist nimodipine, influence of aging and developmental drug treatment.
Topics: Aging; Analysis of Variance; Animals; Calcium Channel Blockers; Cell Count; Cell Death; Functional L | 1995 |
Responses to calcium and binding of 3H-nimodipine in the atrioventricular node, atria, and ventricles of mature and old male Fischer 344 rats.
Topics: Aging; Analysis of Variance; Animals; Atrioventricular Node; Autoradiography; Binding, Competitive; | 1995 |
Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Mice; | 1996 |
Down-regulation of free intracellular calcium in dissociated brain cells of aged mice and rats.
Topics: Aging; Animals; Brain; Calcimycin; Calcium; Calcium Channel Blockers; Down-Regulation; Female; Homeo | 1996 |
In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection.
Topics: Aging; Analysis of Variance; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 1996 |
Nimodipine's protection against corticosterone-induced morphological changes in the hippocampus of young rats.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Calcium Channel Blockers; Corticosterone; Hippocampus | 1997 |
Effects of nimodipine on learning in normotensive and spontaneously hypertensive rats.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Conditioning, Operant; Heart | 1997 |
The effects of chronic administration of nimodipine on age-related changes in nitric oxide and its synthase in senescence-accelerated mouse brain.
Topics: Age Factors; Aging; Animals; Brain; Calcium Channel Blockers; Cerebral Cortex; Mice; Mice, Inbred AK | 1997 |
Chronic nimodipine and acute metrifonate treatment decreases age-related cortical high voltage spindles in rats.
Topics: Aging; Animals; Calcium Channel Blockers; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism | 1997 |
Age-related changes in [3H]nimodipine and [3H]rolipram binding in the rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Autoradiography; Binding Sites; Brain; Calcium | 1997 |
Spontaneously hypertensive rats: a potential model to identify drugs for treatment of learning disorders.
Topics: Aging; Analysis of Variance; Animals; Blood Pressure; Calcium Channel Blockers; Cognition Disorders; | 1998 |
Effect of RGH-2716 on learning and memory deficits of young and aged rats in water-labyrinth.
Topics: Aging; Amnesia, Retrograde; Animals; Diazepam; Learning Disabilities; Male; Maze Learning; Memory; M | 1998 |
Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis.
Topics: Aging; Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Calcium; Calcium Channel Block | 1998 |
Synaptic plasticity in the dentate gyrus of aged rats is altered after chronic nimodipine application.
Topics: Aging; Animals; Ethanol; Hippocampus; Male; Neuronal Plasticity; Nimodipine; Phosphotungstic Acid; R | 1992 |
Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application.
Topics: Aging; Animals; Basement Membrane; Blood Pressure; Brain; Fibrosis; Male; Microcirculation; Microsco | 1992 |
Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner.
Topics: Action Potentials; Aging; Animals; Electrophysiology; In Vitro Techniques; Membrane Potentials; Neur | 1992 |
Putative neurotrophic factors and functional recovery from peripheral nerve damage in the rat.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Anticonvulsants; Female; Hypophysectomy; Melanocyte-Sti | 1991 |
Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
[Calcium antagonists for the aging brain].
Topics: Aging; Animals; Brain Diseases; Calcium Channel Blockers; Nimodipine; Rats | 1991 |
Effects of early onset of nimodipine treatment on microvascular integrity in the aging rat brain.
Topics: Aging; Animals; Brain; Male; Microcirculation; Microscopy, Electron; Nimodipine; Rats; Rats, Inbred | 1990 |
Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine.
Topics: Aging; Animals; Brain; Calcium; Cerebrovascular Disorders; Creatinine; Hypertension; Kidney; Male; M | 1990 |
Nimodipine facilitates associative learning in aging rabbits.
Topics: Aging; Animals; Association Learning; Calcium; Learning; Nimodipine; Rabbits; Vasodilator Agents | 1989 |