nimodipine and Ache
nimodipine has been researched along with Ache in 13 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study." | 9.08 | Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. ( Aguilar, JL; Costa, J; Gomar, C; Mazo, V; Roca, G; Vidal, F, 1996) |
| "Oxytocin has been implicated in the modulation of somatosensory transmission such as nociception and pain." | 7.73 | Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. ( Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK, 2006) |
| "We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study." | 5.08 | Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. ( Aguilar, JL; Costa, J; Gomar, C; Mazo, V; Roca, G; Vidal, F, 1996) |
| "Oxytocin has been implicated in the modulation of somatosensory transmission such as nociception and pain." | 3.73 | Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. ( Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK, 2006) |
| "A model of spinal pain syndrome induced by a generator of abnormally increased excitation in the system of dorsal horns of the spinal cord with penicillin was used to test the calcium channel blockers OF5015 and nimotop, as well as calcium gluconate for their effects." | 3.68 | [The effect of calcium-regulating pharmacological preparations on the formation of a generator of pathologically enhanced excitation in the system of the dorsal horns of the spinal cord]. ( Danilov, EI; Grafova, VN; Reshetniak, VK, 1993) |
| "Nimodipine was further studied using a higher and escalating doses of morphine (20-30 mg/kg twice daily for 14 days)." | 1.35 | Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test. ( Gupta, A; Mishra, P; Ray, SB; Verma, D; Wadhwa, S, 2008) |
| "Pretreatment with nimodipine (40 mg/kg) did not affect the morphine level in the brain and also decreased the brain-to-serum ratio of morphine." | 1.32 | Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice. ( Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, C; Yamamoto, H, 2004) |
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Baraldi, PG | 1 |
| Preti, D | 1 |
| Materazzi, S | 1 |
| Geppetti, P | 1 |
| Ray, SB | 2 |
| Mishra, P | 1 |
| Verma, D | 2 |
| Gupta, A | 1 |
| Wadhwa, S | 2 |
| Shrestha, S | 1 |
| Gracias, NG | 1 |
| Mujenda, F | 1 |
| Khodorova, A | 1 |
| Vasko, MR | 1 |
| Strichartz, GR | 1 |
| Shimizu, N | 1 |
| Kishioka, S | 1 |
| Maeda, T | 1 |
| Fukazawa, Y | 1 |
| Yamamoto, C | 1 |
| Ozaki, M | 1 |
| Yamamoto, H | 1 |
| Reeta, Kh | 1 |
| Mediratta, PK | 1 |
| Rathi, N | 1 |
| Jain, H | 1 |
| Chugh, C | 1 |
| Sharma, KK | 1 |
| Gupta, H | 1 |
| Ahuja, RK | 1 |
| Srivastava, DN | 1 |
| Smith, FL | 1 |
| Stevens, DL | 1 |
| Filos, KS | 1 |
| Goudas, LC | 1 |
| Patroni, O | 1 |
| Tassoudis, V | 1 |
| Danilov, EI | 1 |
| Grafova, VN | 1 |
| Reshetniak, VK | 1 |
| Roca, G | 1 |
| Aguilar, JL | 1 |
| Gomar, C | 1 |
| Mazo, V | 1 |
| Costa, J | 1 |
| Vidal, F | 1 |
| Damaj, MI | 1 |
| Gullapalli, S | 1 |
| Gurumoorthy, K | 1 |
| Kaul, CL | 1 |
| Ramarao, P | 1 |
| Panerai, AE | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Oxytocin Administration on Social Influence Effects on Pain[NCT03060031] | Phase 1 | 51 participants (Actual) | Interventional | 2017-06-21 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for nimodipine and Ache
| Article | Year |
|---|---|
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Pe | 2010 |
Trials
2 trials available for nimodipine and Ache
| Article | Year |
|---|---|
Analgesia with epidural nimodipine.
Topics: Adult; Aged; Analgesia; Analgesia, Epidural; Breast Neoplasms; Female; Humans; Injections, Intraveno | 1993 |
Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Calcium Channel Blocker | 1996 |
Other Studies
10 other studies available for nimodipine and Ache
| Article | Year |
|---|---|
Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Disease Models, Animal; Dos | 2008 |
Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Calcium Chan | 2009 |
Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.
Topics: Analgesia; Animals; Area Under Curve; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Chan | 2004 |
Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.
Topics: Analgesics; Animals; Behavior; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldeh | 2006 |
Intrathecal co-administration of morphine and nimodipine produces higher antinociceptive effect by synergistic interaction as evident by injecting different doses of each drug in rats.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relatio | 2007 |
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Compartmentation; Male; Membrane Potentials; Mice | 1995 |
[The effect of calcium-regulating pharmacological preparations on the formation of a generator of pathologically enhanced excitation in the system of the dorsal horns of the spinal cord].
Topics: Acute Disease; Animals; Calcium Channel Blockers; Calcium Gluconate; Dipyrone; Dose-Response Relatio | 1993 |
The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase | 2000 |
Role of L-type Ca2+ channels in attenuated morphine antinociception in streptozotocin-diabetic rats.
Topics: Analgesics, Opioid; Animals; Brain; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membran | 2002 |
[Potentiation concept in pharmacology].
Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin | 1988 |