Page last updated: 2024-11-01

nimodipine and Ache

nimodipine has been researched along with Ache in 13 studies

Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Research Excerpts

ExcerptRelevanceReference
"We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study."9.08Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. ( Aguilar, JL; Costa, J; Gomar, C; Mazo, V; Roca, G; Vidal, F, 1996)
"Oxytocin has been implicated in the modulation of somatosensory transmission such as nociception and pain."7.73Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. ( Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK, 2006)
"We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study."5.08Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. ( Aguilar, JL; Costa, J; Gomar, C; Mazo, V; Roca, G; Vidal, F, 1996)
"Oxytocin has been implicated in the modulation of somatosensory transmission such as nociception and pain."3.73Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. ( Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK, 2006)
"A model of spinal pain syndrome induced by a generator of abnormally increased excitation in the system of dorsal horns of the spinal cord with penicillin was used to test the calcium channel blockers OF5015 and nimotop, as well as calcium gluconate for their effects."3.68[The effect of calcium-regulating pharmacological preparations on the formation of a generator of pathologically enhanced excitation in the system of the dorsal horns of the spinal cord]. ( Danilov, EI; Grafova, VN; Reshetniak, VK, 1993)
"Nimodipine was further studied using a higher and escalating doses of morphine (20-30 mg/kg twice daily for 14 days)."1.35Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test. ( Gupta, A; Mishra, P; Ray, SB; Verma, D; Wadhwa, S, 2008)
"Pretreatment with nimodipine (40 mg/kg) did not affect the morphine level in the brain and also decreased the brain-to-serum ratio of morphine."1.32Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice. ( Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, C; Yamamoto, H, 2004)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's4 (30.77)18.2507
2000's7 (53.85)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baraldi, PG1
Preti, D1
Materazzi, S1
Geppetti, P1
Ray, SB2
Mishra, P1
Verma, D2
Gupta, A1
Wadhwa, S2
Shrestha, S1
Gracias, NG1
Mujenda, F1
Khodorova, A1
Vasko, MR1
Strichartz, GR1
Shimizu, N1
Kishioka, S1
Maeda, T1
Fukazawa, Y1
Yamamoto, C1
Ozaki, M1
Yamamoto, H1
Reeta, Kh1
Mediratta, PK1
Rathi, N1
Jain, H1
Chugh, C1
Sharma, KK1
Gupta, H1
Ahuja, RK1
Srivastava, DN1
Smith, FL1
Stevens, DL1
Filos, KS1
Goudas, LC1
Patroni, O1
Tassoudis, V1
Danilov, EI1
Grafova, VN1
Reshetniak, VK1
Roca, G1
Aguilar, JL1
Gomar, C1
Mazo, V1
Costa, J1
Vidal, F1
Damaj, MI1
Gullapalli, S1
Gurumoorthy, K1
Kaul, CL1
Ramarao, P1
Panerai, AE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Oxytocin Administration on Social Influence Effects on Pain[NCT03060031]Phase 151 participants (Actual)Interventional2017-06-21Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nimodipine and Ache

ArticleYear
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Pe

2010

Trials

2 trials available for nimodipine and Ache

ArticleYear
Analgesia with epidural nimodipine.
    Lancet (London, England), 1993, Oct-23, Volume: 342, Issue:8878

    Topics: Adult; Aged; Analgesia; Analgesia, Epidural; Breast Neoplasms; Female; Humans; Injections, Intraveno

1993
Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment.
    Pain, 1996, Volume: 68, Issue:2-3

    Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Analysis of Variance; Calcium Channel Blocker

1996

Other Studies

10 other studies available for nimodipine and Ache

ArticleYear
Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test.
    Indian journal of experimental biology, 2008, Volume: 46, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Disease Models, Animal; Dos

2008
Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.
    The journal of pain, 2009, Volume: 10, Issue:7

    Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Calcium Chan

2009
Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.
    Journal of pharmacological sciences, 2004, Volume: 94, Issue:3

    Topics: Analgesia; Animals; Area Under Curve; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Chan

2004
Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.
    Regulatory peptides, 2006, Jul-15, Volume: 135, Issue:1-2

    Topics: Analgesics; Animals; Behavior; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldeh

2006
Intrathecal co-administration of morphine and nimodipine produces higher antinociceptive effect by synergistic interaction as evident by injecting different doses of each drug in rats.
    European journal of pharmacology, 2007, Apr-30, Volume: 561, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relatio

2007
Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1

    Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Compartmentation; Male; Membrane Potentials; Mice

1995
[The effect of calcium-regulating pharmacological preparations on the formation of a generator of pathologically enhanced excitation in the system of the dorsal horns of the spinal cord].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:9

    Topics: Acute Disease; Animals; Calcium Channel Blockers; Calcium Gluconate; Dipyrone; Dose-Response Relatio

1993
The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice.
    European journal of pharmacology, 2000, Sep-15, Volume: 404, Issue:1-2

    Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase

2000
Role of L-type Ca2+ channels in attenuated morphine antinociception in streptozotocin-diabetic rats.
    European journal of pharmacology, 2002, Jan-25, Volume: 435, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Brain; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membran

2002
[Potentiation concept in pharmacology].
    Minerva anestesiologica, 1988, Volume: 54, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin

1988