nimodipine has been researched along with AIDS Dementia Complex in 3 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galgani, S | 1 |
| Balestra, P | 1 |
| Narciso, P | 1 |
| Tozzi, V | 1 |
| Sette, P | 1 |
| Pau, F | 1 |
| Visco, G | 1 |
| Navia, BA | 1 |
| Dafni, U | 1 |
| Simpson, D | 1 |
| Tucker, T | 1 |
| Singer, E | 1 |
| McArthur, JC | 1 |
| Yiannoutsos, C | 1 |
| Zaborski, L | 1 |
| Lipton, SA | 1 |
| Gibbons, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1[NCT00000738] | Phase 1 | 36 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nimodipine and AIDS Dementia Complex
| Article | Year |
|---|---|
Nimodipine plus zidovudine versus zidovudine alone in the treatment of HIV-1-associated cognitive deficits.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Calcium Channel Blockers; Case-Control Studies; Cogni | 1997 |
A phase I/II trial of nimodipine for HIV-related neurologic complications.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Calcium Channel Blockers; Double-Blind Method; Female | 1998 |
1 other study available for nimodipine and AIDS Dementia Complex
| Article | Year |
|---|---|
Is AIDS dementia due to increases in calcium?
Topics: AIDS Dementia Complex; Animals; Calcium; Hippocampus; HIV Envelope Protein gp120; Humans; Neurons; N | 1990 |