Page last updated: 2024-11-01

nimesulide and Pyrexia

nimesulide has been researched along with Pyrexia in 25 studies

nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)."9.09Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999)
"The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever."9.07A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993)
"Intraperitoneal indomethacin at 10 mg kg(-1) attenuated both phases of intravenous LPS (2 microg kg(-1)) fever, but the first more so than the second; at 50 mg kg(-1), it inhibited the febrile response completely."7.71Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs. ( Blatteis, CM; Li, S; Llanos-Q, J; Steiner, AA, 2001)
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)."5.09Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999)
"The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever."5.07A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993)
"A double-blind, multi-centre study was carried out in 42 hospitalized children, aged 6 months to 8 years, suffering from acute respiratory tract infections with fever, to investigate the antipyretic activity of nimesulide."5.07Antipyretic effects of nimesulide in paediatric practice: a double-blind study. ( Lecomte, J; Monti, T; Pochobradsky, MG, 1991)
"Intraperitoneal indomethacin at 10 mg kg(-1) attenuated both phases of intravenous LPS (2 microg kg(-1)) fever, but the first more so than the second; at 50 mg kg(-1), it inhibited the febrile response completely."3.71Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs. ( Blatteis, CM; Li, S; Llanos-Q, J; Steiner, AA, 2001)
" Her mother ingested therapeutic doses of nimesulide, a non-steroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy."3.70Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use. ( Holcberg, G; Landau, D; Marks, K; Polacheck, H; Shelef, I, 1999)
"The present experiment was designed to determine a dosage regimen (dose, interval of administration) in the dog for nimesulide, a nonsteroidal anti-inflammatory drug with in vitro selectivity for the inhibition of cyclo-oxygenase 2 (Cox-2), using a pharmacokinetic/pharmacodynamic (PK/PD) approach."2.70A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog. ( Cester, CC; Haak, T; Laroute, V; Toutain, PL, 2001)
"Nimesulide was studied in comparison with paracetamol, according to a double-blind technique."2.67Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories. ( D'Apuzzo, V; Monti, T, 1992)
"Fever is an important symptom of underlying disease condition and in general is considered harmful in pediatric age group as it may lead to febrile seizures, stupor, dehydration increase work of breathing, discomfort and tachycardia."2.41Antipyretics in children. ( Bhatnagar, SK; Chandra, J, 2002)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's13 (52.00)18.2507
2000's11 (44.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guo, SX1
Cheng, Y1
Locham, KK1
Sodhi, M1
Jindal, G1
Dogan, MD1
Ataoglu, H1
Akarsu, ES1
Amdekar, YK1
Khubchandani, RP1
Werner, MF1
Souza, GE1
Zampronio, AR1
Reiner, M1
Massera, E1
Magni, E1
Cunietti, E2
Monti, M2
Viganò, A2
D'Aprile, E2
Saligari, A2
Scafuro, E2
Scaricabarozzi, I3
Polidori, G1
Titti, G1
Pieragostini, P1
Comito, A1
Tognella, S1
Taniguchi, Y1
Yokoyama, K1
Inui, K1
Deguchi, Y1
Furukawa, K1
Noda, K1
Rajeshwari, K1
Dubey, AP1
Goyal, PK1
Chandra, J2
Unnikrishnan, G1
Kumari, S1
Passah, SM1
Raghavendra, V1
Agrewala, JN1
Kulkarni, SK1
Ulukol, B1
Köksal, Y1
Cin, S1
Landau, D1
Shelef, I1
Polacheck, H1
Marks, K1
Holcberg, G1
Lal, A1
Gomber, S1
Talukdar, B1
Toutain, PL1
Cester, CC1
Haak, T1
Laroute, V1
Sharma, S1
Bhatnagar, SK1
Steiner, AA1
Li, S1
Llanos-Q, J1
Blatteis, CM1
Kapoor, SK1
Sharma, J1
Batra, B1
Paul, E1
Anand, K1
Sharma, D1
Tanaka, K1
Shimotori, T1
Makino, S1
Aikawa, Y1
Inaba, T1
Yoshida, C1
Takano, S1
D'Apuzzo, V1
Monti, T2
Lecomte, J1
Pochobradsky, MG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]11,976 participants (Actual)Interventional2016-03-23Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm189
Placebo Arm230

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

- Birth weight <2500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm1078
Placebo Arm1153

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

- Birth weight <1500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm78
Placebo Arm101

Fetal Outcome 4 - Incidence of Fetal Loss

- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm303
Placebo Arm353

Fetal Outcome 5 - Incidence of Spontaneous Abortion

- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm134
Placebo Arm152

Fetal Outcome 6 - Incidence of All Stillbirth

- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm141
Placebo Arm166

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm42
Placebo Arm30

Incidence of Hypertensive Disorders of Pregnancy

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

InterventionParticipants (Count of Participants)
Intervention Arm352
Placebo Arm325

Incidence of Perinatal Mortality

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm264
Placebo Arm309

Incidence of Preterm Birth

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm668
Placebo Arm754

Incidence of Small for Gestational Age (SGA)

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm1506
Placebo Arm1564

Maternal Outcome 1 - Incidence of Vaginal Bleeding

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm214
Placebo Arm246

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm26
Placebo Arm25

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm54
Placebo Arm43

Maternal Outcome 4 - Incidence of Maternal Mortality

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm9
Placebo Arm12

Maternal Outcome 5 - Incidence of Late Abortion

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm23
Placebo Arm30

Maternal Outcome 6 - Change in Maternal Hemoglobin

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

InterventionParticipants (Count of Participants)
Intervention Arm290
Placebo Arm333

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm8
Placebo Arm21

Reviews

3 reviews available for nimesulide and Pyrexia

ArticleYear
[Research advance on pediatric antipyretic].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2008, Volume: 10, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Fever; Humans; Ibuprofen; Sulfonamides

2008
Nimesulide.
    Indian pediatrics, 1997, Volume: 34, Issue:2

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; Pharmacokinetics; Sulfon

1997
Antipyretics in children.
    Indian journal of pediatrics, 2002, Volume: 69, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Child; Cyclooxygenase Inhibitors; Fever; Humans; I

2002

Trials

11 trials available for nimesulide and Pyrexia

ArticleYear
Nimesulide in the treatment of fever: a double-blind, crossover clinical trial.
    The Journal of international medical research, 1984, Volume: 12, Issue:2

    Topics: Adult; Aged; Aspirin; Body Temperature; Clinical Trials as Topic; Dipyrone; Double-Blind Method; Fem

1984
A comparison of nimesulide vs paracetamol in the treatment of pyrexia in the elderly.
    Drugs, 1993, Volume: 46 Suppl 1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method

1993
A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children.
    Drugs, 1993, Volume: 46 Suppl 1

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Fever; Huma

1993
Nimesulide in the treatment of hyperpyrexia in the aged. Double-blind comparison with paracetamol.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:2

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Bod

1993
Double blind randomized comparative evaluation of nimesulide and paracetamol as antipyretics.
    Indian pediatrics, 1998, Volume: 35, Issue:6

    Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Ax

1998
Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections.
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:9

    Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Infla

1999
Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol.
    Indian journal of pediatrics, 2000, Volume: 67, Issue:12

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Double-Blind Method; Drug

2000
A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog.
    Journal of veterinary pharmacology and therapeutics, 2001, Volume: 24, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cross-Over Studie

2001
Comparison of antipyretic effect of nimesulide and paracetamol in children attending a secondary level hospital.
    Indian pediatrics, 2002, Volume: 39, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

2002
Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories.
    Drugs under experimental and clinical research, 1992, Volume: 18, Issue:2

    Topics: Acetaminophen; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschoo

1992
Antipyretic effects of nimesulide in paediatric practice: a double-blind study.
    Current medical research and opinion, 1991, Volume: 12, Issue:5

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Double-Blind Method

1991

Other Studies

11 other studies available for nimesulide and Pyrexia

ArticleYear
Antipyretic effect of nimesulide and paracetamol in children.
    Indian pediatrics, 2002, Volume: 39, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Huma

2002
Nimesulide and diclofenac inhibit lipopolysaccharide-induced hypothermia and tumour necrosis factor-alpha elevation in rats.
    Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:4

    Topics: Analysis of Variance; Animals; Body Temperature Regulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhib

2002
Nimesulide vs. paracetamol: this trial needs to stand trial.
    Indian pediatrics, 2003, Volume: 40, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Hosp

2003
Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms.
    European journal of pharmacology, 2006, Aug-14, Volume: 543, Issue:1-3

    Topics: Analgesics, Non-Narcotic; Animals; Arachidonic Acid; Body Temperature; Chemokine CCL3; Chemokine CCL

2006
Nimesulide. New clinical opportunities.
    Drugs, 1993, Volume: 46 Suppl 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Inflammation; Pain; Platelet Aggregation; Su

1993
Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide.
    European journal of pharmacology, 1997, Jul-09, Volume: 330, Issue:2-3

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain;

1997
Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adipsia.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase Inhibitors; Dinop

1999
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.
    American journal of perinatology, 1999, Volume: 16, Issue:9

    Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Cough; Female; Feve

1999
Hypothermia with nimesulide.
    Indian pediatrics, 2001, Volume: 38, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Fever; Humans; Hypothermia; India

2001
Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs.
    Neuroimmunomodulation, 2001, Volume: 9, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cycl

2001
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzopyrans; Dogs; Edema;

1992