nimesulide has been researched along with Pyrexia in 25 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Excerpt | Relevance | Reference |
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"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)." | 9.09 | Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999) |
"The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever." | 9.07 | A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993) |
"Intraperitoneal indomethacin at 10 mg kg(-1) attenuated both phases of intravenous LPS (2 microg kg(-1)) fever, but the first more so than the second; at 50 mg kg(-1), it inhibited the febrile response completely." | 7.71 | Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs. ( Blatteis, CM; Li, S; Llanos-Q, J; Steiner, AA, 2001) |
"The aim of this study was to assess and compare the efficacy and tolerability of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections (URTIs)." | 5.09 | Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections. ( Cin, S; Köksal, Y; Ulukol, B, 1999) |
"The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever." | 5.07 | A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children. ( Comito, A; Pieragostini, P; Polidori, G; Scaricabarozzi, I; Titti, G, 1993) |
"A double-blind, multi-centre study was carried out in 42 hospitalized children, aged 6 months to 8 years, suffering from acute respiratory tract infections with fever, to investigate the antipyretic activity of nimesulide." | 5.07 | Antipyretic effects of nimesulide in paediatric practice: a double-blind study. ( Lecomte, J; Monti, T; Pochobradsky, MG, 1991) |
"Intraperitoneal indomethacin at 10 mg kg(-1) attenuated both phases of intravenous LPS (2 microg kg(-1)) fever, but the first more so than the second; at 50 mg kg(-1), it inhibited the febrile response completely." | 3.71 | Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs. ( Blatteis, CM; Li, S; Llanos-Q, J; Steiner, AA, 2001) |
" Her mother ingested therapeutic doses of nimesulide, a non-steroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy." | 3.70 | Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use. ( Holcberg, G; Landau, D; Marks, K; Polacheck, H; Shelef, I, 1999) |
"The present experiment was designed to determine a dosage regimen (dose, interval of administration) in the dog for nimesulide, a nonsteroidal anti-inflammatory drug with in vitro selectivity for the inhibition of cyclo-oxygenase 2 (Cox-2), using a pharmacokinetic/pharmacodynamic (PK/PD) approach." | 2.70 | A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog. ( Cester, CC; Haak, T; Laroute, V; Toutain, PL, 2001) |
"Nimesulide was studied in comparison with paracetamol, according to a double-blind technique." | 2.67 | Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories. ( D'Apuzzo, V; Monti, T, 1992) |
"Fever is an important symptom of underlying disease condition and in general is considered harmful in pediatric age group as it may lead to febrile seizures, stupor, dehydration increase work of breathing, discomfort and tachycardia." | 2.41 | Antipyretics in children. ( Bhatnagar, SK; Chandra, J, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (4.00) | 18.7374 |
1990's | 13 (52.00) | 18.2507 |
2000's | 11 (44.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Guo, SX | 1 |
Cheng, Y | 1 |
Locham, KK | 1 |
Sodhi, M | 1 |
Jindal, G | 1 |
Dogan, MD | 1 |
Ataoglu, H | 1 |
Akarsu, ES | 1 |
Amdekar, YK | 1 |
Khubchandani, RP | 1 |
Werner, MF | 1 |
Souza, GE | 1 |
Zampronio, AR | 1 |
Reiner, M | 1 |
Massera, E | 1 |
Magni, E | 1 |
Cunietti, E | 2 |
Monti, M | 2 |
Viganò, A | 2 |
D'Aprile, E | 2 |
Saligari, A | 2 |
Scafuro, E | 2 |
Scaricabarozzi, I | 3 |
Polidori, G | 1 |
Titti, G | 1 |
Pieragostini, P | 1 |
Comito, A | 1 |
Tognella, S | 1 |
Taniguchi, Y | 1 |
Yokoyama, K | 1 |
Inui, K | 1 |
Deguchi, Y | 1 |
Furukawa, K | 1 |
Noda, K | 1 |
Rajeshwari, K | 1 |
Dubey, AP | 1 |
Goyal, PK | 1 |
Chandra, J | 2 |
Unnikrishnan, G | 1 |
Kumari, S | 1 |
Passah, SM | 1 |
Raghavendra, V | 1 |
Agrewala, JN | 1 |
Kulkarni, SK | 1 |
Ulukol, B | 1 |
Köksal, Y | 1 |
Cin, S | 1 |
Landau, D | 1 |
Shelef, I | 1 |
Polacheck, H | 1 |
Marks, K | 1 |
Holcberg, G | 1 |
Lal, A | 1 |
Gomber, S | 1 |
Talukdar, B | 1 |
Toutain, PL | 1 |
Cester, CC | 1 |
Haak, T | 1 |
Laroute, V | 1 |
Sharma, S | 1 |
Bhatnagar, SK | 1 |
Steiner, AA | 1 |
Li, S | 1 |
Llanos-Q, J | 1 |
Blatteis, CM | 1 |
Kapoor, SK | 1 |
Sharma, J | 1 |
Batra, B | 1 |
Paul, E | 1 |
Anand, K | 1 |
Sharma, D | 1 |
Tanaka, K | 1 |
Shimotori, T | 1 |
Makino, S | 1 |
Aikawa, Y | 1 |
Inaba, T | 1 |
Yoshida, C | 1 |
Takano, S | 1 |
D'Apuzzo, V | 1 |
Monti, T | 2 |
Lecomte, J | 1 |
Pochobradsky, MG | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 189 |
Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 1078 |
Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 78 |
Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 303 |
Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 134 |
Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 141 |
Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 42 |
Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 352 |
Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 264 |
Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 668 |
Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 1506 |
Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 214 |
Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 26 |
Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 54 |
Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 9 |
Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 23 |
Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 290 |
Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 8 |
Placebo Arm | 21 |
3 reviews available for nimesulide and Pyrexia
Article | Year |
---|---|
[Research advance on pediatric antipyretic].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Fever; Humans; Ibuprofen; Sulfonamides | 2008 |
Nimesulide.
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; Pharmacokinetics; Sulfon | 1997 |
Antipyretics in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Child; Cyclooxygenase Inhibitors; Fever; Humans; I | 2002 |
11 trials available for nimesulide and Pyrexia
Article | Year |
---|---|
Nimesulide in the treatment of fever: a double-blind, crossover clinical trial.
Topics: Adult; Aged; Aspirin; Body Temperature; Clinical Trials as Topic; Dipyrone; Double-Blind Method; Fem | 1984 |
A comparison of nimesulide vs paracetamol in the treatment of pyrexia in the elderly.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method | 1993 |
A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Fever; Huma | 1993 |
Nimesulide in the treatment of hyperpyrexia in the aged. Double-blind comparison with paracetamol.
Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Bod | 1993 |
Double blind randomized comparative evaluation of nimesulide and paracetamol as antipyretics.
Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Ax | 1998 |
Assessment of the efficacy and safety of paracetamol, ibuprofen and nimesulide in children with upper respiratory tract infections.
Topics: Acetaminophen; Acute Disease; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Infla | 1999 |
Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Double-Blind Method; Drug | 2000 |
A pharmacokinetic/pharmacodynamic approach vs. a dose titration for the determination of a dosage regimen: the case of nimesulide, a Cox-2 selective nonsteroidal anti-inflammatory drug in the dog.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cross-Over Studie | 2001 |
Comparison of antipyretic effect of nimesulide and paracetamol in children attending a secondary level hospital.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres | 2002 |
Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories.
Topics: Acetaminophen; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschoo | 1992 |
Antipyretic effects of nimesulide in paediatric practice: a double-blind study.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Double-Blind Method | 1991 |
11 other studies available for nimesulide and Pyrexia
Article | Year |
---|---|
Antipyretic effect of nimesulide and paracetamol in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Huma | 2002 |
Nimesulide and diclofenac inhibit lipopolysaccharide-induced hypothermia and tumour necrosis factor-alpha elevation in rats.
Topics: Analysis of Variance; Animals; Body Temperature Regulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2002 |
Nimesulide vs. paracetamol: this trial needs to stand trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Hosp | 2003 |
Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms.
Topics: Analgesics, Non-Narcotic; Animals; Arachidonic Acid; Body Temperature; Chemokine CCL3; Chemokine CCL | 2006 |
Nimesulide. New clinical opportunities.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Inflammation; Pain; Platelet Aggregation; Su | 1993 |
Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Brain; | 1997 |
Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adipsia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase Inhibitors; Dinop | 1999 |
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Cough; Female; Feve | 1999 |
Hypothermia with nimesulide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Fever; Humans; Hypothermia; India | 2001 |
Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cycl | 2001 |
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzopyrans; Dogs; Edema; | 1992 |