nimesulide has been researched along with Pregnancy in 51 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Exposure to nimesulide during the first trimester of pregnancy, and congenital malformations detected at presentation and within 90 days after birth (outcome), were investigated." | 7.88 | Use of Nimesulide During Early Pregnancy and the Risk of Congenital Malformations: A Population-Based Study from Italy. ( Cantarutti, A; Corrao, G; Franchi, M; Merlino, L; Rea, F, 2018) |
| " In this report, we describe the case of a pregnant woman who developed oligohydramnios after taking nimesulide for neuropathic pain." | 7.83 | Lack of pharmacist-physician communication associated with nimesulide-induced oligohydramnios during pregnancy. ( Grincevičienė, Š; Grincevičius, J; Volochovič, J, 2016) |
| " This case report shows a pregnancy with anhydramnios and maternal thrombocytopenia, as side effects of the nimesulide therapy." | 7.72 | Anhydramnios and maternal thrombocytopenia after prolonged use of nimesulide. ( Bracciante, R; Manganelli, F; Paternoster, DM; Snijders, D; Torrisi, A, 2003) |
| "Nimesulide was prescribed for postoperative preterm labor prophylaxis." | 5.31 | Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide. ( Holmes, RP; Stone, PR, 2000) |
| " Exposure to nimesulide during the first trimester of pregnancy, and congenital malformations detected at presentation and within 90 days after birth (outcome), were investigated." | 3.88 | Use of Nimesulide During Early Pregnancy and the Risk of Congenital Malformations: A Population-Based Study from Italy. ( Cantarutti, A; Corrao, G; Franchi, M; Merlino, L; Rea, F, 2018) |
| "We have combined histochemical, immunohistochemical, stereological, morphometric, behavioral, and litter analyses to investigate mouse pregnancy inoculated with LPS with or without pre-treatment with nimesulide 30 min before LPS injections, focusing on DBA(+) uNK cell response and viability of the pregnancy." | 3.83 | COX-2 plays a role in angiogenic DBA(+) uNK cell subsets activation and pregnancy protection in LPS-exposed mice. ( De Almeida, EM; do Amarante-Paffaro, AM; Paffaro, VA; Salles, Éda S; Zavan, B, 2016) |
| "In a term pregnancy, nimesulide administration can rapidly cause premature ductal constriction." | 3.74 | Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide. ( De Biasio, P; Marasini, M; Prefumo, F; Venturini, PL, 2008) |
| "Although the true incidence of the adverse effect of nimesulide ingestion during pregnancy cannot be deduced, we believe that patients and their clinicians should be alerted to the possibility that clinically significant ductal constriction may follow maternal self-medication with just one or two oral doses of nimesulide, at least if the drug is taken near term." | 3.73 | Severe ductal constriction in the third-trimester fetus following maternal self-medication with nimesulide. ( Marasini, M; Paladini, D; Volpe, P, 2005) |
| " This case report shows a pregnancy with anhydramnios and maternal thrombocytopenia, as side effects of the nimesulide therapy." | 3.72 | Anhydramnios and maternal thrombocytopenia after prolonged use of nimesulide. ( Bracciante, R; Manganelli, F; Paternoster, DM; Snijders, D; Torrisi, A, 2003) |
| "We report a case of neonatal transient renal failure after maternal ingestion of diclofenac, paracetamol, and nimesulide during pregnancy." | 3.72 | In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. ( Benini, D; Cuzzolin, L; Fanos, V; Tatò, L, 2004) |
| "We report pregnancy outcome and fetal side effects in women at high risk of second trimester loss and early preterm delivery treated with nimesulide." | 3.72 | Experience of the use of nimesulide, a cyclo-oxygenase-2 selective prostaglandin synthesis inhibitor, in the prevention of preterm labour in 44 high-risk cases. ( Bennett, PR; Groom, KM; Sawdy, RJ, 2004) |
| "Our goal was to test the hypothesis that the previously demonstrated progesterone-independent prolongation of pregnancy in rats treated with cervical application of the cyclooxygenase 2 inhibitor nimesulide is the result of inhibition of cervical ripening." | 3.71 | Inhibition of cervical ripening by local application of cyclooxygenase 2 inhibitor. ( Bukowski, R; Fittkow, C; Garfield, RE; Mackay, L; Saade, GR; Shi, L, 2001) |
| "To investigate the effect of cervical application of nonselective and selective inhibitors of nitric oxide synthases--N-nitro-L-arginine methyl ester, L-N-iminoethyl-lysine, and aminoguanidine--as well as inhibitors of cyclooxygenases--indomethacin, and nimesulide--on timing of delivery and fetal death and disease in pregnant rats." | 3.71 | The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. ( Bukowski, R; Garfield, RE; McKay, L; Saade, GR; Shi, SQ, 2001) |
| " Her mother ingested therapeutic doses of nimesulide, a non-steroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy." | 3.70 | Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use. ( Holcberg, G; Landau, D; Marks, K; Polacheck, H; Shelef, I, 1999) |
| "Pretreatment with nimesulide (10 mg iv, n = 6), a specific inhibitor of PGHS-2, significantly reduced the HPA axis response to NMDA." | 1.36 | Interaction of PGHS-2 and glutamatergic mechanisms controlling the ovine fetal hypothalamus-pituitary-adrenal axis. ( Knutson, N; Wood, CE, 2010) |
| "We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy." | 1.33 | Renal tubular dysgenesis associated with in utero exposure to Nimuselide. ( Ali, US; Andankar, P; Dubhalish, V; Khubchandani, S; Padhye, B; Parekhji, S, 2006) |
| "Premature labor was induced in ewes with long-term catheterized fetuses by infusion of dexamethasone (1 mg/d) starting at 138 +/- 1 days' gestation." | 1.31 | Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist. ( Grigsby, PL; Hirst, JJ; Jenkin, G; Poore, KR, 2000) |
| "Nimesulide was prescribed for postoperative preterm labor prophylaxis." | 1.31 | Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide. ( Holmes, RP; Stone, PR, 2000) |
| "Nimesulide therapy was continued for eight days (5-16) and was associated with a prolongation of pregnancy of 27 days (6-69)." | 1.31 | Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin? ( Bellini, P; Ghidini, A; Locatelli, A; Strobelt, N; Vergani, P, 2001) |
| "The occurrence of chronic renal failure in strict relationship with maternal nimesulide assumption in this case is strongly suggestive for a pharmacological damage, either direct or mediated by renin angiotensin inhibition, and possibly modulated by genetic factors, likely to account for the different outcome of similarly treated patients." | 1.31 | [Neonatal chronic kidney failure associated with cyclo-oxygenase-2 inhibitors administered during pregnancy]. ( Amore, A; Conti, G; Coppo, R; Gianoglio, B; Peruzzi, L; Porcellini, G, 2001) |
| "In nimesulide-treated ewes, maternal plasma PGE2 and ACTH concentrations remained unchanged, while maternal plasma cortisol decreased significantly, recovering to baseline by 3 h." | 1.30 | Prostaglandin regulation of fetal plasma adrenocorticotropin and cortisol concentrations in late-gestation sheep. ( Bennett, PR; Nathanielsz, PW; Shinozuka, N; Unno, N; Wong, CH; Wu, WX, 1998) |
| "In 2 nimesulide-treated ewes labor did not progress to delivery despite membrane rupture." | 1.30 | Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep. ( Hirst, JJ; Poore, KR; Young, IR, 1999) |
| "Nimesulide was effective in antagonizing alcohol-induced preterm labor." | 1.30 | Progesterone and prostaglandin H synthase-2 involvement in alcohol-induced preterm birth in mice. ( Cook, JL; Olson, DM; Randall, CL; White, NM; Zaragoza, DB, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (17.65) | 18.2507 |
| 2000's | 36 (70.59) | 29.6817 |
| 2010's | 6 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cantarutti, A | 1 |
| Franchi, M | 1 |
| Rea, F | 1 |
| Merlino, L | 1 |
| Corrao, G | 1 |
| Grincevičienė, Š | 1 |
| Volochovič, J | 1 |
| Grincevičius, J | 1 |
| Zavan, B | 1 |
| De Almeida, EM | 1 |
| Salles, Éda S | 1 |
| do Amarante-Paffaro, AM | 1 |
| Paffaro, VA | 1 |
| Knutson, N | 1 |
| Wood, CE | 4 |
| Silva, LA | 1 |
| Veira-Filho, LD | 1 |
| Barreto, IS | 1 |
| Cabral, EV | 1 |
| Vieyra, A | 1 |
| Paixão, AD | 1 |
| Westover, AJ | 1 |
| Hooper, SB | 1 |
| Wallace, MJ | 1 |
| Moss, TJ | 1 |
| Simbi, KA | 1 |
| Secchieri, S | 1 |
| Rinaldo, M | 1 |
| Demi, M | 1 |
| Zanardo, V | 1 |
| Paternoster, DM | 1 |
| Snijders, D | 1 |
| Manganelli, F | 1 |
| Torrisi, A | 1 |
| Bracciante, R | 1 |
| Sawdy, RJ | 3 |
| Lye, S | 1 |
| Fisk, NM | 1 |
| Bennett, PR | 6 |
| Sullivan, MH | 1 |
| Wu, WX | 3 |
| Ma, XH | 2 |
| Zhang, Q | 1 |
| Chakrabarty, K | 1 |
| Nathanielsz, PW | 3 |
| Sawdy, R | 3 |
| Pan, H | 1 |
| Sullivan, M | 1 |
| Bennett, P | 2 |
| Loudon, JA | 1 |
| Groom, KM | 2 |
| Benini, D | 1 |
| Fanos, V | 1 |
| Cuzzolin, L | 1 |
| Tatò, L | 1 |
| Shafiq, N | 1 |
| Malhotra, S | 1 |
| Pandhi, P | 1 |
| Karadas, B | 1 |
| Kaya, T | 1 |
| Guvenal, T | 1 |
| Cetin, M | 1 |
| Divrik, I | 1 |
| Cetin, A | 1 |
| Ribeiro, M | 1 |
| Cella, M | 1 |
| Farina, M | 1 |
| Franchi, A | 1 |
| Magnani, C | 1 |
| Moretti, S | 1 |
| Ammenti, A | 1 |
| Di Stefano, L | 1 |
| Di Berardino, C | 1 |
| Marsili, L | 1 |
| Coppola, G | 1 |
| Patacchiola, F | 1 |
| Mascaretti, G | 1 |
| Paladini, D | 1 |
| Marasini, M | 2 |
| Volpe, P | 1 |
| Reimsnider, SK | 1 |
| Sciacca, P | 1 |
| Romeo, MG | 1 |
| Falsaperla, R | 1 |
| Mattia, C | 1 |
| Betta, P | 1 |
| Tornambene, G | 1 |
| Distefano, G | 1 |
| Ali, US | 1 |
| Khubchandani, S | 1 |
| Andankar, P | 1 |
| Parekhji, S | 1 |
| Dubhalish, V | 1 |
| Padhye, B | 1 |
| Cong, J | 2 |
| Diao, HL | 2 |
| Zhao, YC | 1 |
| Ni, H | 1 |
| Yan, YQ | 1 |
| Yang, ZM | 2 |
| Reimsnider, S | 1 |
| Favrais, G | 1 |
| Schwendimann, L | 1 |
| Gressens, P | 1 |
| Lelièvre, V | 1 |
| Manganaro, M | 1 |
| Papoff, P | 1 |
| Cicchetti, R | 1 |
| Caresta, E | 1 |
| Moretti, C | 1 |
| Zhu, H | 1 |
| Ma, H | 1 |
| Tan, HN | 1 |
| Su, RW | 1 |
| Gersting, J | 1 |
| Schaub, CE | 1 |
| Keller-Wood, M | 1 |
| Prefumo, F | 1 |
| De Biasio, P | 1 |
| Venturini, PL | 1 |
| Vago, T | 1 |
| Bevilacqua, M | 1 |
| Norbiato, G | 1 |
| Slater, D | 1 |
| Fisk, N | 1 |
| Edmonds, DK | 1 |
| Unno, N | 2 |
| Wong, CH | 1 |
| Shinozuka, N | 1 |
| Knock, GA | 1 |
| Poston, L | 1 |
| Aaronson, PI | 1 |
| Poore, KR | 2 |
| Young, IR | 1 |
| Hirst, JJ | 2 |
| Peruzzi, L | 2 |
| Gianoglio, B | 2 |
| Porcellini, MG | 1 |
| Coppo, R | 2 |
| Cook, JL | 1 |
| Zaragoza, DB | 1 |
| White, NM | 1 |
| Randall, CL | 1 |
| Olson, DM | 1 |
| Krämer, BK | 1 |
| Balasubramaniam, J | 2 |
| Landau, D | 1 |
| Shelef, I | 1 |
| Polacheck, H | 1 |
| Marks, K | 1 |
| Holcberg, G | 1 |
| Grigsby, PL | 1 |
| Jenkin, G | 1 |
| Holmes, RP | 1 |
| Stone, PR | 1 |
| Pérez-Moreno, J | 1 |
| Llerena Guerrero, RM | 1 |
| Puertas Montenegro, M | 1 |
| Jiménez Arjona, MJ | 1 |
| Locatelli, A | 1 |
| Vergani, P | 1 |
| Bellini, P | 1 |
| Strobelt, N | 1 |
| Ghidini, A | 1 |
| Bukowski, R | 2 |
| Mackay, L | 1 |
| Fittkow, C | 1 |
| Shi, L | 1 |
| Saade, GR | 2 |
| Garfield, RE | 2 |
| Porcellini, G | 1 |
| Conti, G | 1 |
| Amore, A | 1 |
| Slattery, MM | 1 |
| Friel, AM | 1 |
| Healy, DG | 1 |
| Morrison, JJ | 1 |
| McKay, L | 1 |
| Shi, SQ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728] | Phase 3 | 19 participants (Actual) | Interventional | 2013-01-01 | Completed | ||
| Investigation of Ibuprofen in the Delay of Ovulation in NC-IVF (Natural Cycle in Vitro Fertilisation) Therapy With the Objective of Reducing Premature Ovulation and Thus Improving Effectivity (Off Label Use)[NCT02571543] | Phase 2 | 68 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 189 |
| Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1078 |
| Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 78 |
| Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 303 |
| Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 134 |
| Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 141 |
| Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 42 |
| Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 352 |
| Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 264 |
| Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 668 |
| Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1506 |
| Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 214 |
| Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 26 |
| Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 54 |
| Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 9 |
| Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 23 |
| Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 290 |
| Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 8 |
| Placebo Arm | 21 |
1 review available for nimesulide and Pregnancy
| Article | Year |
|---|---|
Prostaglandin inhibitors in preterm labour.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Cyclooxygenase 2; Ductus Arteriosus; Enzyme I | 2003 |
2 trials available for nimesulide and Pregnancy
| Article | Year |
|---|---|
A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor.
Topics: Adult; Amniotic Fluid; Diuresis; Double-Blind Method; Drug Administration Schedule; Ductus Arteriosu | 2003 |
Uterine relaxant effects of cyclooxygenase-2 inhibitors in vitro.
Topics: Adult; Celecoxib; Cesarean Section; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase In | 2001 |
48 other studies available for nimesulide and Pregnancy
| Article | Year |
|---|---|
Use of Nimesulide During Early Pregnancy and the Risk of Congenital Malformations: A Population-Based Study from Italy.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Utilization; Femal | 2018 |
Lack of pharmacist-physician communication associated with nimesulide-induced oligohydramnios during pregnancy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Communication; Female; Humans; Interprofessional Rel | 2016 |
COX-2 plays a role in angiogenic DBA(+) uNK cell subsets activation and pregnancy protection in LPS-exposed mice.
Topics: Actins; Animals; Body Weight; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Embryo Implantation; Fema | 2016 |
Interaction of PGHS-2 and glutamatergic mechanisms controlling the ovine fetal hypothalamus-pituitary-adrenal axis.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; D-Aspartic Acid; Female; Fetus; Hydrocortisone; Hypotha | 2010 |
Prenatal undernutrition changes renovascular responses of nimesulide in rat kidneys.
Topics: Animals; Blood Pressure; Brazil; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Glomerular F | 2011 |
Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation.
Topics: Amniotic Fluid; Animals; Chorioamnionitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprosto | 2012 |
In utero ductal closure following near-term maternal self-medication with nimesulide and acetaminophen.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Cesarean Section | 2002 |
Anhydramnios and maternal thrombocytopenia after prolonged use of nimesulide.
Topics: Adult; Cyclooxygenase Inhibitors; Female; Gestational Age; Humans; Obstetric Labor, Premature; Oligo | 2003 |
The effects of non-steroidal anti-inflammatory compounds on human myometrial contractility.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cycloo | 2003 |
Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium.
Topics: Amino Acid Sequence; Animals; Betamethasone; Cyclooxygenase Inhibitors; DNA-Binding Proteins; Estrad | 2003 |
Effect of selective vs. non-selective cyclo-oxygenase inhibitors on fetal membrane prostaglandin synthesis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cycloox | 2003 |
In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fema | 2004 |
Comparison of nonselective cyclo-oxygenase (COX) inhibitor and selective COX-2 inhibitors on preimplantation loss, postimplantation loss and duration of gestation: an experimental study.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Embryonic Development; Female; Gestational Age; Indom | 2004 |
Comparison of the effects of nimesulide and 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone (DFU) on contractions of isolated pregnant human myometrium.
Topics: Adult; Cesarean Section; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; D | 2004 |
Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinopr | 2004 |
Experience of the use of nimesulide, a cyclo-oxygenase-2 selective prostaglandin synthesis inhibitor, in the prevention of preterm labour in 44 high-risk cases.
Topics: Adult; Cervix Uteri; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Ob | 2004 |
Neonatal chronic renal failure associated with maternal ingestion of Nimesulide as analgesic.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Female; Humans; Infant; I | 2004 |
Venous thromboembolism in pregnancy. A case report of deep venous thrombosis (DVT) in puerperium.
Topics: Adult; Anticoagulants; Betamethasone; Female; Femoral Vein; Glucocorticoids; Heparin, Low-Molecular- | 2004 |
Severe ductal constriction in the third-trimester fetus following maternal self-medication with nimesulide.
Topics: Administration, Oral; Constriction, Pathologic; Cyclooxygenase Inhibitors; Delivery, Obstetric; Duct | 2005 |
Does reduction of circulating prostaglandin E2 reduce fetal hypothalamic-pituitary-adrenal axis activity?
Topics: Adrenocorticotropic Hormone; Animals; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Fe | 2005 |
[Transient right ventricular hypertrophy in a newborn infant exposed in utero to nimesulide].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ductus Arteriosus; Female; Follo | 2005 |
Renal tubular dysgenesis associated with in utero exposure to Nimuselide.
Topics: Abnormalities, Drug-Induced; Cyclooxygenase Inhibitors; Female; Humans; Infant, Newborn; Kidney Tubu | 2006 |
Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Embryo Implantation; Embryo | 2006 |
Differential modulation of ovine fetal ACTH secretion by PGHS-1 and PGHS-2.
Topics: Adrenocorticotropic Hormone; Animals; Blood Gas Analysis; Blood Pressure; Brain; Cyclooxygenase 1; C | 2006 |
Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice.
Topics: Animals; Animals, Newborn; Brain; Cerebral Palsy; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinop | 2007 |
Hypoglycaemia in an infant with severe pulmonary hypertension after prenatal exposure to nimesulide: coincidence or side effect?
Topics: Cyclooxygenase Inhibitors; Female; Humans; Hypertension, Pulmonary; Hypoglycemia; Infant, Newborn; P | 2007 |
Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Decidua; Embryo Implantation; Female; Immunohi | 2007 |
Inhibition of brain prostaglandin endoperoxide synthase-2 prevents the preparturient increase in fetal adrenocorticotropin secretion in the sheep fetus.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; | 2008 |
Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide.
Topics: Acute Disease; Adult; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Ductus Arteriosus; Fema | 2008 |
Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Female; In Vitro Techni | 1995 |
Use of a cyclo-oxygenase type-2-selective non-steroidal anti-inflammatory agent to prevent preterm delivery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 1997 |
Prostaglandin regulation of fetal plasma adrenocorticotropin and cortisol concentrations in late-gestation sheep.
Topics: Adrenocorticotropic Hormone; Animals; Blood Gas Analysis; Dinoprostone; Female; Fetus; Hydrocortison | 1998 |
Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fem | 1998 |
Effect of nimesulide and indomethacin on contractility and the Ca2+ channel current in myometrial smooth muscle from pregnant women.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Calcium Channels; Cyclooxygenase | 1998 |
Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep.
Topics: Animals; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost; Dinoprostone; Electromyography; Female | 1999 |
Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic.
Topics: Adult; Cyclooxygenase Inhibitors; Female; Humans; Infant, Newborn; Kidney Failure, Chronic; Obstetri | 1999 |
Progesterone and prostaglandin H synthase-2 involvement in alcohol-induced preterm birth in mice.
Topics: Animals; Central Nervous System Depressants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 1999 |
Renal effects of cyclo-oxygenase-type-2 inhibition.
Topics: Cyclooxygenase Inhibitors; Female; Humans; Infant, Newborn; Kidney Failure, Chronic; Pregnancy; Sulf | 2000 |
Nimesulide and neonatal renal failure.
Topics: Adult; Cyclooxygenase Inhibitors; Female; Humans; Infant, Newborn; Male; Pregnancy; Renal Insufficie | 2000 |
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Cough; Female; Feve | 1999 |
Selective COX-2 inhibitors and nephrotoxicity.
Topics: Acute Kidney Injury; Animals; Cyclooxygenase Inhibitors; Female; Fetal Diseases; Humans; Kidney Fail | 2000 |
Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist.
Topics: Animals; Arteries; Blood Glucose; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost; Dinoprostone; | 2000 |
Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide.
Topics: Adult; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Iso | 2000 |
[Nimesulide toxic hepatitis in pregnancy].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Female; Huma | 2000 |
Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin?
Topics: Administration, Oral; Adult; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2001 |
Inhibition of cervical ripening by local application of cyclooxygenase 2 inhibitor.
Topics: Administration, Topical; Animals; Cervical Ripening; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2001 |
[Neonatal chronic kidney failure associated with cyclo-oxygenase-2 inhibitors administered during pregnancy].
Topics: Adult; Cyclooxygenase Inhibitors; Female; Humans; Infant, Newborn; Kidney Failure, Chronic; Pregnanc | 2001 |
The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats.
Topics: Administration, Topical; Animals; Cervical Ripening; Cervix Uteri; Cyclooxygenase Inhibitors; Delive | 2001 |